LOCUS       NM_001199125            1818 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 3 (COPS3), transcript variant
            2, mRNA.
ACCESSION   NM_001199125
VERSION     NM_001199125.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Niu,J., Yan,T., Guo,W., Wang,W., Ren,T., Huang,Y., Zhao,Z., Yu,Y.,
            Chen,C., Huang,Q., Lou,J. and Guo,L.
  TITLE     The COPS3-FOXO3 positive feedback loop regulates autophagy to
            promote cisplatin resistance in osteosarcoma
  JOURNAL   Autophagy 19 (6), 1693-1710 (2023)
   PUBMED   36451342
  REMARK    GeneRIF: The COPS3-FOXO3 positive feedback loop regulates autophagy
            to promote cisplatin resistance in osteosarcoma.
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1818)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1818)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1818)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1818)
  AUTHORS   Liu,W., Nichols,A.F., Graham,J.A., Dualan,R., Abbas,A. and Linn,S.
  TITLE     Nuclear transport of human DDB protein induced by ultraviolet light
  JOURNAL   J Biol Chem 275 (28), 21429-21434 (2000)
   PUBMED   10777491
REFERENCE   7  (bases 1 to 1818)
  AUTHORS   Bianchi,E., Denti,S., Granata,A., Bossi,G., Geginat,J., Villa,A.,
            Rogge,L. and Pardi,R.
  TITLE     Integrin LFA-1 interacts with the transcriptional co-activator JAB1
            to modulate AP-1 activity
  JOURNAL   Nature 404 (6778), 617-621 (2000)
   PUBMED   10766246
REFERENCE   8  (bases 1 to 1818)
  AUTHORS   Potocki,L., Chen,K.S. and Lupski,J.R.
  TITLE     Subunit 3 of the COP9 signal transduction complex is conserved from
            plants to humans and maps within the smith-magenis syndrome
            critical region in 17p11.2
  JOURNAL   Genomics 57 (1), 180-182 (1999)
   PUBMED   10191102
REFERENCE   9  (bases 1 to 1818)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1818)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK302304.1, AC055811.20 and
            BU952436.1.
            
            Summary: The protein encoded by this gene possesses kinase activity
            that phosphorylates regulators involved in signal transduction. It
            phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a
            docking site for complex-mediated phosphorylation. The gene is
            located within the Smith-Magenis syndrome region on chromosome 17.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302304.1, AK316400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               AK302304.1         1-642
            643-643             AC055811.20        127265-127265       c
            644-1613            AK302304.1         644-1613
            1614-1818           BU952436.1         1-205               c
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1818
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="COP9 signalosome subunit 3"
                     /db_xref="GeneID:8533"
                     /db_xref="HGNC:HGNC:2239"
                     /db_xref="MIM:604665"
     exon            1..125
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            126..255
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1342
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="isoform 2 is encoded by transcript variant 2; COP9
                     complex subunit 3; JAB1-containing signalosome subunit 3;
                     COP9 signalosome complex subunit 3; COP9 constitutive
                     photomorphogenic homolog subunit 3"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 3 isoform 2"
                     /protein_id="NP_001186054.1"
                     /db_xref="CCDS:CCDS56022.1"
                     /db_xref="GeneID:8533"
                     /db_xref="HGNC:HGNC:2239"
                     /db_xref="MIM:604665"
                     /translation="MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFV
                     KFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIG
                     ILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKH
                     FLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKV
                     QQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVK
                     QCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQK
                     DGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQE
                     DDSGNKPSSYS"
     exon            256..368
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..418
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..511
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..691
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..832
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1006
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1093
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1207
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1288
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1816
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1582..1587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="hexamer: ATTAAA"
     polyA_site      1605
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /note="major polyA site"
     polyA_site      1807
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
ORIGIN      
        1 gagtccgttc tgggtgtctt ggctctatgg ctcgcctctg ccagctcctc cgctgccagg
       61 cggcgcacgc tcgggaacct gtgcgcctat tttggtccta cagaatgctg cggaagctct
      121 cgctcggcaa atgacacagc tttgtgaact gatcaacaag agtggggaac tccttgcgaa
      181 gaacttatcc catctggaca ctgtgctcgg ggctctggat gtacaagaac actccttggg
      241 cgtccttgct gttttgtttg tgaagttttc tatgcccagt gttcctgact tcgaaacgct
      301 attctcacag gttcagctct tcatcagcac ttgtaatggg gagcacattc gatatgcaac
      361 agacactttt gctgggcttt gccatcagct aacaaatgca cttgtggaaa gaaaacagcc
      421 cctgcgagga attggcatcc ttaagcaagc catagacaag atgcagatga atacaaacca
      481 gctgacctca atacatgctg atctctgcca gctttgtttg ctagcaaaat gctttaagcc
      541 tgcccttcca tatcttgacg tggatatgat ggatatctgt aaagagaatg gagcctatga
      601 tgcaaaacac tttttatgtt actattatta tggagggatg atctatactg ggctgaagaa
      661 ctttgaaaga gctctctact tttatgaaca ggctataact actcctgcca tggcggtcag
      721 tcatatcatg ttggaatcat ataaaaagta tattttagtg tctttgatat tacttggcaa
      781 agtacaacag ctaccaaaat atacatctca aattgtgggt agattcatta agcctcttag
      841 caatgcatac cacgagttag cacaagtgta ttcaaccaac aacccctcag aactccgaaa
      901 cctggtgaat aagcacagtg aaaccttcac tcgcgataac aacatggggc tggtgaagca
      961 atgcttgtca tctctttata agaagaatat tcagaggcta acaaagacct ttttaactct
     1021 atcattacaa gatatggcaa gtcgtgtgca gttgtctgga cctcaggagg cagagaaata
     1081 cgttctgcac atgatagaag atggtgagat ttttgcaagt attaaccaga aggacggtat
     1141 ggtcagtttc catgataacc ctgaaaaata taataaccca gccatgcttc ataacattga
     1201 tcaggagatg ctgaagtgca ttgagctgga tgagcggctg aaagccatgg accaggagat
     1261 cacagtgaac cctcagtttg tacaaaagag tatgggctca caagaagatg attcaggaaa
     1321 caaaccatcc agttattctt gaaactaaca tccatcctga gctaaacaag agaaactacc
     1381 atcttggcca gtgacaagtg ttcggagggc agcagagagg accaagcctg tgtcacctgg
     1441 agactaagaa attaagtttt gttttgacat cttcagtcct gtgtgctttc agaaaaccat
     1501 tttctctgca aagaaaggaa acagatttgc aaactttaaa gtctgtcgtg gatttattta
     1561 tcctcagatt attgttactg cattaaatct acctttttgt tttaagttgc ttgaacatta
     1621 atgtgtcttc tgtatcactt ttttctcctc tgaagttttt aataagcaca ttcattgtga
     1681 acagaaatag ctggatttta ggaatttttg gaagatttgg atctgaaagg tttttattta
     1741 ttgacaaatt tgtatctaca aaaaaatcta aaagttgtaa tcattgtctt cagaaaataa
     1801 aagaaaagaa aggccaaa
//
