LOCUS       NM_000096               4452 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ceruloplasmin (CP), transcript variant 1, mRNA.
ACCESSION   NM_000096
VERSION     NM_000096.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4452)
  AUTHORS   Schwantes,A., Wickert,A., Becker,S., Baer,P.C., Weigert,A.,
            Brune,B. and Fuhrmann,D.C.
  TITLE     Tumor associated macrophages transfer ceruloplasmin mRNA to
            fibrosarcoma cells and protect them from ferroptosis
  JOURNAL   Redox Biol 71, 103093 (2024)
   PUBMED   38382185
  REMARK    GeneRIF: Tumor associated macrophages transfer ceruloplasmin mRNA
            to fibrosarcoma cells and protect them from ferroptosis.
REFERENCE   2  (bases 1 to 4452)
  AUTHORS   Elizarova,A.Y., Sokolov,A.V. and Vasilyev,V.B.
  TITLE     Ceruloplasmin Reduces the Lactoferrin/Oleic Acid Antitumor
            Complex-Mediated Release of Heme-Containing Proteins from Blood
            Cells
  JOURNAL   Int J Mol Sci 24 (23), 16711 (2023)
   PUBMED   38069040
  REMARK    GeneRIF: Ceruloplasmin Reduces the Lactoferrin/Oleic Acid Antitumor
            Complex-Mediated Release of Heme-Containing Proteins from Blood
            Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4452)
  AUTHORS   Lucena-Valera,A., Ruz-Zafra,P. and Ampuero,J.
  TITLE     Wilson's disease: overview
  JOURNAL   Med Clin (Barc) 160 (6), 261-267 (2023)
   PUBMED   36697289
  REMARK    GeneRIF: Wilson's disease: overview.
            Review article
REFERENCE   4  (bases 1 to 4452)
  AUTHORS   Stallhofer,J., Veith,L., Diegelmann,J., Probst,P., Brand,S.,
            Schnitzler,F., Olszak,T., Torok,H., Mayerle,J., Stallmach,A. and
            Beigel,F.
  TITLE     Iron Deficiency in Inflammatory Bowel Disease Is Associated With
            Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal
            Ceruloplasmin Expression
  JOURNAL   Clin Transl Gastroenterol 13 (1), e00450 (2022)
   PUBMED   35029158
  REMARK    GeneRIF: Iron Deficiency in Inflammatory Bowel Disease Is
            Associated With Low Levels of Vitamin D Modulating Serum Hepcidin
            and Intestinal Ceruloplasmin Expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4452)
  AUTHORS   Gregory,A. and Hayflick,S.
  TITLE     Neurodegeneration with Brain Iron Accumulation Disorders Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23447832
REFERENCE   6  (bases 1 to 4452)
  AUTHORS   Miyajima,H. and Hosoi,Y.
  TITLE     Aceruloplasminemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301666
REFERENCE   7  (bases 1 to 4452)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
REFERENCE   8  (bases 1 to 4452)
  AUTHORS   Schilsky,M.L., Stockert,R.J. and Pollard,J.W.
  TITLE     Caeruloplasmin biosynthesis by the human uterus
  JOURNAL   Biochem J 288 (Pt 2) (Pt 2), 657-661 (1992)
   PUBMED   1463466
REFERENCE   9  (bases 1 to 4452)
  AUTHORS   Polosatov,M.V., Klimov,P.K., Masevich,C.G., Samartsev,M.A. and
            Wunsch,E.
  TITLE     Interaction of synthetic human big gastrin with blood proteins of
            man and animals
  JOURNAL   Acta Hepatogastroenterol (Stuttg) 26 (2), 154-159 (1979)
   PUBMED   463490
REFERENCE   10 (bases 1 to 4452)
  AUTHORS   Kingston,I.B., Kingston,B.L. and Putnam,F.W.
  TITLE     Chemical evidence that proteolytic cleavage causes the
            heterogeneity present in human ceruloplasmin preparations
  JOURNAL   Proc Natl Acad Sci U S A 74 (12), 5377-5381 (1977)
   PUBMED   146197
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093001.2 and AC131209.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000096.3.
            
            Summary: The protein encoded by this gene is a metalloprotein that
            binds most of the copper in plasma and is involved in the
            peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations
            in this gene cause aceruloplasminemia, which results in iron
            accumulation and tissue damage, and is associated with diabetes and
            neurologic abnormalities. Two transcript variants, one
            protein-coding and the other not protein-coding, have been found
            for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146801.1, AK291219.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264613.11/ ENSP00000264613.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC093001.2         43208-43390         c
            184-431             AC093001.2         34012-34259         c
            432-644             AC093001.2         31728-31940         c
            645-818             AC093001.2         30772-30945         c
            819-1073            AC093001.2         28924-29178         c
            1074-1245           AC093001.2         27729-27900         c
            1246-1385           AC093001.2         23663-23802         c
            1386-1538           AC093001.2         21273-21425         c
            1539-1750           AC093001.2         19928-20139         c
            1751-1901           AC093001.2         9613-9763           c
            1902-2114           AC093001.2         8081-8293           c
            2115-2322           AC093001.2         6800-7007           c
            2323-2462           AC093001.2         5027-5166           c
            2463-2591           AC093001.2         3566-3694           c
            2592-2698           AC131209.2         780-886
            2699-2915           AC131209.2         1811-2027
            2916-3055           AC131209.2         2463-2602
            3056-3218           AC131209.2         4030-4192
            3219-4452           AC131209.2         6712-7945
FEATURES             Location/Qualifiers
     source          1..4452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24-q25.1"
     gene            1..4452
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /note="ceruloplasmin"
                     /db_xref="GeneID:1356"
                     /db_xref="HGNC:HGNC:2295"
                     /db_xref="MIM:117700"
     exon            1..183
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..3235
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /EC_number="1.11.1.9"
                     /EC_number="1.16.3.1"
                     /EC_number="1.11.1.27"
                     /EC_number="1.16.3.4"
                     /note="ceruloplasmin (ferroxidase); cuproxidase
                     ceruloplasmin; ferroxidase ceruloplasmin; glutathione
                     peroxidase ceruloplasmin; glutathione-dependent
                     peroxiredoxin ceruloplasmin"
                     /codon_start=1
                     /product="ceruloplasmin precursor"
                     /protein_id="NP_000087.2"
                     /db_xref="CCDS:CCDS3141.1"
                     /db_xref="GeneID:1356"
                     /db_xref="HGNC:HGNC:2295"
                     /db_xref="MIM:117700"
                     /translation="MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKL
                     ISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETG
                     DKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLL
                     ATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFV
                     VMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMC
                     AEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEW
                     MLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDI
                     FTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILG
                     PVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASH
                     VAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLH
                     ANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMN
                     GFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTS
                     LTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVE
                     VEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVER
                     KAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLT
                     YVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKL
                     EFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGL
                     TMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFP
                     RTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG"
     exon            184..431
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..644
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..818
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1073
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1245
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1385
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1538
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1750
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1901
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2114
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2322
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2462
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2591
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2698
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2915
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3055
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3218
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..4452
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3339..3344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      3361
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /note="major polyA site"
     polyA_site      4063
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /note="major polyA site"
     regulatory      4423..4428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /note="hexamer: AATAAA"
     polyA_site      4452
                     /gene="CP"
                     /gene_synonym="AB073614; CP-2"
                     /note="major polyA site"
ORIGIN      
        1 acttcatttc ttctcaggct ccaagaaggg gaaaaaaatg aagattttga tacttggtat
       61 ttttctgttt ttatgtagta ccccagcctg ggcgaaagaa aagcattatt acattggaat
      121 tattgaaacg acttgggatt atgcctctga ccatggggaa aagaaactta tttctgttga
      181 cacggaacat tccaatatct atcttcaaaa tggcccagat agaattggga gactatataa
      241 gaaggccctt tatcttcagt acacagatga aacctttagg acaactatag aaaaaccggt
      301 ctggcttggg tttttaggcc ctattatcaa agctgaaact ggagataaag tttatgtaca
      361 cttaaaaaac cttgcctcta ggccctacac ctttcattca catggaataa cttactataa
      421 ggaacatgag ggggccatct accctgataa caccacagat tttcaaagag cagatgacaa
      481 agtatatcca ggagagcagt atacatacat gttgcttgcc actgaagaac aaagtcctgg
      541 ggaaggagat ggcaattgtg tgactaggat ttaccattcc cacattgatg ctccaaaaga
      601 tattgcctca ggactcatcg gacctttaat aatctgtaaa aaagattctc tagataaaga
      661 aaaagaaaaa catattgacc gagaatttgt ggtgatgttt tctgtggtgg atgaaaattt
      721 cagctggtac ctagaagaca acattaaaac ctactgctca gaaccagaga aagttgacaa
      781 agacaacgaa gacttccagg agagtaacag aatgtattct gtgaatggat acacttttgg
      841 aagtctccca ggactctcca tgtgtgctga agacagagta aaatggtacc tttttggtat
      901 gggtaatgaa gttgatgtgc acgcagcttt ctttcacggg caagcactga ctaacaagaa
      961 ctaccgtatt gacacaatca acctctttcc tgctaccctg tttgatgctt atatggtggc
     1021 ccagaaccct ggagaatgga tgctcagctg tcagaatcta aaccatctga aagccggttt
     1081 gcaagccttt ttccaggtcc aggagtgtaa caagtcttca tcaaaggata atatccgtgg
     1141 gaagcatgtt agacactact acattgccgc tgaggaaatc atctggaact atgctccctc
     1201 tggtatagac atcttcacta aagaaaactt aacagcacct ggaagtgact cagcggtgtt
     1261 ttttgaacaa ggtaccacaa gaattggagg ctcttataaa aagctggttt atcgtgagta
     1321 cacagatgcc tccttcacaa atcgaaagga gagaggccct gaagaagagc atcttggcat
     1381 cctgggtcct gtcatttggg cagaggtggg agacaccatc agagtaacct tccataacaa
     1441 aggagcatat cccctcagta ttgagccgat tggggtgaga ttcaataaga acaacgaggg
     1501 cacatactat tccccaaatt acaaccccca gagcagaagt gtgcctcctt cagcctccca
     1561 tgtggcaccc acagaaacat tcacctatga atggactgtc cccaaagaag taggacccac
     1621 taatgcagat cctgtgtgtc tagctaagat gtattattct gctgtggaac ccactaaaga
     1681 tatattcact gggcttattg ggccaatgaa aatatgcaag aaaggaagtt tacatgcaaa
     1741 tgggagacag aaagatgtag acaaggaatt ctatttgttt cctacagtat ttgatgagaa
     1801 tgagagttta ctcctggaag ataatattag aatgtttaca actgcacctg atcaggtgga
     1861 taaggaagat gaagactttc aggaatctaa taaaatgcac tccatgaatg gattcatgta
     1921 tgggaatcag ccgggtctca ctatgtgcaa aggagattcg gtcgtgtggt acttattcag
     1981 cgccggaaat gaggccgatg tacatggaat atacttttca ggaaacacat atctgtggag
     2041 aggagaacgg agagacacag caaacctctt ccctcaaaca agtcttacgc tccacatgtg
     2101 gcctgacaca gaggggactt ttaatgttga atgccttaca actgatcatt acacaggcgg
     2161 catgaagcaa aaatatactg tgaaccaatg caggcggcag tctgaggatt ccaccttcta
     2221 cctgggagag aggacatact atatcgcagc agtggaggtg gaatgggatt attccccaca
     2281 aagggagtgg gaaaaggagc tgcatcattt acaagagcag aatgtttcaa atgcattttt
     2341 agataaggga gagttttaca taggctcaaa gtacaagaaa gttgtgtatc ggcagtatac
     2401 tgatagcaca ttccgtgttc cagtggagag aaaagctgaa gaagaacatc tgggaattct
     2461 aggtccacaa cttcatgcag atgttggaga caaagtcaaa attatcttta aaaacatggc
     2521 cacaaggccc tactcaatac atgcccatgg ggtacaaaca gagagttcta cagttactcc
     2581 aacattacca ggtgaaactc tcacttacgt atggaaaatc ccagaaagat ctggagctgg
     2641 aacagaggat tctgcttgta ttccatgggc ttattattca actgtggatc aagttaagga
     2701 cctctacagt ggattaattg gccccctgat tgtttgtcga agaccttact tgaaagtatt
     2761 caatcccaga aggaaactgg aatttgccct tctgtttcta gtttttgatg agaatgaatc
     2821 ttggtactta gatgacaaca tcaaaacata ctctgatcac cccgagaaag taaacaaaga
     2881 tgatgaggaa ttcatagaaa gcaataaaat gcatgctatt aatggaagaa tgtttggaaa
     2941 cctacaaggc ctcacaatgc acgtgggaga tgaagtcaac tggtatctga tgggaatggg
     3001 caatgaaata gacttacaca ctgtacattt tcacggccat agcttccaat acaagcacag
     3061 gggagtttat agttctgatg tctttgacat tttccctgga acataccaaa ccctagaaat
     3121 gtttccaaga acacctggaa tttggttact ccactgccat gtgaccgacc acattcatgc
     3181 tggaatggaa accacttaca ccgttctaca aaatgaagac accaaatctg gctgaatgaa
     3241 ataaattggt gataagtgga aaaaagagaa aaaccaatga ttcataacaa tgtatgtgaa
     3301 agtgtaaaat agaatgttac tttggaatga ctataaacat taaaagaaga ctggaagcat
     3361 acaactttgt acatttgtgg gggaaaacta ttaatttttt gcaaatggaa agatcaacag
     3421 actatataat gatacatgac tgacacttgt acactaggta ataaaactga ttcatacagt
     3481 ctaatgatat caccgctgtt agggttttat aaaactgcat ttaaaaaaag atctatgacc
     3541 agatattctc ctgggtgctc ctcaaaggaa cactattaag gttcattgaa atgttttcaa
     3601 tcattgcctt cccattgatc cttctaacat gctgttgaca tcacacctaa tattcagagg
     3661 gaatgggcaa ggtatgaggg aaggaaataa aaaataaaat aaataaaata gaatgacaca
     3721 aatttgagtt ttgtgaaccc ctgaacagat ggtcttaagg acgttatctg gaactggaga
     3781 aaagcagagt tgagagacaa ttctatagat taaatcctgg taaggacaaa cattgccatt
     3841 agaagaaaag cttcaaaata gacctgtggc agatgtcaca tgagtagaat ttctgcccag
     3901 ccttaactgc attcagagga taatatcaat gaactaaact tgaactaaaa attttttaaa
     3961 caaaaagtta taaatgaaga cacatggttg tgaatacaat gatgtatttc tttattttca
     4021 catacactct agctaaaaga gcaagagtac acatcaacaa aaatggaaac aaggctttgg
     4081 ctgaaaaaaa catgcatttg acaaatcatg ttaatagcta gacaagaaga aagttagctt
     4141 tgtaaacttc tacttcattt gattcagaga aacagagcat gagttttctt aaaagtaaca
     4201 agaaaaggaa caaaaaaaat gaggtttgaa atcttttacc atggcaaaac attaacatct
     4261 ttctcaaaaa catagagaaa tctggaaaaa tcaagaagat aaaattctgg accagttagt
     4321 gacattcttt caagcatact tgtaaaatgt ttccttaaag tgttcttggg atgaaaatga
     4381 ttgtcatgtc tccaacaaca gtgaactgat gttgttcctt ggaataaaag tcaatcccca
     4441 ccttaaaaaa tg
//
