LOCUS       NM_001302                914 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cortistatin (CORT), mRNA.
ACCESSION   NM_001302
VERSION     NM_001302.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Castillo-Gonzalez,J., Ruiz,J.L., Serrano-Martinez,I.,
            Forte-Lago,I., Ubago-Rodriguez,A., Caro,M., Perez-Gomez,J.M.,
            Benitez-Troncoso,A., Andres-Leon,E., Sanchez-Navarro,M., Luque,R.M.
            and Gonzalez-Rey,E.
  TITLE     Cortistatin deficiency reveals a dysfunctional brain endothelium
            with impaired gene pathways, exacerbated immune activation, and
            disrupted barrier integrity
  JOURNAL   J Neuroinflammation 20 (1), 226 (2023)
   PUBMED   37794493
  REMARK    GeneRIF: Cortistatin deficiency reveals a dysfunctional brain
            endothelium with impaired gene pathways, exacerbated immune
            activation, and disrupted barrier integrity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 914)
  AUTHORS   Saez-Martinez,P., Porcel-Pastrana,F., Perez-Gomez,J.M.,
            Pedraza-Arevalo,S., Gomez-Gomez,E., Jimenez-Vacas,J.M., Gahete,M.D.
            and Luque,R.M.
  TITLE     Somatostatin, Cortistatin and Their Receptors Exert Antitumor
            Actions in Androgen-Independent Prostate Cancer Cells: Critical
            Role of Endogenous Cortistatin
  JOURNAL   Int J Mol Sci 23 (21), 13003 (2022)
   PUBMED   36361790
  REMARK    GeneRIF: Somatostatin, Cortistatin and Their Receptors Exert
            Antitumor Actions in Androgen-Independent Prostate Cancer Cells:
            Critical Role of Endogenous Cortistatin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 914)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 914)
  AUTHORS   Zhao,Y., Qiu,C., Wang,W., Peng,J., Cheng,X., Shangguan,Y., Xu,M.,
            Li,J., Qu,R., Chen,X., Jia,S., Luo,D., Liu,L., Li,P., Guo,F.,
            Vasilev,K., Liu,L., Hayball,J., Dong,S., Pan,X., Li,Y., Guo,L.,
            Cheng,L. and Li,W.
  TITLE     Cortistatin protects against intervertebral disc degeneration
            through targeting mitochondrial ROS-dependent NLRP3 inflammasome
            activation
  JOURNAL   Theranostics 10 (15), 7015-7033 (2020)
   PUBMED   32550919
  REMARK    GeneRIF: Cortistatin protects against intervertebral disc
            degeneration through targeting mitochondrial ROS-dependent NLRP3
            inflammasome activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 914)
  AUTHORS   Pan,W., Yang,D., Yu,P. and Yu,H.
  TITLE     Comparison of predictive value of NT-proBNP, sST2 and MMPs in heart
            failure patients with different ejection fractions
  JOURNAL   BMC Cardiovasc Disord 20 (1), 208 (2020)
   PUBMED   32354356
  REMARK    GeneRIF: Comparison of predictive value of NT-proBNP, sST2 and MMPs
            in heart failure patients with different ejection fractions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 914)
  AUTHORS   Spier,A.D. and de Lecea,L.
  TITLE     Cortistatin: a member of the somatostatin neuropeptide family with
            distinct physiological functions
  JOURNAL   Brain Res Brain Res Rev 33 (2-3), 228-241 (2000)
   PUBMED   11011067
  REMARK    Review article
REFERENCE   7  (bases 1 to 914)
  AUTHORS   Ejeskar,K., Abel,F., Sjoberg,R., Backstrom,J., Kogner,P. and
            Martinsson,T.
  TITLE     Fine mapping of the human preprocortistatin gene (CORT) to
            neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence
            of mutations in primary tumors
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 62-66 (2000)
   PUBMED   10894940
REFERENCE   8  (bases 1 to 914)
  AUTHORS   Puebla,L., Mouchantaf,R., Sasi,R., Khare,S., Bennett,H.P., James,S.
            and Patel,Y.C.
  TITLE     Processing of rat preprocortistatin in mouse AtT-20 cells
  JOURNAL   J Neurochem 73 (3), 1273-1277 (1999)
   PUBMED   10461921
  REMARK    GeneRIF: Identifies post-translational cleavage products of the
            homologous rat protein.
REFERENCE   9  (bases 1 to 914)
  AUTHORS   de Lecea,L., Ruiz-Lozano,P., Danielson,P.E., Peelle-Kirley,J.,
            Foye,P.E., Frankel,W.N. and Sutcliffe,J.G.
  TITLE     Cloning, mRNA expression, and chromosomal mapping of mouse and
            human preprocortistatin
  JOURNAL   Genomics 42 (3), 499-506 (1997)
   PUBMED   9205124
REFERENCE   10 (bases 1 to 914)
  AUTHORS   Fukusumi,S., Kitada,C., Takekawa,S., Kizawa,H., Sakamoto,J.,
            Miyamoto,M., Hinuma,S., Kitano,K. and Fujino,M.
  TITLE     Identification and characterization of a novel human
            cortistatin-like peptide
  JOURNAL   Biochem Biophys Res Commun 232 (1), 157-163 (1997)
   PUBMED   9125122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358561.1, BC119724.1,
            BC040034.1 and BF590359.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001302.4.
            
            Summary: This gene encodes a neuropeptide that is structurally
            similar to somatostatin. It binds to all known somatostatin
            receptors, and shares many pharmacological and functional
            properties with somatostatin, including the depression of neuronal
            activity. However, it also has many properties distinct from
            somatostatin, such as induction of slow-wave sleep, apparently by
            antagonism of the excitatory effects of acetylcholine on the
            cortex, reduction of locomotor activity, and activation of cation
            selective currents not responsive to somatostatin. The
            preproprotein undergoes further processing into multiple mature
            products. Read-through transcripts exist between this gene and the
            upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as
            represented in GeneID:100526739. [provided by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040034.1, BI756063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal (PMID:11011067)
            MANE Ensembl match               :: ENST00000377049.4/
                                                ENSP00000366248.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               AY358561.1         313-714
            403-538             BC119724.1         395-530
            539-812             BC040034.1         399-672
            813-914             BF590359.1         13-114              c
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..914
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /note="cortistatin"
                     /db_xref="GeneID:1325"
                     /db_xref="HGNC:HGNC:2257"
                     /db_xref="MIM:602784"
     exon            1..292
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..511
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /note="cortistatin-29; cortistatin-17; cortistatin-14;
                     preprocortistatin; prepro-cortistatin; somatostatin 2"
                     /codon_start=1
                     /product="cortistatin preproprotein"
                     /protein_id="NP_001293.3"
                     /db_xref="CCDS:CCDS117.2"
                     /db_xref="GeneID:1325"
                     /db_xref="HGNC:HGNC:2257"
                     /db_xref="MIM:602784"
                     /translation="MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKS
                     SLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFS
                     SCK"
     exon            293..914
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      555..560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /note="hexamer: AATAAA"
     polyA_site      575
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /note="major polyA site"
     regulatory      794..799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /note="hexamer: AATAAA"
     polyA_site      818
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
     regulatory      896..901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
                     /note="hexamer: ATTAAA"
     polyA_site      914
                     /gene="CORT"
                     /gene_synonym="CST-14; CST-17; CST-29; SST2"
ORIGIN      
        1 gtcactgcgc gagggaagag ggaagaggat ccaggcgtta gacatgtata gacacaaaaa
       61 cagctggaga ttgggcttaa aatacccacc aagctccaaa gaagagaccc aagtccccaa
      121 aacattgatt tcagggctgc caggaaggaa gagcagcagc agggtgggag agaagctcca
      181 gtcagcccac aagatgccat tgtcccccgg cctcctgctg ctgctgctct ccggggccac
      241 ggccaccgct gccctgcccc tggagggtgg ccccaccggc cgagacagcg agcatatgca
      301 ggaagcggca ggaataagga aaagcagcct cctgactttc ctcgcttggt ggtttgagtg
      361 gacctcccag gccagtgccg ggcccctcat aggagaggaa gcccgggagg tggccaggcg
      421 gcaggaaggc gcaccccccc agcaatctgc gcgccgggac agaatgccct gcaggaactt
      481 cttctggaag accttctcct cctgcaaata aaacctcacc catgaatgct cacgcaagtg
      541 taatgacaga cctgaataaa atgtattaag cagcagtgat ctttcctctc ctccttccca
      601 agtcatttga aaagtgtttg ttatttaaat tccaataatg cccaatactg acgtgtcttg
      661 agtaatttgg aacccaaagt gaagatcttt gataaagatt tttttgtggt tcgactggac
      721 tgtgctgagt gcgggcactg ggcttttctt ctgatgttca ttatggtgct gggaagctct
      781 gtctttgatt taaaataaaa tagctaaagg ctacacaatt aagagttcag aataacatct
      841 tatttcagtt tatgaattga tatgaattgt ctaatttaaa aaatatttcc ctcacattaa
      901 aagcaaattt ttaa
//
