LOCUS       NM_144613               1566 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 6B2 (COX6B2), transcript
            variant 2, mRNA.
ACCESSION   NM_144613
VERSION     NM_144613.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1566)
  AUTHORS   Shen,M., Zhao,N., Deng,X. and Deng,M.
  TITLE     [High expression of COX6B2 in gastric cancer is associated with
            poor long-term prognosis and promotes cell proliferation and cell
            cycle progression by inhibiting p53 signaling]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (2), 289-297 (2024)
   PUBMED   38501414
  REMARK    GeneRIF: [High expression of COX6B2 in gastric cancer is associated
            with poor long-term prognosis and promotes cell proliferation and
            cell cycle progression by inhibiting p53 signaling].
REFERENCE   2  (bases 1 to 1566)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1566)
  AUTHORS   Cheng,C.C., Wooten,J., Gibbs,Z.A., McGlynn,K., Mishra,P. and
            Whitehurst,A.W.
  TITLE     Sperm-specific COX6B2 enhances oxidative phosphorylation,
            proliferation, and survival in human lung adenocarcinoma
  JOURNAL   Elife 9, e58108 (2020)
   PUBMED   32990599
  REMARK    GeneRIF: Sperm-specific COX6B2 enhances oxidative phosphorylation,
            proliferation, and survival in human lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1566)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1566)
  AUTHORS   Huttemann,M., Jaradat,S. and Grossman,L.I.
  TITLE     Cytochrome c oxidase of mammals contains a testes-specific isoform
            of subunit VIb--the counterpart to testes-specific cytochrome c?
  JOURNAL   Mol Reprod Dev 66 (1), 8-16 (2003)
   PUBMED   12874793
REFERENCE   6  (bases 1 to 1566)
  AUTHORS   Taanman,J.W., Schrage,C., Ponne,N.J., Das,A.T., Bolhuis,P.A., de
            Vries,H. and Agsteribbe,E.
  TITLE     Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and
            steady-state levels of coxVIb mRNA in different tissues
  JOURNAL   Gene 93 (2), 285-291 (1990)
   PUBMED   2172092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG717038.1 and BC026123.2.
            
            On Nov 23, 2018 this sequence version replaced NM_144613.4.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026123.2, BG716978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326529.9/ ENSP00000320672.3
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               BG717038.1         101-660
            561-1566            BC026123.2         657-1662
FEATURES             Location/Qualifiers
     source          1..1566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1566
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /note="cytochrome c oxidase subunit 6B2"
                     /db_xref="GeneID:125965"
                     /db_xref="HGNC:HGNC:24380"
                     /db_xref="MIM:618127"
     exon            1..70
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /inference="alignment:Splign:2.1.0"
     exon            71..200
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..355
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /note="cytochrome c oxidase subunit VIb, testes-specific;
                     cancer/testis antigen 59; COX VIb-2; cytochrome c oxidase
                     subunit VIb polypeptide 2 (testis)"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 6B2"
                     /protein_id="NP_653214.2"
                     /db_xref="CCDS:CCDS42630.1"
                     /db_xref="GeneID:125965"
                     /db_xref="HGNC:HGNC:24380"
                     /db_xref="MIM:618127"
                     /translation="MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLK
                     TRTRRGKSTQPCEYYFRVYHSLCPISWVESWNEQIKNGIFAGKI"
     exon            201..301
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /inference="alignment:Splign:2.1.0"
     exon            302..469
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1566
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1543..1548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /note="hexamer: AATATA"
     polyA_site      1566
                     /gene="COX6B2"
                     /gene_synonym="COXVIB2; CT59"
                     /note="major polyA site"
ORIGIN      
        1 gcggactcag aagcgagcgg caccccggga ccatcccaca gcagatccag tggccgccaa
       61 cgtcaggctg gagttgcctc cttcgtggat gttggatgtg gaagcccagg agccccccaa
      121 ggggaaatgg tcgacgccgc ccttcgaccc gcgcttcccc agccagaacc agatccgtaa
      181 ctgctaccag aacttcctgg actaccaccg ctgcctcaag accaggaccc gccgcgggaa
      241 gagcacgcag ccctgcgagt actatttccg cgtgtaccac tcgctgtgcc ccatcagctg
      301 ggtggagagc tggaacgagc agatcaagaa cgggattttc gccggcaaaa tctgactgcc
      361 ccagcgcggc ttcctctgaa gatgcagtga tcctgcatct ttttgtctcg cggagccccg
      421 ggtctcggtt atccacccct acctcccagt gtctaagcca cgaataatgc caccagcctt
      481 cgagttcctt gtttcccttg ctctggtctc cacgtgtatg atggggttct caggcccagg
      541 cttcgaccag aggaccctct gccaccaccg tttcttcctg tccttgagct accttggtga
      601 actcatgacc ccaggcccct gctccaccag gatgtccccc aggtcctgcc agctgggaag
      661 tgccagcatg aacgcctcca acttcgtgga agccagggtc ccctgcagct gagggacgcc
      721 aagcagacac acctgccctc cccagccagc tcctgtctgt atgggcgaga tgactgagag
      781 cgcccacgtc cctaaggctg tcctgaccct ccatgctgcg acaaggacag ggaatggtcg
      841 gtcactatgg gcctggtgtc tcccctcccc caccacccgg tgctgcccag ctcaagccag
      901 aagctgactt tggccgccat ggggacatca ggcaaggtct ggagacattt ttggttgggg
      961 cagaggcatg ctcctggcat cgagtgggtg gagaccagag aagccgctca acatcctgca
     1021 atgcatggga caggccctgc ctagaaacac cagctcagca tggcagcagt gcggaggcca
     1081 ggaaaccctg atcgccagtt tctaacgccc tcaccatttt tatttttatt tttatttttt
     1141 ttgagacaga gtttcgctcc tgtcacccag gctggagtac aatgatgcga tctcagctca
     1201 ctgcaacctc tgcctcccgg gttcaagtga ttctcctgcc tcagcctccc gagtagctgg
     1261 gattacaggc atgcaccacc acgcccagct tattttgtat ttttagtaga gacggggttt
     1321 ctccgtgttg gtcaggctgg tctcaaactc ctgacctcag gcaatctgcc cacctcagcc
     1381 tcccaaagtg ctgggattac aggcgtgagc cactgcaccc ggctcaccac tagtttttag
     1441 ccctttttgt tgggggtggg gtgggggcag aggagaggcg gatacagaaa cttgtgagaa
     1501 tgtgatgaac gctctgaacc ccctataaaa aatgtgcatg taaatatata ctctcaacat
     1561 ttaaaa
//
