LOCUS       NM_182971                542 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 8C (COX8C), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_182971
VERSION     NM_182971.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 542)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 542)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 542)
  AUTHORS   Huttemann,M., Schmidt,T.R. and Grossman,L.I.
  TITLE     A third isoform of cytochrome c oxidase subunit VIII is present in
            mammals
  JOURNAL   Gene 312, 95-102 (2003)
   PUBMED   12909344
REFERENCE   4  (bases 1 to 542)
  AUTHORS   Kleeberger,S.R.
  TITLE     Genetic aspects of susceptibility to air pollution
  JOURNAL   Eur Respir J Suppl 40, 52s-56s (2003)
   PUBMED   12762575
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL122023.3, AY161004.1 and BC101125.2.
            
            On May 17, 2019 this sequence version replaced NM_182971.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW269746.1, AI217106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000342144.3/
                                                  ENSP00000340568.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL122023.3         70715-70723
            10-119              AY161004.1         1-110
            120-404             BC101125.2         86-370
            405-540             AY161004.1         396-531
            541-542             AL122023.3         71888-71889
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..542
                     /gene="COX8C"
                     /gene_synonym="COX8-3"
                     /note="cytochrome c oxidase subunit 8C"
                     /db_xref="GeneID:341947"
                     /db_xref="HGNC:HGNC:24382"
                     /db_xref="MIM:616855"
     exon            1..213
                     /gene="COX8C"
                     /gene_synonym="COX8-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..306
                     /gene="COX8C"
                     /gene_synonym="COX8-3"
                     /note="cytochrome c oxidase subunit VIII; COX VIII-3;
                     cytochrome c oxidase subunit 8-3; cytochrome c oxidase
                     subunit VIIIC; cytochrome c oxidase polypeptide 8;
                     cytochrome c oxidase polypeptide VIII"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 8C, mitochondrial"
                     /protein_id="NP_892016.1"
                     /db_xref="CCDS:CCDS9910.1"
                     /db_xref="GeneID:341947"
                     /db_xref="HGNC:HGNC:24382"
                     /db_xref="MIM:616855"
                     /translation="MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEM
                     AVGLVVFFTTFLTPAAYVLGNLKQFRRN"
     exon            214..542
                     /gene="COX8C"
                     /gene_synonym="COX8-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      510..515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX8C"
                     /gene_synonym="COX8-3"
                     /note="hexamer: AATAAA"
     polyA_site      542
                     /gene="COX8C"
                     /gene_synonym="COX8-3"
                     /note="major polyA site"
ORIGIN      
        1 agctgcctca cgagcactgg agcttgcgtt acttggcctc acctcacctg tgctgtccac
       61 gcctggcttt gtctcacctg acgcgatatg cctctcctgc gtgggcgctg tcctgcccgc
      121 cgccactacc gccgcttggc cctgctcggc ctgcagcccg ctccccgctt cgcccactcg
      181 gggcccccgc gccagcggcc cctgtctgcc gcggaaatgg ctgttggact tgtggtgttt
      241 tttacgacct tcttaacacc agctgcatat gtgctaggca acctgaagca gttcagaagg
      301 aattagatgg aagatgatgt tgaacagctg ttaacgtcca aaaaactttc agaaaaagct
      361 gtgtttttgt taacgagcaa aattgcctag ttgagttgat gcaaccattg tggtattcac
      421 tttcctcatg tttatgatga atattttgca cttttttagt actgtgcatt atatagatgt
      481 atagtcaaaa atgttctgct taagtgttaa ataaaacgga aacacttatt cgtgcttggt
      541 aa
//
