LOCUS       NM_001144061            3336 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens COPI coat complex subunit beta 1 (COPB1), transcript
            variant 2, mRNA.
ACCESSION   NM_001144061
VERSION     NM_001144061.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3336)
  AUTHORS   Chen,H., Li,K., Li,Y., Xie,P., He,J. and Zhang,H.
  TITLE     An integrative pan-cancer analysis of COPB1 based on data mining
  JOURNAL   Cancer Biomark 30 (1), 13-27 (2021)
   PUBMED   32986658
  REMARK    GeneRIF: An integrative pan-cancer analysis of COPB1 based on data
            mining.
REFERENCE   2  (bases 1 to 3336)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3336)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3336)
  AUTHORS   Ryu,J., Kim,D.G., Lee,Y.S., Bae,Y., Kim,A., Park,N., Hwang,E.M. and
            Park,J.Y.
  TITLE     Surface expression of TTYH2 is attenuated by direct interaction
            with beta-COP
  JOURNAL   BMB Rep 52 (7), 445-450 (2019)
   PUBMED   30670146
REFERENCE   5  (bases 1 to 3336)
  AUTHORS   Piguet,V., Gu,F., Foti,M., Demaurex,N., Gruenberg,J.,
            Carpentier,J.L. and Trono,D.
  TITLE     Nef-induced CD4 degradation: a diacidic-based motif in Nef
            functions as a lysosomal targeting signal through the binding of
            beta-COP in endosomes
  JOURNAL   Cell 97 (1), 63-73 (1999)
   PUBMED   10199403
REFERENCE   6  (bases 1 to 3336)
  AUTHORS   Hansen,K., Ronnstrand,L., Rorsman,C., Hellman,U. and Heldin,C.H.
  TITLE     Association of coatomer proteins with the beta-receptor for
            platelet-derived growth factor
  JOURNAL   Biochem Biophys Res Commun 235 (3), 455-460 (1997)
   PUBMED   9207175
REFERENCE   7  (bases 1 to 3336)
  AUTHORS   Schekman,R. and Orci,L.
  TITLE     Coat proteins and vesicle budding
  JOURNAL   Science 271 (5255), 1526-1533 (1996)
   PUBMED   8599108
  REMARK    Review article
REFERENCE   8  (bases 1 to 3336)
  AUTHORS   Olivos-Glander,I.M., Janne,P.A. and Nussbaum,R.L.
  TITLE     The oculocerebrorenal syndrome gene product is a 105-kD protein
            localized to the Golgi complex
  JOURNAL   Am J Hum Genet 57 (4), 817-823 (1995)
   PUBMED   7573041
REFERENCE   9  (bases 1 to 3336)
  AUTHORS   Benichou,S., Bomsel,M., Bodeus,M., Durand,H., Doute,M.,
            Letourneur,F., Camonis,J. and Benarous,R.
  TITLE     Physical interaction of the HIV-1 Nef protein with beta-COP, a
            component of non-clathrin-coated vesicles essential for membrane
            traffic
  JOURNAL   J Biol Chem 269 (48), 30073-30076 (1994)
   PUBMED   7982906
REFERENCE   10 (bases 1 to 3336)
  AUTHORS   Duden,R., Griffiths,G., Frank,R., Argos,P. and Kreis,T.E.
  TITLE     Beta-COP, a 110 kd protein associated with non-clathrin-coated
            vesicles and the Golgi complex, shows homology to beta-adaptin
  JOURNAL   Cell 64 (3), 649-665 (1991)
   PUBMED   1840503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA725605.1, AL136593.1 and
            AA443270.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001144061.1.
            
            Summary: This gene encodes a protein subunit of the coatomer
            complex associated with non-clathrin coated vesicles. The coatomer
            complex, also known as the coat protein complex 1, forms in the
            cytoplasm and is recruited to the Golgi by activated guanosine
            triphosphatases. Once at the Golgi membrane, the coatomer complex
            may assist in the movement of protein and lipid components back to
            the endoplasmic reticulum. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136593.1, AF084457.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439561.7/ ENSP00000397873.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA725605.1         65-68
            5-3298              AL136593.1         21-3314
            3299-3336           AA443270.1         16-53               c
FEATURES             Location/Qualifiers
     source          1..3336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..3336
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /note="COPI coat complex subunit beta 1"
                     /db_xref="GeneID:1315"
                     /db_xref="HGNC:HGNC:2231"
                     /db_xref="MIM:600959"
     exon            1..105
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            106..253
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..3024
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /note="beta-cop; beta coat protein; coatomer protein
                     complex subunit beta 1"
                     /codon_start=1
                     /product="coatomer subunit beta"
                     /protein_id="NP_001137533.1"
                     /db_xref="CCDS:CCDS7815.1"
                     /db_xref="GeneID:1315"
                     /db_xref="HGNC:HGNC:2231"
                     /db_xref="MIM:600959"
                     /translation="MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKK
                     VIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVC
                     DAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIY
                     TIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQT
                     FGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPT
                     AIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDL
                     EVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSV
                     RFPDMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIK
                     SVKIYRGALWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITV
                     GPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIAL
                     RYVALVQEKKKQNSFVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECS
                     PLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEM
                     NCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIV
                     LDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGI
                     IFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVN
                     TNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSIFGEDALANVSIEKP
                     IHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI"
     exon            254..483
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            484..653
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            654..768
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            769..861
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            862..999
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1119
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1227
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1374
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1520
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1617
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1778
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1899
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2127
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2307
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2452
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2572
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2718
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2808
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2964
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3336
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3277..3282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /note="hexamer: AATAAA"
     polyA_site      3298
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /note="major polyA site"
     regulatory      3315..3320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /note="hexamer: AATAAA"
     polyA_site      3336
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /note="major polyA site"
ORIGIN      
        1 atagccggag tagacggagc cgcagtagac ggatccgcgg ctgcaccaaa ccactgcccc
       61 tcggagcctg gtagtgggcc acaagccccc agtcccagag gcgtgatttt ctggcatcct
      121 taaatcttgt gtcaaggatt ggttataata taaccagaaa ccatgacggc ggctgagaac
      181 gtatgctaca cgttaattaa cgtgccaatg gattcagaac caccatctga aattagctta
      241 aaaaatgatc tagaaaaagg agatgtaaag tcaaagactg aagctttgaa gaaagtaatc
      301 attatgattc tgaatggtga aaaacttcct ggacttctga tgaccatcat tcgttttgtg
      361 ctacctcttc aggatcacac tatcaagaaa ttacttctgg tattttggga aattgttcct
      421 aaaacaactc cagatgggag acttttacat gagatgatcc ttgtatgtga tgcatacaga
      481 aaggatcttc aacatcctaa tgaatttatt cgaggatcta ctcttcgttt tctttgcaaa
      541 ttgaaagaag cagaattgct agaaccttta atgccagcta ttcgtgcatg tttggagcat
      601 cgacacagct atgttagaag aaatgctgtt ttggccatct ataccatcta tagaaatttt
      661 gaacatctta tacctgatgc tcctgaactg atacatgatt ttctggtgaa tgagaaggat
      721 gcaagttgca aaaggaatgc atttatgatg ctaattcatg cagatcagga tcgagctttg
      781 gattacttaa gtacttgcat tgatcaagtt caaacatttg gagacattct gcagctggtt
      841 attgttgaac tgatttataa ggtctgtcat gctaatccat cagaaagagc tcgttttatt
      901 cgctgcatct ataacttatt acagtcatcc agccctgctg taaaatatga agctgctggg
      961 acattagtga cactctctag tgcaccaact gcaatcaagg ctgctgctca gtgttacatt
     1021 gatttaatta ttaaggagag cgacaacaat gtaaaactca tagttttgga tcgcttgata
     1081 gaattaaaag agcatcctgc tcatgaacga gtactacagg atctggttat ggatatccta
     1141 agagtattga gcacaccaga cttagaagta cgaaagaaaa ctctgcagtt agcactggat
     1201 cttgtctctt ctagaaatgt tgaagagctg gttattgtcc tgaagaagga agtgataaaa
     1261 acaaataatg tgtctgagca tgaagatact gacaaataca gacaactcct agtgcgaaca
     1321 ttgcattcct gttctgtccg atttccagat atggctgcaa atgttattcc tgtgttaatg
     1381 gaatttctca gtgacaacaa cgaagcagca gctgctgatg tcttggagtt tgttcgtgaa
     1441 gccattcagc gctttgataa cctgagaatg cttattgttg agaagatgct tgaagtcttt
     1501 catgctatta aatctgtcaa gatttaccga ggagcattat ggatcctggg agaatactgt
     1561 agtaccaagg aagacattca gagtgtgatg actgagatcc gcaggtccct tggagagatc
     1621 ccaattgtag agtcagaaat aaagaaagaa gctggtgaat taaaacctga agaagaaata
     1681 actgtagggc cagttcagaa attggttact gaaatgggta cctatgcaac tcagagtgcc
     1741 cttagcagtt ctagacccac caagaaagag gaagacagac ctcccttgag aggattcctt
     1801 ctggatggag atttctttgt tgctgcctcc cttgccacaa ctctgaccaa gattgcattg
     1861 cgctatgtag ctttggttca ggagaagaaa aagcaaaatt cttttgttgc tgaggctatg
     1921 ttgctcatgg ctactatcct gcatttggga aaatcctctc ttcctaagaa gccaattact
     1981 gatgatgatg tggatcgaat ttccctgtgc ctcaaggtct tgtctgaatg ttcaccttta
     2041 atgaatgaca ttttcaataa ggaatgcaga cagtcccttt ctcacatgtt atctgctaaa
     2101 ctagaagaag agaaattatc ccaaaagaaa gaatctgaaa agaggaatgt gacagtacag
     2161 cctgatgacc ccatttcctt catgcaacta actgctaaga atgaaatgaa ctgcaaggaa
     2221 gatcagtttc agctgagttt actggcagca atgggtaaca cacagaggaa agaggcagca
     2281 gatcccctag catctaaact taacaaggtc acccaattga caggtttctc agatcctgta
     2341 tatgcagaag cttacgttca tgtcaaccaa tatgatattg tcctggatgt acttgttgtg
     2401 aaccaaacca gtgatacttt gcagaattgc acattagaac tagctacact aggggatctg
     2461 aaacttgtgg aaaagccgtc tcctttgact cttgctcctc atgacttcgc aaatattaaa
     2521 gctaacgtca aagtagcatc aacagaaaat ggaataattt ttggtaatat agtttatgat
     2581 gtctctggag cagcaagtga cagaaattgt gtggttctca gtgatattca catcgacatc
     2641 atggactata tccagcctgc aacttgcact gatgcagaat tccgtcagat gtgggccgaa
     2701 tttgaatggg aaaacaaagt gacagttaac accaacatgg ttgatttaaa tgactactta
     2761 cagcacatat taaagtcaac caatatgaaa tgcctgactc cagaaaaggc cctttctggt
     2821 tactgtggct ttatggcagc caacctttat gctcgttcca tatttggtga agatgcactt
     2881 gcaaatgtca gcattgagaa gccaattcac cagggaccag atgctgctgt taccggccat
     2941 ataagaattc gtgcaaagag ccagggaatg gccttaagtc ttggagataa aatcaacttg
     3001 tcacagaaga aaactagtat ataaaaataa acaaaaagtc cttgaagctt tacagttaat
     3061 ttaggtatgg gcttactgga ctccaacatc ttttgtactc tttcatgctt atatagaatc
     3121 tgagttcatg ctgaatactt ttcagccaat aatttatagc ctttccctta aatcaagatt
     3181 gagtttaaaa ttatagtttg tcttttgtct taacagttct gaatgctgtc ctcaaagtat
     3241 ataatgtttc atgtaccaag acccttttca cagtacaata aacagatcta ttcataaatt
     3301 tttgttattt tataaataaa tgattacata atttta
//
