LOCUS       NM_001870               1762 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens carboxypeptidase A3 (CPA3), mRNA.
ACCESSION   NM_001870
VERSION     NM_001870.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Soria-Castro,R., Meneses-Preza,Y.G., Rodriguez-Lopez,G.M.,
            Romero-Ramirez,S., Sosa-Hernandez,V.A., Cervantes-Diaz,R.,
            Perez-Fragoso,A., Torres-Ruiz,J.J., Gomez-Martin,D.,
            Campillo-Navarro,M., Alvarez-Jimenez,V.D., Perez-Tapia,S.M.,
            Chavez-Blanco,A.D., Estrada-Parra,S., Maravillas-Montero,J.L. and
            Chacon-Salinas,R.
  TITLE     Severe COVID-19 is marked by dysregulated serum levels of
            carboxypeptidase A3 and serotonin
  JOURNAL   J Leukoc Biol 110 (3), 425-431 (2021)
   PUBMED   34057753
  REMARK    GeneRIF: Severe COVID-19 is marked by dysregulated serum levels of
            carboxypeptidase A3 and serotonin.
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Lewicki,L., Siebert,J., Kolinski,T., Piekarska,K.,
            Reiwer-Gostomska,M., Targonski,R., Trzonkowski,P. and
            Marek-Trzonkowska,N.
  TITLE     Mast cell derived carboxypeptidase A3 is decreased among patients
            with advanced coronary artery disease
  JOURNAL   Cardiol J 26 (6), 680-686 (2019)
   PUBMED   29512095
  REMARK    GeneRIF: Decreased serum level of carboxypeptidase is a hallmark of
            more advanced coronary artery disease.
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 1762)
  AUTHORS   Jones,K.D., Gelbart,T., Whisenant,T.C., Waalen,J., Mondala,T.S.,
            Ikle,D.N., Salomon,D.R., Bennett,R.M. and Kurian,S.M.
  TITLE     Genome-wide expression profiling in the peripheral blood of
            patients with fibromyalgia
  JOURNAL   Clin Exp Rheumatol 34 (2 Suppl 96), S89-S98 (2016)
   PUBMED   27157394
  REMARK    GeneRIF: Carboxypeptidase A3 was differentially expressed between
            Fibromyalgia patients and healthy controls.
REFERENCE   5  (bases 1 to 1762)
  AUTHORS   Caughey,G.H.
  TITLE     Mast cell proteases as protective and inflammatory mediators
  JOURNAL   Adv Exp Med Biol 716, 212-234 (2011)
   PUBMED   21713659
  REMARK    Review article
REFERENCE   6  (bases 1 to 1762)
  AUTHORS   Natsuaki,M., Stewart,C.B., Vanderslice,P., Schwartz,L.B.,
            Natsuaki,M., Wintroub,B.U., Rutter,W.J. and Goldstein,S.M.
  TITLE     Human skin mast cell carboxypeptidase: functional characterization,
            cDNA cloning, and genealogy
  JOURNAL   J Invest Dermatol 99 (2), 138-145 (1992)
   PUBMED   1629626
REFERENCE   7  (bases 1 to 1762)
  AUTHORS   Reynolds,D.S., Gurley,D.S. and Austen,K.F.
  TITLE     Cloning and characterization of the novel gene for mast cell
            carboxypeptidase A
  JOURNAL   J Clin Invest 89 (1), 273-282 (1992)
   PUBMED   1729276
REFERENCE   8  (bases 1 to 1762)
  AUTHORS   Reynolds,D.S., Gurley,D.S., Stevens,R.L., Sugarbaker,D.J.,
            Austen,K.F. and Serafin,W.E.
  TITLE     Cloning of cDNAs that encode human mast cell carboxypeptidase A,
            and comparison of the protein with mouse mast cell carboxypeptidase
            A and rat pancreatic carboxypeptidases
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9480-9484 (1989)
   PUBMED   2594780
REFERENCE   9  (bases 1 to 1762)
  AUTHORS   Goldstein,S.M., Kaempfer,C.E., Kealey,J.T. and Wintroub,B.U.
  TITLE     Human mast cell carboxypeptidase. Purification and characterization
  JOURNAL   J Clin Invest 83 (5), 1630-1636 (1989)
   PUBMED   2708524
REFERENCE   10 (bases 1 to 1762)
  AUTHORS   Goldstein,S.M., Kaempfer,C.E., Proud,D., Schwartz,L.B., Irani,A.M.
            and Wintroub,B.U.
  TITLE     Detection and partial characterization of a human mast cell
            carboxypeptidase
  JOURNAL   J Immunol 139 (8), 2724-2729 (1987)
   PUBMED   2443571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG501260.1, M27717.1,
            DR005288.1, BC012613.1, BX105358.1 and AC092979.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001870.3.
            
            Summary: This gene encodes a member of the carboxypeptidase A
            family of zinc metalloproteases. The encoded preproprotein is
            proteolytically processed to generate a mature protease that is
            released by mast cells and may be involved in the degradation of
            endogenous proteins and the inactivation of venom-associated
            peptides. Expression of this gene may be elevated in human asthma
            patients. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.329931.1, BC012613.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296046.4/ ENSP00000296046.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BG501260.1         42-53
            13-523              M27717.1           1-511
            524-588             DR005288.1         514-578
            589-1640            BC012613.1         592-1643
            1641-1650           BX105358.1         584-593
            1651-1762           AC092979.3         49663-49774
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1762
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="carboxypeptidase A3"
                     /db_xref="GeneID:1359"
                     /db_xref="HGNC:HGNC:2298"
                     /db_xref="MIM:114851"
     exon            1..80
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1266
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /EC_number="3.4.17.1"
                     /note="mast cell carboxypeptidase A; tissue
                     carboxypeptidase A; carboxypeptidase A3 (mast cell)"
                     /codon_start=1
                     /product="mast cell carboxypeptidase A preproprotein"
                     /protein_id="NP_001861.2"
                     /db_xref="CCDS:CCDS3138.1"
                     /db_xref="GeneID:1359"
                     /db_xref="HGNC:HGNC:2298"
                     /db_xref="MIM:114851"
                     /translation="MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLA
                     KTNELDFWYPGATHHVAANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEK
                     QFDVKEDIPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIG
                     EKNERRKAIFTDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVF
                     NVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSA
                     PESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIG
                     TDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPES
                     RIKPTCRETMLAVKFIAKYILKHTS"
     exon            81..156
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            157..281
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            282..384
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            385..486
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            487..588
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            589..699
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            700..790
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            791..993
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1078
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1762
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="hexamer: AATAAA"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
     polyA_site      1646
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="major polyA site"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
                     /note="hexamer: AATAAT"
     polyA_site      1762
                     /gene="CPA3"
                     /gene_synonym="MC-CPA"
ORIGIN      
        1 caaagaagaa ccatgaggct catcctgcct gtgggtttga ttgctaccac tcttgcaatt
       61 gctcctgtcc gctttgacag ggagaaggtg ttccgcgtga agccccagga tgaaaaacaa
      121 gcagacatca taaaggactt ggccaaaacc aatgagcttg acttctggta tccaggtgcc
      181 acccaccacg tagctgctaa tatgatggtg gatttccgag ttagtgagaa ggaatcccaa
      241 gccatccagt ctgccttgga tcaaaataaa atgcactatg aaatcttgat tcatgatcta
      301 caagaagaga ttgagaaaca gtttgatgtt aaagaagata tcccaggcag gcacagctac
      361 gcaaaataca ataattggga aaagattgtg gcttggactg aaaagatgat ggataagtat
      421 cctgaaatgg tctctcgtat taaaattgga tctactgttg aagataatcc actatatgtt
      481 ctgaagattg gggaaaagaa tgaaagaaga aaggctattt ttacggattg tggcattcac
      541 gcacgagaat gggtctcccc agcattctgc cagtggtttg tctatcaggc aaccaaaact
      601 tatgggagaa acaaaattat gaccaaactc ttggaccgaa tgaattttta cattcttcct
      661 gtgttcaatg ttgatggata tatttggtca tggacaaaga accgcatgtg gagaaaaaat
      721 cgttccaaga accaaaactc caaatgcatc ggcactgacc tcaacaggaa ttttaatgct
      781 tcatggaact ccattcctaa caccaatgac ccatgtgcag ataactatcg gggctctgca
      841 ccagagtccg agaaagagac gaaagctgtc actaatttca ttagaagcca cctgaatgaa
      901 atcaaggttt acatcacctt ccattcctac tcccagatgc tattgtttcc ctatggatat
      961 acatcaaaac tgccacctaa ccatgaggac ttggccaaag ttgcaaagat tggcactgat
     1021 gttctatcaa ctcgatatga aacccgctac atctatggcc caatagaatc aacaatttac
     1081 ccgatatcag gttcttcttt agactgggct tatgacctgg gcatcaaaca cacatttgcc
     1141 tttgagctcc gagataaagg caaatttggt tttctccttc cagaatcccg gataaagcca
     1201 acgtgcagag agaccatgct agctgtcaaa tttattgcca agtatatcct caagcatact
     1261 tcctaaagaa ctgccctctg tttggaataa gccaattaat ccttttttgt gcctttcatc
     1321 agaaagtcaa tcttcagtta tccccaaatg cagcttctat ttcacctgaa tccttctctt
     1381 gctcatttaa gtcccatgtt actgctgttt gcttttactt actttcagta gcaccataac
     1441 gaagtagctt taagtgaaac cttttaacta cctttctttg ctccaagtga agtttggacc
     1501 cagcagaaag cattattttg aaaggtgata tacagtgggg cacagaaaac aaatgaaaac
     1561 cttcagtttc tcacagattt tcaccatgtg gcttcatcaa tttatgtgct aatacaataa
     1621 aataaaatgc acttaatgct ttaaaattca tctttttatg ataaactata ttctctgtat
     1681 ttctctatag cattaataat caatattaat gccattcatt cagtctgtta ataagaaata
     1741 atatcttcaa ttttcaaaaa ca
//
