LOCUS       NM_022730               2513 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 7B (COPS7B), transcript
            variant 2, mRNA.
ACCESSION   NM_022730
VERSION     NM_022730.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Tang,J., Wang,S., Weng,M., Guo,Q., Ren,L., He,Y., Cui,Z., Cong,M.,
            Qin,M., Yu,J., Su,R. and Li,X.
  TITLE     The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive
            Colorectal Cancer Progression
  JOURNAL   Cancer Res 83 (21), 3593-3610 (2023)
   PUBMED   37560971
  REMARK    GeneRIF: The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to
            Drive Colorectal Cancer Progression.
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Wang,J., Dubiel,D., Wu,Y., Cheng,Y., Wolf,D.A. and Dubiel,W.
  TITLE     CSN7B defines a variant COP9 signalosome complex with distinct
            function in DNA damage response
  JOURNAL   Cell Rep 34 (4), 108662 (2021)
   PUBMED   33503427
  REMARK    GeneRIF: CSN7B defines a variant COP9 signalosome complex with
            distinct function in DNA damage response.
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Fuzesi-Levi,M.G., Ben-Nissan,G., Bianchi,E., Zhou,H., Deery,M.J.,
            Lilley,K.S., Levin,Y. and Sharon,M.
  TITLE     Dynamic regulation of the COP9 signalosome in response to DNA
            damage
  JOURNAL   Mol Cell Biol 34 (6), 1066-1076 (2014)
   PUBMED   24421388
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Hoareau Alves,K., Bochard,V., Rety,S. and Jalinot,P.
  TITLE     Association of the mammalian proto-oncoprotein Int-6 with the three
            protein complexes eIF3, COP9 signalosome and 26S proteasome
  JOURNAL   FEBS Lett 527 (1-3), 15-21 (2002)
   PUBMED   12220626
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Wang,Y., Devereux,W., Stewart,T.M. and Casero,R.A. Jr.
  TITLE     Polyamine-modulated factor 1 binds to the human homologue of the 7a
            subunit of the Arabidopsis COP9 signalosome: implications in gene
            expression
  JOURNAL   Biochem J 366 (Pt 1), 79-86 (2002)
   PUBMED   12020345
REFERENCE   8  (bases 1 to 2513)
  AUTHORS   Lyapina,S., Cope,G., Shevchenko,A., Serino,G., Tsuge,T., Zhou,C.,
            Wolf,D.A., Wei,N., Shevchenko,A. and Deshaies,R.J.
  TITLE     Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome
  JOURNAL   Science 292 (5520), 1382-1385 (2001)
   PUBMED   11337588
REFERENCE   9  (bases 1 to 2513)
  AUTHORS   Bech-Otschir,D., Kraft,R., Huang,X., Henklein,P., Kapelari,B.,
            Pollmann,C. and Dubiel,W.
  TITLE     COP9 signalosome-specific phosphorylation targets p53 to
            degradation by the ubiquitin system
  JOURNAL   EMBO J 20 (7), 1630-1639 (2001)
   PUBMED   11285227
REFERENCE   10 (bases 1 to 2513)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY051259.1, AK022674.1, AC073476.6, AA126041.1 and BE504900.1.
            
            On Jun 3, 2019 this sequence version replaced NM_022730.3.
            
            Transcript Variant: This variant (2) lacks an exon that results in
            a frameshift in the 3' coding region, compared to variant 1. The
            encoded isoform (b) has a distinct C-terminus and is shorter than
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.260210.1,
                                           SRR1803611.200806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350033.8/ ENSP00000272995.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 HY051259.1         64-70
            8-1155              AK022674.1         1-1148
            1156-2058           AC073476.6         135782-136684
            2059-2508           AA126041.1         3-452               c
            2509-2513           BE504900.1         8-12                c
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..2513
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="COP9 signalosome subunit 7B"
                     /db_xref="GeneID:64708"
                     /db_xref="HGNC:HGNC:16760"
                     /db_xref="MIM:616010"
     exon            1..94
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            95..272
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..905
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="isoform b is encoded by transcript variant 2; COP9
                     signalosome complex subunit 7b; signalosome subunit 7b;
                     JAB1-containing signalosome subunit 7b; COP9 constitutive
                     photomorphogenic homolog subunit 7B"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7b isoform b"
                     /protein_id="NP_073567.1"
                     /db_xref="CCDS:CCDS2488.1"
                     /db_xref="GeneID:64708"
                     /db_xref="HGNC:HGNC:16760"
                     /db_xref="MIM:616010"
                     /translation="MAGEQKPSSNLLEQFILLAKGTSGSALTALISQVLEAPGVYVFG
                     ELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSTAQQNKLKHLTIV
                     SLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGR
                     DIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKK
                     TLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH"
     exon            273..348
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            349..437
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            438..640
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            641..746
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            747..2513
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="hexamer: AATACA"
     polyA_site      1983
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="major polyA site"
     regulatory      2161..2166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="hexamer: AATAAA"
     polyA_site      2183
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
     regulatory      2487..2492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="hexamer: AATAAA"
     polyA_site      2513
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
ORIGIN      
        1 ggacgccggg gtgatcatgg acgcttgaca acctgcgggc aggcgccggg aggccgagcc
       61 agcgactaag aggaccgaga ggtggcgtgg acagatttca aggccagaga atggcagggg
      121 aacagaaacc ctcaagtaat ctcctggagc agtttatttt actagccaaa ggtaccagtg
      181 gctcagccct cactgctctc ataagccagg tcttagaggc tcccggagtg tatgtctttg
      241 gagaacttct ggagctggcc aacgtgcagg agcttgcgga aggagctaat gctgcttatt
      301 tgcagttgtt gaacctgttt gcctatggga catacccaga ttacatagcc aacaaggaga
      361 gcctgccaga actgagcaca gctcagcaga acaagctgaa gcatcttacc atcgtgagct
      421 tggcatcaag aatgaagtgt atcccctact ccgtgttgct gaaagacctg gagatgcgga
      481 atctccggga actagaagac cttatcattg aggctgtcta cactgacatc atccagggca
      541 agctggacca gcgaaaccag ctgctggaag tggatttctg cattggccgt gacatccgaa
      601 agaaggatat caataatatt gtcaagaccc tgcatgaatg gtgtgatggc tgtgaagcag
      661 ttctactggg catcgagcag caagttctga gagccaacca gtacaaagag aaccacaacc
      721 gaactcagca gcaggtagaa gcagaggtta ccaacatcaa gaagacactc aaagccaccg
      781 catcctcctc ggctcaggag atggagcagc agctggctga acgggagtgt ccccctcacg
      841 ctgagcagag gcagcccacc aagaagatgt ccaaagtgaa aggtctggtc tccagccgcc
      901 actagggccg gctggggcag ctggcactca ccaggcctgg gtcaggtggg gaggggacac
      961 caagggccca tttcctcccc tctctacctg cagtgagttc cagacctgcc cgtcccctca
     1021 ccagcgcctc cccaccctgt tggtactgtt ccagaaaaac tgttactccc cctcacccac
     1081 tccctccttc cccagttgtt cccttcagac tcaggggctc caccaatgcc atcccaaaac
     1141 agggtcagac actgcccagc ttccctccag gaggttcttg tctctgtgta agggcttgtc
     1201 tccctcccag tttttctttt gctccacgtc attttgtcag gctggttata agccggaggc
     1261 agctttaacc agcccccagg gatgattgtg aaggaggccc ctccccttgt gaggaggggg
     1321 cactcctctc cagcccctgg taccacagtc ctcacgatgg tgcagtgatt tctagccagg
     1381 cgtcaagatg cgctgctttc cctctcctgc ctcatccctt gttggcagct ccagttcagg
     1441 ccgtggaggg acgtgatgct gggctgtgtt tactaaaccc acgggttttc agcctcttaa
     1501 gcccagctcc gatctccaat tagttgagag cgctgggttg actaacctct ggtatctgag
     1561 cacagacaga gggtgctgtg ggtctgctgg gtggcagaaa tggttccttc cggcttggcg
     1621 ttctctcctg gccactcttc ctgctgcctc tgactactca gccttgtttt cggtgtgtag
     1681 gccccagctg cccactggaa ctgccggcta atgcttgctc tcccaagatc tttaactcct
     1741 cctggctgca cctgggtagg gatggtggca tcgatgcccc tctgtctgct gaaggacctg
     1801 ttgctgcttc tgtcttttca cccctccttg gctgatgacc cagagccctc tgatgatggc
     1861 attctcctgg caagagaaaa agacttaact agacttctga acttgaacag tttcaggtta
     1921 tattttaatt tttttttttt tgtacaggtt ctgattctaa tacatttcaa catgcttttg
     1981 tcccccctcg tgtcaatatt tgttatagac taatcgccgg ggatttttca cctggttgga
     2041 gggtgggggt ggggtggggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2101 gtttgtaggt cctggactga ttaaagttca ttgaggaaaa agcacatttt acaacaaaaa
     2161 aataaaagtg tagatttaat gtatgtgact ggggtttggg gttgcatacc tggtggatct
     2221 tgaggggctg ggattagggt ggttcaggaa aatgtgatgc tgtttcccca tgtttagcca
     2281 tggtcaaaaa atggatttct cctttttcta aaatgtccag caactgccta ctgttgatca
     2341 aatgttgaag tattcttgtt tcccttttaa gccaatccat gtgcccacat aacattatgc
     2401 ccaagtggag agttcacttt aatttccaaa gtatgtttca tgcagccccc tgtcagctgc
     2461 tctgtggaaa aggggttctg ttatgaaata aatgttgcac tccctgcatc cca
//
