LOCUS       NM_004236               6576 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 2 (COPS2), transcript variant
            1, mRNA.
ACCESSION   NM_004236
VERSION     NM_004236.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6576)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6576)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6576)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6576)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6576)
  AUTHORS   Zhang,M., Li,L., Xie,W., Wu,J.F., Yao,F., Tan,Y.L., Xia,X.D.,
            Liu,X.Y., Liu,D., Lan,G., Zeng,M.Y., Gong,D., Cheng,H.P., Huang,C.,
            Zhao,Z.W., Zheng,X.L. and Tang,C.K.
  TITLE     Apolipoprotein A-1 binding protein promotes macrophage cholesterol
            efflux by facilitating apolipoprotein A-1 binding to ABCA1 and
            preventing ABCA1 degradation
  JOURNAL   Atherosclerosis 248, 149-159 (2016)
   PUBMED   27017521
  REMARK    GeneRIF: AIBP promotes apoA-1 binding to ABCA1 on the cell membrane
            of macrophages and prevents ABCA1 protein from CSN2-mediated
            degradation so as to prevent foam cell formation
REFERENCE   6  (bases 1 to 6576)
  AUTHORS   Dressel,U., Thormeyer,D., Altincicek,B., Paululat,A., Eggert,M.,
            Schneider,S., Tenbaum,S.P., Renkawitz,R. and Baniahmad,A.
  TITLE     Alien, a highly conserved protein with characteristics of a
            corepressor for members of the nuclear hormone receptor superfamily
  JOURNAL   Mol Cell Biol 19 (5), 3383-3394 (1999)
   PUBMED   10207062
REFERENCE   7  (bases 1 to 6576)
  AUTHORS   Schaefer,L., Beermann,M.L. and Miller,J.B.
  TITLE     Coding sequence, genomic organization, chromosomal localization,
            and expression pattern of the signalosome component Cops2: the
            mouse homologue of Drosophila alien
  JOURNAL   Genomics 56 (3), 310-316 (1999)
   PUBMED   10087198
REFERENCE   8  (bases 1 to 6576)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   9  (bases 1 to 6576)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   10 (bases 1 to 6576)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB059510.1, BC012629.1, CN287009.1, BX648602.1, CN281648.1,
            BM667648.1 and AC013452.9.
            
            On Nov 22, 2018 this sequence version replaced NM_004236.3.
            
            Transcript Variant: This variant (1) has an exon with an
            alternative splice acceptor site in the 5' coding region, compared
            to variant 2, which results in a shorter protein (isoform 1),
            compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222590.1, BC012629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388901.10/ ENSP00000373553.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB059510.1         63-71
            10-1830             BC012629.1         5-1825
            1831-1932           CN287009.1         169-270
            1933-2719           BX648602.1         293-1079
            2720-2720           CN281648.1         453-453
            2721-3953           BX648602.1         1081-2313
            3954-4029           BM667648.1         17-92               c
            4030-6576           AC013452.9         85331-87877         c
FEATURES             Location/Qualifiers
     source          1..6576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..6576
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="COP9 signalosome subunit 2"
                     /db_xref="GeneID:9318"
                     /db_xref="HGNC:HGNC:30747"
                     /db_xref="MIM:604508"
     exon            1..75
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1353
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="isoform 1 is encoded by transcript variant 1; COP9
                     signalosome complex subunit 2; JAB1-containing signalosome
                     subunit 2; TRIP-15; alien homolog; TR-interacting protein
                     15; thyroid receptor-interacting protein 15; COP9
                     constitutive photomorphogenic homolog subunit 2"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 2 isoform 1"
                     /protein_id="NP_004227.1"
                     /db_xref="CCDS:CCDS32235.1"
                     /db_xref="GeneID:9318"
                     /db_xref="HGNC:HGNC:30747"
                     /db_xref="MIM:604508"
                     /translation="MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKE
                     DDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSA
                     VTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYL
                     EREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALY
                     EQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTC
                     LKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNH
                     SNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQC
                     ILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA"
     exon            76..189
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            190..267
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            268..393
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            394..483
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            484..561
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            562..736
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            737..915
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            916..968
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1066
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1149
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1208
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..6576
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1932..1937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: AATAAA"
     polyA_site      1958
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="major polyA site"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: AATAAA"
     polyA_site      3273
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     regulatory      3805..3810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: ATTAAA"
     polyA_site      3834
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     regulatory      3990..3995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: ATTAAA"
     regulatory      4003..4008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: ATTAAA"
     polyA_site      4023
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     polyA_site      4029
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     regulatory      6557..6562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: AATAAA"
     polyA_site      6576
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
ORIGIN      
        1 ctcctccccc tcccggccaa gatgtctgac atggaggatg atttcatgtg cgatgatgag
       61 gaggactacg acctggaata ctctgaagat agtaactccg agccaaatgt ggatttggaa
      121 aatcagtact ataattccaa agcattaaaa gaagatgacc caaaagcggc attaagcagt
      181 ttccaaaagg ttttggaact tgaaggtgaa aaaggagaat ggggatttaa agcactgaaa
      241 caaatgatta agattaactt caagttgaca aactttccag aaatgatgaa tagatataag
      301 cagctattga cctatattcg gagtgcagtc acaagaaatt attctgaaaa atccattaat
      361 tctattcttg attatatctc tacttctaaa cagatggatt tactgcagga attctatgaa
      421 acaacactgg aagctttgaa agatgctaag aatgatagac tgtggtttaa gacaaacaca
      481 aagcttggaa aattatattt agaacgagag gaatatggaa agcttcaaaa aattttacgc
      541 cagttacatc agtcgtgcca gactgatgat ggagaagatg atctgaaaaa aggtacacag
      601 ttattagaaa tatatgcttt ggaaattcaa atgtacacag cacagaaaaa taacaaaaaa
      661 cttaaagcac tctatgaaca gtcacttcac atcaagtctg ccatccctca tccactgatt
      721 atgggagtta tcagagaatg tggtggtaaa atgcacttga gggaaggtga atttgaaaag
      781 gcacacactg atttttttga agccttcaag aattatgatg aatctggaag tccaagacga
      841 accacttgct taaaatattt ggtcttagca aatatgctta tgaaatcggg aataaatcca
      901 tttgactcac aggaggccaa gccgtacaaa aatgatccag aaattttagc aatgacgaat
      961 ttagtaagtg cctatcagaa taatgacatc actgaatttg aaaagattct aaaaacaaat
     1021 cacagcaaca tcatggatga tcctttcata agagaacaca ttgaagagct tttgcgaaac
     1081 atcagaacac aagtgcttat aaaattaatt aagccttaca caagaataca tattcctttt
     1141 atttctaagg agttaaacat agatgtagct gatgtggaga gcttgctggt gcagtgcata
     1201 ttggataaca ctattcatgg ccgaattgat caagtcaacc aactccttga actggatcat
     1261 cagaagaggg gtggtgcacg atatactgca ctagataaat ggaccaacca actaaattct
     1321 ctcaaccagg ctgtagtcag taaactggct taacagagaa caagctttta cagacgtcct
     1381 taaggcaaca gtgcagagat gtaatcctta aaagaactgg gaatggcaaa actactgtcg
     1441 gttgatgtgt cctgaaaatt attggagtta tggcagaagt gcttttttga tcaactggtt
     1501 tgtgttttgc tgctgcattt atcccaagaa aaacagcttt aatctccaga agaaaaccaa
     1561 aataccatgg gatttatgct gtattgacat cttgccctaa acgtacaaca tcatagtaat
     1621 ttgtcatggg caacatgacc agagagaaga tttttgtcat gattttaaat acactgacac
     1681 gctactgttg gttaaattta aacatgtttt acctgcagaa attctctcac aaataacctg
     1741 caataacttg aaatgcatac ccttttgaac acttcctttt ctcatgtata aattaaaatg
     1801 tttgctgcat tttgcaaaat gtcaattctc taaaaatgtg tccgtatatt tctgtacctg
     1861 cagtgtagta aaggtttaga cgaaacccca taattatagt ggcatactgt cacttaggtt
     1921 tcaagcagca aaataaacag tgcagctcag aaattgtagt ttggttcttg atgtgttttt
     1981 attacatttg gagttgtttt gttttttagt accttcgaaa tttcaaatta ttttatcttc
     2041 agttaatgat tttaaaaagc ctgggggcaa ataagttggt tatttgcttt caagttttta
     2101 aaagtagtct ttattgatag agtaaggaga actactttct aacaaaacac gtgcatagtt
     2161 atgacagtga tgctttaaag gaataaaatt cttttttttt aaagagtgat attccttttc
     2221 aaaagaatac taactctcag aatgttcact ttaaacgaat atgccagaac atagacagct
     2281 aaatgaatgt tactctgcat agtgatcatg ctggaaggtt atttcctaat gccagcaatc
     2341 taccattgcc caaaacctgc tgagtttact cttttagaat tgcattcaaa gttaatttgt
     2401 cacacacact aaactttatg attatacatt gttttaaaaa atatagtatt aggaagcttg
     2461 attattttta gttaccatta cttggcacca aatgaaagtt tccaaaactt ccacctaact
     2521 ttgaggtaat gcagaaagta tataactggc tttgaaggca atcccaaaag agttttaaag
     2581 gttttttgag cagtggcagt atacttagga gaatgaactg tggccttcca aggtaactac
     2641 cttaaaggaa ctcagctcat ttgaatgtat tgagttttgg atgtatttgt ttcatttttt
     2701 aaaaagttca cattatttta tagtgtcgaa aggaagaact aggattaaca taatttcttt
     2761 ggtttttcta ttgcttgtta ttattatgta aaaactgggt ggcagttcag aaggaagatt
     2821 gtggttacag aagagtgaca accaagaatt ttttgatcat taaatcagat tttataaaca
     2881 gtggaaggag catggactta aaacaaggca tgcttattcg gttttgtcaa aattttacga
     2941 aaatatgtga tatatattta tactaaaaat atataatcct tagatttaga aaagcaatca
     3001 gttaatgtct ttagcagact aaagcagtat taaacacagg tacaagttgg aaattgtaga
     3061 aaacggaaag aaaacaaaag acaaaatgtc tatggtaggg aataaaagtt taagatatta
     3121 taaaattatg tgtattttct cttttacata aatcatttgt gaaaagtgtg ctaaactttt
     3181 tttacaagag tgatattaat taggatttat ttttcaatat aatttggaga ccctttgtta
     3241 tccaaataaa aatgatgagt ttttgtgcct gtattcaaat atgtatgcat gtgataaccc
     3301 ttgaaagcta aagcccttct taacttttga gttgatggaa ttagaattca aagatttgaa
     3361 tgaaatgatt taacctttat cctccaattc ttacagtgcc cagttctcct gtgctatctt
     3421 tgctttgtac aatagtgcat cttccacttt ctagagagaa agcatgcact tgttatttgg
     3481 aaaactgggc taaatatata acagtatcca aagttatacc ataataattt attgtaattg
     3541 tgtattacat agctttgttt acccagatat aggtgcgttc ttttttttct gttagtcatc
     3601 tgtgactttt gttctggaat acaggttttt aaatatatct taacagtctg actaacttaa
     3661 aataatttat tcttccctta aaacattttt ctgtgttttt gtgcatcaaa tattgtagag
     3721 ttgaaatctt agagattgct tatcgaaata taaatttagg ggaagttaaa aatcgattgg
     3781 caaatttgta gcatttattc actgattaaa tcttttccac ttttgtgaaa accataccag
     3841 tggtttacat catattgtaa tgtgttcatc tcattcttct ttttatccct aaacctagct
     3901 aaaagttact gcaaagaaat ctttggctgc cacaagtaga tgctctctac tacaagagct
     3961 ggatttccat tactcactct tgctcttaca ttaaagttgt tgattaaata ctttttctct
     4021 acatcttaat gtaacataac tgatttcttt ttaaagatga gtatatatgt actaagtaat
     4081 gctctcatta catgagtccc ttctaactac aggctgatac atctttcagg aaaactgaga
     4141 acctaatatt taagtgaggc ctattttaaa tgagctatac tgtgggtggt agtgtttgtt
     4201 accttatgta agacttaggt ttgtcttaga ctgaaaaact cttattctta atatttaaaa
     4261 tatccatgat ggtagaaatt ttgtgggaaa ttttcttttt taatcaatag ttacagttct
     4321 tcagtaaaca caggtatgta tgcttttgtg gtgtcagtgt cagtctaaat ctatgggtga
     4381 agcagttagt ccataagaca aaaaattatt tgcctagtgg attcccttta cctcttttta
     4441 agaagctcag agatctgtaa tcattaattt actaaggatt ttttaaaata ttattttagt
     4501 cacttttaaa cctgaaaatt tctcttttga tttagatttt tgaagtgagg cttgagcata
     4561 cacaagtaaa gctgggagtt tcattcttca tatgggattt atgactaaat atttctagca
     4621 ttttgaagaa gataaacatt ttgaactgaa gtatataaca aaaaaaggaa tttgacattt
     4681 aactattttg tatcaaagtg tttaagaaca ctatccagaa caagagatgg agtatcaggt
     4741 ttcagaatgt gacgcaaaag gcatttggtc ttcatttatg tgaccacaat taaaattttc
     4801 ctcttttttt ctttttctgg aggttttctt ttagttttca ttgttttagg tttttttttc
     4861 ccccaaatca gcatcctatt tatatttgtt tgatacggtt tttttgtttt tgtttttgtt
     4921 ttgctttttt tggaaacagt ttcgctcttg tcacccaggc tggagtgcag tggcgcaatc
     4981 tcagttcact gccacctcca cctcccgggt tcaagcgatt ctcctgcctc aatctccgga
     5041 gtagctggga ttacagacac ccgccaccac gcccagctaa tttttgtgtt tttagtagag
     5101 acaagatttc accatgttgg ccaggctggt ctcaaactcc tgacctcagg cgatccaccg
     5161 ctttggcctc ccatagtgct gggattacag gcgtgagcca ccacgcccag cctgatacag
     5221 ttttaagcag gaatttggca gaaatttcgt aacgaagaca aattggaggt tctctttaac
     5281 tcgagattat taaatttata gtaacttctt gggccattaa aatgtgagtt taaatgccat
     5341 ttggaggatt tgtgttatat taagcaccac aaatttaaac tgtcaactag tgattctaca
     5401 tgtttctcaa aatgctaaag tttagcatca cttacttgct tttgaatttt aaggagattc
     5461 gtcttaggta atgtctcaga agaaaccagt gtgtggttct ctaaaatttt acttttttac
     5521 tgtcacgtat aataatatct aaactacctg tagtagttaa aaatattacg gcatcaaagg
     5581 tatatgccaa gtgtacctta aaaccctgtg acaggaaaaa agaaaaaatt atttcttaag
     5641 tacttactat tcgggggcaa ctttgttccg tgttggcaaa attatgaact ttgctcagaa
     5701 tttccacatg aatagctgac caaaactttt ttgtgtgcat atgtatacat atgtaataag
     5761 tgaaacatac ttgtgggagt acaaaattca tcaccagttt atcacagtaa ttttccagtt
     5821 ttctatttta cttaatatca cttatttctg acacaggcaa atgtcatatg ccatgaaaag
     5881 aattaccagt gtaccagtaa cttgcgtgtt atgactaggt ttcatgtgga agactgtcca
     5941 aatttacata atctagagta attttttaat tctgaagtaa gggcatttta aaattaattg
     6001 ctaaaggttg ttttattgta catccatttt atgggagttt agagtttaga aaaagtaatc
     6061 tctagcgtca tcccatgaag ttgtcaaaag ttttggcatg cttattagca acatattaat
     6121 gccaagtgtt gagtatctaa tttctgttca aatgtttgcc tatcccttac tgtttacgac
     6181 agtaataaat ttttatgcat ctattttaaa taacactgaa gaaaattaaa atatatttca
     6241 agaaatggag caatgacatg gaaaatagaa agttgtttgg ttttgcaatg tgttacataa
     6301 ttggttgcat tataaatttt ctccattttg tttatgataa gctaatataa aaggtatcaa
     6361 attccttgag ctaacactag gtgggaagga agtagtaggt gattaggaat gtaacaggat
     6421 gtctgcctga aatggtcagt tccaccaatt aataattgag aactgattat atgtgcagga
     6481 tgtgtcataa gatgctgtaa ggcttaaata ctcaagggtt tttttattta tctggaagtg
     6541 cacattcctt attggtaata aaaaatacgt aatcta
//
