LOCUS       NM_001330176             929 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coordinator of PRMT5 and differentiation stimulator
            (COPRS), transcript variant 2, mRNA.
ACCESSION   NM_001330176 XM_005258000
VERSION     NM_001330176.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 929)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 929)
  AUTHORS   Paul,C., Sardet,C. and Fabbrizio,E.
  TITLE     The histone- and PRMT5-associated protein COPR5 is required for
            myogenic differentiation
  JOURNAL   Cell Death Differ 19 (5), 900-908 (2012)
   PUBMED   22193545
REFERENCE   3  (bases 1 to 929)
  AUTHORS   Lacroix,M., El Messaoudi,S., Rodier,G., Le Cam,A., Sardet,C. and
            Fabbrizio,E.
  TITLE     The histone-binding protein COPR5 is required for nuclear functions
            of the protein arginine methyltransferase PRMT5
  JOURNAL   EMBO Rep 9 (5), 452-458 (2008)
   PUBMED   18404153
REFERENCE   4  (bases 1 to 929)
  AUTHORS   Douglas,J., Cilliers,D., Coleman,K., Tatton-Brown,K., Barker,K.,
            Bernhard,B., Burn,J., Huson,S., Josifova,D., Lacombe,D., Malik,M.,
            Mansour,S., Reid,E., Cormier-Daire,V., Cole,T. and Rahman,N.
  CONSRTM   Childhood Overgrowth Collaboration
  TITLE     Mutations in RNF135, a gene within the NF1 microdeletion region,
            cause phenotypic abnormalities including overgrowth
  JOURNAL   Nat Genet 39 (8), 963-965 (2007)
   PUBMED   17632510
REFERENCE   5  (bases 1 to 929)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 929)
  AUTHORS   Jenne,D.E., Tinschert,S., Stegmann,E., Reimann,H., Nurnberg,P.,
            Horn,D., Naumann,I., Buske,A. and Thiel,G.
  TITLE     A common set of at least 11 functional genes is lost in the
            majority of NF1 patients with gross deletions
  JOURNAL   Genomics 66 (1), 93-97 (2000)
   PUBMED   10843809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM784600.1, AC004253.2, CD557513.1, BE899028.1 and BQ671018.1.
            
            On May 31, 2019 this sequence version replaced NM_001330176.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.68211.1,
                                           ERR279842.10113.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BM784600.1         113-201
            90-90               AC004253.2         32775-32775
            91-155              BM784600.1         203-267
            156-232             CD557513.1         121-197
            233-233             BE899028.1         83-83
            234-781             CD557513.1         199-746
            782-929             BQ671018.1         274-421
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..929
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="coordinator of PRMT5 and differentiation
                     stimulator"
                     /db_xref="GeneID:55352"
                     /db_xref="HGNC:HGNC:28848"
     exon            1..205
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..661
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cooperator of PRMT5; coordinator of PRMT5, differentiation
                     stimulator"
                     /codon_start=1
                     /product="coordinator of PRMT5 and differentiation
                     stimulator isoform 2"
                     /protein_id="NP_001317105.1"
                     /db_xref="CCDS:CCDS82100.1"
                     /db_xref="GeneID:55352"
                     /db_xref="HGNC:HGNC:28848"
                     /translation="MGGDAGDREPGPAARSLGEGQAGFATADHSSQERETEKAMDRLA
                     RGTQSIPNDSPARGEGTHSEEEGFAMDEEDSDGELNTWELSEGTNCPPKEQPGDLFNE
                     DWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKM
                     VFETGQFDDAED"
     exon            206..272
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..491
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..929
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      909..914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="hexamer: AATAAA"
     polyA_site      929
                     /gene="COPRS"
                     /gene_synonym="C17orf79; COPR5; HSA272196; TTP1"
                     /note="major polyA site"
ORIGIN      
        1 gtttgggctc gcgctcgagc tgaaaacggc caggccgcgg ggccgcgggg ctgcggggcg
       61 gggaaagccg agggcgtggg tgggcgctct gggtcagcag agacggctgt ccgcccgctg
      121 ggcgccgctg cggatttggt aaatgggagg tgacgctggt gaccgagagc cggggcccgc
      181 tgccaggagc ctgggcgagg gccaggctgg ctttgctaca gctgaccact ccagtcagga
      241 gagagagact gagaaggcta tggatcgact agcccgtgga acacagagca ttcctaatga
      301 cagtcctgcc cggggtgagg gcacccattc tgaagaggaa ggctttgcca tggatgagga
      361 ggactctgat ggagaactga atacctggga gctgtcagaa gggacaaact gtccacccaa
      421 ggaacagcct ggcgatcttt ttaatgagga ctgggactcg gagttgaaag cagatcaagg
      481 gaatccatat gatgctgacg acatccagga gagcatttct caagagctta aaccttgggt
      541 gtgctgtgcc ccacaaggag acatgatcta tgaccccagc tggcaccatc cgcctccact
      601 gataccctat tattccaaga tggtctttga aacaggacag tttgacgatg ctgaagattg
      661 agtgtggagc tttctgcctt gtaggtgggc gggcctccac gtcaagatct cttttcctgt
      721 cttggaggtg aaaagtcata tctgagaaaa tgtttgcagt gacccctagt ctggggtaca
      781 cagaccagtg ttccttattg acagtgttca ataaggcccc gtcattctcg ccagtctgtt
      841 gttgttctta atgggctcct ccttgaaatg tgtgtgtgtt tgtgtcaaga ggagttgtgt
      901 tctttgtaaa taaaggttaa aaagagaaa
//
