LOCUS       NM_016129               1651 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 4 (COPS4), transcript variant
            1, mRNA.
ACCESSION   NM_016129
VERSION     NM_016129.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Bech-Otschir,D., Kraft,R., Huang,X., Henklein,P., Kapelari,B.,
            Pollmann,C. and Dubiel,W.
  TITLE     COP9 signalosome-specific phosphorylation targets p53 to
            degradation by the ubiquitin system
  JOURNAL   EMBO J 20 (7), 1630-1639 (2001)
   PUBMED   11285227
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Cohen,H., Azriel,A., Cohen,T., Meraro,D., Hashmueli,S.,
            Bech-Otschir,D., Kraft,R., Dubiel,W. and Levi,B.Z.
  TITLE     Interaction between interferon consensus sequence-binding protein
            and COP9/signalosome subunit CSN2 (Trip15). A possible link between
            interferon regulatory factor signaling and the COP9/signalosome
  JOURNAL   J Biol Chem 275 (50), 39081-39089 (2000)
   PUBMED   10991940
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Naumann,M., Bech-Otschir,D., Huang,X., Ferrell,K. and Dubiel,W.
  TITLE     COP9 signalosome-directed c-Jun activation/stabilization is
            independent of JNK
  JOURNAL   J Biol Chem 274 (50), 35297-35300 (1999)
   PUBMED   10585392
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1651)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001148.1, BC004302.1 and
            BC009292.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016129.2.
            
            Summary: This gene encodes one of eight subunits composing COP9
            signalosome, a highly conserved protein complex that functions as
            an important regulator in multiple signaling pathways. The
            structure and function of COP9 signalosome is similar to that of
            the 19S regulatory particle of 26S proteasome. COP9 signalosome has
            been shown to interact with SCF-type E3 ubiquitin ligases and act
            as a positive regulator of E3 ubiquitin ligases. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005665.1, SRR3476690.835033.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264389.7/ ENSP00000264389.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK001148.1         94-133
            41-1625             BC004302.1         1-1585
            1626-1651           BC009292.2         1586-1611
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..1651
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /note="COP9 signalosome subunit 4"
                     /db_xref="GeneID:51138"
                     /db_xref="HGNC:HGNC:16702"
                     /db_xref="MIM:616008"
     exon            1..116
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1263
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /note="isoform 1 is encoded by transcript variant 1; COP9
                     signalosome complex subunit 4; signalosome subunit 4;
                     JAB1-containing signalosome subunit 4; COP9 constitutive
                     photomorphogenic homolog subunit 4; COP9 constitutive
                     photomorphogenic-like protein subunit 4; testis tissue
                     sperm-binding protein Li 42a"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 4 isoform 1"
                     /protein_id="NP_057213.2"
                     /db_xref="CCDS:CCDS3600.1"
                     /db_xref="GeneID:51138"
                     /db_xref="HGNC:HGNC:16702"
                     /db_xref="MIM:616008"
                     /translation="MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEA
                     LKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQ
                     VASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDD
                     PVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVH
                     ESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGN
                     QLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAK
                     AEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTA
                     PEWTAQAMEAQMAQ"
     exon            117..196
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            197..348
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            349..452
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            453..606
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            607..757
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            758..928
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1044
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1129
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1651
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1624..1629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /note="hexamer: AATAAA"
     polyA_site      1651
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /note="major polyA site"
ORIGIN      
        1 gctgccagag gcccccgcat ccaccgctga gctgggagaa agatggcggc agccgtgcga
       61 caggatttgg cccagctcat gaattcgagc ggctctcata aagatctggc tggcaagtat
      121 cgtcagatcc tggaaaaagc cattcagtta tctggagcag aacaactaga agctttgaaa
      181 gcttttgtgg aagcaatggt aaatgagaat gtcagtctcg tgatctcgcg gcagttgctg
      241 actgattttt gcacacatct tcctaacttg cctgatagca cagccaaaga aatctatcac
      301 ttcaccttgg aaaagatcca gcctagagtc atttcatttg aggagcaggt tgcttccata
      361 agacagcatc ttgcatctat atatgagaaa gaagaagatt ggagaaatgc agcccaagtg
      421 ttggtgggaa ttcctttgga aacaggacaa aaacagtaca atgtagatta taaactggag
      481 acttacttga agattgctag gctatatctg gaggatgatg atccagtcca ggcagaggct
      541 tacataaatc gagcatcgtt gcttcagaat gaatcaacca atgaacaatt acagatacat
      601 tataaggtat gctatgcacg tgttcttgat tatagaagaa aattcattga agctgcacaa
      661 aggtacaatg agctctctta caagacaata gtccacgaaa gtgaaagact agaggcctta
      721 aaacatgctt tgcactgtac gatcttagca tcagcagggc agcagcgttc tcggatgcta
      781 gctactcttt ttaaggatga aaggtgccag caacttgctg cctatgggat cctagagaaa
      841 atgtatctag ataggatcat cagaggaaat caacttcaag aatttgctgc catgctgatg
      901 cctcaccaaa aagcaactac agctgatggt tccagcatct tggacagagc tgttattgaa
      961 cacaatttgt tgtctgcaag caaattatat aataatatta ccttcgaaga acttggagct
     1021 cttttagaga tccctgcagc taaggcggaa aagatagcat ctcaaatgat aaccgaagga
     1081 cgtatgaatg gatttattga ccagattgat ggaatagttc attttgaaac acgagaagcc
     1141 ctgccaacgt gggataagca gatccaatca ctttgtttcc aagtgaataa ccttttggag
     1201 aaaattagtc aaacagcacc agaatggaca gcacaagcca tggaagccca gatggctcag
     1261 tgaatccttg cagaacttct gtgcacatga catctttttc catgttgtgc agatcagttt
     1321 cactatctcc aaagcatttg catcatgacc ttatacattt caatcccttt tatgctggat
     1381 tccgtttaaa gaagacatta ttagagcagg aagtacaagc atttaaaata tgtagttccc
     1441 atatatttca gggtctctgt gtattaagct aactcagatg ttttgaaagc tttttcttta
     1501 aacagaggtg aaatatctgt ggctaaaaag tttgagattt gtgataactt tgtagtcatg
     1561 taaaacttaa gtgcttcatg cctctccaaa tgtggttatt ctaataaatg gagaaatgag
     1621 ccaaataaaa gtagtacttt gtttttagtt a
//
