LOCUS       NM_014325               3814 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens coronin 1C (CORO1C), transcript variant 2, mRNA.
ACCESSION   NM_014325
VERSION     NM_014325.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3814)
  AUTHORS   Fukuda,K., Seki,N., Yasudome,R., Mitsueda,R., Asai,S., Kato,M.,
            Idichi,T., Kurahara,H. and Ohtsuka,T.
  TITLE     Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer
            Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma
  JOURNAL   Genes (Basel) 14 (5), 995 (2023)
   PUBMED   37239355
  REMARK    GeneRIF: Coronin 1C, Regulated by Multiple microRNAs, Facilitates
            Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3814)
  AUTHORS   Zhang,J., Li,H., Li,J. and Ke,S.
  TITLE     CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal
            Squamous Cell Carcinoma Progression
  JOURNAL   Biochem Genet 60 (5), 1615-1629 (2022)
   PUBMED   35064359
  REMARK    GeneRIF: CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate
            Laryngeal Squamous Cell Carcinoma Progression.
REFERENCE   3  (bases 1 to 3814)
  AUTHORS   Li,X., Chen,M., Yuan,Y., Li,J. and Li,F.
  TITLE     CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at
            serine 99 to the leading edge and promotes the migration of gastric
            cancer cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (5), 673-685 (2022)
   PUBMED   35593474
  REMARK    GeneRIF: CORO1C, a novel PAK4 binding protein, recruits
            phospho-PAK4 at serine 99 to the leading edge and promotes the
            migration of gastric cancer cells.
REFERENCE   4  (bases 1 to 3814)
  AUTHORS   Zhang,H., Huang,T., Yuan,S., Long,Y., Tan,S., Niu,G., Zhang,P. and
            Yang,M.
  TITLE     Circ_0020123 plays an oncogenic role in non-small cell lung cancer
            depending on the regulation of miR-512-3p/CORO1C
  JOURNAL   Thorac Cancer 13 (9), 1406-1418 (2022)
   PUBMED   35388975
  REMARK    GeneRIF: Circ_0020123 plays an oncogenic role in non-small cell
            lung cancer depending on the regulation of miR-512-3p/CORO1C.
REFERENCE   5  (bases 1 to 3814)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3814)
  AUTHORS   Spoerl,Z., Stumpf,M., Noegel,A.A. and Hasse,A.
  TITLE     Oligomerization, F-actin interaction, and membrane association of
            the ubiquitous mammalian coronin 3 are mediated by its carboxyl
            terminus
  JOURNAL   J Biol Chem 277 (50), 48858-48867 (2002)
   PUBMED   12377779
  REMARK    GeneRIF: oligomerization, F-actin interaction and membrane
            association are mediated by carboxyl terminus
REFERENCE   7  (bases 1 to 3814)
  AUTHORS   Iizaka,M., Han,H.J., Akashi,H., Furukawa,Y., Nakajima,Y.,
            Sugano,S., Ogawa,M. and Nakamura,Y.
  TITLE     Isolation and chromosomal assignment of a novel human gene, CORO1C,
            homologous to coronin-like actin-binding proteins
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 221-224 (2000)
   PUBMED   10828594
REFERENCE   8  (bases 1 to 3814)
  AUTHORS   de Hostos,E.L.
  TITLE     The coronin family of actin-associated proteins
  JOURNAL   Trends Cell Biol 9 (9), 345-350 (1999)
   PUBMED   10461187
  REMARK    Review article
REFERENCE   9  (bases 1 to 3814)
  AUTHORS   Okumura,M., Kung,C., Wong,S., Rodgers,M. and Thomas,M.L.
  TITLE     Definition of family of coronin-related proteins conserved between
            humans and mice: close genetic linkage between coronin-2 and
            CD45-associated protein
  JOURNAL   DNA Cell Biol 17 (9), 779-787 (1998)
   PUBMED   9778037
REFERENCE   10 (bases 1 to 3814)
  AUTHORS   Wick,M., Burger,C., Brusselbach,S., Lucibello,F.C. and Muller,R.
  TITLE     Identification of serum-inducible genes: different patterns of gene
            regulation during G0-->S and G1-->S progression
  JOURNAL   J Cell Sci 107 (Pt 1), 227-239 (1994)
   PUBMED   8175911
  REMARK    Erratum:[J Cell Sci. 1994 Mar;107 ( Pt 3):preceding table of
            contents.. PMID: 8006057]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB030656.1, AC007569.22 and
            BM677390.1.
            
            On Feb 27, 2020 this sequence version replaced NM_014325.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. Three transcript
            variants encoding two different isoforms have been found for this
            gene. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (2) has an alternate first exon
            and initiates translation at a downstream AUG compared to variant
            1. The resulting isoform (b) is shorter at the N-terminus compared
            to isoform a. Variants 2 and 3 both encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL162070.1, SRR13316199.191304.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261401.8/ ENSP00000261401.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2351              AB030656.1         2-2352
            2352-3692           AC007569.22        22165-23505         c
            3693-3814           BM677390.1         13-134              c
FEATURES             Location/Qualifiers
     source          1..3814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..3814
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /note="coronin 1C"
                     /db_xref="GeneID:23603"
                     /db_xref="HGNC:HGNC:2254"
                     /db_xref="MIM:605269"
     exon            1..90
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            91..290
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1520
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /note="isoform b is encoded by transcript variant 2;
                     coronin-3; coronin, actin binding protein, 1C"
                     /codon_start=1
                     /product="coronin-1C isoform b"
                     /protein_id="NP_055140.1"
                     /db_xref="CCDS:CCDS9120.1"
                     /db_xref="GeneID:23603"
                     /db_xref="HGNC:HGNC:2254"
                     /db_xref="MIM:605269"
                     /translation="MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPR
                     FVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSED
                     CTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNV
                     GTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEG
                     ARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPD
                     TSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIAR
                     FFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKH
                     GYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKS
                     IKDTICNQDERISKLEQQMAKIAA"
     exon            291..413
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..543
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            544..725
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..845
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            846..950
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1096
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1154
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1400
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..3814
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /note="hexamer: ATTATA"
     polyA_site      2357
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /note="major polyA site"
     regulatory      3792..3797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /note="hexamer: GATAAA"
     polyA_site      3814
                     /gene="CORO1C"
                     /gene_synonym="HCRNN4"
                     /note="major polyA site"
ORIGIN      
        1 agtgccaggc tggaggcggc agcggttgga ggcttcgccc ggctttgcag cggggacttc
       61 ggcggcggcg cctcaggcac ctcggcccgg acacgatgag gcgagtggta cgacagagca
      121 agtttcggca tgtatttggg caagcggtga aaaatgacca gtgctatgat gacatccggg
      181 tttctcgtgt gacctgggat agttcctttt gtgctgtcaa tcccagattt gttgccataa
      241 tcatagaggc aagtggggga ggagcgttcc ttgtcctccc tctgcacaag actggtcgaa
      301 ttgacaaatc ttaccctaca gtatgtggcc acacaggacc agtgctggac atagactggt
      361 gcccacataa cgatcaggtc attgccagcg gttcagagga ctgcacggtc atggtatggc
      421 agatcccaga aaatggactc accctttccc tgactgaacc tgtggtgatt ttggaaggcc
      481 actcaaagag agtcggcatc gtggcttggc atccaacggc ccgcaatgtg cttcttagtg
      541 caggctgtga taatgccatt atcatctgga atgtgggaac aggggaagcc cttataaact
      601 tggacgatat gcattcagac atgatttaca atgtgagctg gaaccggaat ggcagtctga
      661 tctgcacagc ttccaaagac aagaaagtga gagtcattga tcccaggaaa caagagattg
      721 ttgctgagaa ggagaaagca catgaaggag caagacccat gagagccatc ttcctggccg
      781 atggcaatgt cttcaccact gggttcagcc gcatgagcga gcggcagctg gctctctgga
      841 atccgaaaaa tatgcaggaa ccaattgctc ttcatgagat ggacactagc aatggggtgt
      901 tgctgccttt ctatgaccct gacaccagca tcatttactt atgtggaaag ggtgacagca
      961 gtattcgcta ttttgagatc acggatgaat ccccgtacgt ccactacctc aacacattca
     1021 gcagcaagga gcctcagaga gggatgggtt acatgcccaa gaggggactt gatgttaaca
     1081 aatgtgagat tgccagattc ttcaaacttc atgagagaaa gtgtgaacct attattatga
     1141 ctgttcccag gaagtctgac cttttccaag atgacctgta tcctgacaca gcggggccag
     1201 aggccgcgct ggaggcagaa gagtggttcg aaggcaagaa tgcagaccca atcctcatct
     1261 ccttgaagca cgggtacatt ccaggcaaaa acagggatct caaggtggtc aagaagaaca
     1321 ttctggatag caagcccact gcaaacaaga agtgcgacct gatcagcatc cccaagaaaa
     1381 ccacagacac ggccagtgtg caaaatgaag ccaagttgga tgagatttta aaagagatca
     1441 aatctataaa agacacaatc tgcaatcaag atgagcgtat ttccaagtta gaacagcaga
     1501 tggcaaagat agcagcctga aggtcccacc cccaccccta cagaaaaaat gggagcaaga
     1561 acttgtgctt gggagctggt tattggtgtg gtcctaggga gggcggaaag ggaggcactg
     1621 ccatttggag acattccatt tcagatttgt caaccagcga taggccacat tccagtaaga
     1681 actcaatttg tctcccaaat ttgcagaaac aaaacgtgat ttaaaagctg agctttttat
     1741 cagaaagctt ttttgatgtt ttaagtgtta tgtgacttgt tgaacttttt aaaaagtgct
     1801 acttttaaaa tcccagatac tctgaatttt agaaaacaaa ctaattctga ttgtgtcgtg
     1861 cccaagtacc cttttttttt taatgaatag ggaccaatgc cacattgctt tttatatttc
     1921 tttctttttt aatgttgcca aaaccaaaag tagctttgtt ttcctttgta ttttgctact
     1981 ttgcagtatt tgtgtgtgtg gttttttttc cttaatttga aagggacagc actgtgtatg
     2041 tttataaact aaatgaagat aagatattat tttgtataaa cattcatctg agaacaatca
     2101 aagcagtagc cacatggtgc tggctccttt gcagcacaaa cctggtcatt ttgatgactg
     2161 tacaacagga agacttgaaa aatcacgtgg attcatatta ccaccgctct catttcatgg
     2221 agtcttctga tcaaaaaagc tcacgtcgta tttcttcttt tcctttctct tttctagaaa
     2281 ttgggtgttt gtaccagaat ggaattttgc ttctcggtta tcctgtgctt cagatgatta
     2341 taatctaacc caaactagca tgtgtttctg cagtttgtta cacacctagg atcatattgc
     2401 attcatcact ttaaacatca tgtttcaggt tttggtcaat acttgacaag ggtgcccagg
     2461 acaggaagac gtgtactgct gagtgttcct tcttgccctt ttcagcagct tgcccagctc
     2521 ttgagtacag tggtggggac taaaaatgtg ggcatgtgga gaggggtatt tgccctgggt
     2581 gatcctgttt ccctgtgctg tccccatgct gtgttggagg aggaagtggc tctccttcca
     2641 ccaacaaagc tcctgctcta ccctcttcct cacatgtgct gcgacctctc tcagggctcc
     2701 cccagccatt ccttctttcc ttcctgcctt ttagctctaa ccacattaag ctaagacaag
     2761 gccagagggt gcgattgaat gagtattgag actgaggaga atgatagaga gtgaagcaga
     2821 aacaggagca cagacctctg ctgtagcttt aatgcataca aacatgtccc tccgcacaac
     2881 taacctgccc tgcctctcca tctctcacca aggctgcgtc aaagcacaga ggctccccgg
     2941 actcggaggg ggccagagac tgagctctgg tcacctgttc attcctcggt tagctggaac
     3001 tttgccccgt ttccagtttc ttatagtgca tgcttgggaa acaagattta aggagcctct
     3061 gttttggaag ggctgtctgt gattgaacgt gaaatgtgta gtgccattgg gaccacgaag
     3121 ggaattcttg cacatgctcg tgctggtgtg ggcatgggac tggctggaaa cgtctgtatg
     3181 cagggagcca gggtgagggc agagtgtggt gacagccgaa cttggagtaa tgtccgtgta
     3241 gaaaaaggac catgttctta tccagccaat actgggagtg ctgtctccac aatttcaggg
     3301 catctgaatg tttgatgtgg ttttgtgtgt gtgtatgtat gtgtttaata ttgaagtgga
     3361 tcatgagatg taaagaaaac aataatggca atgacttata ttcaaatctg tatttgtttc
     3421 tttatcaatg taatctgctg aggacctttt gtctaagatt cagtagtgtt ttaaggttct
     3481 gatatcgaat taatgaagta aagttgttga tggtggtgaa acaccgtagg gcatgtggtt
     3541 caaagagaag caggagggca agggaaagtt accctgatct tagtttgtag cttatgactt
     3601 atttaatgaa tggatgccca gccaagctca gagtaggcgc ccaaagcatt gtggattatt
     3661 ttcctgtttt gtcttttttt tttttttttt ttaagccatg acatcccaga agaggacagt
     3721 gaattactcc taggtcggct cttatagagt ggccatagtg ttctgtcaaa acacttgctt
     3781 ccattttcag agataaaaat cattgattac aaaa
//
