LOCUS       NP_078811                925 aa            linear   PRI 27-APR-2025
DEFINITION  coronin-7 isoform 1 [Homo sapiens].
ACCESSION   NP_078811
VERSION     NP_078811.3
DBSOURCE    REFSEQ: accession NM_024535.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 925)
  AUTHORS   Park,J., Jun,K., Choi,Y., Yoon,E., Kim,W., Jang,Y.G. and Chung,J.
  TITLE     CORO7 functions as a scaffold protein for the core kinase complex
            assembly of the Hippo pathway
  JOURNAL   J Biol Chem 296, 100040 (2021)
   PUBMED   33162394
REFERENCE   2  (residues 1 to 925)
  AUTHORS   Bhattacharya,K., Swaminathan,K., Peche,V.S., Clemen,C.S.,
            Knyphausen,P., Lammers,M., Noegel,A.A. and Rastetter,R.H.
  TITLE     Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin
            organization and Golgi morphology
  JOURNAL   Sci Rep 6, 25411 (2016)
   PUBMED   27143109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 925)
  AUTHORS   Eriksson,A., Williams,M.J., Voisin,S., Hansson,I., Krishnan,A.,
            Philippot,G., Yamskova,O., Herisson,F.M., Dnyansagar,R.,
            Moschonis,G., Manios,Y., Chrousos,G.P., Olszewski,P.K.,
            Frediksson,R. and Schioth,H.B.
  TITLE     Implication of coronin 7 in body weight regulation in humans, mice
            and flies
  JOURNAL   BMC Neurosci 16, 13 (2015)
   PUBMED   25887538
  REMARK    GeneRIF: Obese children had significantly lower methylation levels
            at a CpG site located near coronin 7 (CORO7), which encodes a
            tryptophan-aspartic acid dipeptide (WD)-repeat containing protein
            most likely involved in Golgi complex morphology and function
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 925)
  AUTHORS   Yuan,W.C., Lee,Y.R., Lin,S.Y., Chang,L.Y., Tan,Y.P., Hung,C.C.,
            Kuo,J.C., Liu,C.H., Lin,M.Y., Xu,M., Chen,Z.J. and Chen,R.H.
  TITLE     K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin
            E3 Ligase Regulates Protein Trafficking
  JOURNAL   Mol Cell 54 (4), 586-600 (2014)
   PUBMED   24768539
  REMARK    GeneRIF: Results show that enforced targeting of Crn7 to TGN
            9trans-Golgi network) bypasses the requirement of
            K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi
            trafficking.
REFERENCE   5  (residues 1 to 925)
  AUTHORS   Watanabe,M., Suzuki,T., Kim,M., Abe,Y., Yoshida,Y., Sugano,S. and
            Yamamoto,T.
  TITLE     Coronin7 forms a novel E3 ubiquitin ligase complex to promote the
            degradation of the anti-proliferative protein Tob
  JOURNAL   FEBS Lett 585 (1), 65-70 (2011)
   PUBMED   21130766
  REMARK    GeneRIF: Data show that CRN7 interacted with Cullin1 and Roc1 to
            form a novel SCF-like E3 complex.
REFERENCE   6  (residues 1 to 925)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (residues 1 to 925)
  AUTHORS   Rybakin,V., Rastetter,R.H., Stumpf,M., Uetrecht,A.C., Bear,J.E.,
            Noegel,A.A. and Clemen,C.S.
  TITLE     Molecular mechanism underlying the association of Coronin-7 with
            Golgi membranes
  JOURNAL   Cell Mol Life Sci 65 (15), 2419-2430 (2008)
   PUBMED   18581049
  REMARK    GeneRIF: Sequential events of protein interaction and
            posttranslational modification result in the membrane targeting of
            Crn7.
REFERENCE   8  (residues 1 to 925)
  AUTHORS   Xavier,C.P., Eichinger,L., Fernandez,M.P., Morgan,R.O. and
            Clemen,C.S.
  TITLE     Evolutionary and functional diversity of coronin proteins
  JOURNAL   Subcell Biochem 48, 98-109 (2008)
   PUBMED   18925374
  REMARK    Review article
REFERENCE   9  (residues 1 to 925)
  AUTHORS   Rybakin,V., Gounko,N.V., Spate,K., Honing,S., Majoul,I.V., Duden,R.
            and Noegel,A.A.
  TITLE     Crn7 interacts with AP-1 and is required for the maintenance of
            Golgi morphology and protein export from the Golgi
  JOURNAL   J Biol Chem 281 (41), 31070-31078 (2006)
   PUBMED   16905771
  REMARK    GeneRIF: Crn7 interacts with AP-1 and is required for the
            maintenance of Golgi morphology and protein export from the Golgi
REFERENCE   10 (residues 1 to 925)
  AUTHORS   Rybakin,V., Stumpf,M., Schulze,A., Majoul,I.V., Noegel,A.A. and
            Hasse,A.
  TITLE     Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi
            apparatus
  JOURNAL   FEBS Lett 573 (1-3), 161-167 (2004)
   PUBMED   15327992
  REMARK    GeneRIF: role in the organization of intracellular membrane
            compartments and vesicular trafficking rather than in remodeling
            the cytoskeleton
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR155527.1, BC117291.1 and
            BM671637.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 21, 2008 this sequence version replaced NP_078811.2.
            
            Summary: This gene encodes a member of the coronin protein family.
            However, unlike other coronin proteins, it is not an actin-binding
            protein but rather functions as an F-actin regulator directing
            anterograde Golgi to endosome transport. The encoded protein has
            two tandem WD-40 domain repeats and localizes to the trans-Golgi
            network. The protein undergoes K33-linked polyubiquitination via an
            E3 ligase complex. It is thought to play an essential role in
            maintenance of Golgi apparatus morphology. Alternative splicing
            results in multiple transcripts variants; some of which form
            read-through transcripts with a neighboring gene. [provided by
            RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.256305.1,
                                           SRR1660805.6133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251166.9/ ENSP00000251166.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     Protein         1..925
                     /product="coronin-7 isoform 1"
                     /note="70 kDa WD repeat tumor rejection antigen homolog"
                     /calculated_mol_wt=100474
     Region          6..428
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          75..115
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          81..124
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          124..163
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          129..165
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          166..205
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          172..208
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          209..253
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          215..256
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          263..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          419..461
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Site            462
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D2V7; propagated from
                     UniProtKB/Swiss-Prot (P57737.2)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O35828; propagated from
                     UniProtKB/Swiss-Prot (P57737.2)"
     Region          471..880
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          504..540
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          542..582
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          547..591
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          592..632
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          598..634
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          635..674
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          640..677
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          728..768
                     /region_name="WD 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Region          858..925
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P57737.2)"
     Site            915
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D2V7; propagated from
                     UniProtKB/Swiss-Prot (P57737.2)"
     CDS             1..925
                     /gene="CORO7"
                     /gene_synonym="0610011B16Rik; CRN7; POD1"
                     /coded_by="NM_024535.5:79..2856"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS10513.1"
                     /db_xref="GeneID:79585"
                     /db_xref="HGNC:HGNC:26161"
                     /db_xref="MIM:611668"
ORIGIN      
        1 mnrfrvskfr htearpprre swisdiragt apscrnhiks scsliafnsd rpgvlgivpl
       61 qgqgedkrrv ahlgchsdlv tdldfspfdd fllatgsadr tvklwrlpgp gqalpsapgv
      121 vlgpedlpve vlqfhptsdg ilvsaagttv kvwdaakqqp ltelaahgdl vqsavwsrdg
      181 alvgtackdk qlrifdprtk prasqstqah ensrdsrlaw mgtwehlvst gfnqmrerev
      241 klwdtrffss alasltldts lgclvplldp dsgllvlagk gerqlycyev vpqqpalspv
      301 tqcvlesvlr gaalvprqal avmscevlrv lqlsdtaivp igyhvprkav efhedlfpdt
      361 agcvpatdph swwagdnqqv qkvslnpacr phpsftsclv ppaeplpdta qpavmetpvg
      421 dadasegfss ppssltspst psslgpslss tsgigtspsl rslqsllgps skfrhaqgtv
      481 lhrdshitnl kglnlttpge sdgfcanklr vavpllssgg qvavlelrkp grlpdtalpt
      541 lqngaavtdl awdpfdphrl avagedarir lwrvpaegle evlttpetvl tghtekicsl
      601 rfhplaanvl asssydltvr iwdlqagadr lklqghqdqi fslawspdgq qlatvckdgr
      661 vrvyrprsgp eplqegpgpk ggrgarivwv cdgrcllvsg fdsqserqll lyeaealagg
      721 plavlgldva pstllpsydp dtglvlltgk gdtrvflyel lpespfflec nsftspdphk
      781 glvllpktec dvrevelmrc lrlrqsslep vafrlprvrk effqddvfpd taviwepvls
      841 aeawlqgang qpwllslqpp dmspvsqapr eaparrapss aqyleeksdq qkkeellnam
      901 vaklgnredp lpqdsfegvd edewd
//
