LOCUS       NP_004227                443 aa            linear   PRI 27-APR-2025
DEFINITION  COP9 signalosome complex subunit 2 isoform 1 [Homo sapiens].
ACCESSION   NP_004227
VERSION     NP_004227.1
DBSOURCE    REFSEQ: accession NM_004236.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 443)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 443)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 443)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 443)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 443)
  AUTHORS   Zhang,M., Li,L., Xie,W., Wu,J.F., Yao,F., Tan,Y.L., Xia,X.D.,
            Liu,X.Y., Liu,D., Lan,G., Zeng,M.Y., Gong,D., Cheng,H.P., Huang,C.,
            Zhao,Z.W., Zheng,X.L. and Tang,C.K.
  TITLE     Apolipoprotein A-1 binding protein promotes macrophage cholesterol
            efflux by facilitating apolipoprotein A-1 binding to ABCA1 and
            preventing ABCA1 degradation
  JOURNAL   Atherosclerosis 248, 149-159 (2016)
   PUBMED   27017521
  REMARK    GeneRIF: AIBP promotes apoA-1 binding to ABCA1 on the cell membrane
            of macrophages and prevents ABCA1 protein from CSN2-mediated
            degradation so as to prevent foam cell formation
REFERENCE   6  (residues 1 to 443)
  AUTHORS   Dressel,U., Thormeyer,D., Altincicek,B., Paululat,A., Eggert,M.,
            Schneider,S., Tenbaum,S.P., Renkawitz,R. and Baniahmad,A.
  TITLE     Alien, a highly conserved protein with characteristics of a
            corepressor for members of the nuclear hormone receptor superfamily
  JOURNAL   Mol Cell Biol 19 (5), 3383-3394 (1999)
   PUBMED   10207062
REFERENCE   7  (residues 1 to 443)
  AUTHORS   Schaefer,L., Beermann,M.L. and Miller,J.B.
  TITLE     Coding sequence, genomic organization, chromosomal localization,
            and expression pattern of the signalosome component Cops2: the
            mouse homologue of Drosophila alien
  JOURNAL   Genomics 56 (3), 310-316 (1999)
   PUBMED   10087198
REFERENCE   8  (residues 1 to 443)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   9  (residues 1 to 443)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   10 (residues 1 to 443)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB059510.1, BC012629.1, CN287009.1, BX648602.1, CN281648.1,
            BM667648.1 and AC013452.9.
            
            Transcript Variant: This variant (1) has an exon with an
            alternative splice acceptor site in the 5' coding region, compared
            to variant 2, which results in a shorter protein (isoform 1),
            compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222590.1, BC012629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388901.10/ ENSP00000373553.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     Protein         1..443
                     /product="COP9 signalosome complex subunit 2 isoform 1"
                     /note="COP9 signalosome complex subunit 2; JAB1-containing
                     signalosome subunit 2; TRIP-15; alien homolog;
                     TR-interacting protein 15; thyroid receptor-interacting
                     protein 15; COP9 constitutive photomorphogenic homolog
                     subunit 2"
                     /calculated_mol_wt=51466
     Region          1..275
                     /region_name="Mediates interaction with NIF3L1.
                     /evidence=ECO:0000250|UniProtKB:P61203"
                     /note="propagated from UniProtKB/Swiss-Prot (P61201.1)"
     Region          40..434
                     /region_name="RPN6"
                     /note="26S proteasome regulatory complex component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5159"
                     /db_xref="CDD:227488"
     Region          309..413
                     /region_name="PCI"
                     /note="PCI domain; pfam01399"
                     /db_xref="CDD:460195"
     CDS             1..443
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /coded_by="NM_004236.4:22..1353"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS32235.1"
                     /db_xref="GeneID:9318"
                     /db_xref="HGNC:HGNC:30747"
                     /db_xref="MIM:604508"
ORIGIN      
        1 msdmeddfmc ddeedydley sedsnsepnv dlenqyynsk alkeddpkaa lssfqkvlel
       61 egekgewgfk alkqmikinf kltnfpemmn rykqlltyir savtrnysek sinsildyis
      121 tskqmdllqe fyettlealk dakndrlwfk tntklgklyl ereeygklqk ilrqlhqscq
      181 tddgeddlkk gtqlleiyal eiqmytaqkn nkklkalyeq slhiksaiph plimgvirec
      241 ggkmhlrege fekahtdffe afknydesgs prrttclkyl vlanmlmksg inpfdsqeak
      301 pykndpeila mtnlvsayqn nditefekil ktnhsnimdd pfirehieel lrnirtqvli
      361 klikpytrih ipfiskelni dvadvesllv qcildntihg ridqvnqlle ldhqkrggar
      421 ytaldkwtnq lnslnqavvs kla
//
