LOCUS       NM_003653               1814 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 3 (COPS3), transcript variant
            1, mRNA.
ACCESSION   NM_003653
VERSION     NM_003653.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Niu,J., Yan,T., Guo,W., Wang,W., Ren,T., Huang,Y., Zhao,Z., Yu,Y.,
            Chen,C., Huang,Q., Lou,J. and Guo,L.
  TITLE     The COPS3-FOXO3 positive feedback loop regulates autophagy to
            promote cisplatin resistance in osteosarcoma
  JOURNAL   Autophagy 19 (6), 1693-1710 (2023)
   PUBMED   36451342
  REMARK    GeneRIF: The COPS3-FOXO3 positive feedback loop regulates autophagy
            to promote cisplatin resistance in osteosarcoma.
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1814)
  AUTHORS   Liu,W., Nichols,A.F., Graham,J.A., Dualan,R., Abbas,A. and Linn,S.
  TITLE     Nuclear transport of human DDB protein induced by ultraviolet light
  JOURNAL   J Biol Chem 275 (28), 21429-21434 (2000)
   PUBMED   10777491
REFERENCE   7  (bases 1 to 1814)
  AUTHORS   Bianchi,E., Denti,S., Granata,A., Bossi,G., Geginat,J., Villa,A.,
            Rogge,L. and Pardi,R.
  TITLE     Integrin LFA-1 interacts with the transcriptional co-activator JAB1
            to modulate AP-1 activity
  JOURNAL   Nature 404 (6778), 617-621 (2000)
   PUBMED   10766246
REFERENCE   8  (bases 1 to 1814)
  AUTHORS   Potocki,L., Chen,K.S. and Lupski,J.R.
  TITLE     Subunit 3 of the COP9 signal transduction complex is conserved from
            plants to humans and maps within the smith-magenis syndrome
            critical region in 17p11.2
  JOURNAL   Genomics 57 (1), 180-182 (1999)
   PUBMED   10191102
REFERENCE   9  (bases 1 to 1814)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1814)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001891.1, AC055811.20 and
            BU952436.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003653.3.
            
            Summary: The protein encoded by this gene possesses kinase activity
            that phosphorylates regulators involved in signal transduction. It
            phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a
            docking site for complex-mediated phosphorylation. The gene is
            located within the Smith-Magenis syndrome region on chromosome 17.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.110326.1,
                                           SRR1660805.212192.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268717.10/ ENSP00000268717.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-632               BC001891.1         32-663
            633-633             AC055811.20        127265-127265       c
            634-1523            BC001891.1         665-1554
            1524-1806           BU952436.1         3-285               c
            1807-1814           AC055811.20        109031-109038       c
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1814
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="COP9 signalosome subunit 3"
                     /db_xref="GeneID:8533"
                     /db_xref="HGNC:HGNC:2239"
                     /db_xref="MIM:604665"
     exon            1..115
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1332
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="isoform 1 is encoded by transcript variant 1; COP9
                     complex subunit 3; JAB1-containing signalosome subunit 3;
                     COP9 signalosome complex subunit 3; COP9 constitutive
                     photomorphogenic homolog subunit 3"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 3 isoform 1"
                     /protein_id="NP_003644.2"
                     /db_xref="CCDS:CCDS11183.1"
                     /db_xref="GeneID:8533"
                     /db_xref="HGNC:HGNC:2239"
                     /db_xref="MIM:604665"
                     /translation="MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDT
                     VLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAG
                     LCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALP
                     YLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSH
                     IMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELR
                     NLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEA
                     EKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKA
                     MDQEITVNPQFVQKSMGSQEDDSGNKPSSYS"
     exon            116..245
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            246..358
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..408
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            409..501
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..681
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..822
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..996
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1083
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1197
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1278
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1814
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1572..1577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="hexamer: ATTAAA"
     polyA_site      1595
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="major polyA site"
     regulatory      1786..1791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="hexamer: AATAAA"
     polyA_site      1797
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
     polyA_site      1814
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
ORIGIN      
        1 agagcggcag ccttttcccg cgcgtgctgc cttcgccgct cgggccgccc gggggaaaac
       61 atggcgtctg ccctggagca gttcgtgaac agtgtccgac agctctcagc tcaagggcaa
      121 atgacacagc tttgtgaact gatcaacaag agtggggaac tccttgcgaa gaacttatcc
      181 catctggaca ctgtgctcgg ggctctggat gtacaagaac actccttggg cgtccttgct
      241 gttttgtttg tgaagttttc tatgcccagt gttcctgact tcgaaacgct attctcacag
      301 gttcagctct tcatcagcac ttgtaatggg gagcacattc gatatgcaac agacactttt
      361 gctgggcttt gccatcagct aacaaatgca cttgtggaaa gaaaacagcc cctgcgagga
      421 attggcatcc ttaagcaagc catagacaag atgcagatga atacaaacca gctgacctca
      481 atacatgctg atctctgcca gctttgtttg ctagcaaaat gctttaagcc tgcccttcca
      541 tatcttgacg tggatatgat ggatatctgt aaagagaatg gagcctatga tgcaaaacac
      601 tttttatgtt actattatta tggagggatg atctatactg ggctgaagaa ctttgaaaga
      661 gctctctact tttatgaaca ggctataact actcctgcca tggcggtcag tcatatcatg
      721 ttggaatcat ataaaaagta tattttagtg tctttgatat tacttggcaa agtacaacag
      781 ctaccaaaat atacatctca aattgtgggt agattcatta agcctcttag caatgcatac
      841 cacgagttag cacaagtgta ttcaaccaac aacccctcag aactccgaaa cctggtgaat
      901 aagcacagtg aaaccttcac tcgcgataac aacatggggc tggtgaagca atgcttgtca
      961 tctctttata agaagaatat tcagaggcta acaaagacct ttttaactct atcattacaa
     1021 gatatggcaa gtcgtgtgca gttgtctgga cctcaggagg cagagaaata cgttctgcac
     1081 atgatagaag atggtgagat ttttgcaagt attaaccaga aggacggtat ggtcagtttc
     1141 catgataacc ctgaaaaata taataaccca gccatgcttc ataacattga tcaggagatg
     1201 ctgaagtgca ttgagctgga tgagcggctg aaagccatgg accaggagat cacagtgaac
     1261 cctcagtttg tacaaaagag tatgggctca caagaagatg attcaggaaa caaaccatcc
     1321 agttattctt gaaactaaca tccatcctga gctaaacaag agaaactacc atcttggcca
     1381 gtgacaagtg ttcggagggc agcagagagg accaagcctg tgtcacctgg agactaagaa
     1441 attaagtttt gttttgacat cttcagtcct gtgtgctttc agaaaaccat tttctctgca
     1501 aagaaaggaa acagatttgc aaactttaaa gtctgtcgtg gatttattta tcctcagatt
     1561 attgttactg cattaaatct acctttttgt tttaagttgc ttgaacatta atgtgtcttc
     1621 tgtatcactt ttttctcctc tgaagttttt aataagcaca ttcattgtga acagaaatag
     1681 ctggatttta ggaatttttg gaagatttgg atctgaaagg tttttattta ttgacaaatt
     1741 tgtatctaca aaaaaatcta aaagttgtaa tcattgtctt cagaaaataa aagaaaagaa
     1801 aggccagaca gaca
//
