LOCUS       NM_006091               3545 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens coronin 2B (CORO2B), transcript variant 1, mRNA.
ACCESSION   NM_006091
VERSION     NM_006091.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3545)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3545)
  AUTHORS   Schwarz,A., Moller-Hackbarth,K., Ebarasi,L., Unnersjo Jess,D.,
            Zambrano,S., Blom,H., Wernerson,A., Lal,M. and Patrakka,J.
  TITLE     Coro2b, a podocyte protein downregulated in human diabetic
            nephropathy, is involved in the development of protamine
            sulphate-induced foot process effacement
  JOURNAL   Sci Rep 9 (1), 8888 (2019)
   PUBMED   31221975
  REMARK    GeneRIF: Coro2b, a podocyte protein downregulated in human diabetic
            nephropathy, is involved in the development of protamine
            sulphate-induced foot process effacement.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3545)
  AUTHORS   Rogg,M., Yasuda-Yamahara,M., Abed,A., Dinse,P., Helmstadter,M.,
            Conzelmann,A.C., Frimmel,J., Sellung,D., Biniossek,M.L., Kretz,O.,
            Grahammer,F., Schilling,O., Huber,T.B. and Schell,C.
  TITLE     The WD40-domain containing protein CORO2B is specifically enriched
            in glomerular podocytes and regulates the ventral actin
            cytoskeleton
  JOURNAL   Sci Rep 7 (1), 15910 (2017)
   PUBMED   29162887
  REMARK    GeneRIF: CORO2B is a novel podocyte enriched protein influencing
            cytoskeletal plasticity and stress adaptation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3545)
  AUTHORS   Nakamura,T., Takeuchi,K., Muraoka,S., Takezoe,H., Takahashi,N. and
            Mori,N.
  TITLE     A neurally enriched coronin-like protein, ClipinC, is a novel
            candidate for an actin cytoskeleton-cortical membrane-linking
            protein
  JOURNAL   J Biol Chem 274 (19), 13322-13327 (1999)
   PUBMED   10224093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105014.5, HY150896.1, AB023142.1, AC090734.6 and BQ184259.1.
            
            On Jul 1, 2019 this sequence version replaced NM_006091.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2585791.1,
                                           SRR1803612.228213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261861.10/ ENSP00000261861.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC105014.5         50268-50319
            53-479              HY150896.1         2-428
            480-2282            AB023142.1         208-2010
            2283-2359           AC090734.6         11696-11772
            2360-3541           AB023142.1         2088-3269
            3542-3545           BQ184259.1         16-19               c
FEATURES             Location/Qualifiers
     source          1..3545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..3545
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /note="coronin 2B"
                     /db_xref="GeneID:10391"
                     /db_xref="HGNC:HGNC:2256"
                     /db_xref="MIM:605002"
     exon            1..285
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1713
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clipin C; coronin-like protein C; coronin, actin binding
                     protein, 2B"
                     /codon_start=1
                     /product="coronin-2B isoform 1"
                     /protein_id="NP_006082.3"
                     /db_xref="CCDS:CCDS10229.2"
                     /db_xref="GeneID:10391"
                     /db_xref="HGNC:HGNC:2256"
                     /db_xref="MIM:605002"
                     /translation="MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNH
                     FCAVNTRFLAIVTESAGGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNI
                     IASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDY
                     KVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEA
                     NCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFP
                     FYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSA
                     CEVFRFYKLVTLKGLIEPISMIVPRRSDSYQEDIYPMTPGTEPALTPDEWLGGINRDP
                     VLMSLKEGYKKSSKMVFKAPIKEKKSVVVNGIDLLENVPPRTENELLRMFFRQQDEIR
                     RLKEELAQKDIRIRQLQLELKNLRNSPKNC"
     exon            286..486
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            487..603
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            604..753
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            754..918
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1035
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1140
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1237
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1350
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1441
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1581
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..3545
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3521..3526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /note="hexamer: AATAAA"
     polyA_site      3545
                     /gene="CORO2B"
                     /gene_synonym="CLIPINC"
                     /note="major polyA site"
ORIGIN      
        1 cttcctgcct cgccttcctg cggcgaagga ggctcatcta ttataaatgc acattcgggg
       61 ctgacatcag cgacgagcgg cgggcgagcg ccgacgagcg gtccctgcgc gctgcccgcc
      121 cggagcgcag cccccaggct cggccgagcc gccggcgggg cgcggggagc gagccgggag
      181 ctgccggacc cccttccgcc gccgccccgg gccgccgccg ccgcccccgc acgccgcgcc
      241 cgcgcccccg ctccgccgcg gagtttctgc atgactgtca caaagatgtc ctggcgtccg
      301 caataccgta gctccaagtt ccggaatgtc tacgggaagg tggccaaccg ggagcactgc
      361 ttcgatggga tccccatcac caagaatgtg cacgacaacc acttctgtgc cgtcaacacc
      421 cgcttcctgg ccatcgtcac cgagagcgca gggggcggct ccttcctcgt catccccctg
      481 gagcagacag gcaggattga acccaactac cccaaggtct gcggccacca gggcaatgtg
      541 ctggatatca aatggaaccc cttcatcgac aacatcattg cctcgtgctc ggaggacacg
      601 tcggtgcgga tctgggagat ccccgagggc gggctgaagc ggaacatgac ggaggcgctc
      661 ctggagctgc acgggcacag ccggcgtgtg gggctggtcg agtggcaccc caccaccaac
      721 aacatcctgt tcagcgctgg ctacgactac aaggtcctca tctggaacct ggatgtgggt
      781 gagccggtga agatgattga ctgccacacg gatgtgatcc tctgcatgtc cttcaacacg
      841 gacggcagcc tgctcaccac cacgtgcaag gacaagaagc tgcgtgtgat tgagccccgc
      901 tctggccgtg ttctgcagga ggccaactgc aaaaaccaca gagtgaaccg ggtggtgttc
      961 ctggggaaca tgaagcggct cctcacgaca ggggtctcca ggtggaacac aagacagatt
     1021 gccctctggg accaggagga cctctccatg cccctgatcg aagaggaaat tgatgggctc
     1081 tctggcctcc tgttcccctt ctatgatgct gacacccaca tgctctacct ggctggaaag
     1141 ggtgatggaa acatccggta ctacgagatc agcactgaga agccctacct gagttacctc
     1201 atggagttcc gctccccagc cccgcagaaa ggcctagggg tcatgcccaa gcacgggctg
     1261 gatgtgtcag cctgcgaggt gttccgcttc tacaagctgg tgactctcaa gggcctgatc
     1321 gagcccatct ccatgatcgt gccccggagg tcagattcct accaggaaga catttaccca
     1381 atgacaccag gcacggagcc agcactgacc ccggatgaat ggctgggagg catcaaccga
     1441 gatcccgtgc tgatgtcttt gaaagaaggc tataagaagt cctcaaaaat ggtatttaag
     1501 gctcccatca aagaaaagaa gagtgttgtg gtcaacggaa tagatttatt agaaaatgtc
     1561 ccacccagga cagagaatga gctccttcga atgttcttcc ggcagcagga tgagattcga
     1621 cggttgaaag aggagctggc ccagaaggac atccgcattc ggcagctcca gctggaactg
     1681 aaaaacttgc gcaacagccc caagaactgt tagctcccca gctgggctgt tttctaagcc
     1741 gatctctccg tcgtttctac tcatccctta acttctccct taccagtgac cccagagaca
     1801 gagccaggac aggagtgggg gccagcctga ggacccccgc ctaccacctc gagaactgga
     1861 agccaacctc taacctcctg acctcatgct aataaaagtc cccagcttct ggagaccccc
     1921 tgccggcagc ccctttccct gccaccccag gagccaggct tcccctcagc tgggtgaaga
     1981 ctacagactc cctggggttg gcaggggctc catctcagtg gaccaggaag caagagggga
     2041 agcgggatcc cagctagact tagaacttgg acttttcccc tgtgaagggg gctgccagga
     2101 catctcagca ctcccgcctg gagctctcag catcactgaa ggtaccacag tgtaagtgct
     2161 ggactgcagg ctgcagtgat ccctctttcg tcccaccccc tcttccctca gcagccccgg
     2221 aagcctgcct cacccgacga ggacagcgag cggcccggct cctttctgtc tcttcccttc
     2281 ccaccctctt gtcttcaggg aattcagagg attgctctcc aaggccataa tgaccccttg
     2341 ccttccccat gattctctac aaagctcttg cacacccttt tcccattcaa tttgtgagcc
     2401 aggcagggta gggattagtg tccccctttg acaaatgaca gaactgaggg ttgcaatggg
     2461 gaaatgactt ataaagtcac ccagcaggtc aacaatgggc ccacgaccaa gaccctgggt
     2521 gttcagaccc caaggccagg gcctttcccg ctgcatcaag atgccaatcc ctttgtgggc
     2581 ttcaccagtg cccaagtctc tatggagaat gagaactgga agccactgct accgtctacc
     2641 cagcaccagt agtgccgatg tgccacactg cccagttgag gcccctcacg ctctgtgccc
     2701 ctagatcctt caggtcccca ccctcagctg tcaccaccac cctccccagg ggactccatc
     2761 tgagatgagg cctcgtcctc ctggaagctg aggctgagaa gggtggagct tggccctggg
     2821 gaaggcagac cagggtctga tggcttctag ggatgctctg cgtgtgtctc agcaccgcta
     2881 tctcagccac tttcagcctt atgcacgtag aatgaccaca gccactcgca tccgtatagc
     2941 actttaaagt ttctgcagtc ctttgacaca taggatctca tggagcctca cgtctactcc
     3001 cttctgcaga tgaggaaacc gagagaagtg gcccaaggtc acgcaactct gagatgccac
     3061 atttcatttg atcttgtaca cattttcttt tattccttct tttttcctcc tttcatttcc
     3121 cactacgcac aaagagttta taaacactgt tctcagaaga gtcacagttt ggggtgagat
     3181 ctggaaatca agaaatgggt gtccactctt ttctttcatt agctaggatc tactagatgc
     3241 attatactcc atacctgctt ttcccatggc cgccctacgg aaaatcccat ccacagaggc
     3301 cagggctacc caagcccctc caggtgagct gggcctttcc tttatgaacc tccatcctcc
     3361 cagccagcta cagtagggcc tcctcacccc gtaccccaca gctagacagt gtcagcactc
     3421 atctcctcct cccacatttc tggagctttt ttttttcctt ccccattgac ctttgtggtc
     3481 ttctgtgatt atttatgctg cctcccaagg atagaattga aataaaatgt tttcaactta
     3541 tcaaa
//
