LOCUS       NM_015692               5983 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens C3 and PZP like alpha-2-macroglobulin domain
            containing 8 (CPAMD8), transcript variant 1, mRNA.
ACCESSION   NM_015692
VERSION     NM_015692.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5983)
  AUTHORS   Li,X., Sun,W., Xiao,X., Fang,L., Li,S., Liu,X. and Zhang,Q.
  TITLE     Biallelic variants in CPAMD8 are associated with primary open-angle
            glaucoma and primary angle-closure glaucoma
  JOURNAL   Br J Ophthalmol 106 (12), 1710-1715 (2022)
   PUBMED   34154991
  REMARK    GeneRIF: Biallelic variants in CPAMD8 are associated with primary
            open-angle glaucoma and primary angle-closure glaucoma.
REFERENCE   2  (bases 1 to 5983)
  AUTHORS   Bonet-Fernandez,J.M., Aroca-Aguilar,J.D., Corton,M., Ramirez,A.I.,
            Alexandre-Moreno,S., Garcia-Anton,M.T., Salazar,J.J.,
            Ferre-Fernandez,J.J., Atienzar-Aroca,R., Villaverde,C., Iancu,I.,
            Tamayo,A., Mendez-Hernandez,C.D., Morales-Fernandez,L., Rojas,B.,
            Ayuso,C., Coca-Prados,M., Martinez-de-la-Casa,J.M.,
            Garcia-Feijoo,J. and Escribano,J.
  TITLE     CPAMD8 loss-of-function underlies non-dominant congenital glaucoma
            with variable anterior segment dysgenesis and abnormal
            extracellular matrix
  JOURNAL   Hum Genet 139 (10), 1209-1231 (2020)
   PUBMED   32274568
  REMARK    GeneRIF: CPAMD8 loss-of-function underlies non-dominant congenital
            glaucoma with variable anterior segment dysgenesis and abnormal
            extracellular matrix.
REFERENCE   3  (bases 1 to 5983)
  AUTHORS   Siggs,O.M., Souzeau,E., Taranath,D.A., Dubowsky,A., Chappell,A.,
            Zhou,T., Javadiyan,S., Nicholl,J., Kearns,L.S., Staffieri,S.E.,
            Narita,A., Smith,J.E.H., Pater,J., Hewitt,A.W., Ruddle,J.B.,
            Elder,J.E., Mackey,D.A., Burdon,K.P. and Craig,J.E.
  TITLE     Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and
            Juvenile Open-Angle Glaucoma
  JOURNAL   Ophthalmology 127 (6), 758-766 (2020)
   PUBMED   32085876
  REMARK    GeneRIF: Biallelic CPAMD8 Variants Are a Frequent Cause of
            Childhood and Juvenile Open-Angle Glaucoma.
REFERENCE   4  (bases 1 to 5983)
  AUTHORS   Cheong,S.S., Hentschel,L., Davidson,A.E., Gerrelli,D., Davie,R.,
            Rizzo,R., Pontikos,N., Plagnol,V., Moore,A.T., Sowden,J.C.,
            Michaelides,M., Snead,M., Tuft,S.J. and Hardcastle,A.J.
  TITLE     Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive
            Anterior Segment Dysgenesis
  JOURNAL   Am J Hum Genet 99 (6), 1338-1352 (2016)
   PUBMED   27839872
  REMARK    GeneRIF: study delineates a unique form of recessive anterior
            segment dysgeneses (ASD) and defines a role for CPAMD8, a protein
            of unknown function, in anterior segment development, implying
            another pathway for the pathogenicity of ASD
REFERENCE   5  (bases 1 to 5983)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   6  (bases 1 to 5983)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5983)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum Mol Genet 18 (4), 767-778 (2009)
   PUBMED   19010793
REFERENCE   8  (bases 1 to 5983)
  AUTHORS   Li,Z.F., Wu,X.H. and Engvall,E.
  TITLE     Identification and characterization of CPAMD8, a novel member of
            the complement 3/alpha2-macroglobulin family with a C-terminal
            Kazal domain
  JOURNAL   Genomics 83 (6), 1083-1093 (2004)
   PUBMED   15177561
  REMARK    GeneRIF: a novel member of the complement 3/alpha(2)-macroglobulin
            (C3/alpha(2)M) family named CPAMD8 has been identified and
            characterized.
REFERENCE   9  (bases 1 to 5983)
  AUTHORS   Lambeir,A.M., Durinx,C., Proost,P., Van Damme,J., Scharpe,S. and De
            Meester,I.
  TITLE     Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of
            neuropeptides involved in pancreatic insulin secretion
  JOURNAL   FEBS Lett 507 (3), 327-330 (2001)
   PUBMED   11696365
  REMARK    Erratum:[FEBS Lett 2002 Feb 13;512(1-3):353]
REFERENCE   10 (bases 1 to 5983)
  AUTHORS   Felley,C.P., Qian,J.M., Mantey,S., Pradhan,T. and Jensen,R.T.
  TITLE     Chief cells possess a receptor with high affinity for PACAP and VIP
            that stimulates pepsinogen release
  JOURNAL   Am J Physiol 263 (6 Pt 1), G901-G907 (1992)
   PUBMED   1335692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC067854.1, BP302427.1,
            AY101765.1, AC020908.7, AC008737.11, BF726092.1 and AI670110.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_015692.4.
            
            Summary: This gene encodes a member of the protease inhibitor I39
            (alpha-2-macroglobulin) family of proteins. These proteins are
            important in innate and acquired immunity. The encoded protein is
            membrane-associated and proteolytically processed to generate two
            chains. Mutations in this gene cause a form of anterior segment
            dysgenesis, a developmental disorder of the eye. [provided by
            RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY101765.1, AB033109.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000443236.7/
                                                ENSP00000402505.3
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-926               BC067854.1         6-931
            927-1210            BP302427.1         133-416
            1211-1434           AY101765.1         1060-1283
            1435-1563           AC020908.7         60663-60791         c
            1564-3954           AY101765.1         1413-3803
            3955-4029           AC008737.11        230158-230232       c
            4030-5156           AY101765.1         3879-5005
            5157-5157           BF726092.1         133-133
            5158-5955           AY101765.1         5007-5804
            5956-5956           AI670110.1         36-36               c
            5957-5983           AY101765.1         5806-5832
FEATURES             Location/Qualifiers
     source          1..5983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..5983
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /note="C3 and PZP like alpha-2-macroglobulin domain
                     containing 8"
                     /db_xref="GeneID:27151"
                     /db_xref="HGNC:HGNC:23228"
                     /db_xref="MIM:608841"
     exon            1..260
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..5826
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /note="alpha-2 macroglobulin family protein VIP; C3 and
                     PZP-like alpha-2-macroglobulin domain-containing protein
                     8"
                     /codon_start=1
                     /product="C3 and PZP-like alpha-2-macroglobulin
                     domain-containing protein 8 precursor"
                     /protein_id="NP_056507.3"
                     /db_xref="CCDS:CCDS42519.2"
                     /db_xref="GeneID:27151"
                     /db_xref="HGNC:HGNC:23228"
                     /db_xref="MIM:608841"
                     /translation="MSGALLWPLLPLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAG
                     VEEVISVTIFNSPREVTVQAQLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKV
                     WGRGWQAEEGPLFHNQTSVTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVN
                     EKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKS
                     FEVQKYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYY
                     SHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFD
                     DSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDN
                     IYTSEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSP
                     SQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQR
                     SKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRE
                     NGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVY
                     LLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGIT
                     KDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTE
                     KRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSL
                     LKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKR
                     HVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHAD
                     RRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTR
                     FDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKIL
                     SWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFR
                     IWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGE
                     QNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERD
                     ASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQ
                     GGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYAL
                     TLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVE
                     MTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAG
                     GINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVT
                     YNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQE
                     YKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRV
                     LFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLA
                     RELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGS
                     DGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQ
                     DVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAP
                     QRHSGRVVGAHRPGLLSPVFVYSPAFQSGGEEGLWMSNTCTLR"
     exon            261..412
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            413..435
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            436..601
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            602..654
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            655..672
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            673..727
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            728..841
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            842..926
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1035
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1263
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1434
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1563
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1753
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1926
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2076
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2238
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2381
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2444
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2676
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2830
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2961
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3013
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3312
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3538
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3715
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3797
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..3954
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..4029
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..4195
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4282
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4419
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4575
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4638
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4639..4853
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4854..4941
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4942..5016
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5017..5122
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5123..5233
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5234..5443
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5444..5594
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5983
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5958..5963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /note="hexamer: AATACA"
     polyA_site      5983
                     /gene="CPAMD8"
                     /gene_synonym="ASGD8; K-CAP; VIP"
                     /note="major polyA site"
ORIGIN      
        1 agcttggccg ggcgcggagc ggggcgcatg gcgccgggcg cactgcgcgg gggctgcgaa
       61 caaagggccc ccggcggcgg cgcgaggacg gccgcgctcg gaccctggcc ctggcccagc
      121 cctggcccgg ccccctcccc aggcgcggcg ccccccagga gccgaaaaat gagcggcgcc
      181 ctgctctggc cgttgctccc gctcctgctc ctgctgctgt cggcgcggga cggcgtgcgc
      241 gccgcgcagc ctcaggcccc gggttacttg attgcagctc cctctgtttt tcgcgcgggc
      301 gtggaggaag tcatcagcgt gaccatcttt aactctccaa gggaagtcac ggtccaggct
      361 cagctggtgg cccagggtga gccggtggtg cagagccagg gagccatcct ggataaaggg
      421 acaatcaaac tcaaggtgcc cacgggcctc cggggccaag cgcttctgaa agtgtggggc
      481 cgcggctggc aggcggagga ggggcccctc tttcacaacc agacctcggt gaccgtggac
      541 ggccggggcg cttctgtatt catccagacg gacaagcctg tgtacagacc ccagcaccga
      601 gtgctcataa gcatcttcac cgtctctcca aatctgaggc ctgtcaacga gaagctggaa
      661 gcctacatcc tggacccccg aggctctcgg atgatagagt ggagacactt aaagccgttc
      721 tgctgcggca tcaccaacat gagcttcccc ttgtccgacc agcctgtgtt gggagaatgg
      781 ttcatttttg ttgaaatgca aggccacgcg tacaacaagt cttttgaagt tcagaagtat
      841 gtgttgccca agtttgagct tctgattgac ccgccccggt atatccaaga cctggacgcc
      901 tgtgagacag gcactgtgcg ggccaggtat acctttggga aacctgtggc tggtgcctta
      961 atgatcaaca tgactgttaa tggtgtaggg tactacagcc acgaggtggg acgccctgtc
     1021 ctcagaacaa ccaagatcct cggctcccgg gacttcgaca tctgcgtgag ggacatgatc
     1081 ccagcggacg tccctgagca cttccggggc agggtcagca tctgggccat ggtgaccagt
     1141 gtggacggga gccagcaggt cgcgttcgat gactccaccc ccgtgcagag gcagctggtg
     1201 gacatccggt actccaagga cacgaggaag cagttcaagc cgggcctggc ctacgtgggg
     1261 aaggtggagc tatcctaccc cgatggcagc ccagctgagg gggtgacggt ccagattaag
     1321 gcagagctga caccaaagga taacatctac accagtgaag ttgtgtccca gcgtggacta
     1381 gtggggtttg aaatcccctc catccccacg tcagcccagc acgtgtggct ggagaccaag
     1441 gtgatggcac tgaacgggaa gcctgtgggg gctcagtacc tgcccagcta cctctccctc
     1501 ggcagctggt actcccccag ccagtgctac ctgcagctgc agccaccctc ccacccactg
     1561 caggttgggg aagaagccta tttttctgtg aagtccacat gtccctgcaa ctttaccctg
     1621 tactacgagg tggctgcacg gggcaatatt gtgctatcgg gccagcagcc tgcccacacc
     1681 acccagcagc gaagcaagcg ggcggcccct gccctggaga aaccgattcg tttaacacac
     1741 ctttctgaga cagagccccc accagcccca gaagctgagg tcgacgtgtg tgtgacctct
     1801 cttcatctgg ccgtgacccc cagcatggtc ccccttggtc gcctgctggt cttctacgtc
     1861 agggagaatg gagaaggggt cgccgacagc cttcagtttg cagtcgagac cttcttcgaa
     1921 aaccaggttt cagtgacgta ttcagcaaat gagacccaac ctggggaggt tgtcgacctg
     1981 cggatcaggg ctgcaagggg cagctgtgtg tgcgtcgccg cagttgataa gagtgtctac
     2041 ctgctcaggt ctgggttccg gctgactcct gcccaggttt tccaggaact ggaagattat
     2101 gatgtttctg attcctttgg cgtgtccagg gaggatggtc ctttttggtg ggctgggctg
     2161 acggcacaac gacgccggcg ctcctctgtc ttcccgtggc cttggggcat caccaaggac
     2221 tctgggtttg ccttcaccga aacgggactg gtggtgatga ccgaccgagt gagcctgaac
     2281 caccggcagg acggtggcct ctacaccgat gaggctgtcc ccgctttcca gccccacaca
     2341 gggagcctgg tggcagtggc tccttccagg caccccccca gaacagagaa gagaaaaagg
     2401 actttcttcc ccgaaacatg gatttggcat tgtctcaaca tcagtgaccc atctggtgag
     2461 gggacactca gtgtgaaggt cccggactcc atcaccagct gggtgggtga ggccgtggcc
     2521 ctgtccacct ctcagggctt aggcatcgcc gagccctccc tgctgaagac cttcaagccc
     2581 ttcttcgtgg acttcatgct ccccgctctc atcatccgtg gggagcaggt caagatcccg
     2641 ctcagtgtct acaactacat gggcacctgc gctgaggtgt acatgaagct ctcggttccc
     2701 aagggcatcc agtttgttgg gcatcctggc aaacgccatg tgaccaagaa gatgtgtgtg
     2761 gcccccgggg aggctgagcc catctgggtc gttctgtcct tcagcgacct gggactcaac
     2821 aacatcacgg ccaaagccct tgcttacgga gacacaaatt gctgccggga tgggaggtcc
     2881 agcaaacacc ctgaggagaa tcacgccgac aggagggtcc ccatcggggt ggatcacgtc
     2941 aggcgcagtg tgatggttga ggcggaagga gtcccccggg cgtacaccta cagcgcattc
     3001 ttctgtccca gtgagagagt ccacatctcc acccccaaca agtatgagtt ccagtatgtg
     3061 cagcggccac tgcgcctcac ccgctttgat gtggctgtgc gagctcacaa tgatgcccgt
     3121 gtggccttgt cttctgggcc ccaggacaca gcaggcatga tcgagatcgt cctggggggg
     3181 catcagaaca ccaggtcatg gatctccacc agcaagatgg gagagcccgt ggccagtgca
     3241 cacacggcca agatcctctc ctgggatgaa ttcagaacat tctggatcag ctggcgtggt
     3301 ggccttatcc aggttggcca tggtccagag ccatccaatg agtctgtcat tgtggcctgg
     3361 accctcccga ggccaccaga ggtccagttc attggctttt ccaccggctg gggctccatg
     3421 ggtgaattcc gaatctggag gaagatggag gtggacgaga gctacagcga ggccttcacc
     3481 ctgggggtcc cacacggcgc catccctggg tctgagcgag ccaccgcctc catcatcggg
     3541 gacgtcatgg ggccaaccct gaaccacctc aacaacctcc tgcggctgcc gtttggctgt
     3601 ggagagcaga acatgatcca ctttgcaccc aacgtctttg tcttgaagta tcttcagaaa
     3661 acccagcagc tcagccctga ggtggagaga gagaccaccg actacctagt acaaggctac
     3721 cagcgccagc tgacctacaa gcgccaggat ggctcctaca gcgcgtttgg ggagcgggac
     3781 gcatcgggga gcatgtggct cacagccttt gtcctgaagt ccttcgcaca ggctcgcagc
     3841 tttatcttcg tggacccccg ggagctggct gccgccaaga gctggatcat ccagcagcag
     3901 caggccgatg gctccttcct ggccgtgggc agggtcctga acaaggacat ccagggtggg
     3961 atccacggca ctgtcccgct gacagcctac gtggtggttg ctctcctgga aacaggcaca
     4021 gcctcagagg aggagagagg ctccactgac aaagcgaggc acttcctgga gtctgctgcg
     4081 cccctggcca tggaccctta tagctgtgcc ctgactacct acgcgctgac cctgctccgc
     4141 agcccggcag cccctgaggc actgcgcaag ctccgtagcc tggccatcat gcgagatggg
     4201 gtcacccact ggagcctgtc aaattcctgg gacgtggaca agggcacatt cttgagcttc
     4261 agtgacaggg tctctcagtc agtggtctcg gccgaggtgg aaatgacagc ctacgccctt
     4321 ctgacctaca ctctgctggg tgacgtggct gccgccctgc ctgtggtgaa gtggctgtcc
     4381 cagcagcgaa atgcacttgg gggcttctcc tccactcagg acacctgcgt ggctctgcag
     4441 gccttggctg aatatgccat cttgtcctat gctggaggca tcaacctcac tgtctccctg
     4501 gcctccacca acctggacta ccaggaaacc ttcgagctgc acaggaccaa ccagaaggtt
     4561 ctgcagacag cagcgatccc cagcctcccc acggggctgt ttgtgagtgc caagggggac
     4621 ggctgctgcc tgatgcagat tgatgtcacc tacaatgtgc ctgacccggt ggccaagcca
     4681 gctttccagc tgctcgtaag cctccaggag cctgaggccc agggacgccc gccccccatg
     4741 cctgcctccg cagctgaggg ttcccgagga gactggcccc cagctgacga tgatgaccca
     4801 gcggccgatc agcatcacca ggaatacaag gtgatgctgg aggtgtgcac caggtggctg
     4861 catgcagggt cttccaatat ggctgtcctg gaggtgcccc tgctgtcagg cttccgggca
     4921 gacatcgaga gcctggagca gctgctcctt gacaagcaca tggggatgaa gaggtatgaa
     4981 gtggctggac gccgagtgct cttctacttt gatgagatcc ccagccggtg cctgacgtgc
     5041 gtgcggttcc gtgctctccg ggagtgcgtg gtgggcagga cgtcggcgct gccagtctcc
     5101 gtgtacgact actacgaacc cgccttcgag gccactcgct tctacaacgt cagcacccac
     5161 agcccactcg cccgggaact gtgcgccgga cccgcgtgca acgaagtgga gcgcgcccct
     5221 gcccggggcc cgggctggtt ccccggcgag tcgggccctg ccgtggcccc tgaggagggg
     5281 gcggcgatcg cgcgatgcgg ctgcgaccac gactgcggcg cccaggggaa cccggtgtgc
     5341 ggctccgacg gggtggtcta cgccagcgcc tgccgcctgc gggaggccgc ctgccgccag
     5401 gccgcgcccc tggagcccgc gcctcccagc tgctgcgccc tcgagcagcg gctgccggcc
     5461 tcgtcgtcct ccacctacgg ggatgacctg gcttctgtgg ccccggggcc tttacagcag
     5521 gacgtgaagc tgaatggagc cggccttgag gtggaggact cagaccctga gcctgaaggg
     5581 gaggcggagg acagggtcac agccgggcct cggcctcctg tgagcagcgg gaacctggaa
     5641 agcagcaccc agagcgccag cccgttccac agatggggcc agactccggc ccctcagaga
     5701 catagtggcc gggtggtggg ggcccacagg ccagggcttc tgagccctgt cttcgtctac
     5761 agcccagcct ttcagagtgg tggggaggag ggtttatgga tgtcaaacac ctgcaccttg
     5821 agataatcct acaaccacat gcagttgtgg gaccgcagtt tggtcctggg gaccattcat
     5881 acccacacac ccagcttgtg cctgtggtta acatctcaga aaactctggt aaatgatcac
     5941 tccaggatat tgacaagaat acacgttact gatcttactc aca
//
