LOCUS       NM_016057               1890 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens COPI coat complex subunit zeta 1 (COPZ1), transcript
            variant 1, mRNA.
ACCESSION   NM_016057
VERSION     NM_016057.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Wu,A., Yang,H., Xiao,T., Gu,W., Li,H. and Chen,P.
  TITLE     COPZ1 regulates ferroptosis through NCOA4-mediated ferritinophagy
            in lung adenocarcinoma
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (11), 130706 (2024)
   PUBMED   39181476
  REMARK    GeneRIF: COPZ1 regulates ferroptosis through NCOA4-mediated
            ferritinophagy in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Zhang,Y., Kong,Y., Ma,Y., Ni,S., Wikerholmen,T., Xi,K., Zhao,F.,
            Zhao,Z., Wang,J., Huang,B., Chen,A., Yao,Z., Han,M., Feng,Z.,
            Hu,Y., Thorsen,F., Wang,J. and Li,X.
  TITLE     Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in
            glioblastoma cell lines
  JOURNAL   Oncogene 40 (8), 1425-1439 (2021)
   PUBMED   33420375
  REMARK    GeneRIF: Loss of COPZ1 induces NCOA4 mediated autophagy and
            ferroptosis in glioblastoma cell lines.
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Anania,M.C., Cetti,E., Lecis,D., Todoerti,K., Gulino,A., Mauro,G.,
            Di Marco,T., Cleris,L., Pagliardini,S., Manenti,G., Belmonte,B.,
            Tripodo,C., Neri,A. and Greco,A.
  TITLE     Targeting COPZ1 non-oncogene addiction counteracts the viability of
            thyroid tumor cells
  JOURNAL   Cancer Lett 410, 201-211 (2017)
   PUBMED   28951131
  REMARK    GeneRIF: siRNA-mediated COPZ1 depletion causes abortive autophagy,
            endoplasmic reticulum stress, unfolded protein response and
            apoptosis in thyroid tumor cells.
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Shameer,K., Denny,J.C., Ding,K., Jouni,H., Crosslin,D.R., de
            Andrade,M., Chute,C.G., Peissig,P., Pacheco,J.A., Li,R.,
            Bastarache,L., Kho,A.N., Ritchie,M.D., Masys,D.R., Chisholm,R.L.,
            Larson,E.B., McCarty,C.A., Roden,D.M., Jarvik,G.P. and Kullo,I.J.
  TITLE     A genome- and phenome-wide association study to identify genetic
            variants influencing platelet count and volume and their
            pleiotropic effects
  JOURNAL   Hum Genet 133 (1), 95-109 (2014)
   PUBMED   24026423
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Moelleken,J., Malsam,J., Betts,M.J., Movafeghi,A., Reckmann,I.,
            Meissner,I., Hellwig,A., Russell,R.B., Sollner,T., Brugger,B. and
            Wieland,F.T.
  TITLE     Differential localization of coatomer complex isoforms within the
            Golgi apparatus
  JOURNAL   Proc Natl Acad Sci U S A 104 (11), 4425-4430 (2007)
   PUBMED   17360540
REFERENCE   6  (bases 1 to 1890)
  AUTHORS   Futatsumori,M., Kasai,K., Takatsu,H., Shin,H.W. and Nakayama,K.
  TITLE     Identification and characterization of novel isoforms of COP I
            subunits
  JOURNAL   J Biochem 128 (5), 793-801 (2000)
   PUBMED   11056392
REFERENCE   7  (bases 1 to 1890)
  AUTHORS   Pelham,H.R. and Rothman,J.E.
  TITLE     The debate about transport in the Golgi--two sides of the same
            coin?
  JOURNAL   Cell 102 (6), 713-719 (2000)
   PUBMED   11030615
  REMARK    Review article
REFERENCE   8  (bases 1 to 1890)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   9  (bases 1 to 1890)
  AUTHORS   Schekman,R. and Orci,L.
  TITLE     Coat proteins and vesicle budding
  JOURNAL   Science 271 (5255), 1526-1533 (1996)
   PUBMED   8599108
  REMARK    Review article
REFERENCE   10 (bases 1 to 1890)
  AUTHORS   Kuge,O., Hara-Kuge,S., Orci,L., Ravazzola,M., Amherdt,M.,
            Tanigawa,G., Wieland,F.T. and Rothman,J.E.
  TITLE     zeta-COP, a subunit of coatomer, is required for COP-coated vesicle
            assembly
  JOURNAL   J Cell Biol 123 (6 Pt 2), 1727-1734 (1993)
   PUBMED   8276893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF151878.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016057.2.
            
            Summary: This gene encodes a subunit of the cytoplasmic coatamer
            protein complex, which is involved in autophagy and intracellular
            protein trafficking. The coatomer protein complex is comprised of
            seven subunits and functions as the coat protein of coat protein
            complex (COP)I-vesicles. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025956.1, AK026190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262061.7/ ENSP00000262061.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1890              AF151878.1         5-1894
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1890
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /note="COPI coat complex subunit zeta 1"
                     /db_xref="GeneID:22818"
                     /db_xref="HGNC:HGNC:2243"
                     /db_xref="MIM:615472"
     exon            1..51
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..567
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coatomer subunit zeta-1; zeta-1 COP; zeta-1-coat protein;
                     coatomer protein complex, subunit zeta; coatomer protein
                     complex subunit zeta 1"
                     /codon_start=1
                     /product="coatomer subunit zeta-1 isoform 1"
                     /protein_id="NP_057141.1"
                     /db_xref="CCDS:CCDS8877.1"
                     /db_xref="GeneID:22818"
                     /db_xref="HGNC:HGNC:2243"
                     /db_xref="MIM:615472"
                     /translation="MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAF
                     EKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLS
                     QMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTV
                     SQVLQSAKEQIKWSLLR"
     exon            52..120
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            121..202
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            203..294
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            295..350
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            351..428
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            429..480
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            481..519
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            520..1890
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      903..908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /note="hexamer: ATTAAA"
     polyA_site      921
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /note="major polyA site"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /note="hexamer: AATAAA"
     polyA_site      1890
                     /gene="COPZ1"
                     /gene_synonym="CGI-120; COPZ; HSPC181; zeta-COP;
                     zeta1-COP"
                     /note="major polyA site"
ORIGIN      
        1 gcggctccac gtcggcacca gctgcggggc aagatggagg cgctgatttt ggaaccttcc
       61 ctgtatactg tcaaagccat cctgattctg gacaatgatg gagatcgact ttttgccaag
      121 tactatgacg acacctaccc cagtgtcaag gagcaaaagg cctttgagaa gaacattttc
      181 aacaagaccc atcggactga cagtgaaatt gccctcttgg aaggcctgac agtggtatac
      241 aaaagcagta tagatctcta tttctatgtg attggcagct cctatgaaaa tgagctgatg
      301 cttatggctg ttctgaactg tctcttcgac tcattgagcc agatgctgag gaaaaatgta
      361 gaaaagcgag cactgctgga gaacatggag gggctgttct tggctgtgga tgaaattgta
      421 gatggagggg tgatcctaga gagtgatccc cagcaggtgg tacaccgggt ggcattaagg
      481 ggtgaagatg tcccccttac ggagcagacc gtgtctcagg tgctgcagtc agccaaagaa
      541 cagatcaagt ggtcactcct tcggtgaaga cctcactgtt cctggctctt catcctcttc
      601 aaaaaatttg catgtctgct gtgaattttc atctagttcc ccaatcgatg ctctcagggt
      661 catctcgggg atcacaggga tccttaaatc tccattctgt ttgtggttgc cccctcaacc
      721 tcccctacac ccttcctatt ctttttcatt cttcttgcag ttctgggagt aaagctccca
      781 gcatatttag ataatagggc aggggaagca ccctctttct ttctagactg gattatgctc
      841 acatgctccc ttgccctgac atttttgtaa attctgtgcc ctttgctgta gctacacttc
      901 agattaaagt aggagaaaga atgtgctgag tgttttcctc cctttgcctc tacctggccc
      961 tcatcccaac agcccagcaa ggggagagag aaagagaatt cttttctata gaacgagtgg
     1021 gggcggggat gggtagggat ttatccaatc taagccctaa ccccacttag tgacctcagt
     1081 gttttcttcc attccttctt actgccctgt cctctgcctt ggaagaggct ttgggaatag
     1141 ttcataggga agggacaaca tggaagaaac agcgatttaa attgtattga acagggcata
     1201 taaaatgcat tctgtaccct gatctggcat atagcttcaa aactgcagtg gcgagtgtcc
     1261 atctcttagt tagctacctt aactgtccac ccttactacc tgtgggatcg ttgcctggtt
     1321 tgtcttctct gtgtcctgga gcaaagccag ttcctaaaac taaaactcca ttctagtctt
     1381 gggaagaaaa gtttctactc agaactgggg aaggagtgga acttatgact tgggcctcta
     1441 ggctgtctct gtcccctcag ctccccgaca tgcatttact ctctgccgtg ggtctgcagt
     1501 cgctgcaacc taccctctct ctgcctcagc cttacaccca agcagtaggt ctgtgctctc
     1561 cctgtctcta ggtcgctgag agaggtgctt ttcttcataa aacctttggg gtttggattt
     1621 ccccaggaag atggagaatg gaatactcac tcttgggtct aatctttccc cttgacccag
     1681 aacttcctcc ccacaaaaat gcctttaaaa accttcctga gacttaagca ttctgcccca
     1741 cttactaact gccagttctc cagcactgag gtggggcaga taacggggca tatttaaggg
     1801 ggcatctttg tgtaaaagat gcatggagtc aggagaaaac caccttcata aactgctctg
     1861 tgcaaagagg aataaaacat tttttccaaa
//
