LOCUS       NM_001867                629 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 7C (COX7C), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001867
VERSION     NM_001867.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 629)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 629)
  AUTHORS   Wu,B., Chen,S., Zhuang,L. and Zeng,J.
  TITLE     The expression level of COX7C associates with venous
            thromboembolism in colon cancer patients
  JOURNAL   Clin Exp Med 20 (4), 527-533 (2020)
   PUBMED   32653968
  REMARK    GeneRIF: The expression level of COX7C associates with venous
            thromboembolism in colon cancer patients.
REFERENCE   3  (bases 1 to 629)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 629)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   5  (bases 1 to 629)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   6  (bases 1 to 629)
  AUTHORS   Hofmann,S., Lichtner,P., Schuffenhauer,S., Gerbitz,K.D. and
            Meitinger,T.
  TITLE     Assignment of the human genes coding for cytochrome c oxidase
            subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome
            bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1,
            COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and
            radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 226-227 (1998)
   PUBMED   10072584
REFERENCE   7  (bases 1 to 629)
  AUTHORS   Lenka,N., Vijayasarathy,C., Mullick,J. and Avadhani,N.G.
  TITLE     Structural organization and transcription regulation of nuclear
            genes encoding the mammalian cytochrome c oxidase complex
  JOURNAL   Prog Nucleic Acid Res Mol Biol 61, 309-344 (1998)
   PUBMED   9752724
  REMARK    Review article
REFERENCE   8  (bases 1 to 629)
  AUTHORS   Kaminishi,H., Hamatake,H., Cho,T., Tamaki,T., Suenaga,N., Fujii,T.,
            Hagihara,Y. and Maeda,H.
  TITLE     Activation of blood clotting factors by microbial proteinases
  JOURNAL   FEMS Microbiol Lett 121 (3), 327-332 (1994)
   PUBMED   7926688
REFERENCE   9  (bases 1 to 629)
  AUTHORS   Van Kuilenburg,A.B., Van Beeumen,J.J., Van der Meer,N.M. and
            Muijsers,A.O.
  TITLE     Subunits VIIa,b,c of human cytochrome c oxidase. Identification of
            both 'heart-type' and 'liver-type' isoforms of subunit VIIa in
            human heart
  JOURNAL   Eur J Biochem 203 (1-2), 193-199 (1992)
   PUBMED   1309697
REFERENCE   10 (bases 1 to 629)
  AUTHORS   Koga,Y., Fabrizi,G.M., Mita,S., Arnaudo,E., Lomax,M.I., Aqua,M.S.,
            Grossman,L.I. and Schon,E.A.
  TITLE     Sequence of a cDNA specifying subunit VIIc of human cytochrome c
            oxidase
  JOURNAL   Nucleic Acids Res 18 (3), 684 (1990)
   PUBMED   2155413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108110.3 and BC001005.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001867.2.
            
            Summary: Cytochrome c oxidase (COX), the terminal component of the
            mitochondrial respiratory chain, catalyzes the electron transfer
            from reduced cytochrome c to oxygen. This component is a
            heteromeric complex consisting of 3 catalytic subunits encoded by
            mitochondrial genes and multiple structural subunits encoded by
            nuclear genes. The mitochondrially-encoded subunits function in
            electron transfer, and the nuclear-encoded subunits may function in
            the regulation and assembly of the complex. This nuclear gene
            encodes subunit VIIc, which shares 87% and 85% amino acid sequence
            identity with mouse and bovine COX VIIc, respectively, and is found
            in all tissues. A pseudogene COX7CP1 has been found on chromosome
            13. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD175575.1, SRR5189667.237129.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000247655.4/
                                                  ENSP00000247655.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC108110.3         97983-98008
            27-433              BC001005.2         1-407
            434-629             AC108110.3         100809-101004
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..629
                     /gene="COX7C"
                     /note="cytochrome c oxidase subunit 7C"
                     /db_xref="GeneID:1350"
                     /db_xref="HGNC:HGNC:2292"
                     /db_xref="MIM:603774"
     exon            1..190
                     /gene="COX7C"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..307
                     /gene="COX7C"
                     /EC_number="7.1.1.9"
                     /note="cytochrome-c oxidase chain VIIc; cytochrome c
                     oxidase subunit 7C, mitochondrial; cytochrome c oxidase
                     polypeptide VIIc; cytochrome c oxidase subunit VIIc"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 7C, mitochondrial
                     precursor"
                     /protein_id="NP_001858.1"
                     /db_xref="CCDS:CCDS4063.1"
                     /db_xref="GeneID:1350"
                     /db_xref="HGNC:HGNC:2292"
                     /db_xref="MIM:603774"
                     /translation="MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLY
                     FGSAFATPFLVVRHQLLKT"
     exon            191..334
                     /gene="COX7C"
                     /inference="alignment:Splign:2.1.0"
     exon            335..629
                     /gene="COX7C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      415..420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX7C"
                     /note="hexamer: AATAAA"
     polyA_site      433
                     /gene="COX7C"
                     /note="major polyA site"
     regulatory      607..612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX7C"
                     /note="hexamer: AATAAA"
     polyA_site      629
                     /gene="COX7C"
ORIGIN      
        1 cttttcagtc cttgcgcacc ggggaacaag gtcgtgaaaa aaaaggtctt ggtgaggtgc
       61 cgccatttca tctgtcctca ttctctgcgc ctttcgcaga gcttccagca gcggtatgtt
      121 gggccagagc atccggaggt tcacaacctc tgtggtccgt aggagccact atgaggaggg
      181 ccctgggaag aatttgccat tttcagtgga aaacaagtgg tcgttactag ctaagatgtg
      241 tttgtacttt ggatctgcat ttgctacacc cttccttgta gtaagacacc aactgcttaa
      301 aacataagga tgtttcagtt cctccattta acagatatga agagcatttt aagaggtgca
      361 gcctctggaa gtggatcaaa ctagaactca tatgccatac tagatatgtt tgtcaataaa
      421 cttatgacgt gaatgcttaa tgcctctttt ttgaaatagg gaatgtaata attggccatt
      481 tgcctacttt attatttggg taacattcca gtattactct ctgtgattta gcttatttaa
      541 tggtgttaaa ctgaggttat attaaatttt tgattcccag gtcaggattt tgttggtaat
      601 ttatataata aaagggaaat acaaatcga
//
