LOCUS       NM_001164095            1902 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 7A (COPS7A), transcript
            variant 3, mRNA.
ACCESSION   NM_001164095
VERSION     NM_001164095.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 1902)
  AUTHORS   Lingaraju,G.M., Bunker,R.D., Cavadini,S., Hess,D., Hassiepen,U.,
            Renatus,M., Fischer,E.S. and Thoma,N.H.
  TITLE     Crystal structure of the human COP9 signalosome
  JOURNAL   Nature 512 (7513), 161-165 (2014)
   PUBMED   25043011
REFERENCE   6  (bases 1 to 1902)
  AUTHORS   Wei,N., Serino,G. and Deng,X.W.
  TITLE     The COP9 signalosome: more than a protease
  JOURNAL   Trends Biochem Sci 33 (12), 592-600 (2008)
   PUBMED   18926707
  REMARK    Review article
REFERENCE   7  (bases 1 to 1902)
  AUTHORS   Lyapina,S., Cope,G., Shevchenko,A., Serino,G., Tsuge,T., Zhou,C.,
            Wolf,D.A., Wei,N., Shevchenko,A. and Deshaies,R.J.
  TITLE     Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome
  JOURNAL   Science 292 (5520), 1382-1385 (2001)
   PUBMED   11337588
REFERENCE   8  (bases 1 to 1902)
  AUTHORS   Bech-Otschir,D., Kraft,R., Huang,X., Henklein,P., Kapelari,B.,
            Pollmann,C. and Dubiel,W.
  TITLE     COP9 signalosome-specific phosphorylation targets p53 to
            degradation by the ubiquitin system
  JOURNAL   EMBO J 20 (7), 1630-1639 (2001)
   PUBMED   11285227
REFERENCE   9  (bases 1 to 1902)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1902)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125494.2, HY087807.1,
            AB014764.1, BC011789.2 and BQ008460.1.
            
            On May 31, 2019 this sequence version replaced NM_001164095.2.
            
            Summary: This gene encodes a component of the COP9 signalosome, an
            evolutionarily conserved multi-subunit protease that regulates the
            activity of the ubiquitin conjugation pathway. Alternatively
            spliced transcript variants that encode the same protein have been
            described. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.377276.1,
                                           SRR1803616.9895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC125494.2         74225-74369         c
            146-248             HY087807.1         136-238
            249-1076            AB014764.1         1-828
            1077-1894           BC011789.2         929-1746
            1895-1902           BQ008460.1         27-34               c
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1902
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="COP9 signalosome subunit 7A"
                     /db_xref="GeneID:50813"
                     /db_xref="HGNC:HGNC:16758"
                     /db_xref="MIM:616009"
     exon            1..205
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            206..410
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1076
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="COP9 complex subunit 7a; COP9 constitutive
                     photomorphogenic homolog subunit 7A; dermal
                     papilla-derived protein 10; JAB1-containing signalosome
                     subunit 7a"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7a"
                     /protein_id="NP_001157567.1"
                     /db_xref="CCDS:CCDS8558.1"
                     /db_xref="GeneID:50813"
                     /db_xref="HGNC:HGNC:16758"
                     /db_xref="MIM:616009"
                     /translation="MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFG
                     ELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVV
                     TLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGR
                     DIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKK
                     TIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN"
     exon            411..486
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            487..575
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            576..778
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            779..884
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1036
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1902
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1874..1879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="major polyA site"
ORIGIN      
        1 agtggccaga gcgactcttc agggaggtgg caggaaaggc ttggaacagc tgccggaggt
       61 gacggagcgg cggccccgcc cggtgcgctg gaggtcgaag cttccaggta gcggcccgca
      121 gagcctgacc cagggtacga cgaagcagtc ggcgggagcc cacggtcgct gggcggtgtc
      181 tttaagggag ggggcggagc cacgtctctg gacatcctga gcccaagtcc cccacactca
      241 gtgcagtgat gagtgcggaa gtgaaggtga cagggcagaa ccaggagcaa tttctgctcc
      301 tagccaagtc ggccaagggg gcagcgctgg ccacactcat ccatcaggtg ctggaggccc
      361 ctggtgtcta cgtgtttgga gaactgctgg acatgcccaa tgttagagag ctggctgaga
      421 gtgactttgc ctctaccttc cggctgctca cagtgtttgc ttatgggaca tacgctgact
      481 acttagctga agcccggaat cttcctccac taacagaggc tcagaagaat aagcttcgac
      541 acctctcagt tgtcaccctg gctgctaaag taaagtgtat cccatatgca gtgttgctgg
      601 aggctcttgc cctgcgtaat gtgcggcagc tggaagacct tgtgattgag gctgtgtatg
      661 ctgacgtgct tcgtggctcc ctggaccagc gcaaccagcg gctcgaggtt gactacagca
      721 tcgggcggga catccagcgc caggacctca gtgccattgc ccgaaccctg caggaatggt
      781 gtgtgggctg tgaggtcgtg ctgtcaggca ttgaggagca ggtgagccgt gccaaccaac
      841 acaaggagca gcagctgggc ctgaagcagc agattgagag tgaggttgcc aaccttaaaa
      901 aaaccattaa agttacgacg gcagcagcag ccgcagccac atctcaggac cctgagcaac
      961 acctgactga gctgagggaa ccagctcctg gcaccaacca gcgccagccc agcaagaaag
     1021 cctcaaaggg caaggggctc cgagggagcg ccaagatttg gtccaagtcg aattgaaagg
     1081 actgtcgttt cctccctggg gatgtggggt cccagctgcc tgcctgcctc ttaggagtcc
     1141 tcagagagcc ttctgtgccc ctggccagct gataatccta ggttcatgac ccttcacctc
     1201 ccctaacccc aaacatagat cacaccttct ctagggagga ggcaaatgta ggtcatgttt
     1261 ttgttggtac tttctgtttt ttgtgacttc atgtgttcca ttgctccccg ctgccatgct
     1321 ctctcccttg tttccttaag agctcagcat ctgtccctgt tcattacatg tcattgagta
     1381 ggtgggtagc cctgatgggg gtcgctctgt ctggagcata acccacaggc gttttttctg
     1441 ccaccccatc cctgcatgcc tgatccccag ttcctatacc ctacccctga cctattgagc
     1501 agcctctgaa gagccatagg gcccccacct ttactcacac cctgagaatt ctgggagcca
     1561 gtctgccatg ccaggagtca ctggacatgt tcatcctaga atcctgtcac actacagtca
     1621 tttcttttcc tctctctggc ccttgggtcc tgggaatgct gctgcttcaa ccccagagcc
     1681 taagaatggc agccgtttct taacatgttg agagatgatt ctttcttggc cctggccatc
     1741 tcgggaagct tgatggcaat cctggaaggg tttaatctcc ttttgtgagt ttggtgggga
     1801 agggaagggt atatagattg tattaaaaaa aaaaaggtat atatgcatat atctatatat
     1861 aatatgacgc agaaataaat ctatgagaaa tctatctaca aa
//
