LOCUS       NM_004766               3275 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens COPI coat complex subunit beta 2 (COPB2), transcript
            variant 1, mRNA.
ACCESSION   NM_004766
VERSION     NM_004766.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3275)
  AUTHORS   Kim,S.S., Park,J., Kim,E., Hwang,E.M. and Park,J.Y.
  TITLE     beta-COP Suppresses the Surface Expression of the TREK2
  JOURNAL   Cells 12 (11), 1500 (2023)
   PUBMED   37296621
  REMARK    GeneRIF: beta-COP Suppresses the Surface Expression of the TREK2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3275)
  AUTHORS   Zhou,G., Zhang,S., Jin,M. and Hu,S.
  TITLE     Comprehensive analysis reveals COPB2 and RYK associated with tumor
            stages of larynx squamous cell carcinoma
  JOURNAL   BMC Cancer 22 (1), 667 (2022)
   PUBMED   35715770
  REMARK    GeneRIF: Comprehensive analysis reveals COPB2 and RYK associated
            with tumor stages of larynx squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3275)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3275)
  AUTHORS   Wu,B., Wu,Y., Guo,X., Yue,Y., Li,Y., He,X., Chen,Y., Zhao,W.,
            Liu,J., Wu,X., Shen,A. and Zhang,S.
  TITLE     An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2
            in Human Tumors
  JOURNAL   Biomed Res Int 2021, 7405322 (2021)
   PUBMED   34676262
  REMARK    GeneRIF: An Integrative Pan-Cancer Analysis of the Oncogenic Role
            of COPB2 in Human Tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3275)
  AUTHORS   Cattin-Ortola,J., Welch,L.G., Maslen,S.L., Papa,G., James,L.C. and
            Munro,S.
  TITLE     Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate
            expression at the cell surface and syncytia formation
  JOURNAL   Nat Commun 12 (1), 5333 (2021)
   PUBMED   34504087
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3275)
  AUTHORS   Schekman,R. and Orci,L.
  TITLE     Coat proteins and vesicle budding
  JOURNAL   Science 271 (5255), 1526-1533 (1996)
   PUBMED   8599108
  REMARK    Review article
REFERENCE   7  (bases 1 to 3275)
  AUTHORS   Lowe,M. and Kreis,T.E.
  TITLE     In vitro assembly and disassembly of coatomer
  JOURNAL   J Biol Chem 270 (52), 31364-31371 (1995)
   PUBMED   8537409
REFERENCE   8  (bases 1 to 3275)
  AUTHORS   Cukierman,E., Huber,I., Rotman,M. and Cassel,D.
  TITLE     The ARF1 GTPase-activating protein: zinc finger motif and Golgi
            complex localization
  JOURNAL   Science 270 (5244), 1999-2002 (1995)
   PUBMED   8533093
REFERENCE   9  (bases 1 to 3275)
  AUTHORS   Harrison-Lavoie,K.J., Lewis,V.A., Hynes,G.M., Collison,K.S.,
            Nutland,E. and Willison,K.R.
  TITLE     A 102 kDa subunit of a Golgi-associated particle has homology to
            beta subunits of trimeric G proteins
  JOURNAL   EMBO J 12 (7), 2847-2853 (1993)
   PUBMED   8335000
REFERENCE   10 (bases 1 to 3275)
  AUTHORS   Stenbeck,G., Harter,C., Brecht,A., Herrmann,D., Lottspeich,F.,
            Orci,L. and Wieland,F.T.
  TITLE     beta'-COP, a novel subunit of coatomer
  JOURNAL   EMBO J 12 (7), 2841-2845 (1993)
   PUBMED   8334999
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC347783.1, X70476.1, BC000326.2 and AC024933.34.
            
            On Nov 22, 2018 this sequence version replaced NM_004766.2.
            
            Summary: The Golgi coatomer complex (see MIM 601924) constitutes
            the coat of nonclathrin-coated vesicles and is essential for Golgi
            budding and vesicular trafficking. It consists of 7 protein
            subunits, including COPB2.[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (1) uses an alternate splice donor
            site in the first coding exon and is predicted to encode a protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000326.2, X70476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333188.10/ ENSP00000329419.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DC347783.1         34-61
            29-94               X70476.1           1-66
            95-3090             BC000326.2         74-3069
            3091-3275           AC024933.34        101872-102056       c
FEATURES             Location/Qualifiers
     source          1..3275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..3275
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /note="COPI coat complex subunit beta 2"
                     /db_xref="GeneID:9276"
                     /db_xref="HGNC:HGNC:2232"
                     /db_xref="MIM:606990"
     exon            1..100
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2818
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coatomer binding complex, beta prime subunit;
                     betaprime-COP; coatomer subunit beta'; p102; beta'-coat
                     protein; coatomer protein complex subunit beta prime;
                     coatomer protein complex, subunit beta 2 (beta prime);
                     coatomer protein complex subunit beta 2"
                     /codon_start=1
                     /product="coatomer subunit beta' isoform 1"
                     /protein_id="NP_004757.1"
                     /db_xref="CCDS:CCDS3108.1"
                     /db_xref="GeneID:9276"
                     /db_xref="HGNC:HGNC:2232"
                     /db_xref="MIM:606990"
                     /translation="MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNH
                     ETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYI
                     RCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFAS
                     ASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQN
                     KTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWC
                     VASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDAE
                     IKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQ
                     EFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFY
                     DWDNTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTED
                     GIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGY
                     IPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHF
                     LEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQ
                     FGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAFMSYFLQGKVDA
                     CLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLF
                     PGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGKDFQPSRSTAQQELDGK
                     PASPTPVIVASHTANKEEKSLLELEVDLDNLELEDIDTTDINLDEDILDD"
     exon            101..238
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            239..325
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            326..452
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            453..601
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            602..748
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            749..848
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            849..991
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1191
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1302
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1391
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1498
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1642
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1773
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1981
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2092
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2307
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2400
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2581
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2650
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2722
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..3275
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3071..3076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /note="hexamer: CATAAA"
     polyA_site      3090
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /note="major polyA site"
     regulatory      3202..3207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
                     /note="hexamer: ACTAAA"
     polyA_site      3221
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
     polyA_site      3275
                     /gene="COPB2"
                     /gene_synonym="beta'-COP; MCPH19; OPDD"
ORIGIN      
        1 cgtcagtcag tctgacggtc agtggatcgg tgggtttatc tcaaggcctg agtagccggt
       61 aacaaacgag ggttcccggg attggaccga cgcagccatg cctctgcgac ttgatatcaa
      121 aagaaagcta actgctagat ctgatcgagt taagagtgtg gatctgcatc ctacagagcc
      181 atggatgttg gcaagtcttt acaatggcag tgtgtgtgtt tggaatcatg aaacacagac
      241 actggtgaag acatttgaag tatgtgatct tcctgttcga gctgcaaagt ttgttgcaag
      301 gaagaattgg gttgtgacag gagcggatga catgcagatt agagtgttca attacaatac
      361 tctggagaga gttcatatgt ttgaagcaca ctcagactac attcgctgta ttgctgttca
      421 tccaacccag cctttcattc taactagcag tgatgacatg cttattaagc tctgggactg
      481 ggataaaaaa tggtcttgct cacaagtgtt tgaaggacac acccattatg ttatgcagat
      541 tgtgatcaac cccaaagata acaatcagtt tgccagtgcc tctttggaca ggactatcaa
      601 ggtgtggcag ttgggctctt cgtcaccaaa cttcactttg gaaggacatg agaaaggcgt
      661 gaattgcatt gattactaca gtggtgggga caagccatac ctcatttcag gtgcagatga
      721 ccgtcttgtt aaaatatggg attatcagaa taaaacatgt gtgcagacac tggaaggaca
      781 tgcccaaaat gtgtcttgtg ccagctttca tcctgagttg ccaatcatta tcacaggttc
      841 agaagatgga acagtacgta tttggcattc aagcacctac cggcttgaga gcacactgaa
      901 ttatggaatg gagagggtat ggtgcgtggc cagtctaaga gggtcaaaca atgtcgcttt
      961 gggctatgat gaagggagca tcattgttaa gcttggtcgg gaggaacctg ccatgtccat
     1021 ggatgccaat ggaaagataa tttgggccaa gcattcagaa gtccagcagg ccaacctaaa
     1081 agcaatggga gatgctgaaa ttaaagatgg tgaaagattg ccactggcag taaaggatat
     1141 gggcagttgt gaaatatacc ctcagactat tcagcacaat cctaatgggc ggtttgtggt
     1201 ggtgtgtggt gatggggagt atatcatcta cacagcaatg gcattgagaa acaagagctt
     1261 tggatctgct caggagtttg catgggccca cgattcttca gagtatgcaa taagagagag
     1321 caacagcatt gtaaagatat ttaagaactt taaggaaaaa aaatcattta aaccagattt
     1381 tggagcagaa agtatctacg gcggcttctt attgggagtc agatctgtaa atggcttagc
     1441 cttctatgac tgggacaata cagaactcat acgaagaatt gaaattcagc ccaaacatat
     1501 tttctggtct gactctggag agctagtctg tattgctact gaggaatcat tttttatcct
     1561 taagtatctg tcagaaaaag tcttggctgc acaggaaaca catgagggag ttactgaaga
     1621 tggcattgaa gatgcctttg aggttcttgg tgagattcag gaaattgtga aaacagggct
     1681 ttgggtaggc gattgcttca tttacacaag ttctgtgaac agattaaatt attatgttgg
     1741 aggagaaata gtcaccattg cccacttgga caggacgatg tatctcctag gctacattcc
     1801 taaagacaac aggctttatc tgggggataa agaattgaac atcattagct attccctgct
     1861 ggtttcagtc ctggaatacc agacagctgt catgcggagg gactttagca tggctgataa
     1921 ggtccttcct accattccaa aagaacagag gaccagagtt gcacactttt tggaaaagca
     1981 gggcttcaag cagcaagctc ttacagtatc cacagatcct gagcatcgtt ttgagcttgc
     2041 tcttcagctt ggagagttaa aaattgcata ccagttagca gtggaagcag agtcagaaca
     2101 gaagtggaaa caacttgctg aacttgccat tagtaaatgt cagtttggcc tagcccagga
     2161 gtgcctgcat catgcacagg attatggggg cctgctgctt ttggccactg cctctggaaa
     2221 tgctaatatg gtgaacaagc tagcagaggg tgcggagaga gatggcaaaa ataatgtggc
     2281 attcatgagc tactttttac agggcaaggt tgatgcctgc ctagagctct taattagaac
     2341 tggacggctg ccagaagctg ccttcttggc ccgaacttac ttacccagtc aggtttcaag
     2401 ggtagtgaaa ctctggagag agaatctctc aaaagtcaat cagaaagcag cagaatccct
     2461 tgctgaccca acagagtatg aaaacctgtt ccctggatta aaagaagcct ttgttgttga
     2521 agaatgggtg aaggaaacac atgctgatct gtggccagcc aaacaatacc cacttgtcac
     2581 gccaaatgaa gagagaaatg tcatggaaga gggaaaagac tttcagccct caagatctac
     2641 agctcaacag gaacttgatg ggaaacctgc ttctcctact ccggttattg tggcctccca
     2701 cacagccaac aaagaagaaa agagtttact cgaactagaa gtagatttgg ataatttgga
     2761 attagaagat attgacacaa cagatatcaa tctggatgaa gatattttgg atgattgact
     2821 gtaatgcttt ccatttacct gactaaacag atcattatta tatataggta ttgattgcta
     2881 ccctgaccac agtgctttgg actatgagaa acttcttaga tttttatatg taaatgctgt
     2941 ggaccactgg gagcacaatg cccacatcat cttaagaaga gtttatgtgc agcatttaaa
     3001 tcactgtgtt ttccttgtta actaaaacag acatgggctt tgattttttt catactatta
     3061 gaccatatct cataaaacct tttgaattaa tgaaggtact tgtttccttt ctcaataatg
     3121 aaaataggct tctagtttta gaaggctgag ccgaaactac accttgccta gggatcagcc
     3181 ccactgtctt ttctttgtat aactaaatct gcattttcaa atgttgtcaa tcacattttt
     3241 cttagagctg aatatccagg ctgtaattct ctaaa
//
