LOCUS       NM_024535               3472 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens coronin 7 (CORO7), transcript variant 1, mRNA.
ACCESSION   NM_024535
VERSION     NM_024535.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3472)
  AUTHORS   Park,J., Jun,K., Choi,Y., Yoon,E., Kim,W., Jang,Y.G. and Chung,J.
  TITLE     CORO7 functions as a scaffold protein for the core kinase complex
            assembly of the Hippo pathway
  JOURNAL   J Biol Chem 296, 100040 (2021)
   PUBMED   33162394
REFERENCE   2  (bases 1 to 3472)
  AUTHORS   Bhattacharya,K., Swaminathan,K., Peche,V.S., Clemen,C.S.,
            Knyphausen,P., Lammers,M., Noegel,A.A. and Rastetter,R.H.
  TITLE     Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin
            organization and Golgi morphology
  JOURNAL   Sci Rep 6, 25411 (2016)
   PUBMED   27143109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3472)
  AUTHORS   Eriksson,A., Williams,M.J., Voisin,S., Hansson,I., Krishnan,A.,
            Philippot,G., Yamskova,O., Herisson,F.M., Dnyansagar,R.,
            Moschonis,G., Manios,Y., Chrousos,G.P., Olszewski,P.K.,
            Frediksson,R. and Schioth,H.B.
  TITLE     Implication of coronin 7 in body weight regulation in humans, mice
            and flies
  JOURNAL   BMC Neurosci 16, 13 (2015)
   PUBMED   25887538
  REMARK    GeneRIF: Obese children had significantly lower methylation levels
            at a CpG site located near coronin 7 (CORO7), which encodes a
            tryptophan-aspartic acid dipeptide (WD)-repeat containing protein
            most likely involved in Golgi complex morphology and function
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3472)
  AUTHORS   Yuan,W.C., Lee,Y.R., Lin,S.Y., Chang,L.Y., Tan,Y.P., Hung,C.C.,
            Kuo,J.C., Liu,C.H., Lin,M.Y., Xu,M., Chen,Z.J. and Chen,R.H.
  TITLE     K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin
            E3 Ligase Regulates Protein Trafficking
  JOURNAL   Mol Cell 54 (4), 586-600 (2014)
   PUBMED   24768539
  REMARK    GeneRIF: Results show that enforced targeting of Crn7 to TGN
            9trans-Golgi network) bypasses the requirement of
            K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi
            trafficking.
REFERENCE   5  (bases 1 to 3472)
  AUTHORS   Watanabe,M., Suzuki,T., Kim,M., Abe,Y., Yoshida,Y., Sugano,S. and
            Yamamoto,T.
  TITLE     Coronin7 forms a novel E3 ubiquitin ligase complex to promote the
            degradation of the anti-proliferative protein Tob
  JOURNAL   FEBS Lett 585 (1), 65-70 (2011)
   PUBMED   21130766
  REMARK    GeneRIF: Data show that CRN7 interacted with Cullin1 and Roc1 to
            form a novel SCF-like E3 complex.
REFERENCE   6  (bases 1 to 3472)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3472)
  AUTHORS   Rybakin,V., Rastetter,R.H., Stumpf,M., Uetrecht,A.C., Bear,J.E.,
            Noegel,A.A. and Clemen,C.S.
  TITLE     Molecular mechanism underlying the association of Coronin-7 with
            Golgi membranes
  JOURNAL   Cell Mol Life Sci 65 (15), 2419-2430 (2008)
   PUBMED   18581049
  REMARK    GeneRIF: Sequential events of protein interaction and
            posttranslational modification result in the membrane targeting of
            Crn7.
REFERENCE   8  (bases 1 to 3472)
  AUTHORS   Xavier,C.P., Eichinger,L., Fernandez,M.P., Morgan,R.O. and
            Clemen,C.S.
  TITLE     Evolutionary and functional diversity of coronin proteins
  JOURNAL   Subcell Biochem 48, 98-109 (2008)
   PUBMED   18925374
  REMARK    Review article
REFERENCE   9  (bases 1 to 3472)
  AUTHORS   Rybakin,V., Gounko,N.V., Spate,K., Honing,S., Majoul,I.V., Duden,R.
            and Noegel,A.A.
  TITLE     Crn7 interacts with AP-1 and is required for the maintenance of
            Golgi morphology and protein export from the Golgi
  JOURNAL   J Biol Chem 281 (41), 31070-31078 (2006)
   PUBMED   16905771
  REMARK    GeneRIF: Crn7 interacts with AP-1 and is required for the
            maintenance of Golgi morphology and protein export from the Golgi
REFERENCE   10 (bases 1 to 3472)
  AUTHORS   Rybakin,V., Stumpf,M., Schulze,A., Majoul,I.V., Noegel,A.A. and
            Hasse,A.
  TITLE     Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi
            apparatus
  JOURNAL   FEBS Lett 573 (1-3), 161-167 (2004)
   PUBMED   15327992
  REMARK    GeneRIF: role in the organization of intracellular membrane
            compartments and vesicular trafficking rather than in remodeling
            the cytoskeleton
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR155527.1, BC117291.1 and
            BM671637.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024535.4.
            
            Summary: This gene encodes a member of the coronin protein family.
            However, unlike other coronin proteins, it is not an actin-binding
            protein but rather functions as an F-actin regulator directing
            anterograde Golgi to endosome transport. The encoded protein has
            two tandem WD-40 domain repeats and localizes to the trans-Golgi
            network. The protein undergoes K33-linked polyubiquitination via an
            E3 ligase complex. It is thought to play an essential role in
            maintenance of Golgi apparatus morphology. Alternative splicing
            results in multiple transcripts variants; some of which form
            read-through transcripts with a neighboring gene. [provided by
            RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.256305.1,
                                           SRR1660805.6133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251166.9/ ENSP00000251166.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DR155527.1         594-609
            17-3230             BC117291.1         1-3214
            3231-3472           BM671637.1         18-259              c
FEATURES             Location/Qualifiers
     source          1..3472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3472
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /note="coronin 7"
                     /db_xref="GeneID:79585"
                     /db_xref="HGNC:HGNC:26161"
                     /db_xref="MIM:611668"
     exon            1..138
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2856
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /note="isoform 1 is encoded by transcript variant 1; 70
                     kDa WD repeat tumor rejection antigen homolog"
                     /codon_start=1
                     /product="coronin-7 isoform 1"
                     /protein_id="NP_078811.3"
                     /db_xref="CCDS:CCDS10513.1"
                     /db_xref="GeneID:79585"
                     /db_xref="HGNC:HGNC:26161"
                     /db_xref="MIM:611668"
                     /translation="MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSL
                     IAFNSDRPGVLGIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTV
                     KLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQP
                     LTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRL
                     AWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLV
                     LAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLS
                     DTAIVPIGYHVPRKAVEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH
                     PSFTSCLVPPAEPLPDTAQPAVMETPVGDADASEGFSSPPSSLTSPSTPSSLGPSLSS
                     TSGIGTSPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANK
                     LRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGED
                     ARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDL
                     QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGG
                     RGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDP
                     DTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHKGLVLLPKTECDVREVELM
                     RCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLSAEAWLQGANGQPWLLS
                     LQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAMVAKLGNREDPLPQD
                     SFEGVDEDEWD"
     exon            139..235
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..310
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..381
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..565
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..642
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..693
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..780
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..863
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..918
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..976
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1122
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1215
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1353
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1480
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1656
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1765
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1852
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1995
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2100
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2186
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2328
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2418
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2535
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2671
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2763
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2850
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3472
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3450..3455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /note="hexamer: ATTAAA"
     polyA_site      3472
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcggtt gctcagcgtg cacctgagac ccgacgcccg gggtcctcga agacgcgtcc
       61 gccgccgtgc ccgtcgccat gaaccgcttc agggtgtcca agttccggca caccgaggct
      121 cggccgcccc gccgcgagtc ctggatcagt gacattcgag caggaaccgc cccttcatgc
      181 aggaaccaca tcaaatcaag ctgcagcttg atcgccttca actccgaccg tcctggtgta
      241 ctgggcattg tgcctctgca aggccaagga gaggacaagc gacgcgtggc ccacctgggc
      301 tgccattcag acctagtcac cgacttggac ttctcgccct ttgatgactt cctcctggcc
      361 acaggctcgg ctgacaggac ggtaaaactc tggcgactgc cagggcctgg ccaggccctg
      421 ccctcagcac ccggggtggt gctgggcccc gaggacctcc cagtggaggt actgcagttc
      481 caccccacct ctgacggcat tctggtgagc gcagcaggca ccactgtgaa ggtctgggac
      541 gcagccaagc agcagcccct gacagagctg gcagcccatg gggacctggt gcagagcgcc
      601 gtctggagcc gagatggagc cctggtgggc acggcgtgca aggacaagca gctgcggatc
      661 tttgacccca gaacaaagcc gcgggcctct cagagcacgc aggcccatga gaacagcagg
      721 gatagccggc tggcatggat gggcacctgg gagcaccttg tgtctactgg attcaaccag
      781 atgcgtgagc gcgaagtgaa gctgtgggac acgcggttct tctccagcgc cctggcctcc
      841 ctcaccttgg acacctcgct tgggtgtctc gtgcctctgc tggaccctga ctctgggctc
      901 ctggtcctgg caggaaaggg cgagaggcag ctgtactgtt acgaggtggt cccgcagcag
      961 ccggcgctga gcccagtgac ccagtgtgtc ctggagagcg tgctgcgtgg ggctgccctt
     1021 gtgccccggc aggcgctggc cgtcatgagc tgcgaggtac tccgcgtcct acagctgagc
     1081 gacacagcca tcgtgcccat cggctaccat gtgccccgca aggctgtgga gttccacgag
     1141 gacctgttcc cggacactgc cggctgtgtg cctgccaccg acccccatag ctggtgggct
     1201 ggggacaacc agcaggtgca gaaggtcagc ctcaaccccg cctgccggcc ccacccgagc
     1261 ttcacttcct gtctggtgcc ccctgcggag cccctccctg acacagccca gcctgcggtg
     1321 atggagacac ccgtgggtga tgcagacgca agcgagggtt tctcttcccc tcccagttcg
     1381 ctgacctcgc cctccacgcc ctccagcctg gggccctcac tctccagcac cagtggcatc
     1441 gggaccagcc ccagtttgag gtcgctgcag agcctgctgg gccccagttc caagttccgc
     1501 catgctcagg gcactgtcct gcaccgagac agccacatca ccaacctcaa ggggctcaac
     1561 ctcaccacac ctggtgagag tgacggcttc tgtgccaaca agctgcgtgt ggccgtgccg
     1621 ctgctcagca gcgggggaca ggtggctgtg cttgagctac ggaagcctgg ccgcctgccc
     1681 gacacggcac tgcccacgct gcagaatggg gcagctgtga ctgatctggc ctgggacccc
     1741 tttgaccccc atcgcctcgc tgtggctggt gaggacgcca ggatccgact gtggcgggta
     1801 cccgcagagg gcctggaaga ggtgctcacc acgccagaga ctgtgctcac aggccacacg
     1861 gagaagatct gctccctgcg cttccaccca ctggcagcca atgtgctggc ctcgtcctcc
     1921 tatgacctca ctgttcgcat ctgggacctt caggctggag ctgatcggct gaagctgcag
     1981 ggccaccaag accagatctt cagcctggcc tggagtcctg atgggcagca gctggccact
     2041 gtctgcaagg atgggcgtgt gcgggtctac aggccccgga gtggccctga gcccctgcag
     2101 gaaggcccag ggcccaaggg aggacgcgga gctcgcattg tctgggtatg tgatggtcgc
     2161 tgtctgctgg tgtctggctt tgacagccaa agtgagcgcc agctgctcct atatgaagct
     2221 gaggccctgg ccggcggacc cttggcagtg ttgggcctgg acgtggctcc ctcaaccctg
     2281 ctgcccagct acgacccaga cactggcctg gtgctcctga ccggcaaggg cgacacccgt
     2341 gtattcctgt acgagctgct ccccgagtcc cctttcttcc tggagtgcaa cagcttcacg
     2401 tcgcctgacc cccacaaggg cctcgtcctc ctgcctaaga cggagtgcga cgtgcgggaa
     2461 gtggagctga tgcggtgcct gcggctgcgt cagtcctccc tggagcctgt ggccttccgg
     2521 ctgccccgag tccggaaaga gttcttccag gatgacgtgt tcccagacac ggctgtgatc
     2581 tgggagcctg tgctcagtgc cgaggcctgg ctgcaaggcg ctaatgggca gccctggctt
     2641 ctcagcctgc agcctcctga catgagccca gtgagccaag ccccccgaga ggcccctgct
     2701 cgtcgggccc catcctcagc gcagtacctg gaagaaaagt ctgaccagca aaagaaggag
     2761 gagctgctga atgccatggt ggcaaaactg gggaaccggg aggacccact cccccaggac
     2821 tcctttgaag gcgtggacga ggacgagtgg gactagcctg cgcccccgtc acctccacct
     2881 cacctgtgct gccacttcct agtgcacacc tcacggctca tcctcaagct ggaagatacc
     2941 tctctggccc cggcacatgt cacccctgca ctcctgcctt cccgtgggca cttccacatc
     3001 ctctgggcct ctggcagttc ccagggactg ttttcacctc tgctgtctct ggggtcagct
     3061 gctgctcatc agctgcccgc tagcatgtgg ccaggggtgc agggtggcgg ggggtcagca
     3121 gcatgtccct gggcaggccc tgggcaccct gtctcccctg gtctcactgc tgacctgggc
     3181 tggtcccagc ctggattggc ctcatccagg atctttggtc accccacgct gccccatctt
     3241 gcctgctgtt ccagttctgg tcaagggcct tgggggctgg ccccccacca ggccttctag
     3301 agcagcacca gtctcagggc cctgggacca gctgccctac ttcccaggtt tgtagccagg
     3361 agaagggggc atcacagagc tgatggtcca ataagggggg tgtgagcccc gcagggactg
     3421 gcccgcacct gccttggatg ttttcagcaa ttaaactttt ttaagctggc ca
//
