LOCUS       NM_016429                914 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens COPI coat complex subunit zeta 2 (COPZ2), mRNA.
ACCESSION   NM_016429
VERSION     NM_016429.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Steffens,M., Leu,C., Ruppert,A.K., Zara,F., Striano,P.,
            Robbiano,A., Capovilla,G., Tinuper,P., Gambardella,A., Bianchi,A.,
            La Neve,A., Crichiutti,G., de Kovel,C.G., Kasteleijn-Nolst
            Trenite,D., de Haan,G.J., Lindhout,D., Gaus,V., Schmitz,B.,
            Janz,D., Weber,Y.G., Becker,F., Lerche,H., Steinhoff,B.J.,
            Kleefuss-Lie,A.A., Kunz,W.S., Surges,R., Elger,C.E., Muhle,H., von
            Spiczak,S., Ostertag,P., Helbig,I., Stephani,U., Moller,R.S.,
            Hjalgrim,H., Dibbens,L.M., Bellows,S., Oliver,K., Mullen,S.,
            Scheffer,I.E., Berkovic,S.F., Everett,K.V., Gardiner,M.R.,
            Marini,C., Guerrini,R., Lehesjoki,A.E., Siren,A., Guipponi,M.,
            Malafosse,A., Thomas,P., Nabbout,R., Baulac,S., Leguern,E.,
            Guerrero,R., Serratosa,J.M., Reif,P.S., Rosenow,F., Morzinger,M.,
            Feucht,M., Zimprich,F., Kapser,C., Schankin,C.J., Suls,A.,
            Smets,K., De Jonghe,P., Jordanova,A., Caglayan,H., Yapici,Z.,
            Yalcin,D.A., Baykan,B., Bebek,N., Ozbek,U., Gieger,C.,
            Wichmann,H.E., Balschun,T., Ellinghaus,D., Franke,A., Meesters,C.,
            Becker,T., Wienker,T.F., Hempelmann,A., Schulz,H., Ruschendorf,F.,
            Leber,M., Pauck,S.M., Trucks,H., Toliat,M.R., Nurnberg,P.,
            Avanzini,G., Koeleman,B.P. and Sander,T.
  CONSRTM   EPICURE Consortium; EMINet Consortium
  TITLE     Genome-wide association analysis of genetic generalized epilepsies
            implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
  JOURNAL   Hum Mol Genet 21 (24), 5359-5372 (2012)
   PUBMED   22949513
REFERENCE   2  (bases 1 to 914)
  AUTHORS   Shtutman,M., Baig,M., Levina,E., Hurteau,G., Lim,C.U., Broude,E.,
            Nikiforov,M., Harkins,T.T., Carmack,C.S., Ding,Y., Wieland,F.,
            Buttyan,R. and Roninson,I.B.
  TITLE     Tumor-specific silencing of COPZ2 gene encoding coatomer protein
            complex subunit zeta 2 renders tumor cells dependent on its
            paralogous gene COPZ1
  JOURNAL   Proc Natl Acad Sci U S A 108 (30), 12449-12454 (2011)
   PUBMED   21746916
  REMARK    GeneRIF: The knockdown of COPZ1, but not of COPZ2 encoding isoform
            coatomer protein complex zeta2, caused Golgi apparatus collapse,
            blocked autophagy, and induced apoptosis in both proliferating and
            nondividing tumor cells.
REFERENCE   3  (bases 1 to 914)
  AUTHORS   Yu,W., Lin,J., Jin,C. and Xia,B.
  TITLE     Solution structure of human zeta-COP: direct evidences for
            structural similarity between COP I and clathrin-adaptor coats
  JOURNAL   J Mol Biol 386 (4), 903-912 (2009)
   PUBMED   19167404
  REMARK    GeneRIF: The solution structure of a truncated form (residues
            1-149; zeta-COP149) of human zeta-COP (total 177 residues), is
            reported.
REFERENCE   4  (bases 1 to 914)
  AUTHORS   Wegmann,D., Hess,P., Baier,C., Wieland,F.T. and Reinhard,C.
  TITLE     Novel isotypic gamma/zeta subunits reveal three coatomer complexes
            in mammals
  JOURNAL   Mol Cell Biol 24 (3), 1070-1080 (2004)
   PUBMED   14729954
REFERENCE   5  (bases 1 to 914)
  AUTHORS   Futatsumori,M., Kasai,K., Takatsu,H., Shin,H.W. and Nakayama,K.
  TITLE     Identification and characterization of novel isoforms of COP I
            subunits
  JOURNAL   J Biochem 128 (5), 793-801 (2000)
   PUBMED   11056392
REFERENCE   6  (bases 1 to 914)
  AUTHORS   Sullivan,B.M., Harrison-Lavoie,K.J., Marshansky,V., Lin,H.Y.,
            Kehrl,J.H., Ausiello,D.A., Brown,D. and Druey,K.M.
  TITLE     RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi
            membranes and intracellular transport
  JOURNAL   Mol Biol Cell 11 (9), 3155-3168 (2000)
   PUBMED   10982407
REFERENCE   7  (bases 1 to 914)
  AUTHORS   Lowe,M. and Kreis,T.E.
  TITLE     In vivo assembly of coatomer, the COP-I coat precursor
  JOURNAL   J Biol Chem 271 (48), 30725-30730 (1996)
   PUBMED   8940050
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY179834.1, BC015924.1 and
            BQ002984.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016429.3.
            
            Summary: This gene encodes a member of the adaptor complexes small
            subunit family. The encoded protein is a subunit of the coatomer
            protein complex, a seven-subunit complex that functions in the
            formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles
            function in the retrograde Golgi-to-ER transport of dilysine-tagged
            proteins. [provided by RefSeq, Feb 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015924.1, AB037938.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621465.5/ ENSP00000480707.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                HY179834.1         11-25
            16-910              BC015924.1         1-895
            911-914             BQ002984.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..914
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /note="COPI coat complex subunit zeta 2"
                     /db_xref="GeneID:51226"
                     /db_xref="HGNC:HGNC:19356"
                     /db_xref="MIM:615526"
     exon            1..131
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..653
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /note="nonclathrin coat protein zeta-COP; coatomer protein
                     complex subunit zeta 2; zeta-2 COP; zeta-2-coat protein"
                     /codon_start=1
                     /product="coatomer subunit zeta-2"
                     /protein_id="NP_057513.1"
                     /db_xref="CCDS:CCDS74092.1"
                     /db_xref="GeneID:51226"
                     /db_xref="HGNC:HGNC:19356"
                     /db_xref="MIM:615526"
                     /translation="MQRPEAWPRPHPGEGAAAAQAGGPAPPARAGEPSGLRLQEPSLY
                     TIKAVFILDNDGRRLLAKYYDDTFPSMKEQMVFEKNVFNKTSRTESEIAFFGGMTIVY
                     KNSIDLFLYVVGSSYENELMLMSVLTCLFESLNHMLRKNVEKRWLLENMDGAFLVLDE
                     IVDGGVILESDPQQVIQKVNFRADDGGLTEQSVAQVLQSAKEQIKWSLLK"
     exon            132..206
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            207..288
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            289..380
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            381..436
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            437..514
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            515..566
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            567..605
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            606..914
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      888..893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /note="hexamer: AATAAA"
     polyA_site      914
                     /gene="COPZ2"
                     /gene_synonym="zeta2-COP"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgaggc ggcgagcgga atgcagcggc ccgaggcctg gccacgtccg cacccggggg
       61 agggggccgc ggcggcccag gccgggggcc cggcgccgcc tgctcgagcc ggggagccct
      121 cggggctgcg gttgcaggaa ccttccctct acaccatcaa ggctgttttc atcctagata
      181 atgacgggcg ccggctgctg gccaagtatt atgatgacac attcccctcc atgaaggagc
      241 agatggtttt cgagaaaaat gtcttcaaca agaccagccg gactgagagt gagattgcat
      301 tttttggggg tatgaccatc gtctacaaga acagcattga cctcttccta tacgtggtgg
      361 gctcatccta cgagaatgag ctgatgctca tgtctgttct cacctgcctg tttgagtctc
      421 tgaaccacat gttaaggaag aacgtggaga agcgctggtt gctggagaac atggacggag
      481 ccttcttggt gctggacgag attgtggatg gcggtgtgat tctggagagt gacccccagc
      541 aagtgatcca gaaggtgaat tttagggcag atgatggcgg cttgactgaa cagagtgtgg
      601 cccaggttct tcagtctgcc aaggaacaaa ttaaatggtc gttattgaaa tgaaggctgt
      661 ggattcaagg ctccctgccc cccagatcat ttccccaatc ctggcaaaag cccaaagatc
      721 ccagggtcag gagagacccc tctgtatccc caggtccctc ccagaactga ctcctaaggt
      781 ctccagccag ggcttctgag atgcaaaggt ttggcctcag gagagtcacc ttttctcacg
      841 gccctggcct taactcatat cttaggcatt cctggcccca gggccctaat aaacctgctt
      901 ttgtcttctg ccaa
//
