LOCUS       NM_016128               3078 bp    mRNA    linear   PRI 21-OCT-2024
DEFINITION  Homo sapiens COPI coat complex subunit gamma 1 (COPG1), mRNA.
ACCESSION   NM_016128
VERSION     NM_016128.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3078)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3078)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 3078)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3078)
  AUTHORS   Bainter,W., Platt,C.D., Park,S.Y., Stafstrom,K., Wallace,J.G.,
            Peters,Z.T., Massaad,M.J., Becuwe,M., Salinas,S.A., Jones,J.,
            Beaussant-Cohen,S., Jaber,F., Yang,J.S., Walther,T.C., Orange,J.S.,
            Rao,C., Rakoff-Nahoum,S., Tsokos,M., Naseem,S.U.R., Al-Tamemi,S.,
            Chou,J., Hsu,V.W. and Geha,R.S.
  TITLE     Combined immunodeficiency due to a mutation in the gamma1 subunit
            of the coat protein I complex
  JOURNAL   J Clin Invest 131 (3) (2021)
   PUBMED   33529166
  REMARK    GeneRIF: Combined immunodeficiency due to a mutation in the gamma1
            subunit of the coat protein I complex.
REFERENCE   6  (bases 1 to 3078)
  AUTHORS   Eugster,A., Frigerio,G., Dale,M. and Duden,R.
  TITLE     COP I domains required for coatomer integrity, and novel
            interactions with ARF and ARF-GAP
  JOURNAL   EMBO J 19 (15), 3905-3917 (2000)
   PUBMED   10921873
REFERENCE   7  (bases 1 to 3078)
  AUTHORS   Fischer,K.D., Helms,J.B., Zhao,L. and Wieland,F.T.
  TITLE     Site-specific photocrosslinking to probe interactions of Arf1 with
            proteins involved in budding of COPI vesicles
  JOURNAL   Methods 20 (4), 455-464 (2000)
   PUBMED   10720466
REFERENCE   8  (bases 1 to 3078)
  AUTHORS   Lowe,M. and Kreis,T.E.
  TITLE     In vivo assembly of coatomer, the COP-I coat precursor
  JOURNAL   J Biol Chem 271 (48), 30725-30730 (1996)
   PUBMED   8940050
REFERENCE   9  (bases 1 to 3078)
  AUTHORS   Schekman,R. and Orci,L.
  TITLE     Coat proteins and vesicle budding
  JOURNAL   Science 271 (5255), 1526-1533 (1996)
   PUBMED   8599108
  REMARK    Review article
REFERENCE   10 (bases 1 to 3078)
  AUTHORS   Cukierman,E., Huber,I., Rotman,M. and Cassel,D.
  TITLE     The ARF1 GTPase-activating protein: zinc finger motif and Golgi
            complex localization
  JOURNAL   Science 270 (5244), 1999-2002 (1995)
   PUBMED   8533093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137695.3, BU521557.1, AB047846.1 and AK025147.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016128.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291693.1, SRR1803611.232327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314797.10/ ENSP00000325002.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC137695.3         5912-5915
            5-503               BU521557.1         2-500
            504-2906            AB047846.1         415-2817
            2907-3078           AK025147.1         1859-2030
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..3078
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /note="COPI coat complex subunit gamma 1"
                     /db_xref="GeneID:22820"
                     /db_xref="HGNC:HGNC:2236"
                     /db_xref="MIM:615525"
     exon            1..141
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2729
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /note="coat protein gamma-cop; coatomer protein complex,
                     subunit gamma; coatomer subunit gamma; gamma-COP;
                     gamma-coat protein; gamma-1-COP; gamma-1-coat protein;
                     coatomer protein complex subunit gamma 1"
                     /codon_start=1
                     /product="coatomer subunit gamma-1"
                     /protein_id="NP_057212.1"
                     /db_xref="CCDS:CCDS33851.1"
                     /db_xref="GeneID:22820"
                     /db_xref="HGNC:HGNC:2236"
                     /db_xref="MIM:615525"
                     /translation="MLKKFDKKDEESGGGSNPFQHLEKSAVLQEARVFNETPINPRKC
                     AHILTKILYLINQGEHLGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV
                     IIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSAL
                     VSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLYHVRKNDRLAVNKMISKV
                     TRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVN
                     LPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVT
                     DSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPR
                     KHAVLMNFLFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTV
                     LATRILHLLGQEGPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPS
                     ILVLLKRCVMDDDNEVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLERALQQYT
                     LEPSEKPFDLKSVPLATAPMAEQRTESTPITAVKQPEKVAATRQEIFQEQLAAVPEFR
                     GLGPLFKSSPEPVALTESETEYVIRCTKHTFTNHMVFQFDCTNTLNDQTLENVTVQME
                     PTEAYEVLCYVPARSLPYNQPGTCYTLVALPKEDPTAVACTFSCMMKFTVKDCDPTTG
                     ETDDEGYEDEYVLEDLEVTVADHIQKVMKLNFEAAWDEVGDEFEKEETFTLSTIKTLE
                     EAVGNIVKFLGMHPCERSDKVPDNKNTHTLLLAGVFRGGHDILVRSRLLLLDTVTMQV
                     TARSLEELPVDIILASVG"
     exon            142..194
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            195..275
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            276..347
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            348..427
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            428..503
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            504..596
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            597..683
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            684..841
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            842..975
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1043
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1232
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1328
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1572
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1648
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1752
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1878
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1947
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2090
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2262
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2360
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2499
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2598
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..3078
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /note="hexamer: AATAAA"
     polyA_site      3078
                     /gene="COPG1"
                     /gene_synonym="COPG; IMD128"
                     /note="major polyA site"
ORIGIN      
        1 agtcggggcc cggaagtggt ccctgtagaa ccactgtggc accgctactc cgtgccgcgc
       61 ccgtcgagca ttgcgttgct gcattgcgcc ccaccgactc cactatgttg aagaaattcg
      121 acaagaagga tgaggagtca ggtggaggct ccaacccatt ccagcacctt gagaagagtg
      181 cggtactcca ggaggcccgt gtatttaatg aaactcccat caaccctcgg aaatgtgccc
      241 acatcctcac caagattctt tatctcataa accaggggga gcacctgggg accacggaag
      301 cgaccgaggc cttctttgcc atgaccaagc tctttcagtc caatgatccc acactccgtc
      361 ggatgtgcta cttgaccatc aaggagatgt cttgcattgc agaggatgtc atcattgtca
      421 ccagcagcct aacaaaagac atgactggga aagaagacaa ctaccggggc ccggccgtgc
      481 gagccctctg ccagatcact gatagcacca tgctgcaggc tattgagcgc tacatgaaac
      541 aagccattgt ggacaaggtg cccagtgtct ccagctctgc cctcgtgtct tccttgcacc
      601 tgctgaagtg cagctttgac gtggtcaagc gctgggtgaa tgaggctcag gaggcagcat
      661 ccagtgataa catcatggtc cagtaccacg cactagggct cctgtaccat gtgcgtaaga
      721 atgaccgcct agccgtcaat aagatgatca gcaaggtcac acggcatggc cttaagtctc
      781 cctttgccta ctgcatgatg atccgggtgg ccagcaagca gctggaagag gaggatggca
      841 gccgtgacag cccactgttt gacttcatcg agagctgctt gcgcaacaag cacgagatgg
      901 tggtgtatga agccgcctcg gccatcgtca atctgccagg ctgcagtgcc aaagagctgg
      961 ccccggctgt gtcagtgctc cagcttttct gcagctcacc caaggctgct ctccgctatg
     1021 ctgctgttcg taccctcaat aaggttgcca tgaagcatcc gtcagctgtg acagcttgta
     1081 atctggatct ggagaacctg gtcacagatt caaaccgcag cattgccacg ctggccatca
     1141 ccaccctcct taagacgggc agcgagagca gcatcgaccg cctcatgaag cagatctcct
     1201 ccttcatgtc agaaatctcg gatgaattca aggtggtggt tgtccaggcc atcagtgccc
     1261 tgtgtcagaa atatcctcgc aaacacgccg tccttatgaa cttcctgttc accatgctgc
     1321 gggaagaggg tggctttgag tataagcgcg ctatcgtgga ctgcatcatc agcatcattg
     1381 aagagaactc agagagcaag gagacagggc tgtcacatct gtgcgagttc atcgaggact
     1441 gcgagttcac agtgctggcc acccgtattc tacatctcct gggccaggag gggcccaaga
     1501 ccaccaatcc ctcaaagtac atccgcttca tctataaccg agtggtcttg gagcatgagg
     1561 aggtccgggc aggtgctgtg agtgctctgg cgaagtttgg agcccagaat gaagagatgt
     1621 tacccagtat cttggtgttg ctgaagaggt gtgtgatgga tgatgacaat gaagtaaggg
     1681 accgagccac cttctaccta aatgtcctgg agcagaagca gaaggccctt aatgcaggct
     1741 atatcctaaa tggtctgact gtgtccatcc ctggtctgga gagggctctg cagcagtaca
     1801 ctctagaacc atcagaaaaa ccttttgacc tcaagtctgt gcccctggcc acggcgccca
     1861 tggcagagca gagaacagaa agtaccccca tcacagcagt caaacagcct gagaaagtgg
     1921 cagctaccag gcaggagatc ttccaggagc agttggcagc agtgccagag ttccgcggtc
     1981 ttgggcccct cttcaagtcc tcgcctgagc ccgtggccct caccgagtca gagacggagt
     2041 atgtcatccg ctgcaccaaa cacaccttca ccaaccacat ggtttttcag tttgactgca
     2101 caaacacact caatgaccag accttggaga atgtcacagt gcagatggag cccactgagg
     2161 cctatgaggt gctctgttac gtgcctgccc ggagcctgcc ctacaaccag cccgggacct
     2221 gctacacact ggtggcactg cccaaagaag accccacagc tgtggcctgc acattcagct
     2281 gcatgatgaa gttcactgtc aaggactgtg atcccaccac tggggagact gatgacgaag
     2341 gctatgagga tgagtatgtg ctggaagatc tggaagttac tgtagctgat cacattcaaa
     2401 aggtcatgaa actgaacttc gaagcagcct gggatgaggt aggggatgaa tttgagaagg
     2461 aggaaacgtt caccttgtct accatcaaga cacttgaaga ggctgtgggt aatattgtga
     2521 agttcttggg aatgcaccct tgtgagaggt cagacaaagt gccggataac aagaacaccc
     2581 acacgttgct cctggctggt gtgttccggg gtggtcatga catcctggtg cgctcccggc
     2641 tgctgctttt ggacacagtg acaatgcagg tgacagccag aagtttggag gagctgccag
     2701 tagacatcat cttggcatct gtgggataag aggccagcct gcataggacc tcataccctt
     2761 ccccaacact acctggaagt tgtgccttcc tcatgaaact ggcagaaacc ccttcccaag
     2821 cttctgtatt gaaaaacaat taggaatcat tgcagatttt tttttattct gctcccacct
     2881 cccacccggg actacttgct ggtgactttt tttttttttt tttttaaata ggggatgatt
     2941 ttagcttgtc ctaaatcttg ctgtccaccc ttccaggaaa gggacattgt aaatgaataa
     3001 aacattctca actcctcttg aatctatccc ccaagaaacc atcttatccc tgtaataaat
     3061 cagcatgtat ttattgaa
//
