LOCUS       NM_001163424             418 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 9 (COPS9), transcript variant
            2, mRNA.
ACCESSION   NM_001163424
VERSION     NM_001163424.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Ruidiaz,S.F., Dreier,J.E., Hartmann-Petersen,R. and Kragelund,B.B.
  TITLE     The disordered PCI-binding human proteins CSNAP and DSS1 have
            diverged in structure and function
  JOURNAL   Protein Sci 30 (10), 2069-2082 (2021)
   PUBMED   34272906
  REMARK    GeneRIF: The disordered PCI-binding human proteins CSNAP and DSS1
            have diverged in structure and function.
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 418)
  AUTHORS   Fuzesi-Levi,M.G., Fainer,I., Ivanov Enchev,R., Ben-Nissan,G.,
            Levin,Y., Kupervaser,M., Friedlander,G., Salame,T.M., Nevo,R.,
            Peter,M. and Sharon,M.
  TITLE     CSNAP, the smallest CSN subunit, modulates proteostasis through
            cullin-RING ubiquitin ligases
  JOURNAL   Cell Death Differ 27 (3), 984-998 (2020)
   PUBMED   31367012
  REMARK    GeneRIF: CSNAP, the smallest CSN subunit, modulates proteostasis
            through cullin-RING ubiquitin ligases.
REFERENCE   4  (bases 1 to 418)
  AUTHORS   Rozen,S., Fuzesi-Levi,M.G., Ben-Nissan,G., Mizrachi,L.,
            Gabashvili,A., Levin,Y., Ben-Dor,S., Eisenstein,M. and Sharon,M.
  TITLE     CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome
  JOURNAL   Cell Rep 13 (3), 585-598 (2015)
   PUBMED   26456823
REFERENCE   5  (bases 1 to 418)
  AUTHORS   Ebina,M., Tsuruta,F., Katoh,M.C., Kigoshi,Y., Someya,A. and
            Chiba,T.
  TITLE     Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear
            localization through Nedd8 modification
  JOURNAL   PLoS One 8 (6), e65285 (2013)
   PUBMED   23776465
  REMARK    GeneRIF: Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear
            localization through Nedd8 modification.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013469.8, AF487338.1 and CN304277.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001163424.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region and an alternate splice pattern
            in the 3' coding region, compared to variant 1. The resulting
            isoform (2) lacks an internal segment near the N-terminus and has a
            shorter and distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD176791.1, HY298704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000607357.2/ ENSP00000475979.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC013469.8         6973-6978
            7-314               AF487338.1         10-317
            315-418             CN304277.1         324-427
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..418
                     /gene="COPS9"
                     /gene_synonym="CSNAP; MYEOV2"
                     /note="COP9 signalosome subunit 9"
                     /db_xref="GeneID:150678"
                     /db_xref="HGNC:HGNC:21314"
                     /db_xref="MIM:619349"
     exon            1..84
                     /gene="COPS9"
                     /gene_synonym="CSNAP; MYEOV2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..195
                     /gene="COPS9"
                     /gene_synonym="CSNAP; MYEOV2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     helicase/primase complex protein; myeloma-overexpressed
                     gene 2 protein; myeloma overexpressed 2; CSN acidic
                     protein; COP9 signalosome complex subunit 9"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 9 isoform 2"
                     /protein_id="NP_001156896.1"
                     /db_xref="CCDS:CCDS63183.1"
                     /db_xref="GeneID:150678"
                     /db_xref="HGNC:HGNC:21314"
                     /db_xref="MIM:619349"
                     /translation="MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFF
                     NDFEDLFDDDDIQ"
     exon            85..157
                     /gene="COPS9"
                     /gene_synonym="CSNAP; MYEOV2"
                     /inference="alignment:Splign:2.1.0"
     exon            158..418
                     /gene="COPS9"
                     /gene_synonym="CSNAP; MYEOV2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      399..404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS9"
                     /gene_synonym="CSNAP; MYEOV2"
                     /note="hexamer: ATTAAA"
     polyA_site      418
                     /gene="COPS9"
                     /gene_synonym="CSNAP; MYEOV2"
                     /note="major polyA site"
ORIGIN      
        1 ctagagcgcc gcggccccga gatgaagccg gcggtggacg agatgttccc cgagggcgcc
       61 gggccctacg tggacctgga cgaggcggga ggcagcaccg ggctcttgat ggacttggca
      121 gccaatgaaa aggccgttca tgcagacttt tttaacgatt ttgaagatct ttttgatgat
      181 gatgacatcc agtgagatgc cctctggctg caggcggggc caagcccttg gtacagagcc
      241 gcagtgtgag cctgcgcagg acagtttcag gtggttttaa agaacacgtg gaaatccctt
      301 gaatttagga cctggttaac cagaaagata agactgttct taacgaccta gatgattctg
      361 ttcatctctg aacgggatca ggttttgtcc tcactccaat taaaagaaag caatgtca
//
