LOCUS       NM_001366293             462 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 7A2 (COX7A2), transcript
            variant 4, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001366293
VERSION     NM_001366293.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 462)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   4  (bases 1 to 462)
  AUTHORS   Deng,S., Li,Y., Yi,G., Lei,B., Guo,M., Xiang,W., Chen,Z., Liu,Y.
            and Qi,S.
  TITLE     Overexpression of COX7A2 is associated with a good prognosis in
            patients with glioma
  JOURNAL   J Neurooncol 136 (1), 41-50 (2018)
   PUBMED   29079956
  REMARK    GeneRIF: Overexpression of COX7A2 is associated with a good
            prognosis in patients with glioma. Results suggest that COX7A2
            could be served as a valuable prognostic marker of glioma.
REFERENCE   5  (bases 1 to 462)
  AUTHORS   Elsner,M., Rauser,S., Maier,S., Schone,C., Balluff,B., Meding,S.,
            Jung,G., Nipp,M., Sarioglu,H., Maccarrone,G., Aichler,M.,
            Feuchtinger,A., Langer,R., Jutting,U., Feith,M., Kuster,B.,
            Ueffing,M., Zitzelsberger,H., Hofler,H. and Walch,A.
  TITLE     MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10
            as novel prognostic markers in Barrett's adenocarcinoma
  JOURNAL   J Proteomics 75 (15), 4693-4704 (2012)
   PUBMED   22365974
  REMARK    GeneRIF: COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in
            Barrett's adenocarcinoma.
REFERENCE   6  (bases 1 to 462)
  AUTHORS   Merante,F., Duncan,A.M., Mitchell,G., Duff,C., Rommens,J. and
            Robinson,B.H.
  TITLE     Chromosomal localization of the human liver form cytochrome c
            oxidase subunit VIIa gene
  JOURNAL   Genome 40 (3), 318-324 (1997)
   PUBMED   9202412
REFERENCE   7  (bases 1 to 462)
  AUTHORS   Arnaudo,E., Hirano,M., Seelan,R.S., Milatovich,A., Hsieh,C.L.,
            Fabrizi,G.M., Grossman,L.I., Francke,U. and Schon,E.A.
  TITLE     Tissue-specific expression and chromosome assignment of genes
            specifying two isoforms of subunit VIIa of human cytochrome c
            oxidase
  JOURNAL   Gene 119 (2), 299-305 (1992)
   PUBMED   1327965
REFERENCE   8  (bases 1 to 462)
  AUTHORS   Van Kuilenburg,A.B., Van Beeumen,J.J., Van der Meer,N.M. and
            Muijsers,A.O.
  TITLE     Subunits VIIa,b,c of human cytochrome c oxidase. Identification of
            both 'heart-type' and 'liver-type' isoforms of subunit VIIa in
            human heart
  JOURNAL   Eur J Biochem 203 (1-2), 193-199 (1992)
   PUBMED   1309697
REFERENCE   9  (bases 1 to 462)
  AUTHORS   Van Beeumen,J.J., Van Kuilenburg,A.B., Van Bun,S., Van den
            Bogert,C., Tager,J.M. and Muijsers,A.O.
  TITLE     Demonstration of two isoforms of subunit VIIa of cytochrome c
            oxidase from human skeletal muscle. Implications for mitochondrial
            myopathies
  JOURNAL   FEBS Lett 263 (2), 213-216 (1990)
   PUBMED   2159420
REFERENCE   10 (bases 1 to 462)
  AUTHORS   Fabrizi,G.M., Rizzuto,R., Nakase,H., Mita,S., Lomax,M.I.,
            Grossman,L.I. and Schon,E.A.
  TITLE     Sequence of a cDNA specifying subunit VIIa of human cytochrome c
            oxidase
  JOURNAL   Nucleic Acids Res 17 (17), 7107 (1989)
   PUBMED   2550906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL080250.11.
            
            On Nov 9, 2020 this sequence version replaced NM_001366293.1.
            
            Summary: Cytochrome c oxidase, the terminal component of the
            mitochondrial respiratory chain, catalyzes the electron transfer
            from reduced cytochrome c to oxygen. This component is a
            heteromeric complex consisting of three catalytic subunits encoded
            by mitochondrial genes, and multiple structural subunits encoded by
            nuclear genes. The mitochondrially-encoded subunits function in
            electron transfer, while the nuclear-encoded subunits may function
            in the regulation and assembly of the complex. This nuclear gene
            encodes polypeptide 2 (liver isoform) of subunit VIIa, with this
            polypeptide being present in both muscle and non-muscle tissues. In
            addition to polypeptide 2, subunit VIIa includes polypeptide 1
            (muscle isoform), which is present only in muscle tissues, and a
            related protein, which is present in all tissues. Alternative
            splicing results in multiple transcript variants. Related
            pseudogenes have been identified on chromosomes 4 and 14. [provided
            by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA335821.1, AL038998.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000684430.2/
                                                  ENSP00000506727.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL080250.11        62314-62398         c
            86-175              AL080250.11        59773-59862         c
            176-260             AL080250.11        58898-58982         c
            261-462             AL080250.11        56384-56585         c
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..462
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /note="cytochrome c oxidase subunit 7A2"
                     /db_xref="GeneID:1347"
                     /db_xref="HGNC:HGNC:2288"
                     /db_xref="MIM:123996"
     exon            1..85
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..319
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /EC_number="7.1.1.9"
                     /note="hepatic cytochrome-c oxidase chain VIIa; cytochrome
                     c oxidase polypeptide 7A2, mitochondrial; cytochrome c
                     oxidase polypeptide VIIa-liver/heart; cytochrome c oxidase
                     subunit VIIaL; cytochrome c oxidase subunit VIIa-L;
                     cytochrome c oxidase subunit VIIa-liver/heart; cytochrome
                     c oxidase subunit VIIa polypeptide 2 (liver)"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 7A2, mitochondrial"
                     /protein_id="NP_001353222.1"
                     /db_xref="CCDS:CCDS34486.3"
                     /db_xref="GeneID:1347"
                     /db_xref="HGNC:HGNC:2288"
                     /db_xref="MIM:123996"
                     /translation="MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLY
                     LKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE"
     exon            86..175
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            176..260
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            261..462
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      442..447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /note="hexamer: AATAAA"
     polyA_site      462
                     /gene="COX7A2"
                     /gene_synonym="COX7AL; COX7AL1; COXVIIa-L; COXVIIAL;
                     VIIAL"
                     /note="major polyA site"
ORIGIN      
        1 ggttccggcg tggccatttt cgttggtggt gttcagttgt ggcggttgct ggtcagtaac
       61 agccaagatg ctgcggaatc tgctggctct tcgtcagatt gggcagagga cgataagcac
      121 tgcttcccgc aggcatttta aaaataaagt tccggagaag caaaaactgt tccaggagga
      181 tgatgaaatt ccactgtatc taaagggtgg ggtagctgat gccctcctgt atagagccac
      241 catgattctt acagttggtg gaacagcata tgccatatat gagctggctg tggcttcatt
      301 tcccaagaag caggagtgac ttcagtcatc ccagcaatcg cttggttcag tttcattcag
      361 ctctctatgg accagtaatc tgataaataa ccgagctctt ctttggggat caatatttat
      421 tgacttgtag taactgccac caataaagca gtctttacca tg
//
