LOCUS       NM_001201479            3293 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens CORO7-PAM16 readthrough (CORO7-PAM16), mRNA.
ACCESSION   NM_001201479
VERSION     NM_001201479.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012676.5 and BC032732.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001201479.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring CORO7 (coronin 7) and PAM16
            (presequence translocase-associated motor 16) genes on chromosome
            16. The read-through transcript encodes a fusion protein that
            shares sequence identity with each individual gene product.
            [provided by RefSeq, Jan 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.148416.1, BC032732.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 51025, 79585
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC012676.5         116956-116964       c
            10-3186             BC032732.1         12-3188
            3187-3187           AC012676.5         40725-40725         c
            3188-3293           BC032732.1         3190-3295
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3293
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /note="CORO7-PAM16 readthrough"
                     /db_xref="GeneID:100529144"
                     /db_xref="HGNC:HGNC:44424"
     exon            1..138
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..3225
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /note="70 kDa WD repeat tumor rejection antigen homolog"
                     /codon_start=1
                     /product="CORO7-PAM16 protein"
                     /protein_id="NP_001188408.1"
                     /db_xref="GeneID:100529144"
                     /db_xref="HGNC:HGNC:44424"
                     /translation="MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSL
                     IAFNSDRPGVLGIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTV
                     KLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQP
                     LTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRL
                     AWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLV
                     LAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLS
                     DTAIVPIGYHVPRKAVEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH
                     PSFTSCLVPPAEPLPDTAQPAVMETPVGDADASEGFSSPPSSLTSPSTPSSLGPSLSS
                     TSGIGTSPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANK
                     LRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGED
                     ARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL
                     QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG
                     RGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDP
                     DTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHKGLVLLPKTECDVREVELM
                     RCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLSAEAWLQGANGQPWLLS
                     LQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAMVAKLGNREDPLPQD
                     SFEGVDEDEWAKYLAQIIVMGVQVVGRAFARALRQEFAASRAAADARGRAGHRSAAAS
                     NLSGLSLQEAQQILNVSKLSPEEVQKNYEHLFKVNDKSVGGSFYLQSKVVRAKERLDE
                     ELKIQAQEDREKGQMPHT"
     exon            139..235
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            236..310
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            311..381
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            382..565
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            566..642
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            643..693
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            694..780
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            781..863
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            864..918
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            919..976
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1122
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1215
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1353
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1480
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1656
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1765
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1852
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1995
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2100
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2186
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2328
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2418
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2535
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2671
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2763
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2850
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2935
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3072
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3138
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3293
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3275..3280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /note="hexamer: AATAAA"
     polyA_site      3293
                     /gene="CORO7-PAM16"
                     /gene_synonym="CORO7; Coronin-7; Crn7"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcggtt gctcagcgtg cacctgagac ccgacgcccg gggtcctcga agacgcgtcc
       61 gccgccgtgc ccgtcgccat gaaccgcttc agggtgtcca agttccggca caccgaggct
      121 cggccgcccc gccgcgagtc ctggatcagt gacattcgag caggaaccgc cccttcatgc
      181 aggaaccaca tcaaatcaag ctgcagcttg atcgccttca actccgaccg tcctggtgta
      241 ctgggcattg tgcctctgca aggccaagga gaggacaagc gacgcgtggc ccacctgggc
      301 tgccattcag acctagtcac cgacttggac ttctcgccct ttgatgactt cctcctggcc
      361 acaggctcgg ctgacaggac ggtaaaactc tggcgactgc cagggcctgg ccaggccctg
      421 ccctcagcac ccggggtggt gctgggcccc gaggacctcc cagtggaggt actgcagttc
      481 caccccacct ctgacggcat tctggtgagc gcagcaggca ccactgtgaa ggtctgggac
      541 gcagccaagc agcagcccct gacagagctg gcagcccatg gggacctggt gcagagcgcc
      601 gtctggagcc gagatggagc cctggtgggc acggcgtgca aggacaagca gctgcggatc
      661 tttgacccca gaacaaagcc gcgggcctct cagagcacgc aggcccatga gaacagcagg
      721 gatagccggc tggcatggat gggcacctgg gagcaccttg tgtctactgg attcaaccag
      781 atgcgtgagc gcgaagtgaa gctgtgggac acgcggttct tctccagcgc cctggcctcc
      841 ctcaccttgg acacctcgct tgggtgtctc gtgcctctgc tggaccctga ctctgggctc
      901 ctggtcctgg caggaaaggg cgagaggcag ctgtactgtt acgaggtggt cccgcagcag
      961 ccggcgctga gcccagtgac ccagtgtgtc ctggagagcg tgctgcgtgg ggctgccctt
     1021 gtgccccggc aggcgctggc cgtcatgagc tgcgaggtac tccgcgtcct acagctgagc
     1081 gacacagcca tcgtgcccat cggctaccat gtgccccgca aggctgtgga gttccacgag
     1141 gacctgttcc cggacactgc cggctgtgtg cctgccaccg acccccatag ctggtgggct
     1201 ggggacaacc agcaggtgca gaaggtcagc ctcaaccccg cctgccggcc ccacccgagc
     1261 ttcacttcct gtctggtgcc ccctgcggag cccctccctg acacagccca gcctgcggtg
     1321 atggagacac ccgtgggtga tgcagacgca agcgagggtt tctcttcccc tcccagttcg
     1381 ctgacctcgc cctccacgcc ctccagcctg gggccctcac tctccagcac cagtggcatc
     1441 gggaccagcc ccagtttgag gtcgctgcag agcctgctgg gccccagttc caagttccgc
     1501 catgctcagg gcactgtcct gcaccgagac agccacatca ccaacctcaa ggggctcaac
     1561 ctcaccacac ctggtgagag tgacggcttc tgtgccaaca agctgcgtgt ggccgtgccg
     1621 ctgctcagca gcgggggaca ggtggctgtg cttgagctac ggaagcctgg ccgcctgccc
     1681 gacacggcac tgcccacgct gcagaatggg gcagctgtga ctgatctggc ctgggacccc
     1741 tttgaccccc atcgcctcgc tgtggctggt gaggacgcca ggatccgact gtggcgggta
     1801 cccgcagagg gcctggaaga ggtgctcacc acgccagaga ctgtgctcac aggccacacg
     1861 gagaagatct gctccctgcg cttccaccca ctggcagcca atgtgctggc ctcgtcctcc
     1921 tatgacctca ctgttcgcat ctgggacctt caggctggag ctgatcggct gaagctgcag
     1981 ggccaccaag accagatctt cagcctggcc tggagtcctg atgggcagca gctggccact
     2041 gtctgcaagg atgggcgtgt gcgggtctac aggccccgga gtggccctga gcccctgcag
     2101 gaaggcccag ggcccaaggg aggacgcgga gctcgcattg tctgggtatg tgatggtcgc
     2161 tgtctgctgg tgtctggctt tgacagccaa agtgagcgcc agctgctcct atatgaagct
     2221 gaggccctgg ccggcggacc cttggcagtg ttgggcctgg acgtggctcc ctcaaccctg
     2281 ctgcccagct acgacccaga cactggcctg gtgctcctga ccggcaaggg cgacacccgt
     2341 gtattcctgt acgagctgct ccccgagtcc cctttcttcc tggagtgcaa cagcttcacg
     2401 tcgcctgacc cccacaaggg cctcgtcctc ctgcctaaga cggagtgcga cgtgcgggaa
     2461 gtggagctga tgcggtgcct gcggctgcgt cagtcctccc tggagcctgt ggccttccgg
     2521 ctgccccgag tccggaaaga gttcttccag gatgacgtgt tcccagacac ggctgtgatc
     2581 tgggagcctg tgctcagtgc cgaggcctgg ctgcaaggcg ctaatgggca gccctggctt
     2641 ctcagcctgc agcctcctga catgagccca gtgagccaag ccccccgaga ggcccctgct
     2701 cgtcgggccc catcctcagc gcagtacctg gaagaaaagt ctgaccagca aaagaaggag
     2761 gagctgctga atgccatggt ggcaaaactg gggaaccggg aggacccact cccccaggac
     2821 tcctttgaag gcgtggacga ggacgagtgg gccaagtacc tggcccagat cattgtgatg
     2881 ggcgtgcagg tggtgggcag ggcctttgca cgggccttgc ggcaggagtt tgcagccagc
     2941 cgggccgcag ctgatgcccg aggacgcgct ggacaccggt ctgcagccgc ttccaacctc
     3001 tccggcctca gcctccagga ggcacagcag attctcaacg tgtccaagct gagccctgag
     3061 gaggtccaga agaactatga acacttattt aaggtgaatg ataaatccgt gggtggctcc
     3121 ttctacctgc agtcaaaggt ggtccgcgca aaggagcgcc tggatgagga actcaaaatc
     3181 caggcccagg aggacagaga aaaagggcag atgccccata cgtgactgct cggctccccc
     3241 cgcccacccc gccgcctcta atttatagct tggtaataaa tttcttttct gca
//
