LOCUS       NM_006833               1404 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 6 (COPS6), mRNA.
ACCESSION   NM_006833
VERSION     NM_006833.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1404)
  AUTHORS   Li,K., Zhang,J., Lyu,H., Yang,J., Wei,W., Wang,Y., Luo,H.,
            Zhang,Y., Jiang,X., Yi,H., Wang,M., Zhang,C., Wu,K., Xiao,L.,
            Wen,W., Xu,H., Li,G., Wan,Y., Yang,F., Yang,R., Fu,X., Qin,B.,
            Zhou,Z., Zhang,H. and Lee,M.H.
  TITLE     CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression
            via YAP1 Activation
  JOURNAL   Adv Sci (Weinh) 11 (14), e2306827 (2024)
   PUBMED   38308184
  REMARK    GeneRIF: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma
            Progression via YAP1 Activation.
REFERENCE   2  (bases 1 to 1404)
  AUTHORS   Zou,S., Qin,B., Yang,Z., Wang,W., Zhang,J., Zhang,Y., Meng,M.,
            Feng,J., Xie,Y., Fang,L., Xiao,L., Zhang,P., Meng,X., Choi,H.H.,
            Wen,W., Pan,Q., Ghesquiere,B., Lan,P., Lee,M.H. and Fang,L.
  TITLE     CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development
            and Chemoresistance in Colorectal Cancer
  JOURNAL   Cancer Res 83 (3), 414-427 (2023)
   PUBMED   36512632
  REMARK    GeneRIF: CSN6 Mediates Nucleotide Metabolism to Promote Tumor
            Development and Chemoresistance in Colorectal Cancer.
REFERENCE   3  (bases 1 to 1404)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1404)
  AUTHORS   Zhang,Y., Hou,J., Shi,S., Du,J., Liu,Y., Huang,P., Li,Q., Liu,L.,
            Hu,H., Ji,Y., Guo,L., Shi,Y., Liu,Y. and Cui,H.
  TITLE     CSN6 promotes melanoma proliferation and metastasis by controlling
            the UBR5-mediated ubiquitination and degradation of CDK9
  JOURNAL   Cell Death Dis 12 (1), 118 (2021)
   PUBMED   33483464
  REMARK    GeneRIF: CSN6 promotes melanoma proliferation and metastasis by
            controlling the UBR5-mediated ubiquitination and degradation of
            CDK9.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1404)
  AUTHORS   Wang,X. and Chen,T.
  TITLE     CUL4A regulates endometrial cancer cell proliferation, invasion and
            migration by interacting with CSN6
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179082
  REMARK    GeneRIF: CUL4A regulates endometrial cancer cell proliferation,
            invasion and migration by interacting with CSN6.
REFERENCE   6  (bases 1 to 1404)
  AUTHORS   Di Marzio,P., Choe,S., Ebright,M., Knoblauch,R. and Landau,N.R.
  TITLE     Mutational analysis of cell cycle arrest, nuclear localization and
            virion packaging of human immunodeficiency virus type 1 Vpr
  JOURNAL   J Virol 69 (12), 7909-7916 (1995)
   PUBMED   7494303
REFERENCE   7  (bases 1 to 1404)
  AUTHORS   Re,F., Braaten,D., Franke,E.K. and Luban,J.
  TITLE     Human immunodeficiency virus type 1 Vpr arrests the cell cycle in
            G2 by inhibiting the activation of p34cdc2-cyclin B
  JOURNAL   J Virol 69 (11), 6859-6864 (1995)
   PUBMED   7474100
REFERENCE   8  (bases 1 to 1404)
  AUTHORS   He,J., Choe,S., Walker,R., Di Marzio,P., Morgan,D.O. and
            Landau,N.R.
  TITLE     Human immunodeficiency virus type 1 viral protein R (Vpr) arrests
            cells in the G2 phase of the cell cycle by inhibiting p34cdc2
            activity
  JOURNAL   J Virol 69 (11), 6705-6711 (1995)
   PUBMED   7474080
REFERENCE   9  (bases 1 to 1404)
  AUTHORS   Jowett,J.B., Planelles,V., Poon,B., Shah,N.P., Chen,M.L. and
            Chen,I.S.
  TITLE     The human immunodeficiency virus type 1 vpr gene arrests infected T
            cells in the G2 + M phase of the cell cycle
  JOURNAL   J Virol 69 (10), 6304-6313 (1995)
   PUBMED   7666531
REFERENCE   10 (bases 1 to 1404)
  AUTHORS   Mittmeyer,H.J.
  TITLE     [Distribution pattern of rigor mortis in various joint regions]
  JOURNAL   Beitr Gerichtl Med 33, 85-96 (1975)
   PUBMED   1222062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB990467.1, BC002520.2 and
            CD367717.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006833.4.
            
            Summary: The protein encoded by this gene is one of the eight
            subunits of COP9 signalosome, a highly conserved protein complex
            that functions as an important regulator in multiple signaling
            pathways. The structure and function of COP9 signalosome is similar
            to that of the 19S regulatory particle of 26S proteasome. COP9
            signalosome has been shown to interact with SCF-type E3 ubiquitin
            ligases and act as a positive regulator of E3 ubiquitin ligases.
            This protein belongs to translation initiation factor 3 (eIF3)
            superfamily. It is involved in the regulation of cell cycle and
            likely to be a cellular cofactor for HIV-1 accessory gene product
            Vpr. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.127123.1,
                                           SRR3476690.539176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303904.8/ ENSP00000304102.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CB990467.1         34-50
            18-1124             BC002520.2         1-1107
            1125-1404           CD367717.1         29-308              c
FEATURES             Location/Qualifiers
     source          1..1404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1404
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /note="COP9 signalosome subunit 6"
                     /db_xref="GeneID:10980"
                     /db_xref="HGNC:HGNC:21749"
                     /db_xref="MIM:614729"
     exon            1..98
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1006
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /note="H_NH0506M12.12; COP9 constitutive photomorphogenic
                     homolog subunit 6; MOV34 homolog, 34 kD; SGN6; hVIP;
                     vpr-interacting protein; JAB1-containing signalosome
                     subunit 6"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 6"
                     /protein_id="NP_006824.2"
                     /db_xref="CCDS:CCDS5682.1"
                     /db_xref="GeneID:10980"
                     /db_xref="HGNC:HGNC:21749"
                     /db_xref="MIM:614729"
                     /translation="MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALH
                     PLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDK
                     EYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKH
                     TDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVA
                     EHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFK
                     TDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF"
     exon            99..224
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            225..356
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            357..445
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            446..508
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            509..556
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            557..671
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            672..764
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            765..865
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1404
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1097..1102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /note="hexamer: AATAAA"
     polyA_site      1124
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /note="major polyA site"
     polyA_site      1159
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
                     /note="hexamer: TATAAA"
     polyA_site      1404
                     /gene="COPS6"
                     /gene_synonym="CSN6; MOV34-34KD"
ORIGIN      
        1 gaggctggcg ggcgcgggga aaatggcggc ggcggcggcg gcggctgcag ctacgaacgg
       61 gaccggagga agcagcggga tggaggtgga tgcagcagta gtccccagcg tgatggcctg
      121 cggagtgact gggagtgttt ccgtcgctct ccatcccctt gtcattctca acatctcaga
      181 ccactggatc cgcatgcgct cccaggaggg gcggcctgtg caggtgattg gggctctgat
      241 tggcaagcag gagggccgaa atatcgaggt gatgaactcc tttgagctgc tgtcccacac
      301 cgtggaagag aagattatca ttgacaagga atattattac accaaggagg agcagtttaa
      361 acaggtgttc aaggagctgg agtttctggg ttggtatacc acaggggggc cacctgaccc
      421 ctcggacatc cacgtccata agcaggtgtg tgagatcatc gagagccccc tctttctgaa
      481 gttgaaccct atgaccaagc acacagatct tcctgtcagc gtttttgagt ctgtcattga
      541 tataatcaat ggagaggcca caatgctgtt tgctgagctg acctacactc tggccacaga
      601 ggaagcggaa cgcattggtg tagaccacgt agcccgaatg acagcaacag gcagtggaga
      661 gaactccact gtggctgaac acctgatagc acagcacagc gccatcaaga tgctgcacag
      721 ccgcgtcaag ctcatcttgg agtacgtcaa ggcctctgaa gcgggagagg tcccctttaa
      781 tcatgagatc ctgcgggagg cctatgctct gtgtcactgt ctcccggtgc tcagcacaga
      841 caagttcaag acagattttt atgatcaatg caacgacgtg gggctcatgg cctacctcgg
      901 caccatcacc aaaacgtgca acaccatgaa ccagtttgtg aacaagttca atgtcctcta
      961 cgaccgacaa ggcatcggca ggagaatgcg cgggctcttt ttctgatgag ggtacttgaa
     1021 gggctgatgg acaggggtca ggcaactatc ccaaagggga gggcactaca cttccttgag
     1081 agaaaccgct gtcattaata aaaggggagc agcccctgag cacccctgct ggtggctctg
     1141 tcctctgtta ggcaccacac tggttggtca acttggatgt tcatcgaggc tcattctggc
     1201 cttgctcaga agcccttctg atgctcttca gtgagggagg cactaccatt tgaagtgacc
     1261 ccatgtcagt cacatggact ggtctttagc aaagtccaag gctgcctgct tccacctaag
     1321 tggtctctgt tctacacttt aatgtcaccc tctacatcat cttacctagc ccacccaacc
     1381 ttataaacat gataattgac tact
//
