LOCUS       NM_001316354            1901 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 3 (COPS3), transcript variant
            3, mRNA.
ACCESSION   NM_001316354 XM_005256841
VERSION     NM_001316354.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Niu,J., Yan,T., Guo,W., Wang,W., Ren,T., Huang,Y., Zhao,Z., Yu,Y.,
            Chen,C., Huang,Q., Lou,J. and Guo,L.
  TITLE     The COPS3-FOXO3 positive feedback loop regulates autophagy to
            promote cisplatin resistance in osteosarcoma
  JOURNAL   Autophagy 19 (6), 1693-1710 (2023)
   PUBMED   36451342
  REMARK    GeneRIF: The COPS3-FOXO3 positive feedback loop regulates autophagy
            to promote cisplatin resistance in osteosarcoma.
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Liu,W., Nichols,A.F., Graham,J.A., Dualan,R., Abbas,A. and Linn,S.
  TITLE     Nuclear transport of human DDB protein induced by ultraviolet light
  JOURNAL   J Biol Chem 275 (28), 21429-21434 (2000)
   PUBMED   10777491
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Bianchi,E., Denti,S., Granata,A., Bossi,G., Geginat,J., Villa,A.,
            Rogge,L. and Pardi,R.
  TITLE     Integrin LFA-1 interacts with the transcriptional co-activator JAB1
            to modulate AP-1 activity
  JOURNAL   Nature 404 (6778), 617-621 (2000)
   PUBMED   10766246
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Potocki,L., Chen,K.S. and Lupski,J.R.
  TITLE     Subunit 3 of the COP9 signal transduction complex is conserved from
            plants to humans and maps within the smith-magenis syndrome
            critical region in 17p11.2
  JOURNAL   Genomics 57 (1), 180-182 (1999)
   PUBMED   10191102
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP260214.1, DB493356.1,
            AK297706.1, BC001891.1, BU952436.1 and AC055811.20.
            
            On Aug 13, 2020 this sequence version replaced NM_001316354.1.
            
            Summary: The protein encoded by this gene possesses kinase activity
            that phosphorylates regulators involved in signal transduction. It
            phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a
            docking site for complex-mediated phosphorylation. The gene is
            located within the Smith-Magenis syndrome region on chromosome 17.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (3) contains two alternate splice
            junctions compared to variant 1. The resulting isoform (3) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297706.1, SRR14038195.2245473.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BP260214.1         58-91
            35-55               DB493356.1         91-111
            56-804              AK297706.1         1-749
            805-1610            BC001891.1         749-1554
            1611-1893           BU952436.1         3-285               c
            1894-1901           AC055811.20        109031-109038       c
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1901
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="COP9 signalosome subunit 3"
                     /db_xref="GeneID:8533"
                     /db_xref="HGNC:HGNC:2239"
                     /db_xref="MIM:604665"
     exon            1..115
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            116..264
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            265..377
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            378..427
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..588
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..1419
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="isoform 3 is encoded by transcript variant 3; COP9
                     complex subunit 3; JAB1-containing signalosome subunit 3;
                     COP9 signalosome complex subunit 3; COP9 constitutive
                     photomorphogenic homolog subunit 3"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 3 isoform 3"
                     /protein_id="NP_001303283.1"
                     /db_xref="GeneID:8533"
                     /db_xref="HGNC:HGNC:2239"
                     /db_xref="MIM:604665"
                     /translation="MQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENG
                     AYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSL
                     ILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDN
                     NMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIF
                     ASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK
                     SMGSQEDDSGNKPSSYS"
     exon            589..768
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..909
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1083
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1170
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1284
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1365
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1901
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="hexamer: ATTAAA"
     polyA_site      1682
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="major polyA site"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="hexamer: AATAAA"
     polyA_site      1884
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
     polyA_site      1901
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
ORIGIN      
        1 agagcggcag ccttttcccg cgcgtgctgc cttcgccgct cgggccgccc gggggaaaac
       61 atggcgtctg ccctggagca gttcgtgaac agtgtccgac agctctcagc tcaagtgttg
      121 ttcctgtttt ccagggcaaa tgacacagct ttgtgaactg atcaacaaga gtggggaact
      181 ccttgcgaag aacttatccc atctggacac tgtgctcggg gctctggatg tacaagaaca
      241 ctccttgggc gtccttgctg ttttgtttgt gaagttttct atgcccagtg ttcctgactt
      301 cgaaacgcta ttctcacagg ttcagctctt catcagcact tgtaatgggg agcacattcg
      361 atatgcaaca gacacttttg ctgggctttg ccatcagcta acaaatgcac ttgtggaaag
      421 aaaacagtga caacataaga tccaatgtgc tgccatcttt gagaacttat ctgaaagaga
      481 tgtcatttct gacagcccct gcgaggaatt ggcatcctta agcaagccat agacaagatg
      541 cagatgaata caaaccagct gacctcaata catgctgatc tctgccagct ttgtttgcta
      601 gcaaaatgct ttaagcctgc ccttccatat cttgacgtgg atatgatgga tatctgtaaa
      661 gagaatggag cctatgatgc aaaacacttt ttatgttact attattatgg agggatgatc
      721 tatactgggc tgaagaactt tgaaagagct ctctactttt atgaacaggc tataactact
      781 cctgccatgg cggtcagtca tatcatgttg gaatcatata aaaagtatat tttagtgtct
      841 ttgatattac ttggcaaagt acaacagcta ccaaaatata catctcaaat tgtgggtaga
      901 ttcattaagc ctcttagcaa tgcataccac gagttagcac aagtgtattc aaccaacaac
      961 ccctcagaac tccgaaacct ggtgaataag cacagtgaaa ccttcactcg cgataacaac
     1021 atggggctgg tgaagcaatg cttgtcatct ctttataaga agaatattca gaggctaaca
     1081 aagacctttt taactctatc attacaagat atggcaagtc gtgtgcagtt gtctggacct
     1141 caggaggcag agaaatacgt tctgcacatg atagaagatg gtgagatttt tgcaagtatt
     1201 aaccagaagg acggtatggt cagtttccat gataaccctg aaaaatataa taacccagcc
     1261 atgcttcata acattgatca ggagatgctg aagtgcattg agctggatga gcggctgaaa
     1321 gccatggacc aggagatcac agtgaaccct cagtttgtac aaaagagtat gggctcacaa
     1381 gaagatgatt caggaaacaa accatccagt tattcttgaa actaacatcc atcctgagct
     1441 aaacaagaga aactaccatc ttggccagtg acaagtgttc ggagggcagc agagaggacc
     1501 aagcctgtgt cacctggaga ctaagaaatt aagttttgtt ttgacatctt cagtcctgtg
     1561 tgctttcaga aaaccatttt ctctgcaaag aaaggaaaca gatttgcaaa ctttaaagtc
     1621 tgtcgtggat ttatttatcc tcagattatt gttactgcat taaatctacc tttttgtttt
     1681 aagttgcttg aacattaatg tgtcttctgt atcacttttt tctcctctga agtttttaat
     1741 aagcacattc attgtgaaca gaaatagctg gattttagga atttttggaa gatttggatc
     1801 tgaaaggttt ttatttattg acaaatttgt atctacaaaa aaatctaaaa gttgtaatca
     1861 ttgtcttcag aaaataaaag aaaagaaagg ccagacagac a
//
