LOCUS       NM_032609                669 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_032609
VERSION     NM_032609.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Vogt,S., Ramzan,R., Cybulski,P., Rhiel,A., Weber,P., Ruppert,V.,
            Irqsusi,M., Rohrbach,S., Niemann,B., Mirow,N. and Rastan,A.J.
  TITLE     The ratio of cytochrome c oxidase subunit 4 isoform 4I1 and 4I2
            mRNA is changed in permanent atrial fibrillation
  JOURNAL   ESC Heart Fail 11 (3), 1525-1539 (2024)
   PUBMED   38149324
  REMARK    GeneRIF: The ratio of cytochrome c oxidase subunit 4 isoform 4I1
            and 4I2 mRNA is changed in permanent atrial fibrillation.
REFERENCE   2  (bases 1 to 669)
  AUTHORS   Li,X., Zhuo,R., Mao,Y., Fang,C., Dai,J., Ye,L., Wang,C. and Sun,F.
  TITLE     HIF1A transcriptional regulation of COX4I2 impacts angiogenesis in
            pheochromocytoma
  JOURNAL   Biochem Biophys Res Commun 704, 149638 (2024)
   PUBMED   38422899
  REMARK    GeneRIF: HIF1A transcriptional regulation of COX4I2 impacts
            angiogenesis in pheochromocytoma.
REFERENCE   3  (bases 1 to 669)
  AUTHORS   Li,J.P., Liu,Y.J., Zeng,S.H., Gao,H.J., Chen,Y.G. and Zou,X.
  TITLE     Identification of COX4I2 as a hypoxia-associated gene acting
            through FGF1 to promote EMT and angiogenesis in CRC
  JOURNAL   Cell Mol Biol Lett 27 (1), 76 (2022)
   PUBMED   36064310
  REMARK    GeneRIF: Identification of COX4I2 as a hypoxia-associated gene
            acting through FGF1 to promote EMT and angiogenesis in CRC.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 669)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 669)
  AUTHORS   Douiev,L., Miller,C., Ruppo,S., Benyamini,H., Abu-Libdeh,B. and
            Saada,A.
  TITLE     Upregulation of COX4-2 via HIF-1alpha in Mitochondrial COX4-1
            Deficiency
  JOURNAL   Cells 10 (2), 452 (2021)
   PUBMED   33672589
  REMARK    GeneRIF: Upregulation of COX4-2 via HIF-1alpha in Mitochondrial
            COX4-1 Deficiency.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 669)
  AUTHORS   Lynch,S.R., Sherman,D. and Copeland,R.A.
  TITLE     Cytochrome c binding affects the conformation of cytochrome a in
            cytochrome c oxidase
  JOURNAL   J Biol Chem 267 (1), 298-302 (1992)
   PUBMED   1309738
REFERENCE   7  (bases 1 to 669)
  AUTHORS   Garber,E.A. and Margoliash,E.
  TITLE     Interaction of cytochrome c with cytochrome c oxidase: an
            understanding of the high- to low-affinity transition
  JOURNAL   Biochim Biophys Acta 1015 (2), 279-287 (1990)
   PUBMED   2153405
REFERENCE   8  (bases 1 to 669)
  AUTHORS   Bolli,R., Nalecz,K.A. and Azzi,A.
  TITLE     The interconversion between monomeric and dimeric bovine heart
            cytochrome c oxidase
  JOURNAL   Biochimie 67 (1), 119-128 (1985)
   PUBMED   2986725
REFERENCE   9  (bases 1 to 669)
  AUTHORS   Michel,B. and Bosshard,H.R.
  TITLE     Spectroscopic analysis of the interaction between cytochrome c and
            cytochrome c oxidase
  JOURNAL   J Biol Chem 259 (16), 10085-10091 (1984)
   PUBMED   6088481
REFERENCE   10 (bases 1 to 669)
  AUTHORS   Hare,J.F., Ching,E. and Attardi,G.
  TITLE     Isolation, subunit composition, and site of synthesis of human
            cytochrome c oxidase
  JOURNAL   Biochemistry 19 (10), 2023-2030 (1980)
   PUBMED   6246917
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL117381.32.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_032609.2.
            
            Summary: Cytochrome c oxidase (COX), the terminal enzyme of the
            mitochondrial respiratory chain, catalyzes the electron transfer
            from reduced cytochrome c to oxygen. It is a heteromeric complex
            consisting of 3 catalytic subunits encoded by mitochondrial genes
            and multiple structural subunits encoded by nuclear genes. The
            mitochondrially-encoded subunits function in electron transfer, and
            the nuclear-encoded subunits may be involved in the regulation and
            assembly of the complex. This nuclear gene encodes isoform 2 of
            subunit IV. Isoform 1 of subunit IV is encoded by a different gene,
            however, the two genes show a similar structural organization.
            Subunit IV is the largest nuclear encoded subunit which plays a
            pivotal role in COX regulation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279827.447.1, BC057779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000376075.4/
                                                  ENSP00000365243.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL117381.32        32191-32241
            52-133              AL117381.32        33297-33378
            134-298             AL117381.32        34212-34376
            299-430             AL117381.32        37683-37814
            431-669             AL117381.32        39047-39285
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..669
                     /gene="COX4I2"
                     /gene_synonym="COX4; COX4-2; COX4B; COX4L2; COXIV-2;
                     dJ857M17.2"
                     /note="cytochrome c oxidase subunit 4I2"
                     /db_xref="GeneID:84701"
                     /db_xref="HGNC:HGNC:16232"
                     /db_xref="MIM:607976"
     exon            1..51
                     /gene="COX4I2"
                     /gene_synonym="COX4; COX4-2; COX4B; COX4L2; COXIV-2;
                     dJ857M17.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..567
                     /gene="COX4I2"
                     /gene_synonym="COX4; COX4-2; COX4B; COX4L2; COXIV-2;
                     dJ857M17.2"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit IV-like 2; COX IV-2"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 4 isoform 2,
                     mitochondrial"
                     /protein_id="NP_115998.2"
                     /db_xref="CCDS:CCDS13187.1"
                     /db_xref="GeneID:84701"
                     /db_xref="HGNC:HGNC:16232"
                     /db_xref="MIM:607976"
                     /translation="MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQR
                     YYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEW
                     KTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLAS
                     RWDYEKKQWKK"
     exon            52..133
                     /gene="COX4I2"
                     /gene_synonym="COX4; COX4-2; COX4B; COX4L2; COXIV-2;
                     dJ857M17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..298
                     /gene="COX4I2"
                     /gene_synonym="COX4; COX4-2; COX4B; COX4L2; COXIV-2;
                     dJ857M17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..430
                     /gene="COX4I2"
                     /gene_synonym="COX4; COX4-2; COX4B; COX4L2; COXIV-2;
                     dJ857M17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..669
                     /gene="COX4I2"
                     /gene_synonym="COX4; COX4-2; COX4B; COX4L2; COXIV-2;
                     dJ857M17.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgctcgc tgggcagacc caggtcgcgc tcccactgcc gagcccgcga gatgctcccc
       61 agagctgcct ggagcttggt gctgaggaaa ggtggaggtg gaagacgagg gatgcacagc
      121 tcagaaggca ccacccgtgg tggggggaag atgtccccct acaccaactg ctatgcccag
      181 cgctactacc ccatgccaga agagcccttc tgcacagaac tcaacgctga ggagcaggcc
      241 ctgaaggaga aggagaaggg aagctggacc cagctgaccc acgccgaaaa ggtggccttg
      301 taccggctcc agttcaatga gacctttgcg gagatgaacc gtcgctccaa tgagtggaag
      361 acagtgatgg gttgtgtctt cttcttcatt ggattcgcag ctctggtgat ttggtggcag
      421 cgggtctacg tatttcctcc aaagccgatc accttgacgg acgagcggaa agcccagcag
      481 ctgcagcgca tgctggacat gaaggtgaat cctgtgcagg gcctggcctc ccgctgggac
      541 tatgagaaga agcagtggaa gaagtgactt gcatccccag ctgtctccct gaggctccgc
      601 cctggctggg agcctctggc ggcccctccc ctcccctgcc cttaacccca gtaaagctcc
      661 aaaaaaaaa
//
