LOCUS       NM_020441               4411 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coronin 1B (CORO1B), transcript variant 1, mRNA.
ACCESSION   NM_020441
VERSION     NM_020441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4411)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4411)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4411)
  AUTHORS   Hachimi,M., Grabowski,C., Campanario,S., Herranz,G., Baonza,G.,
            Serrador,J.M., Gomez-Lopez,S., Barea,M.D., Bosch-Fortea,M.,
            Gilmour,D., Bagnat,M., Rodriguez-Fraticelli,A.E. and
            Martin-Belmonte,F.
  TITLE     Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin
            Cortex during Epithelial Morphogenesis
  JOURNAL   Curr Biol 31 (4), 696-706 (2021)
   PUBMED   33275893
  REMARK    GeneRIF: Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the
            Apical Actin Cortex during Epithelial Morphogenesis.
REFERENCE   4  (bases 1 to 4411)
  AUTHORS   Kim,G.Y., Lim,H.J., Kim,W.H. and Park,H.Y.
  TITLE     Coronin 1B regulates the TNFalpha-induced apoptosis of HUVECs by
            mediating the interaction between TRADD and FADD
  JOURNAL   Biochem Biophys Res Commun 526 (4), 999-1004 (2020)
   PUBMED   32303335
  REMARK    GeneRIF: Coronin 1B regulates the TNFalpha-induced apoptosis of
            HUVECs by mediating the interaction between TRADD and FADD.
REFERENCE   5  (bases 1 to 4411)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4411)
  AUTHORS   Cai,L., Marshall,T.W., Uetrecht,A.C., Schafer,D.A. and Bear,J.E.
  TITLE     Coronin 1B coordinates Arp2/3 complex and cofilin activities at the
            leading edge
  JOURNAL   Cell 128 (5), 915-929 (2007)
   PUBMED   17350576
  REMARK    GeneRIF: Study concludes that Coronin 1B's coordination of filament
            formation by Arp2/3 complex and filament turnover by Cofilin is
            required for effective lamellipodial protrusion and cell migration.
REFERENCE   7  (bases 1 to 4411)
  AUTHORS   Cai,L., Holoweckyj,N., Schaller,M.D. and Bear,J.E.
  TITLE     Phosphorylation of coronin 1B by protein kinase C regulates
            interaction with Arp2/3 and cell motility
  JOURNAL   J Biol Chem 280 (36), 31913-31923 (2005)
   PUBMED   16027158
  REMARK    GeneRIF: Coronin 1B regulates leading edge dynamics and controls
            cell motility and interactions with the actin-related protein
            (Arp)2/3 complex
REFERENCE   8  (bases 1 to 4411)
  AUTHORS   Gatfield,J., Albrecht,I., Zanolari,B., Steinmetz,M.O. and
            Pieters,J.
  TITLE     Association of the leukocyte plasma membrane with the actin
            cytoskeleton through coiled coil-mediated trimeric coronin 1
            molecules
  JOURNAL   Mol Biol Cell 16 (6), 2786-2798 (2005)
   PUBMED   15800061
REFERENCE   9  (bases 1 to 4411)
  AUTHORS   Parente,J.A. Jr., Chen,X., Zhou,C., Petropoulos,A.C. and Chew,C.S.
  TITLE     Isolation, cloning, and characterization of a new mammalian coronin
            family member, coroninse, which is regulated within the protein
            kinase C signaling pathway
  JOURNAL   J Biol Chem 274 (5), 3017-3025 (1999)
   PUBMED   9915840
  REMARK    GeneRIF: In rabbits, cholinergic stimulation increases the
            phosphorylation of coronin 1B in gastric mucosal cells
REFERENCE   10 (bases 1 to 4411)
  AUTHORS   Okumura,M., Kung,C., Wong,S., Rodgers,M. and Thomas,M.L.
  TITLE     Definition of family of coronin-related proteins conserved between
            humans and mice: close genetic linkage between coronin-2 and
            CD45-associated protein
  JOURNAL   DNA Cell Biol 17 (9), 779-787 (1998)
   PUBMED   9778037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003419.3 and BC006449.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020441.2.
            
            Summary: Members of the coronin family, such as CORO1B, are WD
            repeat-containing actin-binding proteins that regulate cell
            motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM,
            Mar 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1134815.1, AK000860.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341356.10/ ENSP00000340211.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AP003419.3         123869-123941       c
            74-276              AP003419.3         122893-123095       c
            277-399             AP003419.3         122431-122553       c
            400-529             AP003419.3         122198-122327       c
            530-711             AP003419.3         121798-121979       c
            712-831             AP003419.3         121590-121709       c
            832-936             AP003419.3         120800-120904       c
            937-1082            AP003419.3         120583-120728       c
            1083-1140           AP003419.3         120251-120308       c
            1141-1419           AP003419.3         119136-119414       c
            1420-1845           AP003419.3         118541-118966       c
            1846-1874           BC006449.1         1832-1860
            1875-4411           AP003419.3         115975-118511       c
FEATURES             Location/Qualifiers
     source          1..4411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..4411
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /note="coronin 1B"
                     /db_xref="GeneID:57175"
                     /db_xref="HGNC:HGNC:2253"
                     /db_xref="MIM:609849"
     exon            1..73
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            74..276
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1545
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /note="coronin, actin binding protein, 1B"
                     /codon_start=1
                     /product="coronin-1B"
                     /protein_id="NP_065174.1"
                     /db_xref="CCDS:CCDS8164.1"
                     /db_xref="GeneID:57175"
                     /db_xref="HGNC:HGNC:2253"
                     /db_xref="MIM:609849"
                     /translation="MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVN
                     PKFLAVIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGS
                     EDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIW
                     NVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAH
                     EGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYD
                     PDTSVVYVCGKGDSSIRYFEITEEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEI
                     ARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISL
                     REAYVPSKQRDLKISRRNVLSDSRPAMAPGSSHLGAPASTTTAADATPSGSLARAGEA
                     GKLEEVMQELRALRALVKEQGDRICRLEEQLGRMENGDA"
     exon            277..399
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..529
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..711
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..831
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..936
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1082
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1140
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1419
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..4411
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /note="hexamer: AATAAA"
     polyA_site      1870
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /note="major polyA site"
     regulatory      4390..4395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
                     /note="hexamer: AATAAA"
     polyA_site      4411
                     /gene="CORO1B"
                     /gene_synonym="CORONIN-2"
ORIGIN      
        1 ctgcttccca gaggccggga tccggagccg cccgaagccg gtgccgcagc cccctgcgcc
       61 cccggtgccc ccgacatgtc cttccgcaaa gtggtccggc agagcaaatt ccggcatgtg
      121 ttcgggcagc cggtcaagaa cgaccagtgc tatgaggaca ttcgcgtgtc ccgtgttacc
      181 tgggacagca ccttctgcgc cgtcaacccc aagttcctgg cggtgattgt ggaggccagt
      241 ggagggggtg cctttctggt gctcccccta agcaagacgg gccgcattga caaggcctac
      301 ccgacggtgt gtgggcacac gggacctgtc ctggacatcg actggtgtcc tcacaacgac
      361 gaagtcatag ccagcggctc ggaggactgc acggtcatgg tgtggcagat cccagagaac
      421 gggctgacct ccccgctgac agagccggtg gtggtactgg aggggcacac caagcgagtg
      481 ggcatcatcg cctggcaccc cacggcccga aacgtgctgc tcagtgcagg ctgcgacaac
      541 gtggtactca tctggaatgt gggcacagcg gaggagctgt accgcctgga cagcctgcac
      601 cctgacctca tctacaatgt cagctggaac cacaatggca gcctgttttg ctcagcatgc
      661 aaggacaaga gcgtgcgcat catcgacccc cgtcggggca ccctggtggc agagcgggag
      721 aaggctcatg agggggcccg gcccatgcgg gccatcttcc tggcagatgg caaggtgttc
      781 accacaggct tcagccgaat gagcgagcgg cagctggcgc tctgggaccc agaaaacctc
      841 gaggaaccca tggccctgca ggaactggac tcgagcaacg gggccctgct gcccttctac
      901 gaccccgaca ccagtgtggt ctacgtctgc ggcaagggtg actccagcat ccggtacttt
      961 gagatcacag aggagcctcc ctacatccac ttcctgaaca cgttcaccag caaggagccg
     1021 cagcggggta tgggcagcat gcccaagcgg ggcctggagg tcagcaagtg cgagatcgcc
     1081 cggttctaca aactgcatga gcgcaagtgt gagcccatcg tcatgactgt gccaagaaag
     1141 tcggacctct tccaggatga tctgtacccc gacacagccg ggcccgaggc agccctggag
     1201 gctgaggagt gggtgagcgg gcgggatgcc gacccgatcc tcatctcact gcgggaggcc
     1261 tacgtgccca gcaagcagcg ggacctgaag atcagccggc gcaacgtgtt gtctgacagc
     1321 cggcccgcca tggccccggg ctcctcccac ctaggggccc ccgcctccac caccactgct
     1381 gctgatgcca cccccagcgg cagcctggcc agagccgggg aggctgggaa gctggaggag
     1441 gtgatgcagg agctgcgggc cctgagggcg ctggtcaagg agcagggcga ccgcatctgc
     1501 cgcctggagg agcagctggg ccgcatggag aacggggatg cgtagggcca cagccacacg
     1561 ccaccttcat ctcctccgcc gcccccttcc cactcagctt ctgccagcgg gtcgcaccgg
     1621 gctagctggc tgcccagagc ctctgaggca gcgcaggggt cagttcccac ccccacccgt
     1681 cccaggccca ggccgaagcc agcgcccagc tttcctcact gttcctgtgg aggatgtcta
     1741 cgcccaggcg agctcctcga cctctgaggg accatctccc cgaccactgc ccagccctct
     1801 gctccctccc cagaggaggc gggagggtgg gctctatatt ttcattccaa ataaaattct
     1861 ctttctaaaa gccaggctga cctgctgctg caagggtggg gctgagaagt ctggaaacct
     1921 ggagacagag gatgtcacag gagtcacaca tgtgcagaag gtctgggggc agtgagcagc
     1981 cccacaggca ttgctcccct ggattgtcag gcagggaaac tgaggcagaa gacctgagaa
     2041 cacatgcaag gctgcatcca gcttcaagtt ggtgctgctt cttccttgga ggacaggccc
     2101 ggcagcccag cctcctccag agagactggg gagggtctgg tgtggaccag gggtcctgca
     2161 gcagggaggg gcaggtgggg tatgtgggca ggaagcggaa gcctgggcca cccttcactg
     2221 cagacgagca ctgagctcac ttctcgctcg acacagccag agctggaggt gggtgcccgg
     2281 cacggagggg cctgcggacc aatggtaagc ctcggagccc cccgggttct tgggatgggg
     2341 gccacaggcg gtcggggcta gaatgtctgg gcctgtggag ctaaggaggg ccccacattg
     2401 gccccaggga agaggtgaga cctaagagga gtatggcaga ggctgaacct ttctctcacc
     2461 tgagctgggc tccctgggac tccaggcctg gcccccagca ccccataccg gaccaggccc
     2521 ctgtcaggag ccctgggaag gcccttacct ggtcttcctg tgagcgggaa cttgcattcc
     2581 tggagcctgg gcggacagcc tggggtggtg ggggaggctg gctgcacctc agcacccctc
     2641 ccccgacacc ccccacctag cctgttccga ccgcagactt cctctggcag ctgcgcccgc
     2701 ctcccccagc cccccccagc ccccggccct gcacgcctgt ggccctcagg gactgggagt
     2761 ggaacggaaa ccctgccgct ggggcagccc cgtggtgggg agggaggaag aggggcctca
     2821 cggacccccg tttggggacc tggccaagca gaagatgagc agttgcctct gggtgcatcc
     2881 aggcccctcc atcccccatc ccaggcctca gggagagcca gccctgacac cagctagcaa
     2941 cctccttccc tccctcccat ctcctctccc acccacccag gcagcctaga cacatttaat
     3001 ccatacttat tgagcaccta ctaacatgct tgacccaaaa agcccccgtt tcctagcagc
     3061 ttattgtggg gggtagataa gacaatagac ataaaaaatg agtacagtta tctcctgcgt
     3121 taggtgacat ggaaggaaaa aggcactgag tgctgggggg tgctggggtg ggctgcagtg
     3181 atagacatca gggtagaggt taaggtcagg ttcagcctca ctggggtgaa gtttgagcac
     3241 ggtgagcagg ccatgcagcc cgggggaggg gaggatggga ggaggtggag ctttccgggc
     3301 agagggaaca gccagtgcga aggccccagg caggtggctt aatgcagctg ttgggggagg
     3361 tgagtggtag ggaggaggct ggagggatgg gggctgatct cacagggcca gagcctggtt
     3421 gaccaaataa ggccttggcc ttttctgctt ggctgtccca agaggatccc aaagagaaaa
     3481 aaacgaaagt ggtcttggtc acccagcctg ccccacacca ggccccaccc caggtgctga
     3541 gccctctgag cccctgcctg tctcccacag gctctgccct gcaccttagg gctcgggatg
     3601 ctgctggccc tgccaggggc cttgggctcg ggtggcagcg cggaggacag cgtgggctcc
     3661 agctctgtca ccgttgtcct gctgctgctg ctgctcctac tgctggccac tggcctagca
     3721 ctggcctggc gccgcctcag ccgtgactca gggggctact accacccggc ccgcctaggt
     3781 gccgcgctgt ggggccgcac gcggcgcctg ctctgggcca gccccccagg tcgctggctg
     3841 caggcccgag ctgagctggg gtccacagac aatgaccttg agcgacagga ggatgagcag
     3901 gacacagact atgaccacgt cgcggatggt ggcctgcagg ctgaccctgg ggaaggcgag
     3961 cagcaatgtg gagaggcgtc cagcccagag caggtccccg tgcgggctga ggaagccaga
     4021 gacagtgaca cggagggcga cctggtcctc ggctccccag gaccagcgag cgcagggggc
     4081 agtgctgagg ccctgctgag tgacctgcac gcctttgctg gcagcgcagc ctgggatgac
     4141 agcgccaggg cagctggggg ccagggcctc catgtcaccg cactgtagag gccggtcttg
     4201 gtgtcccatc cctgtcacag ccgctcactc cccgtgcctc tgcttcccaa gatgccatgg
     4261 ctggactgga cccccagccc acatgaccat gcctcagact gtcaccccct accagttccc
     4321 aagtccatgt gtaccccgct caccacggga acggcccccc ccaaccacag gcatcaggca
     4381 accatttgaa ataaaactcc ttcagcctgt g
//
