LOCUS       NM_006837               1296 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 5 (COPS5), mRNA.
ACCESSION   NM_006837
VERSION     NM_006837.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Yang,Y., Song,R., Gao,Y., Yu,H. and Wang,S.
  TITLE     Regulatory mechanisms and therapeutic potential of JAB1 in
            neurological development and disorders
  JOURNAL   Mol Med 29 (1), 80 (2023)
   PUBMED   37365502
  REMARK    GeneRIF: Regulatory mechanisms and therapeutic potential of JAB1 in
            neurological development and disorders.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Zhang,C., Wan,J., Liu,Q., Long,F., Wen,Z. and Liu,Y.
  TITLE     METTL3 upregulates COPS5 expression in osteosarcoma in an
            m6A-related manner to promote osteosarcoma progression
  JOURNAL   Exp Cell Res 420 (2), 113353 (2022)
   PUBMED   36100071
  REMARK    GeneRIF: METTL3 upregulates COPS5 expression in osteosarcoma in an
            m(6)A-related manner to promote osteosarcoma progression.
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Martinez-Iglesias,O., Naidoo,V., Carrera,I. and Cacabelos,R.
  TITLE     Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic
            Mouse Model of Alzheimer's Disease
  JOURNAL   Int J Mol Sci 23 (5), 2446 (2022)
   PUBMED   35269588
  REMARK    GeneRIF: Epigenetic Studies in the Male APP/BIN1/COPS5
            Triple-Transgenic Mouse Model of Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Mazzu,Y.Z., Liao,Y.R., Nandakumar,S., Jehane,L.E., Koche,R.P.,
            Rajanala,S.H., Li,R., Zhao,H., Gerke,T.A., Chakraborty,G.,
            Lee,G.M., Nanjangud,G.J., Gopalan,A., Chen,Y. and Kantoff,P.W.
  TITLE     Prognostic and therapeutic significance of COP9 signalosome subunit
            CSN5 in prostate cancer
  JOURNAL   Oncogene 41 (5), 671-682 (2022)
   PUBMED   34802033
  REMARK    GeneRIF: Prognostic and therapeutic significance of COP9
            signalosome subunit CSN5 in prostate cancer.
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Tomoda,K., Kubota,Y. and Kato,J.
  TITLE     Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is
            instigated by Jab1
  JOURNAL   Nature 398 (6723), 160-165 (1999)
   PUBMED   10086358
REFERENCE   7  (bases 1 to 1296)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   8  (bases 1 to 1296)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   9  (bases 1 to 1296)
  AUTHORS   Asano,K., Vornlocher,H.P., Richter-Cook,N.J., Merrick,W.C.,
            Hinnebusch,A.G. and Hershey,J.W.
  TITLE     Structure of cDNAs encoding human eukaryotic initiation factor 3
            subunits. Possible roles in RNA binding and macromolecular assembly
  JOURNAL   J Biol Chem 272 (43), 27042-27052 (1997)
   PUBMED   9341143
REFERENCE   10 (bases 1 to 1296)
  AUTHORS   Claret,F.X., Hibi,M., Dhut,S., Toda,T. and Karin,M.
  TITLE     A new group of conserved coactivators that increase the specificity
            of AP-1 transcription factors
  JOURNAL   Nature 383 (6599), 453-457 (1996)
   PUBMED   8837781
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI752436.1 and BC001187.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006837.2.
            
            Summary: The protein encoded by this gene is one of the eight
            subunits of COP9 signalosome, a highly conserved protein complex
            that functions as an important regulator in multiple signaling
            pathways. The structure and function of COP9 signalosome is similar
            to that of the 19S regulatory particle of 26S proteasome. COP9
            signalosome has been shown to interact with SCF-type E3 ubiquitin
            ligases and act as a positive regulator of E3 ubiquitin ligases.
            This protein is reported to be involved in the degradation of
            cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known
            to be an coactivator that increases the specificity of JUN/AP1
            transcription factors. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005644.1, BC001187.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357849.9/ ENSP00000350512.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BI752436.1         185-186
            3-1296              BC001187.1         1-1294
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..1296
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /note="COP9 signalosome subunit 5"
                     /db_xref="GeneID:10987"
                     /db_xref="HGNC:HGNC:2240"
                     /db_xref="MIM:604850"
     exon            1..280
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1142
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /note="38 kDa Mov34 homolog; signalosome subunit 5; jun
                     activation domain-binding protein 1; COP9 constitutive
                     photomorphogenic homolog subunit 5; testis secretory
                     sperm-binding protein Li 231m"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 5"
                     /protein_id="NP_006828.2"
                     /db_xref="CCDS:CCDS6198.1"
                     /db_xref="GeneID:10987"
                     /db_xref="HGNC:HGNC:2240"
                     /db_xref="MIM:604850"
                     /translation="MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKP
                     WTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEG
                     TETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQ
                     FQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHC
                     KQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQS
                     EAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
                     "
     exon            281..515
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     exon            516..644
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     exon            645..710
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     exon            711..796
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..908
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1057
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1296
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1275..1280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /note="hexamer: AATAAA"
     polyA_site      1296
                     /gene="COPS5"
                     /gene_synonym="CSN5; JAB1; MOV-34; SGN5"
                     /note="major polyA site"
ORIGIN      
        1 aggtgtcatg gctgccccaa gagtctaggt aagagtttgt tcccgtggtg cggagggtca
       61 aggcccacac ccggaaacct agcgaggtaa agttgcgtct tggttgtaga gacgacaact
      121 tctccgcttc ctcggcgatg gcggcgtccg ggagcggtat ggcccagaaa acctgggaac
      181 tggccaacaa catgcaggaa gctcagagta tcgatgaaat ctacaaatac gacaagaaac
      241 agcagcaaga aatcctggcg gcgaagccct ggactaagga tcaccattac tttaagtact
      301 gcaaaatctc agcattggct ctgctgaaga tggtgatgca tgccagatcg ggaggcaact
      361 tggaagtgat gggtctgatg ctaggaaagg tggatggtga aaccatgatc attatggaca
      421 gttttgcttt gcctgtggag ggcactgaaa cccgagtaaa tgctcaggct gctgcatatg
      481 aatacatggc tgcatacata gaaaatgcaa aacaggttgg ccgccttgaa aatgcaatcg
      541 ggtggtatca tagccaccct ggctatggct gctggctttc tgggattgat gttagtactc
      601 agatgctcaa tcagcagttc caggaaccat ttgtagcagt ggtgattgat ccaacaagaa
      661 caatatccgc agggaaagtg aatcttggcg cctttaggac atacccaaag ggctacaaac
      721 ctcctgatga aggaccttct gagtaccaga ctattccact taataaaata gaagattttg
      781 gtgtacactg caaacaatat tatgccttag aagtctcata tttcaaatcc tctttggatc
      841 gcaaattgct tgagctgttg tggaataaat actgggtgaa tacgttgagt tcttctagct
      901 tgcttactaa tgcagactat accactggtc aggtctttga tttgtctgaa aagttagagc
      961 agtcagaagc ccagctggga cgagggagtt tcatgttggg tttagaaacg catgaccgaa
     1021 aatcagaaga caaacttgcc aaagctacaa gagacagctg taaaactacc atagaagcta
     1081 tccatggatt gatgtctcag gttattaagg ataaactgtt taatcaaatt aacatctctt
     1141 aaacagtctc tgagaagtac tttacctgaa agacagtatg agaaaaatat tcaagtaaca
     1201 ctttaaaacc agttacccaa aatctgatta gaagtataag gtgctctgaa gtgtcctaaa
     1261 tattaatatc ctgtaataaa gctctttaaa atgaaa
//
