LOCUS       NM_001866               2444 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 7B (COX7B), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001866
VERSION     NM_001866.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2444)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2444)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2444)
  AUTHORS   Tanaka,N., Katayama,S., Reddy,A., Nishimura,K., Niwa,N., Hongo,H.,
            Ogihara,K., Kosaka,T., Mizuno,R., Kikuchi,E., Mikami,S.,
            Miyakawa,A., Arenas,E., Kere,J., Oya,M. and Uhlen,P.
  TITLE     Single-cell RNA-seq analysis reveals the platinum resistance gene
            COX7B and the surrogate marker CD63
  JOURNAL   Cancer Med 7 (12), 6193-6204 (2018)
   PUBMED   30367559
  REMARK    GeneRIF: Our results offer a new transcriptome landscape of
            platinum-resistance that provides valuable insights into
            chemosensitivity and drug resistance in cancers, and we identify a
            novel platinum resistance gene, COX7B, and a surrogate marker,
            CD63.
REFERENCE   4  (bases 1 to 2444)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   5  (bases 1 to 2444)
  AUTHORS   Possekel,S., Marsac,C. and Kadenbach,B.
  TITLE     Biochemical analysis of fibroblasts from patients with cytochrome c
            oxidase-associated Leigh syndrome
  JOURNAL   Biochim Biophys Acta 1316 (3), 153-159 (1996)
   PUBMED   8781533
REFERENCE   6  (bases 1 to 2444)
  AUTHORS   Sadlock,J.E., Lightowlers,R.N., Capaldi,R.A. and Schon,E.A.
  TITLE     Isolation of a cDNA specifying subunit VIIb of human cytochrome c
            oxidase
  JOURNAL   Biochim Biophys Acta 1172 (1-2), 223-225 (1993)
   PUBMED   8382530
REFERENCE   7  (bases 1 to 2444)
  AUTHORS   Morleo,M. and Franco,B.
  TITLE     Microphthalmia with Linear Skin Defects Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301767
REFERENCE   8  (bases 1 to 2444)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   9  (bases 1 to 2444)
  AUTHORS   Van Kuilenburg,A.B., Van Beeumen,J.J., Van der Meer,N.M. and
            Muijsers,A.O.
  TITLE     Subunits VIIa,b,c of human cytochrome c oxidase. Identification of
            both 'heart-type' and 'liver-type' isoforms of subunit VIIa in
            human heart
  JOURNAL   Eur J Biochem 203 (1-2), 193-199 (1992)
   PUBMED   1309697
REFERENCE   10 (bases 1 to 2444)
  AUTHORS   Stroh,A. and Kadenbach,B.
  TITLE     Tissue-specific and species-specific distribution of -SH groups in
            cytochrome c oxidase subunits
  JOURNAL   Eur J Biochem 156 (1), 199-204 (1986)
   PUBMED   3007143
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z14244.1 and AL356235.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 13, 2018 this sequence version replaced NM_001866.2.
            
            Summary: Cytochrome c oxidase (COX), the terminal component of the
            mitochondrial respiratory chain, catalyzes the electron transfer
            from reduced cytochrome c to oxygen. This component is a
            heteromeric complex consisting of 3 catalytic subunits encoded by
            mitochondrial genes and multiple structural subunits encoded by
            nuclear genes. The mitochondrially-encoded subunits function in
            electron transfer, and the nuclear-encoded subunits may function in
            the regulation and assembly of the complex. This nuclear gene
            encodes subunit VIIb, which is highly similar to bovine COX VIIb
            protein and is found in all tissues. This gene may have several
            pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq,
            Jun 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA173495.1, SRR3476690.694958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000650309.2/
                                                  ENSP00000497474.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               Z14244.1           17-468
            453-2444            AL356235.22        32749-34740
FEATURES             Location/Qualifiers
     source          1..2444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..2444
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /note="cytochrome c oxidase subunit 7B"
                     /db_xref="GeneID:1349"
                     /db_xref="HGNC:HGNC:2291"
                     /db_xref="MIM:300885"
     exon            1..126
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..329
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /EC_number="7.1.1.9"
                     /note="cytochrome-c oxidase chain VIIb; cytochrome c
                     oxidase subunit 7B, mitochondrial; cytochrome c oxidase
                     polypeptide VIIb; cytochrome c oxidase subunit VIIb"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 7B, mitochondrial
                     precursor"
                     /protein_id="NP_001857.1"
                     /db_xref="CCDS:CCDS14437.1"
                     /db_xref="GeneID:1349"
                     /db_xref="HGNC:HGNC:2291"
                     /db_xref="MIM:300885"
                     /translation="MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLAS
                     GATFCIVTWTYVATQVGIEWNLSPVGRVTPKEWRNQ"
     exon            127..251
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            252..2444
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      430..435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /note="hexamer: AATAAA"
     polyA_site      453
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /note="major polyA site"
     regulatory      2402..2407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
                     /note="hexamer: AATAAA"
     polyA_site      2429
                     /gene="COX7B"
                     /gene_synonym="APLCC; LSDMCA2"
ORIGIN      
        1 gtttttcagc tcacttcaag ggtacctgaa gcgaattggc accaaagcag cagctgtatt
       61 gccgcagttc tagcttcacc ttcacgatgt ttcccttggt caaaagcgca ctaaatcgtc
      121 tccaagttcg aagcattcag caaacaatgg caaggcagag ccaccagaaa cgtacacctg
      181 attttcatga caaatacggt aatgctgtat tagctagtgg agccactttc tgtattgtta
      241 catggacata tgtagcaaca caagtcggaa tagaatggaa cctgtcccct gttggcagag
      301 ttaccccaaa ggaatggagg aatcagtaat catcccagct ggtgtaataa tgaattgttt
      361 aaaaaacagc tcataattga tgccaaatta aagcactgtg tacccattaa gatatggcat
      421 tattgaagaa ataaagtaca tttgaaacct tcattgtagg ttttgtttct ttgtaaatga
      481 aactaagctt gatcacttta gcctttatgt taatattaaa gtcaaatgct gtgcagcttc
      541 ttaaataggt tttttttttt tttttttttt ttttttggga cgaagtctca ctttgtcccc
      601 caggctggag tgcagtggca ccatctcagc tcactgcgac ctctgcctcc tgagttcaag
      661 tgattctcct gtctcagcct cccgagtagc cagaactaca ggcacatgcc atgacgccca
      721 gctaattttt tttttttttg agacggagtc tcactctgtt gcccaggctg gaatgcaatg
      781 gcgtgatctc ggctcctgca acctccgcct cccgggttca agcgattctc ctgtctcagc
      841 cttccaagta gctgggatta caggtgcacg ccaccaggcc cggctaattt ttgtattttt
      901 agtagagacg gggtttcacc atgttggtca ggctggtctc gagctcctga tctcgtgatc
      961 cacccacctt ggtctcccaa agtgctggga ttacaggtgt gagccaccgt gcccggcaat
     1021 ttttgtattt ttagtagaga cagggtttca ccatattggt caggctggtt tcaaactcac
     1081 gacctcaggt gatccgcctg ccttggcctc ccaaagtggt aggattacag gcgtgagcca
     1141 cggcacccag cccttaaatg gcttttatga ggtaatgtga aaggaaaatt tgcctttgac
     1201 ctggaagtca actttatagt aagctgaaat tataaataac tgatcatgga actattgcag
     1261 atcacctttg agccaaaaat ttggcctgga ttttggttat gcctactact atgtgcctct
     1321 catttgtatt tatacctgga attggcatta ttaactcctt ttcactcctg cctagaaaac
     1381 ttaaagtgtc accagaccca agggcggagt ggtcctataa aacaaactcg tagcctgtct
     1441 gaagactagc tactagctcc ttggctgttt tggcatattc atcttgatta tagctcttgg
     1501 tctttcatca tattagggat gtttatgatg ttattaaaga aaatcttgtc aaatgcagtc
     1561 tgttcctagt tatctactat cagtcacctg ttgtataatt ataacaatgt ttggatttgt
     1621 ggattattat tttagtatat aacattggat tttatgtatg ttacctgaag aagagcaata
     1681 tctgtaccac atatttcttt gtttttcttt tttgagatga agtctcactc tgttgcccag
     1741 gctggagtgc agtggtgtga tcttgacaca ctgcaacctt tgcctcccgg attcaagtga
     1801 ttctcctgtc tcagcctccc tagtaactgg aattacaggc gcctgccacc atgcctggct
     1861 aatttttgta tttttagtag agatggggtt tcaccatgtt ggccaacctg gtcttgaact
     1921 cctgacctca ggcgatccac ccacctcagc ctcccaaagt gctaggctta caggcatgag
     1981 acaccgcgcc cggcttatat atcattactt tcttggctga gagctgtagt ctgtggtagt
     2041 tgttttgttt tgttttttgt tttttttttg tagttttctt gatcgtgatc aattaagcag
     2101 aaagtagaat ttcagtcagg taacctgtct atattagcta aattatcttt tgcttattac
     2161 atagagtgct agaagtatgc tgtcatggca tatgtcctag tttctcatca aatggaccaa
     2221 agtcagtgat tttatttgaa gaggaaaaat tgaacgtcat tgtaaattaa gttgcaagtt
     2281 tagtaaccat attgtaccac tgtttgataa atttgaacgc tttatggtat ttcatattta
     2341 gaatgttcaa aatagtactg aagtattcaa atacatacaa ccctgagcga tattgaagta
     2401 aaataaacat gtatttaagg aagtgtcaac cttcaattat atac
//
