LOCUS       NM_001864                340 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 7A1 (COX7A1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001864
VERSION     NM_001864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 340)
  AUTHORS   Wang,S.Y., Yang,X.Q., Wang,Y.X., Shen,A., Liang,C.C., Huang,R.J.,
            Cheng,U.H., Jian,R., An,N., Xiao,Y.L., Wang,L.S., Zhao,Y., Lin,C.,
            Wang,C.P., Yuan,Z.P. and Yuan,S.Q.
  TITLE     Overexpression of COX7A1 Promotes the Resistance of Gastric Cancer
            to Oxaliplatin and Weakens the Efficacy of Immunotherapy
  JOURNAL   Lab Invest 104 (8), 102090 (2024)
   PUBMED   38830579
  REMARK    GeneRIF: Overexpression of COX7A1 Promotes the Resistance of
            Gastric Cancer to Oxaliplatin and Weakens the Efficacy of
            Immunotherapy.
REFERENCE   2  (bases 1 to 340)
  AUTHORS   Feng,Y., Xu,J., Shi,M., Liu,R., Zhao,L., Chen,X., Li,M., Zhao,Y.,
            Chen,J., Du,W. and Liu,P.
  TITLE     COX7A1 enhances the sensitivity of human NSCLC cells to cystine
            deprivation-induced ferroptosis via regulating mitochondrial
            metabolism
  JOURNAL   Cell Death Dis 13 (11), 988 (2022)
   PUBMED   36418320
  REMARK    GeneRIF: COX7A1 enhances the sensitivity of human NSCLC cells to
            cystine deprivation-induced ferroptosis via regulating
            mitochondrial metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 340)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 340)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 340)
  AUTHORS   Mishra,N., Timilsina,U., Ghimire,D., Dubey,R.C. and Gaur,R.
  TITLE     Downregulation of cytochrome c oxidase subunit 7A1 expression is
            important in enhancing cell proliferation in adenocarcinoma cells
  JOURNAL   Biochem Biophys Res Commun 482 (4), 713-719 (2017)
   PUBMED   27866983
  REMARK    GeneRIF: COX7A1 is a novel gene that might play a crucial role in
            the etiology of lung adenocarcinoma and can serve as a biomarker
            for lung cancer disease progression
REFERENCE   6  (bases 1 to 340)
  AUTHORS   Lenka,N., Vijayasarathy,C., Mullick,J. and Avadhani,N.G.
  TITLE     Structural organization and transcription regulation of nuclear
            genes encoding the mammalian cytochrome c oxidase complex
  JOURNAL   Prog Nucleic Acid Res Mol Biol 61, 309-344 (1998)
   PUBMED   9752724
  REMARK    Review article
REFERENCE   7  (bases 1 to 340)
  AUTHORS   Wolz,W., Kress,W. and Mueller,C.R.
  TITLE     Genomic sequence and organization of the human gene for cytochrome
            c oxidase subunit (COX7A1) VIIa-M
  JOURNAL   Genomics 45 (2), 438-442 (1997)
   PUBMED   9344674
REFERENCE   8  (bases 1 to 340)
  AUTHORS   Arnaudo,E., Hirano,M., Seelan,R.S., Milatovich,A., Hsieh,C.L.,
            Fabrizi,G.M., Grossman,L.I., Francke,U. and Schon,E.A.
  TITLE     Tissue-specific expression and chromosome assignment of genes
            specifying two isoforms of subunit VIIa of human cytochrome c
            oxidase
  JOURNAL   Gene 119 (2), 299-305 (1992)
   PUBMED   1327965
REFERENCE   9  (bases 1 to 340)
  AUTHORS   Van Kuilenburg,A.B., Van Beeumen,J.J., Van der Meer,N.M. and
            Muijsers,A.O.
  TITLE     Subunits VIIa,b,c of human cytochrome c oxidase. Identification of
            both 'heart-type' and 'liver-type' isoforms of subunit VIIa in
            human heart
  JOURNAL   Eur J Biochem 203 (1-2), 193-199 (1992)
   PUBMED   1309697
REFERENCE   10 (bases 1 to 340)
  AUTHORS   Fabrizi,G.M., Rizzuto,R., Nakase,H., Mita,S., Lomax,M.I.,
            Grossman,L.I. and Schon,E.A.
  TITLE     Sequence of a cDNA specifying subunit VIIa of human cytochrome c
            oxidase
  JOURNAL   Nucleic Acids Res 17 (17), 7107 (1989)
   PUBMED   2550906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002757.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001864.3.
            
            Summary: Cytochrome c oxidase (COX), the terminal component of the
            mitochondrial respiratory chain, catalyzes the electron transfer
            from reduced cytochrome c to oxygen. This component is a
            heteromeric complex consisting of 3 catalytic subunits encoded by
            mitochondrial genes and multiple structural subunits encoded by
            nuclear genes. The mitochondrially-encoded subunits function in
            electron transfer, and the nuclear-encoded subunits may function in
            the regulation and assembly of the complex. This nuclear gene
            encodes polypeptide 1 (muscle isoform) of subunit VIIa and the
            polypeptide 1 is present only in muscle tissues. Other polypeptides
            of subunit VIIa are present in both muscle and nonmuscle tissues,
            and are encoded by different genes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: F18996.2, BC002757.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000292907.8/
                                                  ENSP00000292907.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               BC002757.2         423-762
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..340
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /note="cytochrome c oxidase subunit 7A1"
                     /db_xref="GeneID:1346"
                     /db_xref="HGNC:HGNC:2287"
                     /db_xref="MIM:123995"
     exon            1..55
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..280
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 7A1, mitochondrial;
                     cytochrome c oxidase subunit VIIa-H; cytochrome c oxidase
                     subunit VIIa-M; cytochrome c oxidase subunit VIIa-heart;
                     cytochrome c oxidase subunit VIIa-muscle; cytochrome c
                     oxidase subunit VIIa polypeptide 1 (muscle)"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 7A1, mitochondrial
                     precursor"
                     /protein_id="NP_001855.1"
                     /db_xref="CCDS:CCDS12490.1"
                     /db_xref="GeneID:1346"
                     /db_xref="HGNC:HGNC:2287"
                     /db_xref="MIM:123995"
                     /translation="MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLK
                     GGIVDNILYRVTMTLCLGGTVYSLYSLGWASFPRN"
     exon            56..142
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     exon            143..227
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     exon            228..340
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      323..328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /note="hexamer: AATAAA"
     polyA_site      340
                     /gene="COX7A1"
                     /gene_synonym="COX7A; COX7AH; COX7AM"
                     /note="major polyA site"
ORIGIN      
        1 ggagaaggga ggtgactccg gcggaagagg acaaggcaga atgcaggccc ttcgggtgtc
       61 ccaggcgctg atccgctcct tcagctccac cgcccggaac cgctttcaga accgagtgcg
      121 cgagaaacag aagctcttcc aggaggacaa tgacatcccg ttgtacctga agggcggcat
      181 cgttgacaac atcctgtacc gagtgacaat gacgctgtgt ctgggcggca ctgtctacag
      241 cttgtactcc cttggctggg cctccttccc caggaattaa gaccaagaag cctggggggc
      301 ctgagagact tgaacaagtg tcaataaacg ctggcctctg
//
