LOCUS       NM_001143887            6597 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens COP9 signalosome subunit 2 (COPS2), transcript variant
            2, mRNA.
ACCESSION   NM_001143887
VERSION     NM_001143887.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6597)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6597)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6597)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6597)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6597)
  AUTHORS   Zhang,M., Li,L., Xie,W., Wu,J.F., Yao,F., Tan,Y.L., Xia,X.D.,
            Liu,X.Y., Liu,D., Lan,G., Zeng,M.Y., Gong,D., Cheng,H.P., Huang,C.,
            Zhao,Z.W., Zheng,X.L. and Tang,C.K.
  TITLE     Apolipoprotein A-1 binding protein promotes macrophage cholesterol
            efflux by facilitating apolipoprotein A-1 binding to ABCA1 and
            preventing ABCA1 degradation
  JOURNAL   Atherosclerosis 248, 149-159 (2016)
   PUBMED   27017521
  REMARK    GeneRIF: AIBP promotes apoA-1 binding to ABCA1 on the cell membrane
            of macrophages and prevents ABCA1 protein from CSN2-mediated
            degradation so as to prevent foam cell formation
REFERENCE   6  (bases 1 to 6597)
  AUTHORS   Dressel,U., Thormeyer,D., Altincicek,B., Paululat,A., Eggert,M.,
            Schneider,S., Tenbaum,S.P., Renkawitz,R. and Baniahmad,A.
  TITLE     Alien, a highly conserved protein with characteristics of a
            corepressor for members of the nuclear hormone receptor superfamily
  JOURNAL   Mol Cell Biol 19 (5), 3383-3394 (1999)
   PUBMED   10207062
REFERENCE   7  (bases 1 to 6597)
  AUTHORS   Schaefer,L., Beermann,M.L. and Miller,J.B.
  TITLE     Coding sequence, genomic organization, chromosomal localization,
            and expression pattern of the signalosome component Cops2: the
            mouse homologue of Drosophila alien
  JOURNAL   Genomics 56 (3), 310-316 (1999)
   PUBMED   10087198
REFERENCE   8  (bases 1 to 6597)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   9  (bases 1 to 6597)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
REFERENCE   10 (bases 1 to 6597)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB059510.1, AB209799.1, BX648602.1, CN281648.1, BM667648.1 and
            AC013452.9.
            
            On May 31, 2019 this sequence version replaced NM_001143887.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.14374.1,
                                           SRR1803616.197929.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB059510.1         63-78
            17-1971             AB209799.1         1-1955
            1972-2740           BX648602.1         311-1079
            2741-2741           CN281648.1         453-453
            2742-3974           BX648602.1         1081-2313
            3975-4050           BM667648.1         17-92               c
            4051-6597           AC013452.9         85331-87877         c
FEATURES             Location/Qualifiers
     source          1..6597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..6597
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="COP9 signalosome subunit 2"
                     /db_xref="GeneID:9318"
                     /db_xref="HGNC:HGNC:30747"
                     /db_xref="MIM:604508"
     exon            1..75
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1374
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="isoform 2 is encoded by transcript variant 2; COP9
                     signalosome complex subunit 2; JAB1-containing signalosome
                     subunit 2; TRIP-15; alien homolog; TR-interacting protein
                     15; thyroid receptor-interacting protein 15; COP9
                     constitutive photomorphogenic homolog subunit 2"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 2 isoform 2"
                     /protein_id="NP_001137359.1"
                     /db_xref="CCDS:CCDS45257.1"
                     /db_xref="GeneID:9318"
                     /db_xref="HGNC:HGNC:30747"
                     /db_xref="MIM:604508"
                     /translation="MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKE
                     DDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSA
                     VTRNYSEKSINSILDYISTSKQNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNT
                     KLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNN
                     KKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESG
                     SPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFE
                     KILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADV
                     ESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
                     "
     exon            76..189
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            190..267
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            268..393
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            394..504
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            505..582
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            583..757
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            758..936
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            937..989
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1087
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1170
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1229
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..6597
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1953..1958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: AATAAA"
     polyA_site      1979
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="major polyA site"
     regulatory      3266..3271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: AATAAA"
     polyA_site      3294
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: ATTAAA"
     polyA_site      3855
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     regulatory      4011..4016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: ATTAAA"
     regulatory      4024..4029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: ATTAAA"
     polyA_site      4044
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     polyA_site      4050
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
     regulatory      6578..6583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
                     /note="hexamer: AATAAA"
     polyA_site      6597
                     /gene="COPS2"
                     /gene_synonym="ALIEN; CSN2; SGN2; TRIP15"
ORIGIN      
        1 ctcctccccc tcccggccaa gatgtctgac atggaggatg atttcatgtg cgatgatgag
       61 gaggactacg acctggaata ctctgaagat agtaactccg agccaaatgt ggatttggaa
      121 aatcagtact ataattccaa agcattaaaa gaagatgacc caaaagcggc attaagcagt
      181 ttccaaaagg ttttggaact tgaaggtgaa aaaggagaat ggggatttaa agcactgaaa
      241 caaatgatta agattaactt caagttgaca aactttccag aaatgatgaa tagatataag
      301 cagctattga cctatattcg gagtgcagtc acaagaaatt attctgaaaa atccattaat
      361 tctattcttg attatatctc tacttctaaa cagaattctg attttttatg tcagatggat
      421 ttactgcagg aattctatga aacaacactg gaagctttga aagatgctaa gaatgataga
      481 ctgtggttta agacaaacac aaagcttgga aaattatatt tagaacgaga ggaatatgga
      541 aagcttcaaa aaattttacg ccagttacat cagtcgtgcc agactgatga tggagaagat
      601 gatctgaaaa aaggtacaca gttattagaa atatatgctt tggaaattca aatgtacaca
      661 gcacagaaaa ataacaaaaa acttaaagca ctctatgaac agtcacttca catcaagtct
      721 gccatccctc atccactgat tatgggagtt atcagagaat gtggtggtaa aatgcacttg
      781 agggaaggtg aatttgaaaa ggcacacact gatttttttg aagccttcaa gaattatgat
      841 gaatctggaa gtccaagacg aaccacttgc ttaaaatatt tggtcttagc aaatatgctt
      901 atgaaatcgg gaataaatcc atttgactca caggaggcca agccgtacaa aaatgatcca
      961 gaaattttag caatgacgaa tttagtaagt gcctatcaga ataatgacat cactgaattt
     1021 gaaaagattc taaaaacaaa tcacagcaac atcatggatg atcctttcat aagagaacac
     1081 attgaagagc ttttgcgaaa catcagaaca caagtgctta taaaattaat taagccttac
     1141 acaagaatac atattccttt tatttctaag gagttaaaca tagatgtagc tgatgtggag
     1201 agcttgctgg tgcagtgcat attggataac actattcatg gccgaattga tcaagtcaac
     1261 caactccttg aactggatca tcagaagagg ggtggtgcac gatatactgc actagataaa
     1321 tggaccaacc aactaaattc tctcaaccag gctgtagtca gtaaactggc ttaacagaga
     1381 acaagctttt acagacgtcc ttaaggcaac agtgcagaga tgtaatcctt aaaagaactg
     1441 ggaatggcaa aactactgtc ggttgatgtg tcctgaaaat tattggagtt atggcagaag
     1501 tgcttttttg atcaactggt ttgtgttttg ctgctgcatt tatcccaaga aaaacagctt
     1561 taatctccag aagaaaacca aaataccatg ggatttatgc tgtattgaca tcttgcccta
     1621 aacgtacaac atcatagtaa tttgtcatgg gcaacatgac cagagagaag atttttgtca
     1681 tgattttaaa tacactgaca cgctactgtt ggttaaattt aaacatgttt tacctgcaga
     1741 aattctctca caaataacct gcaataactt gaaatgcata cccttttgaa cacttccttt
     1801 tctcatgtat aaattaaaat gtttgctgca ttttgcaaaa tgtcaattct ctaaaaatgt
     1861 gtccgtatat ttctgtacct gcagtgtagt aaaggtttag acgaaacccc ataattatag
     1921 tggcatactg tcacttaggt ttcaagcagc aaaataaaca gtgcagctca gaaattgtag
     1981 tttggttctt gatgtgtttt tattacattt ggagttgttt tgttttttag taccttcgaa
     2041 atttcaaatt attttatctt cagttaatga ttttaaaaag cctgggggca aataagttgg
     2101 ttatttgctt tcaagttttt aaaagtagtc tttattgata gagtaaggag aactactttc
     2161 taacaaaaca cgtgcatagt tatgacagtg atgctttaaa ggaataaaat tctttttttt
     2221 taaagagtga tattcctttt caaaagaata ctaactctca gaatgttcac tttaaacgaa
     2281 tatgccagaa catagacagc taaatgaatg ttactctgca tagtgatcat gctggaaggt
     2341 tatttcctaa tgccagcaat ctaccattgc ccaaaacctg ctgagtttac tcttttagaa
     2401 ttgcattcaa agttaatttg tcacacacac taaactttat gattatacat tgttttaaaa
     2461 aatatagtat taggaagctt gattattttt agttaccatt acttggcacc aaatgaaagt
     2521 ttccaaaact tccacctaac tttgaggtaa tgcagaaagt atataactgg ctttgaaggc
     2581 aatcccaaaa gagttttaaa ggttttttga gcagtggcag tatacttagg agaatgaact
     2641 gtggccttcc aaggtaacta ccttaaagga actcagctca tttgaatgta ttgagttttg
     2701 gatgtatttg tttcattttt taaaaagttc acattatttt atagtgtcga aaggaagaac
     2761 taggattaac ataatttctt tggtttttct attgcttgtt attattatgt aaaaactggg
     2821 tggcagttca gaaggaagat tgtggttaca gaagagtgac aaccaagaat tttttgatca
     2881 ttaaatcaga ttttataaac agtggaagga gcatggactt aaaacaaggc atgcttattc
     2941 ggttttgtca aaattttacg aaaatatgtg atatatattt atactaaaaa tatataatcc
     3001 ttagatttag aaaagcaatc agttaatgtc tttagcagac taaagcagta ttaaacacag
     3061 gtacaagttg gaaattgtag aaaacggaaa gaaaacaaaa gacaaaatgt ctatggtagg
     3121 gaataaaagt ttaagatatt ataaaattat gtgtattttc tcttttacat aaatcatttg
     3181 tgaaaagtgt gctaaacttt ttttacaaga gtgatattaa ttaggattta tttttcaata
     3241 taatttggag accctttgtt atccaaataa aaatgatgag tttttgtgcc tgtattcaaa
     3301 tatgtatgca tgtgataacc cttgaaagct aaagcccttc ttaacttttg agttgatgga
     3361 attagaattc aaagatttga atgaaatgat ttaaccttta tcctccaatt cttacagtgc
     3421 ccagttctcc tgtgctatct ttgctttgta caatagtgca tcttccactt tctagagaga
     3481 aagcatgcac ttgttatttg gaaaactggg ctaaatatat aacagtatcc aaagttatac
     3541 cataataatt tattgtaatt gtgtattaca tagctttgtt tacccagata taggtgcgtt
     3601 cttttttttc tgttagtcat ctgtgacttt tgttctggaa tacaggtttt taaatatatc
     3661 ttaacagtct gactaactta aaataattta ttcttccctt aaaacatttt tctgtgtttt
     3721 tgtgcatcaa atattgtaga gttgaaatct tagagattgc ttatcgaaat ataaatttag
     3781 gggaagttaa aaatcgattg gcaaatttgt agcatttatt cactgattaa atcttttcca
     3841 cttttgtgaa aaccatacca gtggtttaca tcatattgta atgtgttcat ctcattcttc
     3901 tttttatccc taaacctagc taaaagttac tgcaaagaaa tctttggctg ccacaagtag
     3961 atgctctcta ctacaagagc tggatttcca ttactcactc ttgctcttac attaaagttg
     4021 ttgattaaat actttttctc tacatcttaa tgtaacataa ctgatttctt tttaaagatg
     4081 agtatatatg tactaagtaa tgctctcatt acatgagtcc cttctaacta caggctgata
     4141 catctttcag gaaaactgag aacctaatat ttaagtgagg cctattttaa atgagctata
     4201 ctgtgggtgg tagtgtttgt taccttatgt aagacttagg tttgtcttag actgaaaaac
     4261 tcttattctt aatatttaaa atatccatga tggtagaaat tttgtgggaa attttctttt
     4321 ttaatcaata gttacagttc ttcagtaaac acaggtatgt atgcttttgt ggtgtcagtg
     4381 tcagtctaaa tctatgggtg aagcagttag tccataagac aaaaaattat ttgcctagtg
     4441 gattcccttt acctcttttt aagaagctca gagatctgta atcattaatt tactaaggat
     4501 tttttaaaat attattttag tcacttttaa acctgaaaat ttctcttttg atttagattt
     4561 ttgaagtgag gcttgagcat acacaagtaa agctgggagt ttcattcttc atatgggatt
     4621 tatgactaaa tatttctagc attttgaaga agataaacat tttgaactga agtatataac
     4681 aaaaaaagga atttgacatt taactatttt gtatcaaagt gtttaagaac actatccaga
     4741 acaagagatg gagtatcagg tttcagaatg tgacgcaaaa ggcatttggt cttcatttat
     4801 gtgaccacaa ttaaaatttt cctctttttt tctttttctg gaggttttct tttagttttc
     4861 attgttttag gttttttttt cccccaaatc agcatcctat ttatatttgt ttgatacggt
     4921 ttttttgttt ttgtttttgt tttgcttttt ttggaaacag tttcgctctt gtcacccagg
     4981 ctggagtgca gtggcgcaat ctcagttcac tgccacctcc acctcccggg ttcaagcgat
     5041 tctcctgcct caatctccgg agtagctggg attacagaca cccgccacca cgcccagcta
     5101 atttttgtgt ttttagtaga gacaagattt caccatgttg gccaggctgg tctcaaactc
     5161 ctgacctcag gcgatccacc gctttggcct cccatagtgc tgggattaca ggcgtgagcc
     5221 accacgccca gcctgataca gttttaagca ggaatttggc agaaatttcg taacgaagac
     5281 aaattggagg ttctctttaa ctcgagatta ttaaatttat agtaacttct tgggccatta
     5341 aaatgtgagt ttaaatgcca tttggaggat ttgtgttata ttaagcacca caaatttaaa
     5401 ctgtcaacta gtgattctac atgtttctca aaatgctaaa gtttagcatc acttacttgc
     5461 ttttgaattt taaggagatt cgtcttaggt aatgtctcag aagaaaccag tgtgtggttc
     5521 tctaaaattt tactttttta ctgtcacgta taataatatc taaactacct gtagtagtta
     5581 aaaatattac ggcatcaaag gtatatgcca agtgtacctt aaaaccctgt gacaggaaaa
     5641 aagaaaaaat tatttcttaa gtacttacta ttcgggggca actttgttcc gtgttggcaa
     5701 aattatgaac tttgctcaga atttccacat gaatagctga ccaaaacttt tttgtgtgca
     5761 tatgtataca tatgtaataa gtgaaacata cttgtgggag tacaaaattc atcaccagtt
     5821 tatcacagta attttccagt tttctatttt acttaatatc acttatttct gacacaggca
     5881 aatgtcatat gccatgaaaa gaattaccag tgtaccagta acttgcgtgt tatgactagg
     5941 tttcatgtgg aagactgtcc aaatttacat aatctagagt aattttttaa ttctgaagta
     6001 agggcatttt aaaattaatt gctaaaggtt gttttattgt acatccattt tatgggagtt
     6061 tagagtttag aaaaagtaat ctctagcgtc atcccatgaa gttgtcaaaa gttttggcat
     6121 gcttattagc aacatattaa tgccaagtgt tgagtatcta atttctgttc aaatgtttgc
     6181 ctatccctta ctgtttacga cagtaataaa tttttatgca tctattttaa ataacactga
     6241 agaaaattaa aatatatttc aagaaatgga gcaatgacat ggaaaataga aagttgtttg
     6301 gttttgcaat gtgttacata attggttgca ttataaattt tctccatttt gtttatgata
     6361 agctaatata aaaggtatca aattccttga gctaacacta ggtgggaagg aagtagtagg
     6421 tgattaggaa tgtaacagga tgtctgcctg aaatggtcag ttccaccaat taataattga
     6481 gaactgatta tatgtgcagg atgtgtcata agatgctgta aggcttaaat actcaagggt
     6541 ttttttattt atctggaagt gcacattcct tattggtaat aaaaaatacg taatcta
//
