LOCUS       NM_001031617            4839 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase assembly factor COX19 (COX19),
            mRNA.
ACCESSION   NM_001031617
VERSION     NM_001031617.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Gao,S., Zhang,H., Zhang,X., Wang,J., Bai,W. and Jiang,B.
  TITLE     COX19 Is a New Target of MACC1 and Promotes Colorectal Cancer
            Progression by Regulating Copper Transport in Mitochondria
  JOURNAL   J Nutr 154 (2), 381-394 (2024)
   PUBMED   38141772
  REMARK    GeneRIF: COX19 Is a New Target of MACC1 and Promotes Colorectal
            Cancer Progression by Regulating Copper Transport in Mitochondria.
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 4839)
  AUTHORS   Wang,H., St Julien,K.R., Stevenson,D.K., Hoffmann,T.J., Witte,J.S.,
            Lazzeroni,L.C., Krasnow,M.A., Quaintance,C.C., Oehlert,J.W.,
            Jelliffe-Pawlowski,L.L., Gould,J.B., Shaw,G.M. and O'Brodovich,H.M.
  TITLE     A genome-wide association study (GWAS) for bronchopulmonary
            dysplasia
  JOURNAL   Pediatrics 132 (2), 290-297 (2013)
   PUBMED   23897914
REFERENCE   4  (bases 1 to 4839)
  AUTHORS   Fischer,M., Horn,S., Belkacemi,A., Kojer,K., Petrungaro,C.,
            Habich,M., Ali,M., Kuttner,V., Bien,M., Kauff,F., Dengjel,J.,
            Herrmann,J.M. and Riemer,J.
  TITLE     Protein import and oxidative folding in the mitochondrial
            intermembrane space of intact mammalian cells
  JOURNAL   Mol Biol Cell 24 (14), 2160-2170 (2013)
   PUBMED   23676665
REFERENCE   5  (bases 1 to 4839)
  AUTHORS   Leary,S.C., Cobine,P.A., Nishimura,T., Verdijk,R.M., de Krijger,R.,
            de Coo,R., Tarnopolsky,M.A., Winge,D.R. and Shoubridge,E.A.
  TITLE     COX19 mediates the transduction of a mitochondrial redox signal
            from SCO1 that regulates ATP7A-mediated cellular copper efflux
  JOURNAL   Mol Biol Cell 24 (6), 683-691 (2013)
   PUBMED   23345593
  REMARK    GeneRIF: COX19 is necessary for the transduction of a
            SCO1-dependent mitochondrial redox signal that regulates
            ATP7A-mediated cellular copper efflux.
REFERENCE   6  (bases 1 to 4839)
  AUTHORS   Sacconi,S., Trevisson,E., Pistollato,F., Baldoin,M.C.,
            Rezzonico,R., Bourget,I., Desnuelle,C., Tenconi,R., Basso,G.,
            DiMauro,S. and Salviati,L.
  TITLE     hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase
            assembly
  JOURNAL   Biochem Biophys Res Commun 337 (3), 832-839 (2005)
   PUBMED   16212937
  REMARK    GeneRIF: Both hCox18p and hCox19p present significant amino acid
            identity with the corresponding yeast polypeptides and reveal
            highly conserved functional domains.
REFERENCE   7  (bases 1 to 4839)
  AUTHORS   Tay,S.K., Nesti,C., Mancuso,M., Schon,E.A., Shanske,S., Bonilla,E.,
            Davidson,M.M. and Dimauro,S.
  TITLE     Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase
            deficiency
  JOURNAL   Arch Neurol 61 (12), 1935-1937 (2004)
   PUBMED   15596615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY957566.1, AC073957.7 and AA437231.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001031617.2.
            
            Summary: COX19 encodes a cytochrome c oxidase (COX)-assembly
            protein. The S. cerevisiae Cox19 protein may play a role in metal
            transport to the mitochondrial intermembrane space and assembly of
            complex IV of the mitochondrial respiratory chain (Sacconi et al.,
            2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY957566.1, SRR1660803.247765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154125 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344111.4/ ENSP00000342015.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2129              AY957566.1         1-2129
            2130-4804           AC073957.7         85947-88621         c
            4805-4839           AA437231.1         8-42                c
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..4839
                     /gene="COX19"
                     /note="cytochrome c oxidase assembly factor COX19"
                     /db_xref="GeneID:90639"
                     /db_xref="HGNC:HGNC:28074"
                     /db_xref="MIM:610429"
     exon            1..122
                     /gene="COX19"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..313
                     /gene="COX19"
                     /note="hCOX19; COX19 cytochrome c oxidase assembly
                     homolog; cytochrome c oxidase assembly homolog 19; COX19,
                     cytochrome c oxidase assembly factor"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly protein COX19"
                     /protein_id="NP_001026788.1"
                     /db_xref="CCDS:CCDS34582.1"
                     /db_xref="GeneID:90639"
                     /db_xref="HGNC:HGNC:28074"
                     /db_xref="MIM:610429"
                     /translation="MSTAMNFGTKSFQPRPPDKGSFPLDHLGECKSFKEKFMKCLHNN
                     NFENALCRKESKEYLECRMERKLMLQEPLEKLGFGDLTSGKSEAKK"
     exon            123..234
                     /gene="COX19"
                     /inference="alignment:Splign:2.1.0"
     exon            235..4839
                     /gene="COX19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      309..314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX19"
                     /note="hexamer: AATGAA"
     polyA_site      328
                     /gene="COX19"
                     /note="major polyA site"
     regulatory      2730..2735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX19"
                     /note="hexamer: AATAAA"
     polyA_site      2751
                     /gene="COX19"
                     /note="major polyA site"
     regulatory      4818..4823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COX19"
                     /note="hexamer: ATTAAA"
     polyA_site      4839
                     /gene="COX19"
                     /note="major polyA site"
ORIGIN      
        1 gtacgctcgc aaggcgctcg cagactccgg agtcgccaac atgtcgaccg ccatgaattt
       61 cgggaccaag agcttccagc cgcggccccc ggacaagggc agcttcccgc tggatcactt
      121 aggtgaatgt aaaagcttta aagagaaatt catgaagtgt cttcataaca ataattttga
      181 aaatgctttg tgcagaaagg aatcaaaaga atatttagaa tgcaggatgg agagaaaatt
      241 gatgctacaa gaaccattgg agaaactggg atttggagac ttgactagtg gaaaatcaga
      301 ggcaaaaaaa tgaattttga tgagaagacc cctgggccgt gttcagtggt ctctcaggac
      361 ggagggcatc atcctgcctc ttaggttggc tgaggcctgc gtgtggtgtc cttagaaatg
      421 ggcttcgaat agaagctcca gccctgtggg ggcgtctcct gggtagggag tggcgtcccg
      481 ttttccctta ggagggtgtt tctgcattga acccctgagt gggacggcgt tcccggcaaa
      541 gctgggaggg aggcgagcgt ggggcaagac ccttgtcttc gaggccgggg ccctcttgta
      601 tggggcggtt ttatgttgca gtcctctgat actttctgag ttcaaagagg taaatgtata
      661 aatttcagtc ccttctgaac acagatatca tcagaaaatt accattccct agcaggatgt
      721 tttcgtgttt gtattcgtat atgccagttc atttcctttg aaaaaaaaaa aaagtggaac
      781 acaaagtagg aagtgagaac cttctggctt tggatggatt gacttcttga ttctttctgg
      841 ttttgcctga acaccaagta gcttcataat caaagggtca ttttctggtt tgtatcagac
      901 cgtatttata aagttgggta tttaatttca gtaactcctg tattttaaca gaaaaagaac
      961 ctgagtccat ttgcagttag gctcgcacca gctgtcttct gtgccagcca gctccgcccg
     1021 agaccccggc acgtgttcgc agcacagcct ggcaggggcc ctgagcggag ttctcagccc
     1081 gtctgtgcca aagttgcctg tgggtcacgg aaacccggcc catgtccacc cagtgcgtca
     1141 ggccagccgg ggcccaaacc tgtggatgga acgcaggtgc ctgcacatct ggggcctcag
     1201 ccagacctgt ctccttccca ggcactgtcg gaaaggggct ggctcctgtc tggtcagtgg
     1261 aggatggtgg caggagacgg ggtggggagg tccaggtcac gtcctctctg gcgaccctgg
     1321 cagtggctgt ctccaagccc tggcaggtgg ggccaccaat ctggccgacc tcaggctctg
     1381 ggaaacaggc tgccctcgtc cctctgcctg tgggtggctg aggcttctca gcccatctcc
     1441 agttctctgc agcaaaggcc ctctgtttct gtcctgcagt ggtggccctt tcgtggttaa
     1501 acatgtccct cccctcctca cagaactgag tacctattgc ggctgggccc gcccaaccct
     1561 gtgtccctgc acccatgggt tctaccacct gattcggctg cagctgtcac tgtcccgtgt
     1621 ctgctctctg tcaggcctct gagtgctgca gacgtattaa catatcaccg ctagttgatg
     1681 gaaagtcttg tttcttatta gaatattttg tgtaggcaca gggttgcccc agcactgtct
     1741 atagcaaccc cagtgtcctc acagtgcacg tgagccgtga cgcagccacc gtggagtcgg
     1801 cgctgacgcg gtgtggccac gtgccatgag ctcgccaacg cagtgcggct atatggcgtg
     1861 agcttactgt gaagtggaga caggcaggga cacaggaaac tacaaacgag aaatccagaa
     1921 ggaggagctg gaactgatgg gcatagccgg ccgcgagccc ctccgagcac ccctgggggt
     1981 ggagttctgg ctgtcatggc agagggtttc acatgctcaa aaagtaaatg aaccaggatg
     2041 tgaggggaac acaacagacc atgccgacgg agctcccggg cccaggccgg ggcctcttcc
     2101 catcgcactc tgacccgccg tcgggagtgc ccaggcccgg gtcgggcctg cctctccgct
     2161 cgcaccgcac tctgacccat caggagtgtg gggaagaccg tcgaccaaag gtgggaaaga
     2221 caggaaagat actgtactct aagtagtaaa tttgtttttt gcgtggacga ttctgaagct
     2281 gtattctgag atggaaaaaa ctagaaatac atcgtggatg atgagagcca ggtgtattga
     2341 gctcctgctt ttctaacgta caaaggtaac tggatagaga aacggagtga tcgccctcac
     2401 ctggccaggg tgtgctccga gaccccagca ggtgccgaag ccgcggatag tcccgaatcc
     2461 tgtccaggcg ctgttttttc ctgtacgtac ctgtgatcaa gtctgagatg tgacagcaaa
     2521 actgacagaa cttcgtgctt ccctcttcaa aatgtcacag atgggcactg tgttcttacc
     2581 ggagatctta gcaacctcgg catctggctg tttttcttat aggtcaggag tttccacctt
     2641 ttcccttaaa ggaagcgctt ggcagcttct ctggtgtgtc tgagtcgcca gcatcaccac
     2701 tgtcctgttc tggggccatt cttaagtaaa ataaaagctt cttggaccca agcaccacat
     2761 caccgcgatg gctggtctga tcaccgagat ggctgctgag tgcctggcag gcagggtggc
     2821 gtggatggcc cgaaacgctg gacggaggga gggttgatgt cccagcagga cggctgctca
     2881 gaacagcaca gaatcaaaaa ctcatgaatg gtttatttct ggaattttcc acttagtatt
     2941 tttggactgt ggctgaccat gggtaactga aaccgtgtgt aagggggact gttgtgaggg
     3001 gctgtgcaca aatgcttccc agctcttgag ggcctggacg cagtgacccg tgcactcagg
     3061 gtcttggccc tgataccatt ctgtaaccaa aaggaaccag ggccaggcca gagaaggtat
     3121 cagatgagct agagagtgaa gaattgctgg gatgaggaga cttgttgaaa taacacgggg
     3181 ggatgggaag gagcatacgg tggccagcct ggggcagtgt gagcgtgaaa ataaacaggc
     3241 tgggcgcagc ggctcacgcc tgcaatccca gcactttagg aggccaaggt gggaggatca
     3301 cttgaggcta ggagttcaag accagcctgg gcaacatggg tgaaaccctg tctctacaaa
     3361 acaagaaaag tcagccgtgc gtggtgtcac ccgcctgtag tcccagatac tcaggaagct
     3421 gaggcaggag gatcacttga gccagaggtt aagtctgcag tgagctgtga ttgtaccact
     3481 gctctccagc ctgagcaaca gagccggacc ctgtctcacc aaaggaaaaa aaaaaaaaaa
     3541 aaagaaagaa aattaattat tgtaatgggc tgtagccctc agaataaatt gatatccagt
     3601 agtctataca acataagtaa ttgcgtaaac atgtcagtgg ggggagggcc aggtctgtct
     3661 tattaattct aatatagaag aaattttggg aacaggaaac tgctgttgca gaaaccacac
     3721 tggtgacagg tgcagattac aaccctcagc gggccgggcg ccagtggctc acgcctataa
     3781 tcccaacact ttgggaggcc gaggcaggca gatcacttga ggccaggagt tcaaggccag
     3841 cctggccaac atggagaaac cctgtctcta ctaaaaatac aaaaattagc tggggctggt
     3901 ggcgtgtgtc tgtaatccag ctattcggga ggccgaggtg ggagaattgc ctaaaccagg
     3961 aggcagaggt tgcagtgagc agggattgtg ccaccacact ccagcctggg cgacagaacc
     4021 gtctcaaaaa aaaaccctca gttgccatga agtgagtggt gacgtgtggt gtgaagcagg
     4081 tgtctgctgt cttgagaaac ctccccttga gatgcatagt gacctccgag gagacagtca
     4141 tgtcacagca gaacggcaga ggccccctta acccagcagc caccgccggg agcgagccgc
     4201 acaggccgca ccgacctggg ggcgtccctg agggcacggt atcacctctg gttctcttgc
     4261 ccaactgcat ggcctgaatg taatcccaag gagacaacag acacagaccc aaaccgagga
     4321 gccttctgcg aagtgactgg cagcgctggc ccagtgttat gtaagatgtt atttggggaa
     4381 ctgggtatac acactgtcct atttttggaa ctttttggaa gtctgaaatt attttgaaat
     4441 gaggaaaaaa aaatatgctt tgtatgaaac tatagtggaa tagattgagt cgattctcgt
     4501 ttcaaaataa cttcaaagag tttccaatag gcatgatgcc ggcatgaatg gtttcagcag
     4561 gtcacaggca gagaagccgg aatcccaaaa tagcgccatt gtgtggacaa cctgactcct
     4621 tacaaacgtg cagtggcttc ccaacgctgc ctttgagttt ctgggtctgg ctgctgaatg
     4681 tgttgtgctt aagaatccag acaccctgct gttcctgcca gagcttctca cgagatattt
     4741 cgggtagttc atcatctgtc atgtgcagaa tgcattttat ttctcataga cgcttgtcat
     4801 gataagctgg ccacattatt aaaaggctcc caaagacaa
//
