LOCUS       NM_052820               5456 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coronin 2A (CORO2A), transcript variant 2, mRNA.
ACCESSION   NM_052820
VERSION     NM_052820.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5456)
  AUTHORS   Kase-Kato,I., Asai,S., Minemura,C., Tsuneizumi,K., Oshima,S.,
            Koma,A., Kasamatsu,A., Hanazawa,T., Uzawa,K. and Seki,N.
  TITLE     Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates
            Migration and Invasion Abilities in Oral Squamous Cell Carcinoma
  JOURNAL   Int J Mol Sci 22 (23), 12684 (2021)
   PUBMED   34884487
  REMARK    GeneRIF: Molecular Pathogenesis of the Coronin Family: CORO2A
            Facilitates Migration and Invasion Abilities in Oral Squamous Cell
            Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5456)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5456)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5456)
  AUTHORS   Lim,K.H., Choi,J.H., Park,J.H., Cho,H.J., Park,J.J., Lee,E.J.,
            Li,L., Choi,Y.K. and Baek,K.H.
  TITLE     Ubiquitin specific protease 19 involved in transcriptional
            repression of retinoic acid receptor by stabilizing CORO2A
  JOURNAL   Oncotarget 7 (23), 34759-34772 (2016)
   PUBMED   27129179
  REMARK    GeneRIF: The regulation of CORO2A through the deubiquitinating
            activity of USP19 affected the transcriptional repression activity
            of the retinoic acid receptor (RAR), suggesting that USP19 may be
            involved in the regulation of RAR-mediated adipogenesis.
REFERENCE   5  (bases 1 to 5456)
  AUTHORS   Rastetter,R.H., Blomacher,M., Drebber,U., Marko,M., Behrens,J.,
            Solga,R., Hojeili,S., Bhattacharya,K., Wunderlich,C.M.,
            Wunderlich,F.T., Odenthal,M., Ziemann,A., Eichinger,L. and
            Clemen,C.S.
  TITLE     Coronin 2A (CRN5) expression is associated with colorectal
            adenoma-adenocarcinoma sequence and oncogenic signalling
  JOURNAL   BMC Cancer 15, 638 (2015)
   PUBMED   26373535
  REMARK    GeneRIF: increased expression of coronin 2A is associated with the
            malignant phenotype of human colon carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5456)
  AUTHORS   Marshall,T.W., Aloor,H.L. and Bear,J.E.
  TITLE     Coronin 2A regulates a subset of focal-adhesion-turnover events
            through the cofilin pathway
  JOURNAL   J Cell Sci 122 (Pt 17), 3061-3069 (2009)
   PUBMED   19654210
  REMARK    GeneRIF: Coronin 2A and cofilin regulate a subset of
            focal-adhesion-turnover events.
REFERENCE   7  (bases 1 to 5456)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 5456)
  AUTHORS   Yoon,H.G., Chan,D.W., Reynolds,A.B., Qin,J. and Wong,J.
  TITLE     N-CoR mediates DNA methylation-dependent repression through a
            methyl CpG binding protein Kaiso
  JOURNAL   Mol Cell 12 (3), 723-734 (2003)
   PUBMED   14527417
REFERENCE   9  (bases 1 to 5456)
  AUTHORS   Yoon,H.G., Chan,D.W., Huang,Z.Q., Li,J., Fondell,J.D., Qin,J. and
            Wong,J.
  TITLE     Purification and functional characterization of the human N-CoR
            complex: the roles of HDAC3, TBL1 and TBLR1
  JOURNAL   EMBO J 22 (6), 1336-1346 (2003)
   PUBMED   12628926
  REMARK    GeneRIF: This protein is one of 10-12 associated proteins in the
            purified N-CoR complex.
REFERENCE   10 (bases 1 to 5456)
  AUTHORS   Zaphiropoulos,P.G. and Toftgard,R.
  TITLE     cDNA cloning of a novel WD repeat protein mapping to the 9q22.3
            chromosomal region
  JOURNAL   DNA Cell Biol 15 (12), 1049-1056 (1996)
   PUBMED   8985118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC011690.2, AK292788.1,
            AL137073.13 and BM976925.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052820.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This protein contains
            5 WD repeats, and has a structural similarity with actin-binding
            proteins: the D. discoideum coronin and the human p57 protein,
            suggesting that this protein may also be an actin-binding protein
            that regulates cell motility. Alternative splicing of this gene
            generates 2 transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR
            transcribed from an alternate exon, as compared to variant 1.
            Variants 1 and 2 encode the same protein and contain the same 3'
            UTR.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011690.2, AK292788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375077.5/ ENSP00000364218.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-603               BC011690.2         4-606
            604-2236            AK292788.1         585-2217
            2237-4716           AL137073.13        100887-103366       c
            4717-5456           BM976925.1         15-754              c
FEATURES             Location/Qualifiers
     source          1..5456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..5456
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /note="coronin 2A"
                     /db_xref="GeneID:7464"
                     /db_xref="HGNC:HGNC:2255"
                     /db_xref="MIM:602159"
     exon            1..79
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1657
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /note="WD protein IR10; coronin-like protein B; WD-repeat
                     protein 2; WD repeat-containing protein 2; coronin, actin
                     binding protein, 2A"
                     /codon_start=1
                     /product="coronin-2A"
                     /protein_id="NP_438171.1"
                     /db_xref="CCDS:CCDS6735.1"
                     /db_xref="GeneID:7464"
                     /db_xref="HGNC:HGNC:2255"
                     /db_xref="MIM:602159"
                     /translation="MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVN
                     PHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCS
                     EDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIW
                     NLDTKESVITSPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEA
                     SYKGHRASKVLFLGNLKKLMSTGTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFP
                     FYDADTSMLYVVGKGDGNIRYYEVSADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSS
                     CEIFRFYKLITTKSLIEPISMIVPRRSESYQEDIYPPTAGAQPSLTAQEWLSGMNRDP
                     ILVSLRPGSELLRPHPLPAERPIFNSMAPASPRLLNQTEKLAAEDGWRSSSLLEEKMP
                     RWAAEHRLEEKKTWLTNGFDVFECPPPKTENELLQMFYRQQEEIRRLRELLTQREVQA
                     KQLELEIKNLRMGSEQL"
     exon            80..280
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..397
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..547
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            548..727
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..844
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..949
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1046
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1159
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1250
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1525
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..5456
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1969
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
     regulatory      5430..5435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /note="hexamer: AATAAA"
     polyA_site      5456
                     /gene="CORO2A"
                     /gene_synonym="CLIPINB; IR10; WDR2"
                     /note="major polyA site"
ORIGIN      
        1 gagtcggcgg gcggcgagga gcgcggagcc ggagctggac gccgccgccg ccaccgccac
       61 ctgcgcggca gtcatcaaga tgtcatggca cccccagtac cggagctcca agttccgtca
      121 tgtctttggc aaaccagcca gcaaggagaa ctgctacgac tccgtgccta tcacccgcag
      181 cgttcacgac aaccacttct gtgccgtgaa cccccacttc attgcagttg tgactgagtg
      241 tgctggtgga ggggccttcc tcgtcatccc cctgcaccag acagggaagt tggaccccca
      301 ctacccaaaa gtctgcgggc acagaggcaa cgttttggat gtcaagtgga acccttttga
      361 tgattttgag atcgcctcct gttctgaaga tgccacaatt aagatctgga gcatccccaa
      421 gcagctgctg accaggaacc tcacggccta caggaaggaa ctcgtgggcc acgcgcgcag
      481 agtaggcctg gtggagtggc accccacggc cgccaacatc ctcttcagtg ctggctatga
      541 ctacaaggtg atgatctgga acctggatac aaaggagtct gtcatcacaa gccccatgag
      601 tacgattagc tgtcaccaag atgtgatcct ctccatgtcc ttcaacacca acggcagcct
      661 gttggccacc acctgcaaag accgcaagat tcgggttatt gacccccgag cagggaccgt
      721 cctccaggag gccagctaca aagggcaccg ggccagcaaa gtgctgtttc tggggaacct
      781 gaagaagctg atgtccacag gcacatcccg atggaacaac cggcaggtgg ccttgtggga
      841 ccaggataac ctctctgtgc ctctgatgga ggaggacctg gacggctcct cgggcgtgct
      901 gtttcccttc tatgacgcgg acaccagcat gctctacgtg gtggggaagg gagatggcaa
      961 catccgctac tacgaggtga gcgccgacaa gcctcacctg agctacctga ctgagtaccg
     1021 ctcctataac ccacagaagg ggatcggtgt catgccaaag agaggactcg acgtgtcctc
     1081 ctgcgagatc ttccgcttct acaagctgat cacaaccaaa agcctcatcg agcccatctc
     1141 catgattgtg ccccggcggt cagaatccta ccaagaggac atataccctc caacagcagg
     1201 ggcccagccc tccctgacgg cccaggagtg gctcagcggg atgaatcgag acccaatcct
     1261 ggtgtccctt aggcctggct ctgagctgct gagaccccac ccactgcctg cagagagacc
     1321 tatcttcaat tccatggccc cagcctcacc ccggctcttg aatcagacag aaaagctggc
     1381 tgcagaagat ggctggaggt cttcctccct gttggaggag aagatgccaa ggtgggcagc
     1441 agaacacagg ctggaggaga agaaaacctg gctgacaaat ggctttgacg ttttcgaatg
     1501 ccccccacca aagacagaga atgagttgct gcagatgttc taccggcaac aggaggagat
     1561 ccgaaggctc cgggagctgt tgacccagcg agaggtccag gccaaacagt tggaactgga
     1621 gatcaaaaac ttgcggatgg gctcagagca gctctgagca gagacctctg ccctcctcac
     1681 cctcagggac accactcggc tccatgggga ggtttagaac caaaccacaa gtcccctcaa
     1741 ggacaaccac tatttctata ttttttacca gaaaacaaaa ctctccatcg ctgaaagaga
     1801 ttccagtggg acatggtgcc gtttttctgt ttgccttctt gcaacaacag tttctgaatt
     1861 gactttgttt tcagatgatg ccttctgttg aattctgtta ttaagggccc atgatgagct
     1921 gtaacttctc aagaggaaag aacacagtag aaaactagag ctggaaggat ctaggttgac
     1981 ctgtctgtga ttttcaaact gtggtccaga gaatagggga agactgggcc agacgcagtg
     2041 gctcatgcct gtaatcccag cactctggga ggctgaggtg ggcggattgc ttgaggtcgg
     2101 gagtttgaaa ccagtctcac caggcgcagt ggctcacgcc tgtaattcca gcatgttggg
     2161 aggccgaggc tggtggatca cgaggtcagc agttcgagac cagcctgacc aacatggtga
     2221 aaccccatct ctactaaaaa tacaaaaaaa ttagctgggc gtggtggcag gcgcctgtaa
     2281 ttccagcgac ttgggaggct gaggcaggag aattgcttga aaccggaagg cgggggttgc
     2341 agtgagctga gattgtgcca ctgcactcta acctgggcaa taagagcaaa agtctgtctc
     2401 aaaaaaaaaa aaaaaagaaa gaaaccagcc tggccaacat ggtgaaaccc cgtctctact
     2461 aaaaatacaa aaattaggca gggcgtggtg gttcacgcct ataatcccag aactttggga
     2521 ggccaagctg ggcggatctt ctgaggtcag gagttcaaga ccagcctggc caacatggtg
     2581 aaaccccgtc tccactaaaa ataaaaaatt aaccaggcat ggtggtgcat gcctgtaatc
     2641 ccagctattt gggaggctga ggcaggagaa tcgcttgagc ctgggaggcg gaggttgcag
     2701 tgaaccaaga tcatgccact tcactccagc ctgggtgaca gagtgagact ccgtctcaaa
     2761 aaaaaaaagt tggccagccg tggtggtgag cgtctgtagt ccctgctatt cgggaggctg
     2821 agataggaga attgcttgaa cctgggaggt ggaggttgct atgagccacg attgcggact
     2881 gcactgcagc ctgggtgaca gagcgagact ccatctccaa aaaaaaaaaa aaaaagagag
     2941 agagaatagg ggaagactaa gcaggaaggc tgtgtctccc ttccccacac tgtattccaa
     3001 ccagacagct cccttctatt ttatatgttg ggctagtatg aaaaacaatt ctgctaggaa
     3061 aaaaaaattt ttttagaagt ttgaaagcta gtgatttgac ccaagttcct cattttacag
     3121 ctggggaaac taaggcctag agagaggcaa gtgatatttg tttcatggca gggctgggct
     3181 gagatcctgc ttttctgggt ctgtcttttt gctcttttgg gtctgatgca gttctcagcc
     3241 caaagagtag aaatctgttg cttctggcct cagctgtgcc ccagcttact cagtgacctc
     3301 ttgcaagtcc tgccctctct ggtctcagtt tcttcatctg aaccaggggt accctggaac
     3361 aagctgctct ctgcaggatc tgccacctga aaccttgacc taagagaaaa ctacctgtgg
     3421 ggtgatctgg gtttgctaca gaaactaacg gacactggca aggggtcaga ggcattcaac
     3481 ccaattctac aacacaggca ggtggtcaaa accaaccttt ccaaccagaa tcagcctgat
     3541 atggatagat gctgtccctt atggagggac gcagacttca gaactgtgcc catgactgct
     3601 gactgccacc accaaggccc tcaggtacac agcctgcctc ctgcaggatg atgtgggcag
     3661 atttcagccc tagttaacag aagagtcccc caggaggtag ggggccccca tcactggaga
     3721 catgccagca gagcctctgg ccacctaacc aggaggtctt ctgaaatgac tatacgaggt
     3781 aaagaagtag taccagatgg tcccaaagtt cccttttagc ctgaaagctt ttctttgtcc
     3841 ctccttagtg aatctgtgtt ccgagcccta ctctaaagtt cagtggtcaa tacaatagtc
     3901 caccaagaga ctgggaatga ttagaagtga aattggtccc tccttaccaa ggaggggcag
     3961 atgatctcca ttgcacaggg cgattagatt ctggagctga ggtggggact gcaggaggcc
     4021 acctagtctg gtaggtttca acccaagctg tgtacattag aattcccttg ggagcgtgca
     4081 ggaaatacag atgcccatgc cacattccag accaactgaa gctgaatctc cagagtaggg
     4141 cctgtatggt catataagct ccacaggtga tctgcagtac agtgaagatg gaagactgca
     4201 tgtgtaccta tttgcaataa agatgaagag gacagcaagc tccagacagg agctgggact
     4261 caacccagat ctcttaagtc ctgcctggtg gctccttaaa agtccagaag tgttgcccca
     4321 agccctccct caacatctct gggaaccgca gctgcagcac gatgggggtt cagtgcccct
     4381 gtttgcccct tacccagctg tggtttattc tgcttgtatg tctgcacagg ccggatgctc
     4441 gtgttccttg tcttattctc catttactca gtcactgggg ctcactcccg tctgatgcac
     4501 tagccaagat tgccttagtg tgctccagaa aagaaggcca aatcccaggc attgtcaggg
     4561 cagcagagct ctacaggata ggcttacctt tcccacctgt gtggctagca cttcacagtt
     4621 tacaaattcc tcccacctcc actcagtgac acatgctgtt ctaacacagg tcaggcaggc
     4681 attacagtcc ccatgttcag aatcaaagac ctagcctcag agaagtgaag aaacatcatg
     4741 ccaaggtcat tgactgccaa gcggtagagg tggggttgca tccagagagc ttcccggtat
     4801 gcctctgcac aatgccattc cttggccagc tccctccacc ccaagggacc cagactgcac
     4861 acttaacaaa caggacacag gtgtctttga acaaactttt ttgtattatt atttttacat
     4921 ctagaataaa ttatttaaat tatttcacag caagggagag ggataggtaa tttttatcag
     4981 atattttttt aaaccatctg ttttttaaat tacatttttg tttatgttct tgagctgatg
     5041 tagtggaact tgcctagcac attcaggtcc cagccagttg gcagagcatg ctctcatctc
     5101 cttattccat accctgggcg tcccctttct gttgactcag gaactttctg agaatgagga
     5161 cagcactagg agatgagctt tggcaggtat ccaccttaac gctacaataa ttgtgcttcc
     5221 tgaaacaaaa cttgagattg tatcatagaa ggaaacagga agtcagaaat caaatctatg
     5281 cttttaattg aaaccgtgcc tgaaacagtt tgaatgattg ttttaatgtt gtttctgaaa
     5341 ttccttgtac ctttgtgaaa aataatgata ataaataaaa gtgaaaataa atagatgtgg
     5401 aatatgcaat ggaaataatg taacaaaata ataaacatct ggccatttta ctacaa
//
