LOCUS       NM_004374                744 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 6C (COX6C), mRNA.
ACCESSION   NM_004374
VERSION     NM_004374.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 744)
  AUTHORS   Liu,S., Shao,F., Wang,Y., Zhang,Y., Yu,H., Zhang,N., He,L.,
            Kong,Q., Jiang,H. and Dong,Z.
  TITLE     COX6C expression driven by copy amplification of 8q22.2 regulates
            cell proliferation via mediation of mitosis by ROS-AMPK signaling
            in lung adenocarcinoma
  JOURNAL   Cell Death Dis 15 (1), 74 (2024)
   PUBMED   38242874
  REMARK    GeneRIF: COX6C expression driven by copy amplification of 8q22.2
            regulates cell proliferation via mediation of mitosis by ROS-AMPK
            signaling in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 744)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 744)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 744)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 744)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   6  (bases 1 to 744)
  AUTHORS   Kish,S.J., Mastrogiacomo,F., Guttman,M., Furukawa,Y., Taanman,J.W.,
            Dozic,S., Pandolfo,M., Lamarche,J., DiStefano,L. and Chang,L.J.
  TITLE     Decreased brain protein levels of cytochrome oxidase subunits in
            Alzheimer's disease and in hereditary spinocerebellar ataxia
            disorders: a nonspecific change?
  JOURNAL   J Neurochem 72 (2), 700-707 (1999)
   PUBMED   9930743
REFERENCE   7  (bases 1 to 744)
  AUTHORS   Hofmann,S., Lichtner,P., Schuffenhauer,S., Gerbitz,K.D. and
            Meitinger,T.
  TITLE     Assignment of the human genes coding for cytochrome c oxidase
            subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome
            bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1,
            COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and
            radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 226-227 (1998)
   PUBMED   10072584
REFERENCE   8  (bases 1 to 744)
  AUTHORS   Lenka,N., Vijayasarathy,C., Mullick,J. and Avadhani,N.G.
  TITLE     Structural organization and transcription regulation of nuclear
            genes encoding the mammalian cytochrome c oxidase complex
  JOURNAL   Prog Nucleic Acid Res Mol Biol 61, 309-344 (1998)
   PUBMED   9752724
  REMARK    Review article
REFERENCE   9  (bases 1 to 744)
  AUTHORS   Wang,F.L., Wang,Y., Wong,W.K., Liu,Y., Addivinola,F.J., Liang,P.,
            Chen,L.B., Kantoff,P.W. and Pardee,A.B.
  TITLE     Two differentially expressed genes in normal human prostate tissue
            and in carcinoma
  JOURNAL   Cancer Res 56 (16), 3634-3637 (1996)
   PUBMED   8705997
REFERENCE   10 (bases 1 to 744)
  AUTHORS   Otsuka,M., Mizuno,Y., Yoshida,M., Kagawa,Y. and Ohta,S.
  TITLE     Nucleotide sequence of cDNA encoding human cytochrome c oxidase
            subunit VIc
  JOURNAL   Nucleic Acids Res 16 (22), 10916 (1988)
   PUBMED   2849755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105328.13.
            
            On Nov 23, 2018 this sequence version replaced NM_004374.3.
            
            Summary: Cytochrome c oxidase, the terminal enzyme of the
            mitochondrial respiratory chain, catalyzes the electron transfer
            from reduced cytochrome c to oxygen. It is a heteromeric complex
            consisting of 3 catalytic subunits encoded by mitochondrial genes
            and multiple structural subunits encoded by nuclear genes. The
            mitochondrially-encoded subunits function in electron transfer, and
            the nuclear-encoded subunits may be involved in the regulation and
            assembly of the complex. This nuclear gene encodes subunit VIc,
            which has 77% amino acid sequence identity with mouse subunit VIc.
            This gene is up-regulated in prostate cancer cells. A pseudogene
            has been found on chromosomes 16p12. [provided by RefSeq, Jul
            2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA181749.1, SRR1660807.118684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000520468.7/
                                                  ENSP00000428895.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC105328.13        50855-50923
            70-214              AC105328.13        52510-52654
            215-343             AC105328.13        56944-57072
            344-744             AC105328.13        66297-66697
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..744
                     /gene="COX6C"
                     /note="cytochrome c oxidase subunit 6C"
                     /db_xref="GeneID:1345"
                     /db_xref="HGNC:HGNC:2285"
                     /db_xref="MIM:124090"
     exon            1..69
                     /gene="COX6C"
                     /inference="alignment:Splign:2.1.0"
     exon            70..214
                     /gene="COX6C"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..328
                     /gene="COX6C"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit VIc preprotein;
                     cytochrome c oxidase polypeptide VIc; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 6C"
                     /protein_id="NP_004365.1"
                     /db_xref="CCDS:CCDS6284.1"
                     /db_xref="GeneID:1345"
                     /db_xref="HGNC:HGNC:2285"
                     /db_xref="MIM:124090"
                     /translation="MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQ
                     RKKAYADFYRNYDVMKDFEEMRKAGIFQSVK"
     exon            215..343
                     /gene="COX6C"
                     /inference="alignment:Splign:2.1.0"
     exon            344..744
                     /gene="COX6C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      442..447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX6C"
                     /note="hexamer: AATAAA"
     regulatory      453..458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX6C"
                     /note="hexamer: AACAAA"
     polyA_site      460
                     /gene="COX6C"
                     /note="major polyA site"
     polyA_site      473
                     /gene="COX6C"
     regulatory      653..658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX6C"
                     /note="hexamer: ATTAAA"
     polyA_site      673
                     /gene="COX6C"
     regulatory      721..726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX6C"
                     /note="hexamer: AATAAA"
     polyA_site      744
                     /gene="COX6C"
ORIGIN      
        1 attctgcgcc tgcgcgcggc tacagcacgg ttcgtttttc ctttagtcag gaaggacgtt
       61 ggtgttgagg ttagcatacg tatcaaggac agtaactacc atggctcccg aagttttgcc
      121 aaaacctcgg atgcgtggcc ttctggccag gcgtctgcga aatcatatgg ctgtagcatt
      181 cgtgctatcc ctgggggttg cagctttgta taagtttcgt gtggctgatc aaagaaagaa
      241 ggcatacgca gatttctaca gaaactacga tgtcatgaaa gattttgagg agatgaggaa
      301 ggctggtatc tttcagagtg taaagtaatc ttggaatata aagaatttct tcaggttgaa
      361 ttacctagaa gtttgtcact gacttgtgtt cctgaactat gacacatgaa tatgtgggct
      421 aagaaatagt tcctcttgat aaataaacaa ttaacaaata ctttggacag taagtctttc
      481 tcagttctta atgataatgc agggcactta ctagcataag aattggtttg ggatttaact
      541 gtttatgaag ctaacttgat ttccgtgttt tgttaaaatt tcattgttct agcacatctt
      601 taactgtgat agtttgtccg tttcattgca gttacttggt cttgggctat ggattaaaaa
      661 gtgttcttca tgagcctgta agactactgt actgtgggct ctaagaagag atagaatcct
      721 aataaaatct atccttggcc ttca
//
