LOCUS       NM_006587               4967 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens corin, serine peptidase (CORIN), transcript variant 1,
            mRNA.
ACCESSION   NM_006587
VERSION     NM_006587.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4967)
  AUTHORS   Zhu,D., Huang,M.F., Xu,A., Gao,X., Huang,Y.W., Phan,T.T.T., Lu,L.,
            Chi,T.Y., Dai,Y., Pang,L.K., Gingold,J.A., Tu,J., Huo,Z.,
            Bazer,D.A., Shoemaker,R., Wang,J., Ambrose,C.G., Shen,J.,
            Kameoka,J., Zhao,Z., Wang,L.L., Zhang,Y., Zhao,R. and Lee,D.F.
  TITLE     Systematic transcriptome profiling of hPSC-derived osteoblasts
            unveils CORIN's mastery in governing osteogenesis through CEBPD
            modulation
  JOURNAL   J Biol Chem 300 (8), 107494 (2024)
   PUBMED   38925326
  REMARK    GeneRIF: Systematic transcriptome profiling of hPSC-derived
            osteoblasts unveils CORIN's mastery in governing osteogenesis
            through CEBPD modulation.
REFERENCE   2  (bases 1 to 4967)
  AUTHORS   Abassi,Z., Hamo-Giladi,D.B., Kinaneh,S. and Heyman,S.N.
  TITLE     The endocrine basis of the cardio-renal axis: New perspectives
            regarding corin
  JOURNAL   Physiol Rep 12 (13), e16105 (2024)
   PUBMED   38942727
  REMARK    GeneRIF: The endocrine basis of the cardio-renal axis: New
            perspectives regarding corin.
            Review article
REFERENCE   3  (bases 1 to 4967)
  AUTHORS   Dominy,J., Koch,C., Lamarche,L., Denning,D., Gurtan,A., Khan,M.Z.,
            Rasheed,A., Mian,M.R., Jahanzaib,M., Khalid,S. and Saleheen,D.
  TITLE     Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and
            Fibrosis
  JOURNAL   N Engl J Med 390 (16), 1537-1538 (2024)
   PUBMED   38657259
  REMARK    GeneRIF: Corin and Left Atrial Cardiomyopathy, Hypertension,
            Arrhythmia, and Fibrosis.
REFERENCE   4  (bases 1 to 4967)
  AUTHORS   Fan,W., Mao,Y., Wu,L., Feng,P., Zhang,X., Hu,J., Jin,Y., Yang,X.,
            Li,H., Liu,Q. and Peng,H.
  TITLE     Association between CORIN promoter methylation and hypertensive
            disorders of pregnancy - A nested case-control study
  JOURNAL   Placenta 148, 77-83 (2024)
   PUBMED   38417305
  REMARK    GeneRIF: Association between CORIN promoter methylation and
            hypertensive disorders of pregnancy - A nested case-control study.
REFERENCE   5  (bases 1 to 4967)
  AUTHORS   Baris Feldman,H., Chai Gadot,C., Zahler,D., Mory,A., Aviram,G.,
            Elhanan,E., Shefer,G., Goldiner,I., Amir,Y., Kurolap,A. and
            Ablin,J.N.
  TITLE     Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and
            Fibrosis
  JOURNAL   N Engl J Med 389 (18), 1685-1692 (2023)
   PUBMED   37913506
  REMARK    GeneRIF: Corin and Left Atrial Cardiomyopathy, Hypertension,
            Arrhythmia, and Fibrosis.
REFERENCE   6  (bases 1 to 4967)
  AUTHORS   Pan,J., Hinzmann,B., Yan,W., Wu,F., Morser,J. and Wu,Q.
  TITLE     Genomic structures of the human and murine corin genes and
            functional GATA elements in their promoters
  JOURNAL   J Biol Chem 277 (41), 38390-38398 (2002)
   PUBMED   12154094
  REMARK    GeneRIF: These data indicate that the GATA element and its binding
            to GATA-4 are essential for cardiac expression of the human and
            murine corin genes.
REFERENCE   7  (bases 1 to 4967)
  AUTHORS   Wu,F., Yan,W., Pan,J., Morser,J. and Wu,Q.
  TITLE     Processing of pro-atrial natriuretic peptide by corin in cardiac
            myocytes
  JOURNAL   J Biol Chem 277 (19), 16900-16905 (2002)
   PUBMED   11884416
  REMARK    GeneRIF: Processing of pro-atrial natriuretic peptide by corin in
            cardiac myocytes.
REFERENCE   8  (bases 1 to 4967)
  AUTHORS   Hooper,J.D., Scarman,A.L., Clarke,B.E., Normyle,J.F. and
            Antalis,T.M.
  TITLE     Localization of the mosaic transmembrane serine protease corin to
            heart myocytes
  JOURNAL   Eur J Biochem 267 (23), 6931-6937 (2000)
   PUBMED   11082206
REFERENCE   9  (bases 1 to 4967)
  AUTHORS   Yan,W., Wu,F., Morser,J. and Wu,Q.
  TITLE     Corin, a transmembrane cardiac serine protease, acts as a
            pro-atrial natriuretic peptide-converting enzyme
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8525-8529 (2000)
   PUBMED   10880574
REFERENCE   10 (bases 1 to 4967)
  AUTHORS   Yan,W., Sheng,N., Seto,M., Morser,J. and Wu,Q.
  TITLE     Corin, a mosaic transmembrane serine protease encoded by a novel
            cDNA from human heart
  JOURNAL   J Biol Chem 274 (21), 14926-14935 (1999)
   PUBMED   10329693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK304466.1, AF133845.1,
            AC092597.1 and AI378383.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006587.3.
            
            Summary: This gene encodes a member of the type II transmembrane
            serine protease class of the trypsin superfamily. Members of this
            family are composed of multiple structurally distinct domains. The
            encoded protein converts pro-atrial natriuretic peptide to
            biologically active atrial natriuretic peptide, a cardiac hormone
            that regulates blood volume and pressure. This protein may also
            function as a pro-brain-type natriuretic peptide convertase.
            Multiple alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF133845.1, BC110451.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273857.9/ ENSP00000273857.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AK304466.1         40-195
            157-1233            AF133845.1         132-1208
            1234-1250           AC092597.1         55255-55271
            1251-1707           AK304466.1         1179-1635
            1708-4958           AF133845.1         1683-4933
            4959-4967           AI378383.1         10-18               c
FEATURES             Location/Qualifiers
     source          1..4967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..4967
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /note="corin, serine peptidase"
                     /db_xref="GeneID:10699"
                     /db_xref="HGNC:HGNC:19012"
                     /db_xref="MIM:605236"
     exon            1..181
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3247
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pro-ANP-converting enzyme; pro-ANP-convertase; atrial
                     natriuretic peptide-converting enzyme; transmembrane
                     protease serine 10; heart-specific serine proteinase ATC2"
                     /codon_start=1
                     /product="atrial natriuretic peptide-converting enzyme
                     isoform 1"
                     /protein_id="NP_006578.2"
                     /db_xref="CCDS:CCDS3477.1"
                     /db_xref="GeneID:10699"
                     /db_xref="HGNC:HGNC:19012"
                     /db_xref="MIM:605236"
                     /translation="MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLL
                     RFLLLVLIPCICALVLLLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTI
                     YNQSTVVSTAHPDQHVPAWTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLL
                     SVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEA
                     AKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFL
                     CASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDL
                     SDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQC
                     IPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLN
                     NCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMF
                     FSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSD
                     NQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWEC
                     PSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSD
                     SSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKL
                     IQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARM
                     NKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKV
                     VLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLP
                     NPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAG
                     YESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWI
                     KRQIYIQTFLLN"
     exon            182..326
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            327..527
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            528..735
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            736..917
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1031
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1139
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1250
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1367
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1475
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1707
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1853
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1961
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2075
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2186
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2316
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2433
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2483
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2658
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2930
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3064
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..4967
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4947..4952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /note="hexamer: AATAAA"
     polyA_site      4967
                     /gene="CORIN"
                     /gene_synonym="ATC2; CMH30; CRN; Lrp4; PEE5; TMPRSS10"
                     /note="major polyA site"
ORIGIN      
        1 agtttgtctc tcttgagctt ggagaaaatc atccgtagtg cctccccggg ggacacgtag
       61 aggagagaaa agcgaccaag ataaaagtgg acagaagaat aagcgagact ttttatccat
      121 gaaacagtct cctgccctcg ctccggaaga gcgctgccgc agagccgggt ccccaaagcc
      181 ggtcttgaga gctgatgaca ataacatggg caatggctgc tctcagaagc tggcgactgc
      241 taacctcctc cggttcctat tgctggtcct gattccatgt atctgtgctc tcgttctctt
      301 gctggtgatc ctgctttcct atgttggaac attacaaaag gtctatttta aatcaaatgg
      361 gagtgaacct ttggtcactg atggtgaaat ccaagggtcc gatgttattc ttacaaatac
      421 aatttataac cagagcactg tggtgtctac tgcacatccc gaccaacacg ttccagcctg
      481 gactacggat gcttctctcc caggggacca aagtcacagg aatacaagtg cctgtatgaa
      541 catcacccac agccagtgtc agatgctgcc ctaccacgcc acgctgacac ctctcctctc
      601 agttgtcaga aacatggaaa tggaaaagtt cctcaagttt ttcacatatc tccatcgcct
      661 cagttgctat caacatatca tgctgtttgg ctgtaccctc gccttccctg agtgcatcat
      721 tgatggcgat gacagtcatg gactcctgcc ctgtaggtcc ttctgtgagg ctgcaaaaga
      781 aggctgtgaa tcagtcctgg ggatggtgaa ttactcctgg ccggatttcc tcagatgctc
      841 ccagtttaga aaccaaactg aaagcagcaa tgtcagcaga atttgcttct cacctcagca
      901 ggaaaacgga aagcaattgc tctgtggaag gggtgagaac tttctgtgtg ccagtggaat
      961 ctgcatcccc gggaaactgc aatgtaatgg ctacaacgac tgtgacgact ggagtgacga
     1021 ggctcattgc aactgcagcg agaatctgtt tcactgtcac acaggcaagt gccttaatta
     1081 cagccttgtg tgtgatggat atgatgactg tggggatttg agtgatgagc aaaactgtga
     1141 ttgcaatccc acaacagagc atcgctgcgg ggacgggcgc tgcatcgcca tggagtgggt
     1201 gtgtgatggt gaccacgact gtgtggataa gtctgacgag gtcaactgct cctgtcacag
     1261 ccagggtctg gtggaatgca gaaatggaca atgtatcccc agcacgtttc aatgtgatgg
     1321 tgacgaggac tgcaaggatg ggagtgatga ggagaactgc agcgtcattc agacttcatg
     1381 tcaagaagga gaccaaagat gcctctacaa tccctgcctt gattcatgtg gtggtagctc
     1441 tctctgtgac ccgaacaaca gtctgaataa ctgtagtcaa tgtgaaccaa ttacattgga
     1501 actctgcatg aatttgccct acaacagtac aagttatcca aattattttg gccacaggac
     1561 tcaaaaggaa gcatccatca gctgggagtc ttctcttttc cctgcacttg ttcaaaccaa
     1621 ctgttataaa tacctcatgt tcttttcttg caccattttg gtaccaaaat gtgatgtgaa
     1681 tacaggcgag catatccctc cttgcagggc attgtgtgaa cactctaaag aacgctgtga
     1741 gtctgttctt gggattgtgg gcctacagtg gcctgaagac acagattgca gtcaatttcc
     1801 agaggaaaat tcagacaatc aaacctgcct gatgcctgat gaatatgtgg aagaatgctc
     1861 acctagtcat ttcaagtgcc gctcaggaca gtgtgttctg gcttccagaa gatgtgatgg
     1921 ccaggccgac tgtgacgatg acagtgatga ggaaaactgt ggttgtaaag agagagatct
     1981 ttgggaatgt ccatccaata aacaatgttt gaagcacaca gtgatctgcg atgggttccc
     2041 agactgccct gattacatgg acgagaaaaa ctgctcattt tgccaagatg atgagctgga
     2101 atgtgcaaac catgcgtgtg tgtcacgtga cctgtggtgt gatggtgaag ccgactgctc
     2161 agacagttca gatgaatggg actgtgtgac cctctctata aatgtgaact cctcttcctt
     2221 tctgatggtt cacagagctg ccacagaaca ccatgtgtgt gcagatggct ggcaggagat
     2281 attgagtcag ctggcctgca agcagatggg tttaggagaa ccatctgtga ccaaattgat
     2341 acaggaacag gagaaagagc cgcggtggct gacattacac tccaactggg agagcctcaa
     2401 tgggaccact ttacatgaac ttctagtaaa tgggcagtct tgtgagagca gaagtaaaat
     2461 ttctcttctg tgtactaaac aagactgtgg gcgccgccct gctgcccgaa tgaacaaaag
     2521 gatccttgga ggtcggacga gtcgccctgg aaggtggcca tggcagtgtt ctctgcagag
     2581 tgaacccagt ggacatatct gtggctgtgt cctcattgcc aagaagtggg ttctgacagt
     2641 tgcccactgc ttcgagggga gagagaatgc tgcagtttgg aaagtggtgc ttggcatcaa
     2701 caatctagac catccatcag tgttcatgca gacacgcttt gtgaagacca tcatcctgca
     2761 tccccgctac agtcgagcag tggtggacta tgacatcagc atcgttgagc tgagtgaaga
     2821 catcagtgag actggctacg tccggcctgt ctgcttgccc aacccggagc agtggctaga
     2881 gcctgacacg tactgctata tcacaggctg gggccacatg ggcaataaaa tgccatttaa
     2941 gctgcaagag ggagaggtcc gcattatttc tctggaacat tgtcagtcct actttgacat
     3001 gaagaccatc accactcgga tgatatgtgc tggctatgag tctggcacag ttgattcatg
     3061 catgggtgac agcggtgggc ctcttgtttg tgagaagcct ggaggacggt ggacattatt
     3121 tggattaact tcatggggct ccgtctgctt ttccaaagtc ctggggcctg gcgtttatag
     3181 taatgtgtca tatttcgtcg aatggattaa aagacagatt tacatccaga cctttctcct
     3241 aaactaatta taaggatgat cagagacttt tgccagctac actaaaagaa aatggccttc
     3301 ttgactgtga agagctgcct gcagagagct gtacagaagc acttttcatg gacagaaatg
     3361 ctcaatcgtg cactgcaaat ttgcatgttt gttttggact aatttttttc aatttatttt
     3421 ttcaccttca tttttctctt atttcaagtt caatgaaaga ctttacaaaa gcaaacaaag
     3481 cagactttgt ccttttgcca ggcctaacca tgactgcagc acaaaattat cgactctggc
     3541 gagatttaaa atcaggtgct acagtaacag gttatggaat ggtctctttt atcctatcac
     3601 aaaaaaagac atagatattt aggctgatta attatctcta ccagtttttg tttctcaagc
     3661 tcagtgcata gtggtaaatt tcagtgttaa cattggagac ttgcttttct ttttcttttt
     3721 ttatacccca caattctttt ttattacact tcgaatttta gggtacacga gcacaacgtg
     3781 caggttagtt acatatgtat acatgtgcca tgttggtgtg ctgaacccag taactcgtca
     3841 tttgatttat taaaagccaa gataatttac atgtttaaag tatttactat tacccccttc
     3901 taatgtttgc ataattctga gaactgataa aagacagcaa taaaagacca gtgtcatcca
     3961 tttaggtagc aagacatatt gaatgcaaag ttctttagat atcaatatta acacttgaca
     4021 ttattggacc ccccattctg gatgtatatc aagatcataa ttttatagaa gagtctctat
     4081 agaactgtcc tcatagctgg gtttgttcag gatatatgag ttggctgatt gagactgcaa
     4141 caactacatc tatatttatg ggcaatattt tgttttactt atgtggcaaa gaactggata
     4201 ttaaactttg caaaagagaa tttagatgag agatgcaatt ttttaaaaag aaaattaatt
     4261 tgcatccctc gtttaattaa atttattttt cagttttctt gcgttcatcc ataccaacaa
     4321 agtcataaag agcatatttt agagcacagt aagactttgc atggagtaaa acattttgta
     4381 attttcctca aaagatgttt aatatctggt ttcttctcat tggtaattaa aattttagaa
     4441 atgattttta gctctaggcc actttacgca actcaatttc tgaagcaatt agtggtaaaa
     4501 agtatttttc cccactaaaa aactttaaaa cacaaatctt catatatact taatttaatt
     4561 agtcaggcat ccattttgcc ttttaaacaa ctaggattcc ctactaacct ccaccagcaa
     4621 cctggactgc ctcagcattc caaatagata ctacctgcaa ttttatacat gtatttttgt
     4681 atcttttctg tgtgtaaaca tagttgaaat tcaaaaagtt gtagcaattt ctatactatt
     4741 catctcctgt ccttcagttt gtataaacct aaggagagtg tgaaatccag caactgaatt
     4801 gtggtcacga ttgtatgaaa gttcaagaac atatgtcagt tttgttacag ttgtagctac
     4861 atactcaatg tatcaacttt tagcctgctc aacttaggct cagtgaaata tatatattat
     4921 acttatttta aataattctt aatacaaata aaatggtaat ggtctaa
//
