LOCUS       NM_006710               3438 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant
            1, mRNA.
ACCESSION   NM_006710
VERSION     NM_006710.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3438)
  AUTHORS   Liu,J., Han,D., Xuan,J., Xie,J., Wang,W., Zhou,Q. and Chen,K.
  TITLE     COP9 signalosome complex is a prognostic biomarker and corresponds
            with immune infiltration in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 16 (6), 5264-5287 (2024)
   PUBMED   38466642
  REMARK    GeneRIF: COP9 signalosome complex is a prognostic biomarker and
            corresponds with immune infiltration in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 3438)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3438)
  AUTHORS   Sun,L.
  TITLE     COPS8 in cutaneous melanoma: an oncogene that accelerates the
            malignant development of tumor cells and predicts poor prognosis
  JOURNAL   Biosci Biotechnol Biochem 85 (2), 242-250 (2021)
   PUBMED   33604618
  REMARK    GeneRIF: COPS8 in cutaneous melanoma: an oncogene that accelerates
            the malignant development of tumor cells and predicts poor
            prognosis.
REFERENCE   4  (bases 1 to 3438)
  AUTHORS   Ju,S., Wang,F., Wang,Y. and Ju,S.
  TITLE     CSN8 is a key regulator in hypoxia-induced epithelial-mesenchymal
            transition and dormancy of colorectal cancer cells
  JOURNAL   Mol Cancer 19 (1), 168 (2020)
   PUBMED   33261601
  REMARK    GeneRIF: CSN8 is a key regulator in hypoxia-induced
            epithelial-mesenchymal transition and dormancy of colorectal cancer
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3438)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3438)
  AUTHORS   Cohen,H., Azriel,A., Cohen,T., Meraro,D., Hashmueli,S.,
            Bech-Otschir,D., Kraft,R., Dubiel,W. and Levi,B.Z.
  TITLE     Interaction between interferon consensus sequence-binding protein
            and COP9/signalosome subunit CSN2 (Trip15). A possible link between
            interferon regulatory factor signaling and the COP9/signalosome
  JOURNAL   J Biol Chem 275 (50), 39081-39089 (2000)
   PUBMED   10991940
REFERENCE   7  (bases 1 to 3438)
  AUTHORS   Naumann,M., Bech-Otschir,D., Huang,X., Ferrell,K. and Dubiel,W.
  TITLE     COP9 signalosome-directed c-Jun activation/stabilization is
            independent of JNK
  JOURNAL   J Biol Chem 274 (50), 35297-35300 (1999)
   PUBMED   10585392
REFERENCE   8  (bases 1 to 3438)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   9  (bases 1 to 3438)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   10 (bases 1 to 3438)
  AUTHORS   Chamovitz,D.A. and Deng,X.W.
  TITLE     The novel components of the Arabidopsis light signaling pathway may
            define a group of general developmental regulators shared by both
            animal and plant kingdoms
  JOURNAL   Cell 82 (3), 353-354 (1995)
   PUBMED   7634324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036499.1, BC003090.1,
            AL038738.1 and AC105760.3.
            
            On Nov 23, 2018 this sequence version replaced NM_006710.4.
            
            Summary: The protein encoded by this gene is one of the eight
            subunits of COP9 signalosome, a highly conserved protein complex
            that functions as an important regulator in multiple signaling
            pathways. The structure and function of COP9 signalosome is similar
            to that of the 19S regulatory particle of 26S proteasome. COP9
            signalosome has been shown to interact with SCF-type E3 ubiquitin
            ligases and act as a positive regulator of E3 ubiquitin ligases.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.64047.1,
                                           SRR1660803.87842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354371.7/ ENSP00000346340.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               BC036499.1         583-736
            155-1649            BC003090.1         127-1621
            1650-1810           AL038738.1         17-177              c
            1811-3438           AC105760.3         62928-64555
FEATURES             Location/Qualifiers
     source          1..3438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..3438
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="COP9 signalosome subunit 8"
                     /db_xref="GeneID:10920"
                     /db_xref="HGNC:HGNC:24335"
                     /db_xref="MIM:616011"
     exon            1..154
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..706
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="isoform 1 is encoded by transcript variant 1; COP9
                     signalosome complex subunit 8; COP9 homolog; signalosome
                     subunit 8; JAB1-containing signalosome subunit 8; COP9
                     constitutive photomorphogenic homolog subunit 8"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 8 isoform 1"
                     /protein_id="NP_006701.1"
                     /db_xref="CCDS:CCDS2517.1"
                     /db_xref="GeneID:10920"
                     /db_xref="HGNC:HGNC:24335"
                     /db_xref="MIM:616011"
                     /translation="MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALY
                     LLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETV
                     QPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTR
                     MVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN"
     exon            155..225
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            226..274
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            275..407
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            408..515
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            516..578
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            579..626
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     exon            627..3438
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: AATAAA"
     polyA_site      1657
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="major polyA site"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: ATTATA"
     polyA_site      1814
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
     polyA_site      2893
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
     regulatory      3087..3092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: GATAAA"
     polyA_site      3103
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
     regulatory      3409..3414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /note="hexamer: AATAAA"
     polyA_site      3438
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
ORIGIN      
        1 atcgcgggcg cgacgcctga gggacagtct ggggtttggc tgtccggacg gtgcagcggc
       61 gaggccggcc gcgaagatgc cagtggcggt gatggcggaa agcgccttta gtttcaaaaa
      121 gttgctggat cagtgcgaga accaggagct cgaggcccct ggaggaattg ctacaccccc
      181 agtgtatggt cagcttctag ctttatattt gctccataat gacatgaata atgcaagata
      241 tctttggaaa agaataccac ctgctataaa atctgcaaat tctgaacttg ggggaatttg
      301 gtcagtagga caaagaatct ggcagagaga tttccctggg atctatacaa ccatcaacgc
      361 tcaccagtgg tctgagacgg tccagccaat tatggaagca cttagagatg caacaaggag
      421 acgcgccttt gccctggtct ctcaagcgta tacttcaatc atcgccgatg attttgcagc
      481 ctttgttgga cttcctgtag aagaggctgt gaaaggcata ttagaacaag gatggcaagc
      541 tgattccacc acaagaatgg ttctgcccag aaagccagtt gcaggggccc tggatgtttc
      601 ctttaacaag tttattccct tatcagagcc tgctccagtt cccccaatac ccaatgaaca
      661 gcagttagcc agactgacgg attatgtggc tttccttgaa aactgattta tcactctgag
      721 ttcaagattc atcttcagaa tcctgtatac tgacaaacgt agaaatgtaa agtttgtatt
      781 ttcaatttat tggatggctt aagcacctca gcattcctta ctatgtgata aaatacatat
      841 agaatataag atatactata tacattttgt ccataaacgt tatgctgaat agttgttgaa
      901 acagttctca ttttgtagta tttaataatc tggatggagc ctgtcagtat tacagttagt
      961 tttctagtga ctcataaaat aagatttcct gtttcatgta gaatagtgtt tgtcaactgt
     1021 cttttctctg tcccagcaca tgccgtactc ttatatgtac cattggttga taattataat
     1081 gattcatttg gacttgaaga aagattgtcc ccaggcacag tatctgaatc actggggatt
     1141 atgattcacc ctctttggag aacatgctct cttttcaccc cccacctcct gagagccact
     1201 aatgtaagat acagaaacat agctgaggaa caaatagacc atttccatac taaaccagtt
     1261 tgttaacttt agattttttc caatagtgtg agtatatcca ttgctggcag tggagggctt
     1321 gccatgaaaa tgcaacttat ttaagacatt tatgagacat attaacttgt gctgtcgcct
     1381 tttagaagga gaaacttaag tgtggaatgc attatatggg caaagaagct atgaagatac
     1441 atgatacact ttgtacaact atcctgcagc ccattggttg cttatattta tcgcttggct
     1501 caagttctgc cctttggaga aatactgagc aagtctttca ttctctgtgt gacagccctc
     1561 tgaatatttg aagttgtttg ttgtaactta aggttataac agcccttagt tcatttactc
     1621 tgcatttgtt caataaatat ttaactgaat tcttcaatta tttcatctaa gatagtttct
     1681 ggaaatttca ctctcgatct ttctgtggac acaatctatt ttgtcattgt gtctatatga
     1741 atctcttaag tagaaatgag ttgtatggtg aatctgtgta gtgataatta tataatttat
     1801 ttattttgaa tgcattttag tggctatttc agtttttctt aacatatatg ggaatacttt
     1861 ttgaattgca attttattta acccggatag gtaagtcata ttaaaattcc ttgttttaca
     1921 gttgaggaaa tgggaattca agaagtcaga ggatcaggag agtgatcaag agaatgacag
     1981 tgccagtttt tttaacttcc aggtattaag tacaaattgt atccatggtt attttttaaa
     2041 agcagattag agtcaatcca aatattcatt aataggggat tgtttgaata aacagcagtg
     2101 tagactacgc aggtgtaaaa ggagtgaaga tctctatact aaactggaat gatctccaga
     2161 gtgagaacat agaaagcaca tgtagtttat atggttattt tgagggtaac aaaaggagaa
     2221 tgattacaat tatatatatg tacatatttc cttatatttc aaaactaagc aattggggga
     2281 tatatacaaa atgaatataa tagttcccta aagaggaagg agaggacagt gaactactac
     2341 atagagaaaa aataatctca agtgatcaaa cacaatattt caattttaca ttgtcagtgg
     2401 gatatacact aaggacagaa aaaaatctta gactaatgaa tgtggttttt catgattaat
     2461 ttcacaaaat cttgatatct tttttattat taaaagtata gattaaatta ataatcatgt
     2521 aacattagac cccagtaatc ttaaatttga catggaaacc tcattatatg ctttattttt
     2581 ctttgtaaac agtaaatatt tcccactcct gtctacatga aaaggtctag agtaattaca
     2641 gttcagtaac aatgagcacc actagtaccc agatggtgtt ctttcatttt catttgcaat
     2701 taaaaggaat cagaacttat ttgcaaaaca gctaatagtt ccagggcagt aagtgtacaa
     2761 gttcatatct ggtacaagat gtccaggatt caaggaggct cttaaagact tgggattctg
     2821 tcaaagggtt atacaagcca acttgaaggg atttctacag gccatgtaaa aatgagacag
     2881 tttgagcatg aaatatttgt atatgtgtct gtttttaact cttaataacc tcatcactgt
     2941 acaagaaagg cagggtaagt gcttgatttc acttcccttt attatcagtt ctcaggacaa
     3001 attgatatgc tgccaatctc taaagcaaca aaatcgaacc tgtagggtag tcaaaaagct
     3061 catgctggaa aattccaccg aataaagata aaagttagaa aaacggtact tgcagccctt
     3121 aatgaaacaa agaagggatc atggaaatat atatcaatgc tgttgagacc acagggtaag
     3181 aaattgagat tgagcatgaa atatgtccag tacatccatc agcctgtctt tgtgctctgg
     3241 ctatttctga gccagccatc tgtgtacaag tgtagcctga cagcaccctg tttcagatcc
     3301 attggatatc tctaaaattt gctctgggac ttaccctggc actactatca ggatgcccac
     3361 acaaacctga ttgggcagcc catcagcagt tgtgaacatg acatggtgaa taaacactct
     3421 cttccttgtc tcagggca
//
