LOCUS       XM_017002073           19646 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript
            variant X23, mRNA.
ACCESSION   XM_017002073
VERSION     XM_017002073.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017002073.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..19646
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="COP1 E3 ubiquitin ligase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 11 ESTs, 245 long SRA reads, 1 Protein, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
     CDS             117..1664
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase COP1 isoform X23"
                     /protein_id="XP_016857562.1"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
                     /translation="MLWTILTICILISWESHAAQLQILMEFLKVARRNKREEMSGLYS
                     PVSEDSTVPQFEAPSPSHSLEFSSDMHRIFVNGILIISIIDSTEYSQPPGFSGSSQTK
                     KQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRY
                     NSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDI
                     HYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWS
                     VDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCA
                     DHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
                     SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRK
                     EDDTNEFVSAVCWRALPDGYPRIAWEKQRSHLCHIQSWSHRWKFRSAKVFPTVAAANL
                     FFLYRSD"
     polyA_site      19646
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ccccatctgc tttgatatga ttgaagaagc atacatgaca aaatgtggcc acagcttttg
       61 ctacaagtgt attcatcaga gtttggagga caataataga tgtcccaagt gtaactatgt
      121 tgtggacaat attgaccatc tgtatcctaa tttcttggga atcacatgca gcccaactac
      181 agattcttat ggaattcctc aaggttgcaa gaagaaataa gagagaggaa atgagtggct
      241 tatactctcc tgtcagtgag gatagcacag tgcctcaatt tgaagctcct tctccatcac
      301 acagccttga attcagttct gatatgcaca ggatctttgt caatggaata cttattatta
      361 gtattattga ttccacagaa tacagccaac ctccaggttt cagtggcagt tctcagacaa
      421 agaaacagcc ttggtataat agcacgttag catcaagacg aaaacgactt actgctcatt
      481 ttgaagactt ggagcagtgt tacttttcta caaggatgtc tcgtatctca gatgacagtc
      541 gaactgcaag ccagttggat gaatttcagg aatgcttgtc caagtttact cgatataatt
      601 cagtacgacc tttagccaca ttgtcatatg ctagtgatct ctataatggt tccagtatag
      661 tctctagtat tgaatttgac cgggattgtg actattttgc gattgctgga gttacaaaga
      721 agattaaagt ctatgaatat gacactgtca tccaggatgc agtggatatt cattaccctg
      781 agaatgaaat gacctgcaat tcgaaaatca gctgtatcag ttggagtagt taccataaga
      841 acctgttagc tagcagtgat tatgaaggca ctgttatttt atgggatgga ttcacaggac
      901 agaggtcaaa ggtctatcag gagcatgaga agaggtgttg gagtgttgac tttaatttga
      961 tggatcctaa actcttggct tcaggttctg atgatgcaaa agtgaagctg tggtctacca
     1021 atctagacaa ctcagtggca agcattgagg caaaggctaa tgtgtgctgt gttaaattca
     1081 gcccctcttc cagataccat ttggctttcg gctgtgcaga tcactgtgtc cactactatg
     1141 atcttcgtaa cactaaacag ccaatcatgg tattcaaagg acaccgtaaa gcagtctctt
     1201 atgcaaagtt tgtgagtggt gaggaaattg tctctgcctc aacagacagt cagctaaaac
     1261 tgtggaatgt agggaaacca tactgcctac gttccttcaa gggtcatatc aatgaaaaaa
     1321 actttgtagg cctggcttcc aatggagatt atatagcttg tggaagtgaa aataactctc
     1381 tctacctgta ctataaagga ctttctaaga ctttgctaac ttttaagttt gatacagtca
     1441 aaagtgttct cgacaaagac cgaaaagaag atgatacaaa tgaatttgtt agtgctgtgt
     1501 gctggagggc actaccagat gggtatccta gaattgcatg ggagaagcaa agatcccatc
     1561 tctgtcacat ccaatcttgg agccaccggt ggaaatttag aagtgccaaa gtgtttccaa
     1621 cagtcgctgc cgcaaaccta ttctttcttt acaggagtga ttaggtactg tctcaaaccc
     1681 tcctgagtgc cacatcagga ggctctctat ggtctgttgg tcactttgga agatgtagag
     1741 actaaatcca agggagacat tagataataa gccagggttc tcatcagtct cctcagtagc
     1801 aaaagcaaag gctagaacat tctggtagtg ctcattatta attggaacat tacagctgga
     1861 gtcaaagatc tgcctcctga aaggtactgt gttctgatgt ttacagccaa attccattaa
     1921 acattgactg atttattaca atggatacaa ctcagaaata gctcatggga agagatgcat
     1981 agggcaaggt attggagagt ggcgggtgga gtacacagaa taggtctgtg ctggtgactc
     2041 ttggaaacac tttggcattt tcttcccaga tgggtaccct cctagtacct caatgttttc
     2101 accaacctgg aggccctgga acctccattt tcaacaaact ccctttggga tttatatata
     2161 ataaaatgct ataaaatatc agtttttgag ctcttttctg tttgtatatt tgcttaataa
     2221 gaatttgcta aatgaataaa ttttatctga ttaagttttc aaggacccaa atgaccaaaa
     2281 taagaactta ctgtaagact caaaatataa caaatgaggt taatttaaat caggcagtga
     2341 gtttttggag aatatgttct gtacaacaaa aaaaaagtta ctacaaaata cccttccaac
     2401 tttgacatat taacatcctt atttccttct ggctttatca gtctttctaa gtcatttaag
     2461 tctaaaaccc cagaatcatt attgttgcat ctctttattt tccatctaat tattcatcaa
     2521 atagcagtaa tgctttcttt gaaatgtctt ctatatatct ttgttttcgt ttctgctttt
     2581 catctcctca tttctgttcc ttccccttcc ccttctctcg atttacttct aacagcttta
     2641 tgtccctttc agtcggcctt tatgcactac caaatattca tctttataca gagataatca
     2701 atcaaacatt gcttgttacc tttagttgac ccaggtcttt cagaaaagtt tttttcaaat
     2761 tcagcatttg catgtacctc tatctggtat attttggcca acactaaaaa taaggggaaa
     2821 ttttgataaa tatattacct gaacttgtta gttatttaat ctatttcact tcagatatct
     2881 gtatctaatt ttaaaattat atttaccctt actattaaat atgatcctta agaaaattat
     2941 aggaaaaagt acaatagaaa aaaatactca aaggtaactc agatttcaaa atttactagt
     3001 atttagaaaa ttagccttta taataagtat agaacaatgt cgttcctata tctacttctt
     3061 aactgctcta tttcctgatc tcatgtgttt gcacttagac tatcgtatct aaactattac
     3121 attcaagatt ttcaataatc taatataatg ctatccatct aactttattt ctgttttcta
     3181 acacagttca cctacttcat taagaaagtt tcttcattgt cccatactat tcccattccg
     3241 gcttctaaac tcgtattcat gttgttcttc atattgcctt atcctcttat ttctgcttaa
     3301 ctaagttctc atcatttttt agcccaatca ctgcttctct ttccctcttt taaccatttt
     3361 atctccttgg tttctggttt ctcacagcta ttgatgaacc tatagaatgc agtctaccaa
     3421 ctgatgttca cattcatctt gaattgtttg ttatgcttca ttagtgttgc cccaggtaca
     3481 ttccttgctt caacttggag agcaaaaaaa tacaaacacc agcagctacc agagtaagag
     3541 ctacttagtt ttctaggaaa gaggagttaa agattgagtg agaataaaat ttaagtctgc
     3601 ctaacccaga gagcctactt ttatcaattt cataagatca taaatatact gactagaata
     3661 atacactagt attattacta ctagtacact gtgatactga cagtactaat atgatactaa
     3721 tagtactatc attgcttgag ataactaccc tttaactgta aagaaattaa ggttatatag
     3781 tattttagta aaagcaacta ccattcattt gtttagtgcc tatagtgtgc cagttactct
     3841 ttggttacat gctgtaaggg agaaaagatt tttctcacct gttggcttga ttcatgacgg
     3901 agacctctgt aagttttaca tgacatagaa gttttacgtg acacagaagg cttcagaaat
     3961 gaagacccaa agaatgggta aacttgtata tgtttatgct taggtttgat gaagaaatga
     4021 atagtctcat ggagaagtat gattggagga caaaggggta tgatctaatg gtaataaact
     4081 gggggcaact tagcaagacc tgtttgttga gcttcttctc tgtgtctctg tctccagaga
     4141 taagggcatt cctttcctca ggtaaggata ggcaactctg gaatgagagt cttatgacct
     4201 gcttcagtgg aagggcagag aattctttta tgacctgctt cagaggagaa gtgtgggaga
     4261 aggtcttcct gcttctgctg ttttttcaaa taccaaggtg actatttgga ggtagtgtgt
     4321 tctggtccct aacaatgctc tactgtgttt tccttgaatc ttcatacaga ttctacctaa
     4381 gagtatctgc tttatatttg gagaaattga atgtctaaaa ggattaagca gaaccaaaat
     4441 tcagatccag gtttccatgc cttgaatgta ttgctttttc tgttaacatg gtattcccca
     4501 aatagtactg aattctagaa tcagctttac cagagtagtc tggaggaaat ttgcgaatag
     4561 ctctcttaaa tatgcacggt tctatgctca gaggagctct tctcagtatt aatcagcaat
     4621 ccagtcattt ttttcccctc atacttgtca ttgtaagcac atttttctca agctttactc
     4681 agaagatcat ccagagatat taactgttaa catgtgctgc aagttgaaag tgtttagaga
     4741 gaatatttga gtgcagtgtg acaaggataa tcaagttgtt tagggccagt tggcgagaag
     4801 actttggaaa gcattgagaa aggaatgatg aatgtatgtg ttgttttgta tctaaatcct
     4861 tcttcccttg tgtatgttct tcacagcctt ttctccctga ataaggatca ctttgacttt
     4921 gtatgctaag tgtgccttct taatggttct tttcctgtta tctgaatcct gaagtatatt
     4981 taaatgagaa tttgatgcag ttagttaatt ggaatataaa agactggtta acaaaagtct
     5041 tcttaataat gaagcacacc agaaatggaa gctgctggaa ccagccatgt ggacaaatga
     5101 aaaaatgcct tttgtctaca gattgcagcg atcctacata aatatatgga ggtctctgtc
     5161 tggcttagga cagctggcta agtctgatcg ttcccctccg tacagccttt aaaactgcca
     5221 ctctaaatac ttggtttcct tgccatttta ttcagtatct gctggttatg agtactgtat
     5281 tattttttaa atgggcaacc aagtaaagtt acctctgtat ccgtctgaac tggtttttga
     5341 ggtatcttac gagttttgaa aataggtgtt atttgcttat ttaaggaacc tacaaccagg
     5401 aagtagaatg aatgtggaaa tattattctt ctcttgccga gcatggtggc tcacacctgt
     5461 aatcccagca ctttgggagg ttgaggcaga tggatcactg aatgtcagga gttcaagacc
     5521 agcctggcac caacatagtg aaatcctgtc tctactgaaa acacaaaaat tagccaggtg
     5581 tgttggcagg cgcctgtaat cccagctact tgagaggctg agacaggaga atcacatgaa
     5641 cctgggaggc gaaggttgca gtgagctgcg attgtgccat tgcactctag gctaggtgac
     5701 ggtgcgagac tccatctcaa aaaaaaaaga aaaaagaaat attattcttc taaggggcca
     5761 cattggctta acgaattcag ggttaccagt gaaggtcaat actttagata tgaaggagct
     5821 aatcagagat agcttccgtg aagattttct cattaagaaa gtgatttctc caaaatccag
     5881 tttatgtaat tttttaaggc tgtaaccaaa gttcagaaat aaccatttgc agaggaaagc
     5941 tgctgctaag tattaacctt cttagtactg aattcaaaat cttggttttt cctgttgtgt
     6001 gttttgctgt taagttgtgg ggagaggttg ctcccaccta cctcccctaa cttctacaac
     6061 ttacagcagc cacagctggg tttgtttgtt tgtttgtttg tttgtttgtt tgttttttga
     6121 gactgagtct cactgtgtca cccaggttgg agtgcagtgg cataatctca gctcactgca
     6181 acccctgcct cctgggttca agcaattctc atgcctcagc ctcctgagta gctggaatta
     6241 caggggacca ccatgcctgg ctaatttttg tatttttagt agagatgagc tttcaacggc
     6301 gcggtggctc acgccagtag tcccatcact ttgggaggct gaggcgggtg gatcacctga
     6361 ggtcaggagt ttaataccag cctgggttta tttataacta attgtatgag gatccttgtt
     6421 tgtggttctg aaatcccata tttcttaccc tgagcagttt ttgcattaga cagttgtcaa
     6481 atgagtagcc atacttttct aggcccttta gaaatccact gttctgttca ttctaatgaa
     6541 cgattttaag attttgtaag gaaggatact agtggagaag aaagaagaga tttgggatta
     6601 actgattttg aaagtgttcc tttgtgatga agaaatccca attccccaga tctcaaattg
     6661 ggattttgtg tatggggggt ggaagattgg aaggagagtg ggaatttggc ctgtcaatgc
     6721 catgtatgtt gactttggaa cactctttac cactttggtt ctgtggccaa gccttttcct
     6781 ctgttgatat tacttgaaat aatacttata gggagatata taaaagacca aattttccat
     6841 gtaacaaggc ttttaggagc ctaggtttat gacatttgaa atgtaatgta tatttataat
     6901 gtatgagaac tgaggctctc ttgtacatag tcagtgacca cccaagacac ctttcttctt
     6961 tcttccattt tgctttaata aattcaggat gaagcccaga catgtgataa gcttactggg
     7021 tcaatatgat acagatcagc attggtatat ttctcagttt tcacaagttg attcctggct
     7081 ttgctctttc ttagctgtgt gtatgaattt ggacaagtta ttaagtctaa gactatgttt
     7141 actctttgta aattgatgat aaaaatagta ccttcctcat tgggttgcca tgcagattaa
     7201 gtgaagtaat ccatataaaa ttcttaacta agtcactgac ctatagtgct caataaatat
     7261 gtgataatga aacaggtttt taagtgtttg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     7321 tgtattgcaa acacaattca gacagctaat tcactcaacc cccttggatt ttttatagaa
     7381 tgcagggaag gctaactaac attttagttt aaagaccaag accttttatt gatagattgt
     7441 agttttgtgt tcattctttc ttagacatat ttatatatat ttttaccaag tcaactctga
     7501 aagaccacat actgaaagaa aagtcaggga caaaaagaaa ctattaggct tacaaatggc
     7561 atttaaaaac ctttgaagat gatattggaa cctatgtttg aatgtctttg tatggactct
     7621 cacttggttt caaaatgcag cgtagattta tgtctaggat aaagtaaaga aacactccgg
     7681 tcaaataagg ggattcttat gatgaatcaa acccagataa gtggctgggt gcggtggctc
     7741 acgcttgtaa tcccaacact ttaggaggct gaggcgggtg ggtcacgagg tcaggagttc
     7801 gagaccagcc tgaccaacat gatgaaaccc cgtctccaaa tacaaaaatt agctgggttt
     7861 ggtggcacgc acatgtaatc ccagctactc aggaggctga agcaggagga tcacttgaac
     7921 ccgggaagcg gaggttgcag tgagccgaga ctgcaccact gcagtccagc ctgagcgaca
     7981 gagcgagact ccatctcaaa aacaaacaaa caaacaaaaa caaaacaaaa aaaaaaccca
     8041 gataagtgaa atgaatttct ctgagctcca aaaacaaaag aaatttgaat tttaaaagat
     8101 gtactagaaa gtgctttaaa taaaagaatg attctgcgtg tcaggaaatc aacagtggcc
     8161 caataggatg aagtaacaaa atgtcagcac gagtgatgaa attggacaat tgaatagtat
     8221 cacttaacaa ggcgttgaac aaagaaaaat ttaagaatcc ctatatctta tatctgtatt
     8281 tcttctcaag ggcaagggag aggatgttca taaggcaact atagatcatg catcaaaaga
     8341 agggcaaatt tatttgaaat tgttctgtgg ctgtaggatc ctgagtgaaa atcagatttg
     8401 actatacaca gagtccatga cctcctacat gaggagagaa gctattttag ttttcaggat
     8461 gcaattgcag tacaaatagt aacagcccac cctgaagaca gaaaaaaaaa atggagcaaa
     8521 agcccattct tttatgttta taatcttggt atgaaaaaga gcttaaggca ggtatggtct
     8581 tttattttca gtgacatgaa atcatctttg tatgagtgca aattaacact ctcttttctg
     8641 gcaatgagaa aacaagacat ttgtgttcat aaagagaatg cctttgtcca aataagacaa
     8701 gaggctctta tggagagaat attaaggaat taacagatat agtatagatt gtgagttttt
     8761 ttgtgtgaag cctagttacc tcaaattttt attctttata tttacttaag gaaggatatt
     8821 taaattcagc catgtttctc actgttctgt gccctccagg gagctgtatt tgcagatact
     8881 gtatgttgtt catagtgatt taccatttcc atttaatcaa atgcttgtta aaggacttaa
     8941 atggacatac aatttaaact tagtgggcac actttaagaa gaaaattcag tgattatagg
     9001 acaaattgtt taaggcagaa ctgcttataa ctttgctagc catctcagct gcagtttctg
     9061 cttttagagg acaaatgtaa atagtatttc agtgtacttt acattttctg tgtcactaat
     9121 agtgttctac cacttgaaag gggaactaaa attaaaaatc atcttctggg ctttttttcc
     9181 ccagtaaaat tttcaaggaa cttaccttcc tttgtcatga agttgtttta ggggagaaaa
     9241 catttctgat ttttgttggc ttttttttgt ttttgttttg tttttagatc cttatttagc
     9301 aaggttatgc ttttaaacat ctaagggtag agggtgggat atgtgtcatt tattaccttc
     9361 tgtcttgggg taatgttctg attgagagtg ctggagccaa gttgccaggt ttgcctccta
     9421 tcaccattaa gtattagctg taagactttg ggaaagttat ttaacctttc tgtgcctcag
     9481 tttcctcttc tgtgaaatta gattaatagt atcttgcatg taatattctg aaataaaatt
     9541 agaaaataca tggaaagtac taagaaaata gttggcacaa gataaatgat caatcagtaa
     9601 atgttgctgt catctttaac attttatata cgaatccaca taactggaca actgtacttg
     9661 tttttagttc atcaaatatt gtgcaatatg aaaatatatt ctctgcattt aagtgattta
     9721 caacctagta aatagaaata ttcataaata actatagtat gaacccaaat gaaagaaatc
     9781 tttataagat cattacccct gaaattattg accctagagg gaagacgtta cttctaactt
     9841 ggagaatgat ggaatacttt atgaagatag gggcttttga gctgggcttc ataaagatat
     9901 aaagggtttc agaagtctaa agacaaaggg aaaggaaggt acctggacaa aagaccataa
     9961 acaaacacat ctattaagta ccaaccaggc agtatactaa gtgctatctt aatttaaaat
    10021 catcatcatc aatcttttaa ggcatatatg cttgagttcc tttaaaagtg aaattgacgc
    10081 tcagatttgc ccaagattac acagctaaat aagggataca gttggaatta gaacccaggt
    10141 cgggctggct gtaaaacgta caccctttct gctatactgc agaaagctag agaacagtgt
    10201 aaacaaaggc gcagatgagg gaaagtgcaa tagatgttta agaaacttct aataaagtgt
    10261 ctaagtagga tggtggagta gggactttat tgagagatga ggccagagag tgtgctagat
    10321 attatagtct tgaatgccat actgagagaa aaaaaaaaag tttagacctt cttctgtagg
    10381 cattaaatgc ctaaagccca ctgtgaagat aatcccatga gagtattatc atagcagtgg
    10441 gtatagtgca ttgtaatgag agattaaaag tagagagtct actcaggtag gttattaaat
    10501 aatttaatta ttcagggttt tttttttctg tgttcagttt ccttctgggg aataagaata
    10561 acagaaaaca cccacatgta acattcatgt ttttcaagat gttaagtttg ccctcacata
    10621 ttaaaaaaaa tgtttatttg acgatgtttc attatattca cttcaaacaa taaatcttga
    10681 actatgtttg cggatataat cattaacttc taccttctag tacacaactt aatttttttt
    10741 ctgcttttcc aagaattcac ttatttaact taacacatgt gaattgaaga gttttgttaa
    10801 gagataggat taaaggagat gactctaggt gcccagggag ggggaggtgc ggtgagagat
    10861 ggctgaagga atagaacact ggtgggaagc aaagttcttt tctaccctct taggttctct
    10921 ggctaggtct gtgaaataaa ctgacaactg atggattaac agaaaaggca tacaaattta
    10981 tttgatattc aaagttttac atgaatcagc tgccaggggt gggttggaat agtgggggat
    11041 atctcgtaga aagaaaaccc ccaatgaaaa ggctcggttt ggaggttttt ataccattta
    11101 gacaagaaga caaatttaaa gggaagcgac aagacaaagg aaagggactt tgagcttcta
    11161 ggagtgatga acaataggaa ggcaaatatt aatatataag aaactaatgg tagataaggg
    11221 ctagttagtg aggtttgtgc agattttttc tcagtaccat ctcatctttg gtaataataa
    11281 taaggttgtt atccctttcc tggtacagga agtaactggg gtacagggaa ttcctctctt
    11341 tcacaagagg aatttattgt ctgttttcag gcagatagaa ggagagcaga aagctctcct
    11401 cagttgcttt cagctcaaaa taatctttcc accagagtag catattttgg gatggcatat
    11461 tctgatctac aacaccaaag aaaaactgct cctatctatt ttttgcataa aggcagtcac
    11521 tgacttttgt tatccataaa taaaattcac agataaatta atcttactta ttttctaacc
    11581 ctggtatgct acagtttaca tgcttacccc acctcatatt ttcatctcgt taactaatac
    11641 ataagctgct ttctccacac aatttgtcat cattccaaaa ccattttttt ttttcaaatt
    11701 tattccatgt gcatgaccgt gtccctttgc ctaacatatc catcttttct cctgtgaaat
    11761 ttcaagtttt attcttccat tgttccattt gtgacctaat ctgtgaagcc tttcttatct
    11821 tttccaagta aaggatcact ctcttcttac ttcttcagtt gcccctttga gctctataat
    11881 atattctttt tttttttttt ttttttttga gacagggtct cactctgtta cccaggctgg
    11941 aatgcagtgg cccaattcag gcccattgca gccttgacct cccaggctca ggtgatcctc
    12001 ccgcctcagc ctcccaaagt gctgggatta caggcatgag ccaccacacc cagcctattt
    12061 ctttctgtta aaagtccatt tcccctgttg gcctatggtc ttaagatcag acatcatgtc
    12121 ttattctcct ttgaaattcc aggacccagc acaattatct ggcatgtgat atctacccta
    12181 atggacggat aatgatggat gaataaagtg gcatgaaatt aataaacttc atgccaaagt
    12241 cactactgta taatgaaacg actgtgatga ttgaaagtta ttctctctgt gaatcaattt
    12301 gggagcgttt ctttatgtct tagtcagggt tctccaaagg gacagaagta ataggacatg
    12361 tatagttaga tctatgacag ggtttttatt tggggtatta gctcacatga ttacagaggg
    12421 tgagacatac catgatatgc cagggaggcc agtagcatgg cagaatctta ggctaaaggc
    12481 ctgagaattt gagggcccat tgatgcaagt cccagagtcc aaaagctgga gaatctggac
    12541 ttctgatggc caaggccagg agaagagtgt cccagctcca ggagagagga agcaaattca
    12601 cctttctgct ccctttttgt ctatccaggc ccccagctga ttggatggtg cctatccaca
    12661 ttgagggctg aacttcccca ctcagtcaac cgactcacac accagtctct tctggaaaca
    12721 ccctcacaga cttacccaga agtagtgctt tgccagttct ctaagtatcc ctttatccag
    12781 tcaagttgaa acctaaaatt acccatcaca ctgttacctt ggacatcagg agtagctttc
    12841 tggcgaagcc tctgtcaaag ccagtttcta atggctaagt tagccaggga cttataaagg
    12901 ccctttataa tgcaaacttg accatttggt ggagttgctt ttgatgttac cagtaccatc
    12961 taatgtccaa atccaataac atattattac taaacagtct tcatttcctc atgatttttg
    13021 acaattttga cttgcttctc tttcttaaac tcttctttta gcctccataa tagtcttctg
    13081 ttttgcttcc tgcccctttg ttcattttgg gctcctttgc ttgccttcct tgaactgcta
    13141 agccagaagc aattttccct cacttaaaga tcacttataa gatacatact ttatgccagg
    13201 cacttatgta tgtgtctgtt tgatcataaa aatggttctg ttagcttagt tttattagca
    13261 ttgttttata gttatggaga ctgagattca gagaggtcaa gtaacttgcc cataatgaaa
    13321 agtctagaag cgttagagct ttgaattgaa atctttcaga ctccaaagac atttaatcta
    13381 ctctgtcact ctgtctatgt tttgtccacc tgttaatttg attttaggaa tacagattgt
    13441 cgtatataaa ttctggtcca tttcctcctg aaaaccagtt actggcattt ccatgaatat
    13501 agaaaactct gtaaaattgt tttttctata agagaagcct acagacctct cttaggtgat
    13561 gaagaggctt agaattgaat atcaaatttg gcttgccact taaaacagaa tggagtctca
    13621 agttgcaagt agggttgttt gttaaacctg aaacacaaaa caagataaag ggaggatata
    13681 accaccaaat agaaaacttt tgactctgta cattttgaga aagccctgaa gatgtatttg
    13741 atctattata caattcaggt ttacattaat gatggtaatt tacctagaaa gatttcacac
    13801 ctgataatag tagttgactc tctagggaga tgagagacac tcagttttcc cctactcttt
    13861 tgtactgtgt gaatttttac cacatgtgta tattatctat tcaagttaac caataaacat
    13921 atttttctaa ataagagaaa ggtatctagg tagtccttaa gggatccatt atttattatc
    13981 cccattttta atccaaccat cttgctaaac tctcttatta attttaatta ttcatttcta
    14041 cgttccttgg atttttttat gcacacaatt aattcatcca caaataatta aagtttagtg
    14101 tctgcttttc cagtacttat acctttatat ctttattcat ttgccgtatt ttgatggcca
    14161 gaacatctaa tgtaatgtta aataaaagta atggtatctg gcatcgttga cttgttcctc
    14221 accaaaggga aagcttttaa agatgttatc attaagtatg tctgctgtaa gagttttgta
    14281 gatacatacc cttacaaaga agtttccttc agttctcaat gtgctgagag ttcttaccat
    14341 aaatgaatgc taaagtatat tactgctttt ttgtacctat ttaacatgat ataatatttt
    14401 tctttcaaat attgatctag taggtgaaat ttttttttaa cctaatatta aaccaacttt
    14461 acattcgctg gaataagccc aacttggtca agatttattc tccttatata ttgttaaaat
    14521 caacttgcta ctattttgtt taggattttt tcatttgtct ttatgaataa cattggccta
    14581 taatcttttc cttttttgca ttgtccatgt caggttttga tttcatgggt atattaactt
    14641 cataaagcaa attaaggagt tctttcctcc tttgatgtgg aaaaatttgt gtaatacgaa
    14701 attatttctt tcttgaatat tggctgaact cgtagatgaa gtcatgtaag cctgaggtag
    14761 aaatattttt gactgtcgat ttatgaattt aatacctgta ggatgattct tgctttctat
    14821 ttcttcttga ttagttgggt aagtttttat aggaattttt ccacttggct taaatattaa
    14881 aatttattaa cataaagtct tttcagtttc ttttttctat aacattattt attctcattc
    14941 tgagggaagt catcaattta acgtaatgct taacatttgg agaaataaat tttaaagaag
    15001 ggttatattc tgattttgtt taatagttat cttctggtta ataaaaggag gagaaatgta
    15061 gggtggaaat gcttatcata gtaaatagca aggtttatat ataaaaccat ctatattgaa
    15121 cagggagaga ggaatgacaa aaatatttac ctttcttttt gataattcag tgccttattt
    15181 tgggggaaat atttagcttc atagctgaaa tggctttgat attatacctg aatggttaca
    15241 gagatctcat aaatatagta gtgataaggg gtttatatat tatgttggga aatcagaaaa
    15301 tatttaaatc atgaataatg acttttaatt gttaaagacc aatattgagt ttaaagttaa
    15361 cttataaaat acgtatttgt tcttgtgtgt ttgttcccag ctttttaaaa ttgatattat
    15421 tgaaatataa tttacataaa tataaactac atacatttta agagtattca gtgaattttt
    15481 acaagtgtat acatcagtat aactactacc ttaattcagt tataacaaca ttttcatcac
    15541 ccaaaaagtt accttgtgtc actttgtaat cagtcccctc ccttctccac tacaagctac
    15601 tgctaatcca ctttatgtta tcataagtta agttttgctt attctaggat ttcatataac
    15661 aggaatgata cagtatgtaa ttttttgcac ctggctcctt ttatttagca tgatactttg
    15721 aaatgcttgt gttattgcct gtatctgtag ttccttctta ttagtaatcc attttataac
    15781 tatgcaacaa attttgtatc tattcaccaa tctttaatat tgcccttgtt tccagttttg
    15841 aactattttt aataaagccg ctgtaaacat tcataaataa gtgtttatgt gactatatac
    15901 catcatttct tttggataaa tacctaggag tggcattatg agattgtaga gtagttgtaa
    15961 gtttagcctt ataagaaact gtcaaacctt tttccatagt tgttgtatta cattcattgg
    16021 tcacttaaca atggggatac gttttgagaa atgccattag gtgatttgat ttcatcattg
    16081 cacaaacatc atagagtgta cttcccaaac ctggatggta tagcctagta cataccttag
    16141 ctatgtggta tagcctgttg ctcctaggct acaaatttgt acagcatgtt actacactga
    16201 atagtgtagg cagttgtaac acaatgggat ttgtgtatct aaacacagaa aagctatagt
    16261 aaaaatacaa tataaaaggt aaaaaatggt acacctgcct agggcattac catgaatgga
    16321 gcttggtgga gtagaagctg ctctcggtga gtcagggagt gagtggtgag tgaacgtgaa
    16381 gacccagaca ttattgtaca ttactgtaga ctttatcaac actgtatacc taagctacac
    16441 taatttattt taaaatgttt tctttcttca ataataaatt aactatagtt tactgtaact
    16501 ttttacttta taattttaat ttttttcact ttttgactct tttgtaataa cttttagctt
    16561 aaaacacaaa cacattgtac agctgtacag atttttcctt attctgtaag ctttcttcca
    16621 tttttaaatg tatttattta tttttacttt ttaaacattt tttgttaagc tcatcaacat
    16681 cactgtcttc tacatcttgt cccatcggaa tgtcttcagg gacaataaca cacatagagc
    16741 tgtcatctcc tatggtaaca atgctttctt ctggagtatc tcctgaagga cctgcctgag
    16801 cctattttac agtaactttt tttgttaata agtagaagga gtataatcta aattaatgat
    16861 taagaagtat agtacaataa tcttattgga ccaccatcat atatgtgacc catcgttgac
    16921 caaaatgtca ttgtgcagtg catgactata ttttgcactc ctgccagcat cctaaaatca
    16981 ttccatttgt tacatatttt tgccaacact tgatattgtc actttaagaa aaagatttag
    17041 ttgttctagt aagtgtggat ggtattttaa aatttttgat gaagtccaat ttatcagggt
    17101 tttttttttc ctttattgta catgtttttt gcatcctaaa aaatagttgc caacccaaag
    17161 attttctctg attttttttc ttgaagtttt attgtttcag cttttacatg tatgtcttag
    17221 atctatttag aattaatttt gggaatggta tgatagaagg attgaagttt acttttttct
    17281 gtatatacag ttgttttagc acacatatgg ttgtttcaca tacctgcagt tgtttcaaca
    17341 gcatttgtaa aaattactct attttttttt taacttgcca agttgttttg aaattcagtt
    17401 gattatggat ggatctgttt ctggaatttc ttttctgtgc ctttgattta tatgtctatc
    17461 ctaataatac tacactgtat tgattcctaa tgcttttatt aacagtagaa cttcaaatca
    17521 tgttgtgtaa gtccctagtt ttattttttc tttttcaaaa ttattttaac tattataatg
    17581 tctttgcttt ttcatttaaa tttttgaatc actttgccag tttctactag aaaagtttgt
    17641 atgattttaa ttggaattgc attgagccta tagataatgt aagaagaatt ggcattgtga
    17701 cactattgag tctctggtct atgaacatgg tataactgtc aatttattta ggtattcttt
    17761 aacatctcta agcattgttt ggtaattttt agtatgtagg ccgtgtgtgt gtgtgtgtgt
    17821 gtgtgtgtgt gtgtgtggtt tgtctctaaa tgattcatgc tttttatggt actataaatg
    17881 gtatttttta aattctattt gcttatcatt tattgttagt ttatggaagt gaactgattt
    17941 tggtataatt gactttgtgt ctgacaatct tgctgaagac aatttattta ttctagtggc
    18001 ttatttttaa ggtacattag gattttccac ataggccatc atctcttttg caaatgaaga
    18061 cagttttctt ttttcagatc catatgcttt ttccttttct tgactgtcgc actgggttgt
    18121 acctctaata cagtgttgaa tacaaatggt gagagaaagc atgttcacct tgttcctagt
    18181 ctgagagaga aagggttcag tatttcacca ctaagtatga tgttagttgt aagtttttca
    18241 taggtattcc ttatcacctt gaagaagttc ctttctattc ttagtttgct gaagggatga
    18301 tgaatgctct caagtgcatt ttctgtgttg tgattacatt actttttctt ttttttgttt
    18361 tgaggcaggg tctcactcct gtcacccagg cgagagtaca gtgacacaat cacagctcac
    18421 tacagccttc ccaggctcag gtgattctcc cacctcaacc ttctgggtag ctgggactac
    18481 aggtgcatgc caccacaccc atctaatttt ttgtgttttt gatagagagg gtttcgccat
    18541 attgcccagg ctggtctcac actcctggac tcaagcaatc cacctgcctt agcttcccag
    18601 agtgctatca caggcatgag ccaccctacc tggccttttc tattctcttt acatagtgaa
    18661 ttatatatat atatttttta atgttgaaaa ccaattttaa tatctggatg aattccattt
    18721 agacatgatg cattattctt tttgtatatg actgaattat ctttacttgt attttgttaa
    18781 ggttttttac atctgtttat aaaagtagtt ggtaatttta tttgtttttg taatgtcttt
    18841 ctctggtttt gtttgattta caagctgagt ttggaaatgt tccttagtct tcatttttaa
    18901 caactttttc tttcttctgt cataattggg aatttgtatc tttcatagaa tttgttcatt
    18961 tcattacctg tcagttttat tgacatacaa ttgttcatgt ttattttcta attattcttt
    19021 taatatctat agaatatcta gtgatatccc ataatttatt actgatattg ttaacttaca
    19081 ttttcttttt gttaaggcgt atcaatttta ttgatttttt tcaatgaatt aacttttcat
    19141 ttcaatactt ttttaccttt ttctggtttt attttgattt ctgctcttca tgactgtcat
    19201 tcttgtactt acgtcatgtg taacttgctc ttttcctagc ttcttaaggt gcaagttact
    19261 atatcattaa tgttcaacct tcctgcttta ctaataagta ttggaagcta taactttcta
    19321 ggcattgttt taggtgcatt acacaaattt tgatatgttg catttttatt atcttttagt
    19381 tcaaaatggt ttctcatttc catccctggg ttatttggga gtatattttt aaatttgcaa
    19441 atacttgtgg atttttccag atttcttttt gttattcttt tctactttag ttctgtttct
    19501 tcagagaaca tacttgtatg attttagccc tttaaattta ctgtgatttg ttttatggtc
    19561 tgacacatct ttgttgggga ctagtacgca tgcatttgaa aagaatgtgt attctgtcat
    19621 ttaaataaaa ctttctgtaa atgtca
//
