LOCUS       NM_032854               2677 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens coronin 6 (CORO6), transcript variant 1, mRNA.
ACCESSION   NM_032854 XM_005258047
VERSION     NM_032854.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2677)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2677)
  AUTHORS   Cardinali,B., Cappella,M., Provenzano,C., Garcia-Manteiga,J.M.,
            Lazarevic,D., Cittaro,D., Martelli,F. and Falcone,G.
  TITLE     MicroRNA-222 regulates muscle alternative splicing through Rbm24
            during differentiation of skeletal muscle cells
  JOURNAL   Cell Death Dis 7 (2), e2086 (2016)
   PUBMED   26844700
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2677)
  AUTHORS   Morris,M.R., Ricketts,C.J., Gentle,D., McRonald,F., Carli,N.,
            Khalili,H., Brown,M., Kishida,T., Yao,M., Banks,R.E., Clarke,N.,
            Latif,F. and Maher,E.R.
  TITLE     Genome-wide methylation analysis identifies epigenetically
            inactivated candidate tumour suppressor genes in renal cell
            carcinoma
  JOURNAL   Oncogene 30 (12), 1390-1401 (2011)
   PUBMED   21132003
REFERENCE   4  (bases 1 to 2677)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104564.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Oct 30, 2020 this sequence version replaced
            XM_005258047.4, NM_032854.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138525.2512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388767.8/ ENSP00000373419.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC104564.11        98598-98822
            226-486             AC104564.11        100026-100286
            487-609             AC104564.11        101737-101859
            610-739             AC104564.11        102321-102450
            740-921             AC104564.11        102539-102720
            922-1041            AC104564.11        103891-104010
            1042-1146           AC104564.11        104468-104572
            1147-1292           AC104564.11        104663-104808
            1293-1350           AC104564.11        105174-105231
            1351-1581           AC104564.11        105335-105565
            1582-2677           AC104564.11        105653-106748
FEATURES             Location/Qualifiers
     source          1..2677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..2677
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /note="coronin 6"
                     /db_xref="GeneID:84940"
                     /db_xref="HGNC:HGNC:21356"
     exon            1..225
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            226..486
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1707
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coronin, actin binding protein 6; clipin-E; coronin-like
                     protein E"
                     /codon_start=1
                     /product="coronin-6 isoform 1"
                     /protein_id="NP_116243.2"
                     /db_xref="CCDS:CCDS11252.2"
                     /db_xref="GeneID:84940"
                     /db_xref="HGNC:HGNC:21356"
                     /translation="MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNP
                     KFLAIIVEAGGGGAFIVLPLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASD
                     DTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWN
                     VGTGEVLLSLDDMHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAERFAAHE
                     GMRPMRAVFTRQGHIFTTGFTRMSQRELGLWDPNNFEEPVALQEMDTSNGVLLPFYDP
                     DSSIVYLCGKGDSSIRYFEITDEPPFVHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIA
                     RFYKLHERKCEPIIMTVPRKSDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR
                     DGYVPPKHRELRVTKRNILDVRPPSGPRRSQSASDAPLSQQHTLETLLEEIKALRERV
                     QAQEQRITALENMLCELVDGTD"
     exon            487..609
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            610..739
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            740..921
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1041
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1146
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1292
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1350
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1581
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..2677
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /note="hexamer: AACAAG"
     regulatory      2438..2443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /note="hexamer: AATGAA"
     polyA_site      2444
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /note="major polyA site"
     polyA_site      2462
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /note="major polyA site"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /note="hexamer: AGTAAA"
     polyA_site      2677
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
ORIGIN      
        1 gccctcttag gttgatggca gcggcagctg gggctgcagc ggcgccgggc tctagagagc
       61 cgcaggatcg gccagagtgc ggagctggac acccgggtcc cagatactac agacacccgg
      121 agaggtggct ccttcgccct gaagccttcc tcggccccct acgcactcgg gccccttccg
      181 cagaggattc gcagcgtgag cgccccgcag cccgctcagg accagctcac aggactaagg
      241 accaaaggca tttctgggca ctgagatcct acctctctgc ctgcagctat gagcagacgt
      301 gtggttcggc aaagcaagtt ccgccatgtg tttgggcagg cagcaaaggc cgaccaggcc
      361 tacgaggaca tccgtgtgtc caaggtcaca tgggacagct ccttctgtgc cgtcaacccc
      421 aaattcctgg ccattattgt ggaggctgga ggcgggggtg ccttcatcgt cctgcctctg
      481 gccaagacag ggcgagtgga taagaactac ccactggtca ctgggcacac tgcccctgtg
      541 ctggatattg actggtgtcc acacaatgac aacgttatcg ccagtgcctc agacgacacc
      601 accatcatgg tgtggcagat tccagactat acccccatgc gcaacattac ggaacctatc
      661 atcacacttg agggccactc caagcgtgtg ggcatcctct cctggcaccc tactgccagg
      721 aatgtcctgc tcagtgcagg tggtgacaat gtgatcatca tctggaatgt gggcaccggg
      781 gaggtgctgc tgagcctgga tgatatgcac ccagacgtca tccacagtgt gtgctggaac
      841 agcaacggta gcctgctagc caccacctgc aaggacaaga ccttgcgcat cattgacccc
      901 agaaaaggcc aagtggtggc ggagaggttt gcggcccacg aggggatgag gcccatgcgg
      961 gccgtcttca cgcgccaggg ccatatcttc accacgggct tcacccgcat gagccagcga
     1021 gagctgggcc tgtgggaccc gaacaacttc gaggagccag tggcactgca ggagatggac
     1081 acaagcaacg gggtcctatt gcccttttac gatcccgact ccagcatcgt ctacctgtgt
     1141 ggcaagggcg acagcagcat tcggtacttt gagattaccg acgagccgcc tttcgtgcac
     1201 tacctgaaca cgttcagcag caaagagccg cagcggggca tgggtttcat gcccaaaagg
     1261 ggactggatg tcagcaagtg tgagatcgcc cggttctaca agctacacga aagaaagtgt
     1321 gaacctatca tcatgactgt gccccgcaag tcagacctct tccaggacga tctgtacccg
     1381 gatacgccag gcccggagcc ggccctagaa gcggacgaat ggctatccgg ccaggacgcc
     1441 gaacccgtgc tcatttcgct gagggacggc tatgtgcccc ccaagcaccg cgagctccgg
     1501 gtcacgaagc gcaacatcct ggacgtgcgc ccgccctccg gcccccgccg cagccagtcg
     1561 gccagcgacg cccccttgtc gcagcagcac accctggaga cgctgctgga agagatcaag
     1621 gccctccgcg agcgggtgca ggcccaggag cagcgcatca cggctctgga gaacatgctg
     1681 tgcgagctgg tggacggcac ggactagccc cgcgcgccag gcaggcggag cggggcgggg
     1741 cgcacaagct cggccccgcc ccggctttta gtcccgaact ccggaccccg ccttcttggg
     1801 ctgggcccgg gggcgggact ggggagggaa ctccgcccct cgcgggagac cagaactctt
     1861 ggagcttagg ggagacccac gtcgctccag cggaggctgg actgcgagcc tcgtctggga
     1921 ctcggctgga gctggcctag ggaggcctgg ggtaacctgg ggggctcagc aatggtgctg
     1981 cacggcgagg tggtgtcccc ctttgtcctc cgcccagggc agggaaagtg cttagtatta
     2041 gcgtgatgct tggggttatt ggagcctgag cttgacctca aacgggtggc gatttgatgg
     2101 gtacccccag gctggggaaa atgacagcgc ttctcctaat cagctcactg gattccatca
     2161 ccctgagcgg taaaccagat gggcgtcacc ccagttctgc agacacatac acaacccgtt
     2221 tgctgcagag ccggacccag tggctacacc cacagcggtc tgtggtagag aactctcttc
     2281 cttctttcca ccgacagggg cgagggctgc ttcctcgcgg cagcccccgc gaagaaatct
     2341 cgagagaact ggcatgagga gttaggttca tcacaaatac acacacactg cccccaaccc
     2401 tctgccgttg cctctctcag aaaaacaaga cgtactgaat gaaatatttt actaagcgtt
     2461 cagtctgtgc ctcctgcatg ggtgggagtg aggggaacga gacccccagc ctctgcaaat
     2521 gctaccccca ggctcctggg agacctggcg atgcactcct gggctcaggg tccatcaggc
     2581 agcctcttac cctagagctc tctccactct gaggttcaga aggaccccaa cccacaccgt
     2641 aggcgttccc cccaagtaaa gttaggtagc aaaagcc
//
