LOCUS       NP_006701                209 aa            linear   PRI 20-SEP-2024
DEFINITION  COP9 signalosome complex subunit 8 isoform 1 [Homo sapiens].
ACCESSION   NP_006701
VERSION     NP_006701.1
DBSOURCE    REFSEQ: accession NM_006710.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 209)
  AUTHORS   Liu,J., Han,D., Xuan,J., Xie,J., Wang,W., Zhou,Q. and Chen,K.
  TITLE     COP9 signalosome complex is a prognostic biomarker and corresponds
            with immune infiltration in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 16 (6), 5264-5287 (2024)
   PUBMED   38466642
  REMARK    GeneRIF: COP9 signalosome complex is a prognostic biomarker and
            corresponds with immune infiltration in hepatocellular carcinoma.
REFERENCE   2  (residues 1 to 209)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 209)
  AUTHORS   Sun,L.
  TITLE     COPS8 in cutaneous melanoma: an oncogene that accelerates the
            malignant development of tumor cells and predicts poor prognosis
  JOURNAL   Biosci Biotechnol Biochem 85 (2), 242-250 (2021)
   PUBMED   33604618
  REMARK    GeneRIF: COPS8 in cutaneous melanoma: an oncogene that accelerates
            the malignant development of tumor cells and predicts poor
            prognosis.
REFERENCE   4  (residues 1 to 209)
  AUTHORS   Ju,S., Wang,F., Wang,Y. and Ju,S.
  TITLE     CSN8 is a key regulator in hypoxia-induced epithelial-mesenchymal
            transition and dormancy of colorectal cancer cells
  JOURNAL   Mol Cancer 19 (1), 168 (2020)
   PUBMED   33261601
  REMARK    GeneRIF: CSN8 is a key regulator in hypoxia-induced
            epithelial-mesenchymal transition and dormancy of colorectal cancer
            cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 209)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 209)
  AUTHORS   Cohen,H., Azriel,A., Cohen,T., Meraro,D., Hashmueli,S.,
            Bech-Otschir,D., Kraft,R., Dubiel,W. and Levi,B.Z.
  TITLE     Interaction between interferon consensus sequence-binding protein
            and COP9/signalosome subunit CSN2 (Trip15). A possible link between
            interferon regulatory factor signaling and the COP9/signalosome
  JOURNAL   J Biol Chem 275 (50), 39081-39089 (2000)
   PUBMED   10991940
REFERENCE   7  (residues 1 to 209)
  AUTHORS   Naumann,M., Bech-Otschir,D., Huang,X., Ferrell,K. and Dubiel,W.
  TITLE     COP9 signalosome-directed c-Jun activation/stabilization is
            independent of JNK
  JOURNAL   J Biol Chem 274 (50), 35297-35300 (1999)
   PUBMED   10585392
REFERENCE   8  (residues 1 to 209)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   9  (residues 1 to 209)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   10 (residues 1 to 209)
  AUTHORS   Chamovitz,D.A. and Deng,X.W.
  TITLE     The novel components of the Arabidopsis light signaling pathway may
            define a group of general developmental regulators shared by both
            animal and plant kingdoms
  JOURNAL   Cell 82 (3), 353-354 (1995)
   PUBMED   7634324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036499.1, BC003090.1,
            AL038738.1 and AC105760.3.
            
            Summary: The protein encoded by this gene is one of the eight
            subunits of COP9 signalosome, a highly conserved protein complex
            that functions as an important regulator in multiple signaling
            pathways. The structure and function of COP9 signalosome is similar
            to that of the 19S regulatory particle of 26S proteasome. COP9
            signalosome has been shown to interact with SCF-type E3 ubiquitin
            ligases and act as a positive regulator of E3 ubiquitin ligases.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.64047.1,
                                           SRR1660803.87842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354371.7/ ENSP00000346340.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..209
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     Protein         1..209
                     /product="COP9 signalosome complex subunit 8 isoform 1"
                     /note="COP9 signalosome complex subunit 8; COP9 homolog;
                     signalosome subunit 8; JAB1-containing signalosome subunit
                     8; COP9 constitutive photomorphogenic homolog subunit 8"
                     /calculated_mol_wt=23095
     Region          31..166
                     /region_name="CSN8_PSD8_EIF3K"
                     /note="CSN8/PSMD8/EIF3K family; pfam10075"
                     /db_xref="CDD:462954"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:18850735,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q99627.1)"
     CDS             1..209
                     /gene="COPS8"
                     /gene_synonym="COP9; CSN8; SGN8"
                     /coded_by="NM_006710.5:77..706"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2517.1"
                     /db_xref="GeneID:10920"
                     /db_xref="HGNC:HGNC:24335"
                     /db_xref="MIM:616011"
ORIGIN      
        1 mpvavmaesa fsfkklldqc enqeleapgg iatppvygql lalyllhndm nnarylwkri
       61 ppaiksanse lggiwsvgqr iwqrdfpgiy ttinahqwse tvqpimealr datrrrafal
      121 vsqaytsiia ddfaafvglp veeavkgile qgwqadsttr mvlprkpvag aldvsfnkfi
      181 plsepapvpp ipneqqlarl tdyvaflen
//
