LOCUS       XM_047427798            2531 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript
            variant X25, mRNA.
ACCESSION   XM_047427798
VERSION     XM_047427798.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 46% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..2531
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="COP1 E3 ubiquitin ligase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 38
                     ESTs, 274 long SRA reads, 2 Proteins, and 73% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 75 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
     CDS             758..2209
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase COP1 isoform X25"
                     /protein_id="XP_047283754.1"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
                     /translation="MWPQLLESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEED
                     IKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYN
                     STLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPL
                     ATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENE
                     MTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLM
                     DPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHY
                     YDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHI
                     NEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNE
                     FVSAVCWRALPDGESNVLIAANSQGTIKVLELV"
ORIGIN      
        1 gctcgcgcgc gcgcgcacgg ccggccacgg cgcgccgggg ttggctgcta cagggaccgc
       61 ggtggcggcg gcggcctcga cagcggtagt gccttctact ccgctttttt agtttcctcc
      121 gccccctccc gtgggacgct gttgtgtggc tgccttaaaa aaaaacgcaa ctttattgtt
      181 cctcagcccc acctccggct cggcgggcgt cctcaggatg cactgaggct gaggggaggg
      241 gaggcggcgg agggtcgagg tcgcggtccc tctcctccga gcgcccggct ggaggggagg
      301 gagtcacgat gtctggtagc cgccaggccg ggtcgggctc cgctgggaca agccccgggt
      361 cctcggcggc ctcctcggtg acttccgcct cctcgtcttt atcctcttcc ccgtcgccgc
      421 cttccgtggc ggtttcggcg gcagcgctgg tgtccggcgg ggtggcccag gccgccggct
      481 cgggcggcct cgggggcccg gtgcggcctg tgttggtggc gcccgccgta tcgggtagcg
      541 gcggcggggc ggtgtccacg ggcctgtccc ggcacagctg cgcggccagg cccagcgccg
      601 gcgtaggagg cagcagctcc agcctaggca gcggcagcag gaagcgacct ctcctcgccc
      661 ccctctgcaa cgggctcatc aactcctacg aggacaaaag caacgacttc gtatgcccca
      721 tctgctttga tatgattgaa gaagcataca tgacaaaatg tggccacagc ttttggaatc
      781 acatgcagcc caactacaga ttcttatgga attcctcaag gttgcaagaa gaaataagag
      841 agagcaactg gaacagatcc agaaggagct aagtgttttg gaagaggata ttaagagagt
      901 ggaagaaatg agtggcttat actctcctgt cagtgaggat agcacagtgc ctcaatttga
      961 agctccttct ccatcacaca gtagtattat tgattccaca gaatacagcc aacctccagg
     1021 tttcagtggc agttctcaga caaagaaaca gccttggtat aatagcacgt tagcatcaag
     1081 acgaaaacga cttactgctc attttgaaga cttggagcag tgttactttt ctacaaggat
     1141 gtctcgtatc tcagatgaca gtcgaactgc aagccagttg gatgaatttc aggaatgctt
     1201 gtccaagttt actcgatata attcagtacg acctttagcc acattgtcat atgctagtga
     1261 tctctataat ggttccagta tagtctctag tattgaattt gaccgggatt gtgactattt
     1321 tgcgattgct ggagttacaa agaagattaa agtctatgaa tatgacactg tcatccagga
     1381 tgcagtggat attcattacc ctgagaatga aatgacctgc aattcgaaaa tcagctgtat
     1441 cagttggagt agttaccata agaacctgtt agctagcagt gattatgaag gcactgttat
     1501 tttatgggat ggattcacag gacagaggtc aaaggtctat caggagcatg agaagaggtg
     1561 ttggagtgtt gactttaatt tgatggatcc taaactcttg gcttcaggtt ctgatgatgc
     1621 aaaagtgaag ctgtggtcta ccaatctaga caactcagtg gcaagcattg aggcaaaggc
     1681 taatgtgtgc tgtgttaaat tcagcccctc ttccagatac catttggctt tcggctgtgc
     1741 agatcactgt gtccactact atgatcttcg taacactaaa cagccaatca tggtattcaa
     1801 aggacaccgt aaagcagtct cttatgcaaa gtttgtgagt ggtgaggaaa ttgtctctgc
     1861 ctcaacagac agtcagctaa aactgtggaa tgtagggaaa ccatactgcc tacgttcctt
     1921 caagggtcat atcaatgaaa aaaactttgt aggcctggct tccaatggag attatatagc
     1981 ttgtggaagt gaaaataact ctctctacct gtactataaa ggactttcta agactttgct
     2041 aacttttaag tttgatacag tcaaaagtgt tctcgacaaa gaccgaaaag aagatgatac
     2101 aaatgaattt gttagtgctg tgtgctggag ggcactacca gatggggagt ccaatgtgct
     2161 gattgctgct aacagtcagg gtacaattaa ggtgctagaa ttggtatgaa gggttaactc
     2221 aagtcaaatt gtacttgatc ctgctgaaat acatctgcag ctgacaatga gagaagaaac
     2281 agaaaatgtc atgtgatgtc tctccccaaa gtcatcatgg gttttggatt tgttttgaat
     2341 atttttttct ttttttcttt tccctccttt atgacctttg ggacattggg aatacccagc
     2401 caactctcca ccatcaatgt aactccatgg acattgctgc tcttggtggt gttatctaat
     2461 ttttgtgata gggaaacaaa ttcttttgaa taaaaataaa taacaaaaca ataaaagttt
     2521 attgagccac a
//
