LOCUS       NM_001164094            1831 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 7A (COPS7A), transcript
            variant 2, mRNA.
ACCESSION   NM_001164094
VERSION     NM_001164094.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Lingaraju,G.M., Bunker,R.D., Cavadini,S., Hess,D., Hassiepen,U.,
            Renatus,M., Fischer,E.S. and Thoma,N.H.
  TITLE     Crystal structure of the human COP9 signalosome
  JOURNAL   Nature 512 (7513), 161-165 (2014)
   PUBMED   25043011
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Wei,N., Serino,G. and Deng,X.W.
  TITLE     The COP9 signalosome: more than a protease
  JOURNAL   Trends Biochem Sci 33 (12), 592-600 (2008)
   PUBMED   18926707
  REMARK    Review article
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Lyapina,S., Cope,G., Shevchenko,A., Serino,G., Tsuge,T., Zhou,C.,
            Wolf,D.A., Wei,N., Shevchenko,A. and Deshaies,R.J.
  TITLE     Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome
  JOURNAL   Science 292 (5520), 1382-1385 (2001)
   PUBMED   11337588
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Bech-Otschir,D., Kraft,R., Huang,X., Henklein,P., Kapelari,B.,
            Pollmann,C. and Dubiel,W.
  TITLE     COP9 signalosome-specific phosphorylation targets p53 to
            degradation by the ubiquitin system
  JOURNAL   EMBO J 20 (7), 1630-1639 (2001)
   PUBMED   11285227
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1831)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA043679.1, BC011789.2 and
            BQ008460.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001164094.1.
            
            Summary: This gene encodes a component of the COP9 signalosome, an
            evolutionarily conserved multi-subunit protease that regulates the
            activity of the ubiquitin conjugation pathway. Alternatively
            spliced transcript variants that encode the same protein have been
            described. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.279294.1,
                                           SRR1803613.226456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543155.6/ ENSP00000438115.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                DA043679.1         63-139
            78-1823             BC011789.2         1-1746
            1824-1831           BQ008460.1         27-34               c
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1831
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="COP9 signalosome subunit 7A"
                     /db_xref="GeneID:50813"
                     /db_xref="HGNC:HGNC:16758"
                     /db_xref="MIM:616009"
     exon            1..134
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            135..339
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1005
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="COP9 complex subunit 7a; COP9 constitutive
                     photomorphogenic homolog subunit 7A; dermal
                     papilla-derived protein 10; JAB1-containing signalosome
                     subunit 7a"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7a"
                     /protein_id="NP_001157566.1"
                     /db_xref="CCDS:CCDS8558.1"
                     /db_xref="GeneID:50813"
                     /db_xref="HGNC:HGNC:16758"
                     /db_xref="MIM:616009"
                     /translation="MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFG
                     ELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVV
                     TLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGR
                     DIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKK
                     TIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN"
     exon            340..415
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            416..504
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            505..707
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            708..813
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            814..965
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1831
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="hexamer: AATAAA"
     polyA_site      1831
                     /gene="COPS7A"
                     /gene_synonym="CSN7; CSN7A; SGN7a"
                     /note="major polyA site"
ORIGIN      
        1 agtggccaga gcgactcttc agggaggtgg caggaaaggc ttggaacagc tgccggaggt
       61 gacggagcgg cggccccgcc cggtgcgctg gaggtcgaag cttccaggta gcggcccgca
      121 gagcctgacc caggctctgg acatcctgag cccaagtccc ccacactcag tgcagtgatg
      181 agtgcggaag tgaaggtgac agggcagaac caggagcaat ttctgctcct agccaagtcg
      241 gccaaggggg cagcgctggc cacactcatc catcaggtgc tggaggcccc tggtgtctac
      301 gtgtttggag aactgctgga catgcccaat gttagagagc tggctgagag tgactttgcc
      361 tctaccttcc ggctgctcac agtgtttgct tatgggacat acgctgacta cttagctgaa
      421 gcccggaatc ttcctccact aacagaggct cagaagaata agcttcgaca cctctcagtt
      481 gtcaccctgg ctgctaaagt aaagtgtatc ccatatgcag tgttgctgga ggctcttgcc
      541 ctgcgtaatg tgcggcagct ggaagacctt gtgattgagg ctgtgtatgc tgacgtgctt
      601 cgtggctccc tggaccagcg caaccagcgg ctcgaggttg actacagcat cgggcgggac
      661 atccagcgcc aggacctcag tgccattgcc cgaaccctgc aggaatggtg tgtgggctgt
      721 gaggtcgtgc tgtcaggcat tgaggagcag gtgagccgtg ccaaccaaca caaggagcag
      781 cagctgggcc tgaagcagca gattgagagt gaggttgcca accttaaaaa aaccattaaa
      841 gttacgacgg cagcagcagc cgcagccaca tctcaggacc ctgagcaaca cctgactgag
      901 ctgagggaac cagctcctgg caccaaccag cgccagccca gcaagaaagc ctcaaagggc
      961 aaggggctcc gagggagcgc caagatttgg tccaagtcga attgaaagga ctgtcgtttc
     1021 ctccctgggg atgtggggtc ccagctgcct gcctgcctct taggagtcct cagagagcct
     1081 tctgtgcccc tggccagctg ataatcctag gttcatgacc cttcacctcc cctaacccca
     1141 aacatagatc acaccttctc tagggaggag gcaaatgtag gtcatgtttt tgttggtact
     1201 ttctgttttt tgtgacttca tgtgttccat tgctccccgc tgccatgctc tctcccttgt
     1261 ttccttaaga gctcagcatc tgtccctgtt cattacatgt cattgagtag gtgggtagcc
     1321 ctgatggggg tcgctctgtc tggagcataa cccacaggcg ttttttctgc caccccatcc
     1381 ctgcatgcct gatccccagt tcctataccc tacccctgac ctattgagca gcctctgaag
     1441 agccataggg cccccacctt tactcacacc ctgagaattc tgggagccag tctgccatgc
     1501 caggagtcac tggacatgtt catcctagaa tcctgtcaca ctacagtcat ttcttttcct
     1561 ctctctggcc cttgggtcct gggaatgctg ctgcttcaac cccagagcct aagaatggca
     1621 gccgtttctt aacatgttga gagatgattc tttcttggcc ctggccatct cgggaagctt
     1681 gatggcaatc ctggaagggt ttaatctcct tttgtgagtt tggtggggaa gggaagggta
     1741 tatagattgt attaaaaaaa aaaaggtata tatgcatata tctatatata atatgacgca
     1801 gaaataaatc tatgagaaat ctatctacaa a
//
