LOCUS       NM_001290033            3116 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens COPI coat complex subunit gamma 2 (COPG2), transcript
            variant 2, mRNA.
ACCESSION   NM_001290033
VERSION     NM_001290033.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Amano,G., Matsuzaki,S., Mori,Y., Miyoshi,K., Han,S., Shikada,S.,
            Takamura,H., Yoshimura,T. and Katayama,T.
  TITLE     SCYL1 arginine methylation by PRMT1 is essential for neurite
            outgrowth via Golgi morphogenesis
  JOURNAL   Mol Biol Cell 31 (18), 1963-1973 (2020)
   PUBMED   32583741
  REMARK    GeneRIF: SCYL1 arginine methylation by PRMT1 is essential for
            neurite outgrowth via Golgi morphogenesis.
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Schneider,E., Mayer,S., El Hajj,N., Jensen,L.R., Kuss,A.W.,
            Zischler,H., Kondova,I., Bontrop,R.E., Navarro,B., Fuchs,E.,
            Zechner,U. and Haaf,T.
  TITLE     Methylation and expression analyses of the 7q autism susceptibility
            locus genes MEST, COPG2, and TSGA14 in human and anthropoid primate
            cortices
  JOURNAL   Cytogenet Genome Res 136 (4), 278-287 (2012)
   PUBMED   22456293
  REMARK    GeneRIF: In cortices, the MEST promoter was hemimethylated, as
            expected for a differentially methylated imprinting control region,
            whereas the COPG2 and TSGA14 promoters were completely
            demethylated, typical for transcriptionally active non-imprinted
            genes.
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Wegmann,D., Hess,P., Baier,C., Wieland,F.T. and Reinhard,C.
  TITLE     Novel isotypic gamma/zeta subunits reveal three coatomer complexes
            in mammals
  JOURNAL   Mol Cell Biol 24 (3), 1070-1080 (2004)
   PUBMED   14729954
REFERENCE   5  (bases 1 to 3116)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3116)
  AUTHORS   Yamasaki,K., Hayashida,S., Miura,K., Masuzaki,H., Ishimaru,T.,
            Niikawa,N. and Kishino,T.
  TITLE     The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain
            escapes genomic imprinting
  JOURNAL   Genomics 68 (3), 330-335 (2000)
   PUBMED   10995575
REFERENCE   7  (bases 1 to 3116)
  AUTHORS   Harter,C. and Wieland,F.T.
  TITLE     A single binding site for dilysine retrieval motifs and p23 within
            the gamma subunit of coatomer
  JOURNAL   Proc Natl Acad Sci U S A 95 (20), 11649-11654 (1998)
   PUBMED   9751720
REFERENCE   8  (bases 1 to 3116)
  AUTHORS   Lowe,M. and Kreis,T.E.
  TITLE     In vivo assembly of coatomer, the COP-I coat precursor
  JOURNAL   J Biol Chem 271 (48), 30725-30730 (1996)
   PUBMED   8940050
REFERENCE   9  (bases 1 to 3116)
  AUTHORS   Newman,A., Suarez,C., Lee,W.S. and Honrubia,V.
  TITLE     Afferent innervation of the vestibular nuclei in the chinchilla.
            II. Description of the vestibular nerve and nuclei
  JOURNAL   Brain Res 597 (2), 278-297 (1992)
   PUBMED   1472999
REFERENCE   10 (bases 1 to 3116)
  AUTHORS   Waters,M.G., Serafini,T. and Rothman,J.E.
  TITLE     'Coatomer': a cytosolic protein complex containing subunits of
            non-clathrin-coated Golgi transport vesicles
  JOURNAL   Nature 349 (6306), 248-251 (1991)
   PUBMED   1898986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX353590.2, BC110796.1 and AL162012.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001290033.1.
            
            Transcript Variant: This variant (2) lacks several exons and its
            3'-terminal exon extends past a splice site that is used in variant
            1. The encoded isoform (2) has a shorter and distinct C-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110796.1, SRR14038191.1820144.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BX353590.2         11-53
            44-2470             BC110796.1         1-2427
            2471-3116           AL162012.1         613-1258
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..3116
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /note="COPI coat complex subunit gamma 2"
                     /db_xref="GeneID:26958"
                     /db_xref="HGNC:HGNC:2237"
                     /db_xref="MIM:604355"
     exon            1..117
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2261
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /note="isoform 2 is encoded by transcript variant 2; coat
                     protein, nonclathrin, gamma-2-cop; coatomer subunit
                     gamma-2; gamma-2-coat protein; testicular secretory
                     protein Li 12; coatomer protein complex subunit gamma 2"
                     /codon_start=1
                     /product="coatomer subunit gamma-2 isoform 2"
                     /protein_id="NP_001276962.1"
                     /db_xref="CCDS:CCDS78275.1"
                     /db_xref="GeneID:26958"
                     /db_xref="HGNC:HGNC:2237"
                     /db_xref="MIM:604355"
                     /translation="MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRC
                     LHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDV
                     IIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSAL
                     VSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKF
                     TKSGLKSQFAYCMLIRIASRLLKETEDGHESPLFDFIESCLRNKHEMVIYEAASAIIH
                     LPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLIT
                     DSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYPR
                     KHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTV
                     LATKILHLLGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPS
                     ILVLLQRCMMDTDDEVRDRATFYLNVLQQRQMALNATYIFNGLTVSVPGMEKALHQYT
                     LEPSEKPFDMKSIPLAMAPVFEQKAEITLVATKPEKLAPSRQDIFQEQLAAIPEFLNI
                     GPLFKSSEPVQLTEAETEYFVRCIKHMFTNHIVFQFDCTNTLNDQLLEKVTVQMEPSD
                     SYEVLSCIPAPSLPYNQPGICYTLVRLPDDDPTAGTNPQKGGDT"
     exon            118..170
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            171..251
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            252..323
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            324..403
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            404..479
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            480..572
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            573..659
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            660..817
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            818..951
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1019
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1208
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1304
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1548
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1624
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1728
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1854
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1917
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2057
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..3116
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2440..2445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /note="hexamer: AGTAAA"
     polyA_site      2462
                     /gene="COPG2"
                     /gene_synonym="2-COP; gamma-2-COP"
                     /note="major polyA site"
ORIGIN      
        1 cttcctgcag cctcttccgc tcgccggctg cggcgcctgg gacggttgcg gtgggtctgg
       61 gcgctgggaa gtcgtccaag atgattaaaa aattcgacaa gaaggacgag gagtctggta
      121 gtggctccaa tcctttccag catctggaga agagtgctgt tttacaggag gctcgtatat
      181 tcaatgaaac tccaatcaat ccaagaagat gtttgcatat tcttacaaag attctttact
      241 tactgaacca gggtgaacac tttggaacaa cggaagctac agaagccttc tttgcaatga
      301 cgcgattgtt tcaatctaat gatcaaacat tgaggagaat gtgctacctt accatcaaag
      361 aaatggctac catctctgag gatgtgataa ttgtcacaag cagtctgact aaagacatga
      421 ctggaaaaga agatgtatac cgaggcccgg ccatcagagc tctctgcagg atcaccgatg
      481 gaacaatgtt gcaagccatt gaaagataca tgaagcaggc cattgtggat aaagtttcca
      541 gtgtatccag ttcagcactg gtatcttccc tgcacatgat gaagataagc tatgatgtgg
      601 ttaagcgctg gatcaatgaa gcccaagaag ctgcatcaag tgataatatt atggtccagt
      661 accatgcatt gggagtcctg tatcacctta gaaagaatga tcgacttgct gtttccaaga
      721 tgttgaataa gtttactaaa tctggtctca agtcacagtt tgcttactgc atgctgatcc
      781 gaattgccag tcgcttacta aaagaaactg aggatggcca tgaaagtcca ctgtttgatt
      841 tcattgagag ctgcttgcga aataaacatg aaatggttat ttatgaagct gcttcagcta
      901 tcatccatct tcctaactgc actgcaagag agttggcacc tgctgtttca gttcttcaac
      961 ttttctgtag ttctcctaag ccagccttga gatatgcagc tgtgaggacc ttgaacaagg
     1021 tggcaatgaa gcacccctct gctgttactg cctgcaatct ggacttagaa aacttaatca
     1081 cagactcaaa cagaagcatt gctaccttag ccattactac actcctcaaa acaggaagtg
     1141 agagcagtgt ggaccggctc atgaagcaga tatcttcttt tgtgtctgaa atctcagatg
     1201 agttcaaggt ggtggttgta caggcaatta gtgctctctg tcagaaatac cctcgaaagc
     1261 acagtgtcat gatgactttc ctctccaaca tgctccgaga tgatggaggc tttgagtaca
     1321 agcgggccat tgtggactgt ataatcagca ttgtggaaga gaaccctgag agtaaagaag
     1381 caggcctagc ccacctttgt gaattcattg aggactgtga acacactgtt ctggctacta
     1441 agattctaca cttgttgggc aaagagggcc ctagaacgcc tgtcccctcc aaatatatcc
     1501 gttttatttt taatagggtt gtcctggaga atgaggctgt cagagctgct gctgtgagtg
     1561 ctttggctaa atttggggct cagaatgaga gtcttctccc aagcatcctt gtactcttac
     1621 agaggtgtat gatggatact gatgacgagg tacgagacag agctaccttc tatctgaatg
     1681 tgctgcagca gaggcagatg gcactaaatg ccacatatat ctttaatggt ttgacggtct
     1741 ctgtaccagg gatggaaaaa gccttacacc agtacacgtt ggagccttca gaaaaaccgt
     1801 ttgacatgaa atcaattcct cttgctatgg ctcctgtctt tgaacagaaa gcagaaatca
     1861 cacttgtggc tactaagcca gagaagttgg ctccttccag gcaagacatt ttccaagaac
     1921 aattggctgc cattcctgag tttctgaata taggaccctt gttcaagtct tctgagcctg
     1981 ttcaacttac agaagcagag acagaatatt ttgttcgatg tatcaagcac atgtttacca
     2041 atcacatcgt gttccagttt gactgcacca acactctcaa tgaccagctg ctggaaaaag
     2101 tgacagtgca gatggagcca tcagattcct atgaagtgct gtcttgtatc ccagccccca
     2161 gccttcctta taaccaacca ggaatatgtt acactcttgt tcgtttgcct gatgatgacc
     2221 ctacagcagg tactaaccct cagaagggag gagatacgtg attcagaatg catttccttg
     2281 tgagctcttc aactcttcaa atgctcagtt taagaatgtg atgcttttct agaatttaat
     2341 gatgagtgtt tgtgtgtgtg tgtttgtgtg tgtgtgaata tatatattta taaaatggtt
     2401 tactgctgca gaaatattaa ttttaaaact aaatctctga gtaaaatttg ctgaacactt
     2461 aatcttaaaa gagaaactga gtgtgtatag cagtagcaca aaaaggaact caagctttct
     2521 gttggaataa tgtgaccact tgtgagagtt catatacctg gtctcctgtg aagaatcttg
     2581 accctcttct cctcaaagtt tctatctagt tagatagaac ttggttatgt agtagattgt
     2641 tggcatttta aaatacatca tttttgaagg tcctgtagca taaggctggt gtctgagagc
     2701 atgtctcagc ctagtgagta gcttagccaa ccatgtgtgt ccacattaag aagggctttt
     2761 aattccctcc ttgacccata tgcagtcttt gcagggtgga gaaatagccc ctaaaagaca
     2821 gccaactagt gccaatagta gtatttactt atttggagac ttgggaaggt gaatgtcaag
     2881 tatttattct acttgattcc ccccatcatc attttcctcc ttgatttctt ctcttctcat
     2941 gttcagtgca caatattcgt aactgttacc cagttttcac agaaataagc acacacatca
     3001 catttatgtt ttgaacaact tttactgctc gtaagtacag gagaaacaga agttaaaaaa
     3061 ttaacaaata ctgggaaagt tacagagtta caataaatca taaaagcact agtaaa
//
