LOCUS       NP_001137533             953 aa            linear   PRI 30-APR-2025
DEFINITION  coatomer subunit beta [Homo sapiens].
ACCESSION   NP_001137533
VERSION     NP_001137533.1
DBSOURCE    REFSEQ: accession NM_001144061.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 953)
  AUTHORS   Chen,H., Li,K., Li,Y., Xie,P., He,J. and Zhang,H.
  TITLE     An integrative pan-cancer analysis of COPB1 based on data mining
  JOURNAL   Cancer Biomark 30 (1), 13-27 (2021)
   PUBMED   32986658
  REMARK    GeneRIF: An integrative pan-cancer analysis of COPB1 based on data
            mining.
REFERENCE   2  (residues 1 to 953)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 953)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 953)
  AUTHORS   Ryu,J., Kim,D.G., Lee,Y.S., Bae,Y., Kim,A., Park,N., Hwang,E.M. and
            Park,J.Y.
  TITLE     Surface expression of TTYH2 is attenuated by direct interaction
            with beta-COP
  JOURNAL   BMB Rep 52 (7), 445-450 (2019)
   PUBMED   30670146
REFERENCE   5  (residues 1 to 953)
  AUTHORS   Piguet,V., Gu,F., Foti,M., Demaurex,N., Gruenberg,J.,
            Carpentier,J.L. and Trono,D.
  TITLE     Nef-induced CD4 degradation: a diacidic-based motif in Nef
            functions as a lysosomal targeting signal through the binding of
            beta-COP in endosomes
  JOURNAL   Cell 97 (1), 63-73 (1999)
   PUBMED   10199403
REFERENCE   6  (residues 1 to 953)
  AUTHORS   Hansen,K., Ronnstrand,L., Rorsman,C., Hellman,U. and Heldin,C.H.
  TITLE     Association of coatomer proteins with the beta-receptor for
            platelet-derived growth factor
  JOURNAL   Biochem Biophys Res Commun 235 (3), 455-460 (1997)
   PUBMED   9207175
REFERENCE   7  (residues 1 to 953)
  AUTHORS   Schekman,R. and Orci,L.
  TITLE     Coat proteins and vesicle budding
  JOURNAL   Science 271 (5255), 1526-1533 (1996)
   PUBMED   8599108
  REMARK    Review article
REFERENCE   8  (residues 1 to 953)
  AUTHORS   Olivos-Glander,I.M., Janne,P.A. and Nussbaum,R.L.
  TITLE     The oculocerebrorenal syndrome gene product is a 105-kD protein
            localized to the Golgi complex
  JOURNAL   Am J Hum Genet 57 (4), 817-823 (1995)
   PUBMED   7573041
REFERENCE   9  (residues 1 to 953)
  AUTHORS   Benichou,S., Bomsel,M., Bodeus,M., Durand,H., Doute,M.,
            Letourneur,F., Camonis,J. and Benarous,R.
  TITLE     Physical interaction of the HIV-1 Nef protein with beta-COP, a
            component of non-clathrin-coated vesicles essential for membrane
            traffic
  JOURNAL   J Biol Chem 269 (48), 30073-30076 (1994)
   PUBMED   7982906
REFERENCE   10 (residues 1 to 953)
  AUTHORS   Duden,R., Griffiths,G., Frank,R., Argos,P. and Kreis,T.E.
  TITLE     Beta-COP, a 110 kd protein associated with non-clathrin-coated
            vesicles and the Golgi complex, shows homology to beta-adaptin
  JOURNAL   Cell 64 (3), 649-665 (1991)
   PUBMED   1840503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA725605.1, AL136593.1 and
            AA443270.1.
            
            Summary: This gene encodes a protein subunit of the coatomer
            complex associated with non-clathrin coated vesicles. The coatomer
            complex, also known as the coat protein complex 1, forms in the
            cytoplasm and is recruited to the Golgi by activated guanosine
            triphosphatases. Once at the Golgi membrane, the coatomer complex
            may assist in the movement of protein and lipid components back to
            the endoplasmic reticulum. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136593.1, AF084457.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439561.7/ ENSP00000397873.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     Protein         1..953
                     /product="coatomer subunit beta"
                     /note="beta-cop; beta coat protein; coatomer protein
                     complex subunit beta 1"
                     /calculated_mol_wt=107012
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0007744|PubMed:19413330,
                     ECO:0007744|PubMed:22223895; propagated from
                     UniProtKB/Swiss-Prot (P53618.3)"
     Region          18..550
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          96..131
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P53618.3)"
     Region          132..168
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P53618.3)"
     Region          137..161
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(153..154,157,160..161,191..192,195,207..208,211,
                     262..263,266,269..270,299..300,303,306..307,338..339,342)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          173..211
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          221..272
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          240..276
                     /region_name="HEAT 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P53618.3)"
     Region          277..314
                     /region_name="HEAT 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P53618.3)"
     Region          280..307
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          316..353
                     /region_name="HEAT 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P53618.3)"
     Region          318..342
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          396..433
                     /region_name="HEAT 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P53618.3)"
     Site            494
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIF7; propagated from
                     UniProtKB/Swiss-Prot (P53618.3)"
     Region          667..807
                     /region_name="Coatamer_beta_C"
                     /note="Coatomer beta C-terminal region; pfam07718"
                     /db_xref="CDD:462245"
     Region          813..944
                     /region_name="Coatomer_b_Cpla"
                     /note="Coatomer beta subunit appendage platform;
                     pfam14806"
                     /db_xref="CDD:434227"
     CDS             1..953
                     /gene="COPB1"
                     /gene_synonym="BARMACS; COPB"
                     /coded_by="NM_001144061.2:163..3024"
                     /db_xref="CCDS:CCDS7815.1"
                     /db_xref="GeneID:1315"
                     /db_xref="HGNC:HGNC:2231"
                     /db_xref="MIM:600959"
ORIGIN      
        1 mtaaenvcyt linvpmdsep pseislkndl ekgdvkskte alkkviimil ngeklpgllm
       61 tiirfvlplq dhtikklllv fweivpkttp dgrllhemil vcdayrkdlq hpnefirgst
      121 lrflcklkea elleplmpai raclehrhsy vrrnavlaiy tiyrnfehli pdapelihdf
      181 lvnekdasck rnafmmliha dqdraldyls tcidqvqtfg dilqlvivel iykvchanps
      241 erarfirciy nllqssspav kyeaagtlvt lssaptaika aaqcyidlii kesdnnvkli
      301 vldrlielke hpahervlqd lvmdilrvls tpdlevrkkt lqlaldlvss rnveelvivl
      361 kkeviktnnv sehedtdkyr qllvrtlhsc svrfpdmaan vipvlmefls dnneaaaadv
      421 lefvreaiqr fdnlrmlive kmlevfhaik svkiyrgalw ilgeycstke diqsvmteir
      481 rslgeipive seikkeagel kpeeeitvgp vqklvtemgt yatqsalsss rptkkeedrp
      541 plrgflldgd ffvaaslatt ltkialryva lvqekkkqns fvaeamllma tilhlgkssl
      601 pkkpitdddv drislclkvl secsplmndi fnkecrqsls hmlsakleee klsqkkesek
      661 rnvtvqpddp isfmqltakn emnckedqfq lsllaamgnt qrkeaadpla sklnkvtqlt
      721 gfsdpvyaea yvhvnqydiv ldvlvvnqts dtlqnctlel atlgdlklve kpspltlaph
      781 dfanikanvk vastengiif gnivydvsga asdrncvvls dihidimdyi qpatctdaef
      841 rqmwaefewe nkvtvntnmv dlndylqhil kstnmkcltp ekalsgycgf maanlyarsi
      901 fgedalanvs iekpihqgpd aavtghirir aksqgmalsl gdkinlsqkk tsi
//
