LOCUS       NM_001282951            2407 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 7B (COPS7B), transcript
            variant 4, mRNA.
ACCESSION   NM_001282951 XM_005246771
VERSION     NM_001282951.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Tang,J., Wang,S., Weng,M., Guo,Q., Ren,L., He,Y., Cui,Z., Cong,M.,
            Qin,M., Yu,J., Su,R. and Li,X.
  TITLE     The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive
            Colorectal Cancer Progression
  JOURNAL   Cancer Res 83 (21), 3593-3610 (2023)
   PUBMED   37560971
  REMARK    GeneRIF: The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to
            Drive Colorectal Cancer Progression.
REFERENCE   2  (bases 1 to 2407)
  AUTHORS   Wang,J., Dubiel,D., Wu,Y., Cheng,Y., Wolf,D.A. and Dubiel,W.
  TITLE     CSN7B defines a variant COP9 signalosome complex with distinct
            function in DNA damage response
  JOURNAL   Cell Rep 34 (4), 108662 (2021)
   PUBMED   33503427
  REMARK    GeneRIF: CSN7B defines a variant COP9 signalosome complex with
            distinct function in DNA damage response.
REFERENCE   3  (bases 1 to 2407)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2407)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2407)
  AUTHORS   Fuzesi-Levi,M.G., Ben-Nissan,G., Bianchi,E., Zhou,H., Deery,M.J.,
            Lilley,K.S., Levin,Y. and Sharon,M.
  TITLE     Dynamic regulation of the COP9 signalosome in response to DNA
            damage
  JOURNAL   Mol Cell Biol 34 (6), 1066-1076 (2014)
   PUBMED   24421388
REFERENCE   6  (bases 1 to 2407)
  AUTHORS   Hoareau Alves,K., Bochard,V., Rety,S. and Jalinot,P.
  TITLE     Association of the mammalian proto-oncoprotein Int-6 with the three
            protein complexes eIF3, COP9 signalosome and 26S proteasome
  JOURNAL   FEBS Lett 527 (1-3), 15-21 (2002)
   PUBMED   12220626
REFERENCE   7  (bases 1 to 2407)
  AUTHORS   Wang,Y., Devereux,W., Stewart,T.M. and Casero,R.A. Jr.
  TITLE     Polyamine-modulated factor 1 binds to the human homologue of the 7a
            subunit of the Arabidopsis COP9 signalosome: implications in gene
            expression
  JOURNAL   Biochem J 366 (Pt 1), 79-86 (2002)
   PUBMED   12020345
REFERENCE   8  (bases 1 to 2407)
  AUTHORS   Lyapina,S., Cope,G., Shevchenko,A., Serino,G., Tsuge,T., Zhou,C.,
            Wolf,D.A., Wei,N., Shevchenko,A. and Deshaies,R.J.
  TITLE     Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome
  JOURNAL   Science 292 (5520), 1382-1385 (2001)
   PUBMED   11337588
REFERENCE   9  (bases 1 to 2407)
  AUTHORS   Bech-Otschir,D., Kraft,R., Huang,X., Henklein,P., Kapelari,B.,
            Pollmann,C. and Dubiel,W.
  TITLE     COP9 signalosome-specific phosphorylation targets p53 to
            degradation by the ubiquitin system
  JOURNAL   EMBO J 20 (7), 1630-1639 (2001)
   PUBMED   11285227
REFERENCE   10 (bases 1 to 2407)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA754035.1, BI906506.1, AC073476.6, AA126041.1 and BE504900.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001282951.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks
            two exons that result in the loss of an in-frame segment in the 5'
            coding region, and lacks an exon that results in a frameshift in
            the 3' coding region, compared to variant 1. The encoded isoform
            (d) has a distinct C-terminus and is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3991365.1, BI906506.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA754035.1         62-72
            12-627              BI906506.1         1-616
            628-648             BI906506.1         618-638
            649-1952            AC073476.6         135381-136684
            1953-2402           AA126041.1         3-452               c
            2403-2407           BE504900.1         8-12                c
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..2407
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="COP9 signalosome subunit 7B"
                     /db_xref="GeneID:64708"
                     /db_xref="HGNC:HGNC:16760"
                     /db_xref="MIM:616010"
     exon            1..153
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            154..331
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..799
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="isoform d is encoded by transcript variant 4; COP9
                     signalosome complex subunit 7b; signalosome subunit 7b;
                     JAB1-containing signalosome subunit 7b; COP9 constitutive
                     photomorphogenic homolog subunit 7B"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7b isoform d"
                     /protein_id="NP_001269880.1"
                     /db_xref="CCDS:CCDS74668.1"
                     /db_xref="GeneID:64708"
                     /db_xref="HGNC:HGNC:16760"
                     /db_xref="MIM:616010"
                     /translation="MAGEQKPSSNLLEQFILLAKGTSGSALTALISQVLEAPGVYVFG
                     ELLELANVQECIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFC
                     IGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTN
                     IKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH"
     exon            332..534
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            535..640
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     exon            641..2407
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="hexamer: AATACA"
     polyA_site      1877
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="major polyA site"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="hexamer: AATAAA"
     polyA_site      2077
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
                     /note="hexamer: AATAAA"
     polyA_site      2407
                     /gene="COPS7B"
                     /gene_synonym="CSN7B; SGN7b"
ORIGIN      
        1 gcgcaaattc acaaacccgc ccgctgagtt ggtcgtttcg gaatcccgag acttgaaacc
       61 caacgggaag acccttctca ccctcaaaag aagatgacag cccgcagaga gttaacttct
      121 gtttacatgg aactcagaca tctgcaaatc atgatttcaa ggccagagaa tggcagggga
      181 acagaaaccc tcaagtaatc tcctggagca gtttatttta ctagccaaag gtaccagtgg
      241 ctcagccctc actgctctca taagccaggt cttagaggct cccggagtgt atgtctttgg
      301 agaacttctg gagctggcca acgtgcagga gtgtatcccc tactccgtgt tgctgaaaga
      361 cctggagatg cggaatctcc gggaactaga agaccttatc attgaggctg tctacactga
      421 catcatccag ggcaagctgg accagcgaaa ccagctgctg gaagtggatt tctgcattgg
      481 ccgtgacatc cgaaagaagg atatcaataa tattgtcaag accctgcatg aatggtgtga
      541 tggctgtgaa gcagttctac tgggcatcga gcagcaagtt ctgagagcca accagtacaa
      601 agagaaccac aaccgaactc agcagcaggt agaagcagag gttaccaaca tcaagaagac
      661 actcaaagcc accgcatcct cctcggctca ggagatggag cagcagctgg ctgaacggga
      721 gtgtccccct cacgctgagc agaggcagcc caccaagaag atgtccaaag tgaaaggtct
      781 ggtctccagc cgccactagg gccggctggg gcagctggca ctcaccaggc ctgggtcagg
      841 tggggagggg acaccaaggg cccatttcct cccctctcta cctgcagtga gttccagacc
      901 tgcccgtccc ctcaccagcg cctccccacc ctgttggtac tgttccagaa aaactgttac
      961 tccccctcac ccactccctc cttccccagt tgttcccttc agactcaggg gctccaccaa
     1021 tgccatccca aaacagggtc agacactgcc cagcttccct ccaggaggtt cttgtctctg
     1081 tgtaagggct tgtctccctc ccagtttttc ttttgctcca cgtcattttg tcaggctggt
     1141 tataagccgg aggcagcttt aaccagcccc cagggatgat tgtgaaggag gcccctcccc
     1201 ttgtgaggag ggggcactcc tctccagccc ctggtaccac agtcctcacg atggtgcagt
     1261 gatttctagc caggcgtcaa gatgcgctgc tttccctctc ctgcctcatc ccttgttggc
     1321 agctccagtt caggccgtgg agggacgtga tgctgggctg tgtttactaa acccacgggt
     1381 tttcagcctc ttaagcccag ctccgatctc caattagttg agagcgctgg gttgactaac
     1441 ctctggtatc tgagcacaga cagagggtgc tgtgggtctg ctgggtggca gaaatggttc
     1501 cttccggctt ggcgttctct cctggccact cttcctgctg cctctgacta ctcagccttg
     1561 ttttcggtgt gtaggcccca gctgcccact ggaactgccg gctaatgctt gctctcccaa
     1621 gatctttaac tcctcctggc tgcacctggg tagggatggt ggcatcgatg cccctctgtc
     1681 tgctgaagga cctgttgctg cttctgtctt ttcacccctc cttggctgat gacccagagc
     1741 cctctgatga tggcattctc ctggcaagag aaaaagactt aactagactt ctgaacttga
     1801 acagtttcag gttatatttt aatttttttt tttttgtaca ggttctgatt ctaatacatt
     1861 tcaacatgct tttgtccccc ctcgtgtcaa tatttgttat agactaatcg ccggggattt
     1921 ttcacctggt tggagggtgg gggtggggtg gggtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1981 gtgtgtgtgt gtgtgtttgt aggtcctgga ctgattaaag ttcattgagg aaaaagcaca
     2041 ttttacaaca aaaaaataaa agtgtagatt taatgtatgt gactggggtt tggggttgca
     2101 tacctggtgg atcttgaggg gctgggatta gggtggttca ggaaaatgtg atgctgtttc
     2161 cccatgttta gccatggtca aaaaatggat ttctcctttt tctaaaatgt ccagcaactg
     2221 cctactgttg atcaaatgtt gaagtattct tgtttccctt ttaagccaat ccatgtgccc
     2281 acataacatt atgcccaagt ggagagttca ctttaatttc caaagtatgt ttcatgcagc
     2341 cccctgtcag ctgctctgtg gaaaaggggt tctgttatga aataaatgtt gcactccctg
     2401 catccca
//
