LOCUS       NM_198189               3503 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant
            2, mRNA.
ACCESSION   NM_198189
VERSION     NM_198189.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3503)
  AUTHORS   Liu,J., Han,D., Xuan,J., Xie,J., Wang,W., Zhou,Q. and Chen,K.
  TITLE     COP9 signalosome complex is a prognostic biomarker and corresponds
            with immune infiltration in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 16 (6), 5264-5287 (2024)
   PUBMED   38466642
  REMARK    GeneRIF: COP9 signalosome complex is a prognostic biomarker and
            corresponds with immune infiltration in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 3503)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3503)
  AUTHORS   Sun,L.
  TITLE     COPS8 in cutaneous melanoma: an oncogene that accelerates the
            malignant development of tumor cells and predicts poor prognosis
  JOURNAL   Biosci Biotechnol Biochem 85 (2), 242-250 (2021)
   PUBMED   33604618
  REMARK    GeneRIF: COPS8 in cutaneous melanoma: an oncogene that accelerates
            the malignant development of tumor cells and predicts poor
            prognosis.
REFERENCE   4  (bases 1 to 3503)
  AUTHORS   Ju,S., Wang,F., Wang,Y. and Ju,S.
  TITLE     CSN8 is a key regulator in hypoxia-induced epithelial-mesenchymal
            transition and dormancy of colorectal cancer cells
  JOURNAL   Mol Cancer 19 (1), 168 (2020)
   PUBMED   33261601
  REMARK    GeneRIF: CSN8 is a key regulator in hypoxia-induced
            epithelial-mesenchymal transition and dormancy of colorectal cancer
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3503)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3503)
  AUTHORS   Cohen,H., Azriel,A., Cohen,T., Meraro,D., Hashmueli,S.,
            Bech-Otschir,D., Kraft,R., Dubiel,W. and Levi,B.Z.
  TITLE     Interaction between interferon consensus sequence-binding protein
            and COP9/signalosome subunit CSN2 (Trip15). A possible link between
            interferon regulatory factor signaling and the COP9/signalosome
  JOURNAL   J Biol Chem 275 (50), 39081-39089 (2000)
   PUBMED   10991940
REFERENCE   7  (bases 1 to 3503)
  AUTHORS   Naumann,M., Bech-Otschir,D., Huang,X., Ferrell,K. and Dubiel,W.
  TITLE     COP9 signalosome-directed c-Jun activation/stabilization is
            independent of JNK
  JOURNAL   J Biol Chem 274 (50), 35297-35300 (1999)
   PUBMED   10585392
REFERENCE   8  (bases 1 to 3503)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   9  (bases 1 to 3503)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   10 (bases 1 to 3503)
  AUTHORS   Chamovitz,D.A. and Deng,X.W.
  TITLE     The novel components of the Arabidopsis light signaling pathway may
            define a group of general developmental regulators shared by both
            animal and plant kingdoms
  JOURNAL   Cell 82 (3), 353-354 (1995)
   PUBMED   7634324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF979628.1, BC003090.1,
            AL038738.1 and AC105760.3.
            
            On Aug 14, 2020 this sequence version replaced NM_198189.2.
            
            Summary: The protein encoded by this gene is one of the eight
            subunits of COP9 signalosome, a highly conserved protein complex
            that functions as an important regulator in multiple signaling
            pathways. The structure and function of COP9 signalosome is similar
            to that of the 19S regulatory particle of 26S proteasome. COP9
            signalosome has been shown to interact with SCF-type E3 ubiquitin
            ligases and act as a positive regulator of E3 ubiquitin ligases.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains an additional exon
            compared to variant 1, resulting in translation initiation from a
            downstream start codon and an isoform (2) with a shorter N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289891.1, SRR14038194.541193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               BF979628.1         13-251
            240-1714            BC003090.1         147-1621
            1715-1875           AL038738.1         17-177              c
            1876-3503           AC105760.3         62928-64555
FEATURES             Location/Qualifiers
     source          1..3503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..3503
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="COP9 signalosome subunit 8"
                     /db_xref="GeneID:10920"
                     /db_xref="HGNC:HGNC:24335"
                     /db_xref="MIM:616011"
     exon            1..154
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            155..219
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            220..290
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..771
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="isoform 2 is encoded by transcript variant 2; COP9
                     signalosome complex subunit 8; COP9 homolog; signalosome
                     subunit 8; JAB1-containing signalosome subunit 8; COP9
                     constitutive photomorphogenic homolog subunit 8"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 8 isoform 2"
                     /protein_id="NP_937832.1"
                     /db_xref="CCDS:CCDS42835.1"
                     /db_xref="GeneID:10920"
                     /db_xref="HGNC:HGNC:24335"
                     /db_xref="MIM:616011"
                     /translation="MNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTI
                     NAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQ
                     GWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
                     "
     exon            291..339
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            340..472
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            473..580
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            581..643
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            644..691
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            692..3503
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: AATAAA"
     polyA_site      1722
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="major polyA site"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: ATTATA"
     polyA_site      1879
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
     polyA_site      2958
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: GATAAA"
     polyA_site      3168
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
     regulatory      3474..3479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: AATAAA"
     polyA_site      3503
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
ORIGIN      
        1 atcgcgggcg cgacgcctga gggacagtct ggggtttggc tgtccggacg gtgcagcggc
       61 gaggccggcc gcgaagatgc cagtggcggt gatggcggaa agcgccttta gtttcaaaaa
      121 gttgctggat cagtgcgaga accaggagct cgaggacgct tgatgtaatg ggcagaatca
      181 gaatgcttca ggaatctgtc gaatttgttt cttataatag cccctggagg aattgctaca
      241 cccccagtgt atggtcagct tctagcttta tatttgctcc ataatgacat gaataatgca
      301 agatatcttt ggaaaagaat accacctgct ataaaatctg caaattctga acttggggga
      361 atttggtcag taggacaaag aatctggcag agagatttcc ctgggatcta tacaaccatc
      421 aacgctcacc agtggtctga gacggtccag ccaattatgg aagcacttag agatgcaaca
      481 aggagacgcg cctttgccct ggtctctcaa gcgtatactt caatcatcgc cgatgatttt
      541 gcagcctttg ttggacttcc tgtagaagag gctgtgaaag gcatattaga acaaggatgg
      601 caagctgatt ccaccacaag aatggttctg cccagaaagc cagttgcagg ggccctggat
      661 gtttccttta acaagtttat tcccttatca gagcctgctc cagttccccc aatacccaat
      721 gaacagcagt tagccagact gacggattat gtggctttcc ttgaaaactg atttatcact
      781 ctgagttcaa gattcatctt cagaatcctg tatactgaca aacgtagaaa tgtaaagttt
      841 gtattttcaa tttattggat ggcttaagca cctcagcatt ccttactatg tgataaaata
      901 catatagaat ataagatata ctatatacat tttgtccata aacgttatgc tgaatagttg
      961 ttgaaacagt tctcattttg tagtatttaa taatctggat ggagcctgtc agtattacag
     1021 ttagttttct agtgactcat aaaataagat ttcctgtttc atgtagaata gtgtttgtca
     1081 actgtctttt ctctgtccca gcacatgccg tactcttata tgtaccattg gttgataatt
     1141 ataatgattc atttggactt gaagaaagat tgtccccagg cacagtatct gaatcactgg
     1201 ggattatgat tcaccctctt tggagaacat gctctctttt caccccccac ctcctgagag
     1261 ccactaatgt aagatacaga aacatagctg aggaacaaat agaccatttc catactaaac
     1321 cagtttgtta actttagatt ttttccaata gtgtgagtat atccattgct ggcagtggag
     1381 ggcttgccat gaaaatgcaa cttatttaag acatttatga gacatattaa cttgtgctgt
     1441 cgccttttag aaggagaaac ttaagtgtgg aatgcattat atgggcaaag aagctatgaa
     1501 gatacatgat acactttgta caactatcct gcagcccatt ggttgcttat atttatcgct
     1561 tggctcaagt tctgcccttt ggagaaatac tgagcaagtc tttcattctc tgtgtgacag
     1621 ccctctgaat atttgaagtt gtttgttgta acttaaggtt ataacagccc ttagttcatt
     1681 tactctgcat ttgttcaata aatatttaac tgaattcttc aattatttca tctaagatag
     1741 tttctggaaa tttcactctc gatctttctg tggacacaat ctattttgtc attgtgtcta
     1801 tatgaatctc ttaagtagaa atgagttgta tggtgaatct gtgtagtgat aattatataa
     1861 tttatttatt ttgaatgcat tttagtggct atttcagttt ttcttaacat atatgggaat
     1921 actttttgaa ttgcaatttt atttaacccg gataggtaag tcatattaaa attccttgtt
     1981 ttacagttga ggaaatggga attcaagaag tcagaggatc aggagagtga tcaagagaat
     2041 gacagtgcca gtttttttaa cttccaggta ttaagtacaa attgtatcca tggttatttt
     2101 ttaaaagcag attagagtca atccaaatat tcattaatag gggattgttt gaataaacag
     2161 cagtgtagac tacgcaggtg taaaaggagt gaagatctct atactaaact ggaatgatct
     2221 ccagagtgag aacatagaaa gcacatgtag tttatatggt tattttgagg gtaacaaaag
     2281 gagaatgatt acaattatat atatgtacat atttccttat atttcaaaac taagcaattg
     2341 ggggatatat acaaaatgaa tataatagtt ccctaaagag gaaggagagg acagtgaact
     2401 actacataga gaaaaaataa tctcaagtga tcaaacacaa tatttcaatt ttacattgtc
     2461 agtgggatat acactaagga cagaaaaaaa tcttagacta atgaatgtgg tttttcatga
     2521 ttaatttcac aaaatcttga tatctttttt attattaaaa gtatagatta aattaataat
     2581 catgtaacat tagaccccag taatcttaaa tttgacatgg aaacctcatt atatgcttta
     2641 tttttctttg taaacagtaa atatttccca ctcctgtcta catgaaaagg tctagagtaa
     2701 ttacagttca gtaacaatga gcaccactag tacccagatg gtgttctttc attttcattt
     2761 gcaattaaaa ggaatcagaa cttatttgca aaacagctaa tagttccagg gcagtaagtg
     2821 tacaagttca tatctggtac aagatgtcca ggattcaagg aggctcttaa agacttggga
     2881 ttctgtcaaa gggttataca agccaacttg aagggatttc tacaggccat gtaaaaatga
     2941 gacagtttga gcatgaaata tttgtatatg tgtctgtttt taactcttaa taacctcatc
     3001 actgtacaag aaaggcaggg taagtgcttg atttcacttc cctttattat cagttctcag
     3061 gacaaattga tatgctgcca atctctaaag caacaaaatc gaacctgtag ggtagtcaaa
     3121 aagctcatgc tggaaaattc caccgaataa agataaaagt tagaaaaacg gtacttgcag
     3181 cccttaatga aacaaagaag ggatcatgga aatatatatc aatgctgttg agaccacagg
     3241 gtaagaaatt gagattgagc atgaaatatg tccagtacat ccatcagcct gtctttgtgc
     3301 tctggctatt tctgagccag ccatctgtgt acaagtgtag cctgacagca ccctgtttca
     3361 gatccattgg atatctctaa aatttgctct gggacttacc ctggcactac tatcaggatg
     3421 cccacacaaa cctgattggg cagcccatca gcagttgtga acatgacatg gtgaataaac
     3481 actctcttcc ttgtctcagg gca
//
