LOCUS       NM_018405                868 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coordinator of PRMT5 and differentiation stimulator
            (COPRS), transcript variant 1, mRNA.
ACCESSION   NM_018405
VERSION     NM_018405.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 868)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 868)
  AUTHORS   Paul,C., Sardet,C. and Fabbrizio,E.
  TITLE     The histone- and PRMT5-associated protein COPR5 is required for
            myogenic differentiation
  JOURNAL   Cell Death Differ 19 (5), 900-908 (2012)
   PUBMED   22193545
REFERENCE   3  (bases 1 to 868)
  AUTHORS   Lacroix,M., El Messaoudi,S., Rodier,G., Le Cam,A., Sardet,C. and
            Fabbrizio,E.
  TITLE     The histone-binding protein COPR5 is required for nuclear functions
            of the protein arginine methyltransferase PRMT5
  JOURNAL   EMBO Rep 9 (5), 452-458 (2008)
   PUBMED   18404153
REFERENCE   4  (bases 1 to 868)
  AUTHORS   Douglas,J., Cilliers,D., Coleman,K., Tatton-Brown,K., Barker,K.,
            Bernhard,B., Burn,J., Huson,S., Josifova,D., Lacombe,D., Malik,M.,
            Mansour,S., Reid,E., Cormier-Daire,V., Cole,T. and Rahman,N.
  CONSRTM   Childhood Overgrowth Collaboration
  TITLE     Mutations in RNF135, a gene within the NF1 microdeletion region,
            cause phenotypic abnormalities including overgrowth
  JOURNAL   Nat Genet 39 (8), 963-965 (2007)
   PUBMED   17632510
REFERENCE   5  (bases 1 to 868)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 868)
  AUTHORS   Jenne,D.E., Tinschert,S., Stegmann,E., Reimann,H., Nurnberg,P.,
            Horn,D., Naumann,I., Buske,A. and Thiel,G.
  TITLE     A common set of at least 11 functional genes is lost in the
            majority of NF1 patients with gross deletions
  JOURNAL   Genomics 66 (1), 93-97 (2000)
   PUBMED   10843809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB472863.1, AF407672.1 and BQ671018.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018405.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.74258.1,
                                           SRR1163657.196388.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302362.11/ ENSP00000304327.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                DB472863.1         94-138
            46-600              AF407672.1         1-555
            601-868             BQ671018.1         154-421
FEATURES             Location/Qualifiers
     source          1..868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..868
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="coordinator of PRMT5 and differentiation
                     stimulator"
                     /db_xref="GeneID:55352"
                     /db_xref="HGNC:HGNC:28848"
     exon            1..144
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..600
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cooperator of PRMT5; coordinator of PRMT5, differentiation
                     stimulator"
                     /codon_start=1
                     /product="coordinator of PRMT5 and differentiation
                     stimulator isoform 1"
                     /protein_id="NP_060875.2"
                     /db_xref="CCDS:CCDS11268.1"
                     /db_xref="GeneID:55352"
                     /db_xref="HGNC:HGNC:28848"
                     /translation="MDLQAAGAQAQGAAEPSRGPPLPSARGAPPSPEAGFATADHSSQ
                     ERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMDEEDSDGELNTWELSEGTNC
                     PPKEQPGDLFNEDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWH
                     HPPPLIPYYSKMVFETGQFDDAED"
     exon            145..211
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..430
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..868
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      848..853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="hexamer: AATAAA"
     polyA_site      868
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="major polyA site"
ORIGIN      
        1 acgtggccca cggcgtccag ggcgaccagc cgcgggccgc agggcatgga ccttcaggcc
       61 gccggggccc aggcgcaggg ggccgcggag ccgtctcggg gcccgccgct gcctagcgcg
      121 cggggggcgc cccccagccc ggaggctggc tttgctacag ctgaccactc cagtcaggag
      181 agagagactg agaaggctat ggatcgacta gcccgtggaa cacagagcat tcctaatgac
      241 agtcctgccc ggggtgaggg cacccattct gaagaggaag gctttgccat ggatgaggag
      301 gactctgatg gagaactgaa tacctgggag ctgtcagaag ggacaaactg tccacccaag
      361 gaacagcctg gcgatctttt taatgaggac tgggactcgg agttgaaagc agatcaaggg
      421 aatccatatg atgctgacga catccaggag agcatttctc aagagcttaa accttgggtg
      481 tgctgtgccc cacaaggaga catgatctat gaccccagct ggcaccatcc gcctccactg
      541 ataccctatt attccaagat ggtctttgaa acaggacagt ttgacgatgc tgaagattga
      601 gtgtggagct ttctgccttg taggtgggcg ggcctccacg tcaagatctc ttttcctgtc
      661 ttggaggtga aaagtcatat ctgagaaaat gtttgcagtg acccctagtc tggggtacac
      721 agaccagtgt tccttattga cagtgttcaa taaggccccg tcattctcgc cagtctgttg
      781 ttgttcttaa tgggctcctc cttgaaatgt gtgtgtgttt gtgtcaagag gagttgtgtt
      841 ctttgtaaat aaaggttaaa aagagaaa
//
